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Items: 1 to 20 of 33

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
A TBR1-K228E Mutation Induces Tbr1 Upregulation, Altered Cortical Distribution of Interneurons, Increased Inhibitory Synaptic Transmission, and Autistic-Like Behavioral Deficits in Mice
Chaehyun Yook, Kyungdeok Kim, Doyoun Kim, Hyojin Kang, Sun-Gyun Kim, Eunjoon Kim, Soo Young Kim
Front Mol Neurosci. 2019; 12: 241. Published online 2019 Oct 9. doi: 10.3389/fnmol.2019.00241
PMCID:
PMC6797848
AbstractArticlePDF–6.4M
3.
microRNA-142–mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance
Nelomi Anandagoda, Joanna C.D. Willis, Arnulf Hertweck, Luke B. Roberts, Ian Jackson, M. Refik Gökmen, Richard G. Jenner, Jane K. Howard, Graham M. Lord
J Clin Invest. 2019 Mar 1; 129(3): 1257–1271. Published online 2019 Feb 11. doi: 10.1172/JCI124725
PMCID:
PMC6391082
AbstractArticlePDF–8.2M
4.
Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance
Wenmin Xia, Ariane R. Pessentheiner, Dina C. Hofer, Melina Amor, Renate Schreiber, Gabriele Schoiswohl, Thomas O. Eichmann, Evelyn Walenta, Bianca Itariu, Gerhard Prager, Hubert Hackl, Thomas Stulnig, Dagmar Kratky, Thomas Rülicke, Juliane G. Bogner-Strauss
Cell Rep. Author manuscript; available in PMC 2019 Feb 26.
Published in final edited form as: Cell Rep. 2018 May 15; 23(7): 1948–1961. doi: 10.1016/j.celrep.2018.04.055
PMCID:
PMC6390945
AbstractArticlePDF–2.1M
5.
A pathophysiological role of PDE3 in allergic airway inflammation
Jan Beute, Melanie Lukkes, Ewout P. Koekoek, Hedwika Nastiti, Keerthana Ganesh, Marjolein J.W. de Bruijn, Steve Hockman, Menno van Nimwegen, Gert-Jan Braunstahl, Louis Boon, Bart N. Lambrecht, Vince C. Manganiello, Rudi W. Hendriks, Alex KleinJan
JCI Insight. 2018 Jan 25; 3(2): e94888. Published online 2018 Jan 25. doi: 10.1172/jci.insight.94888
PMCID:
PMC5821178
AbstractArticlePDF–5.7M
6.
White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function
Youn Wook Chung, Faiyaz Ahmad, Yan Tang, Steven C. Hockman, Hyun Jung Kee, Karin Berger, Emilia Guirguis, Young Hun Choi, Dan M. Schimel, Angel M. Aponte, Sunhee Park, Eva Degerman, Vincent C. Manganiello
Sci Rep. 2017; 7: 40445. Published online 2017 Jan 13. doi: 10.1038/srep40445
PMCID:
PMC5234021
AbstractArticlePDF–1.9M
7.
Targeting CAG repeat RNAs reduces Huntington’s disease phenotype independently of huntingtin levels
Laura Rué, Mónica Bañez-Coronel, Jordi Creus-Muncunill, Albert Giralt, Rafael Alcalá-Vida, Gartze Mentxaka, Birgit Kagerbauer, M. Teresa Zomeño-Abellán, Zeus Aranda, Veronica Venturi, Esther Pérez-Navarro, Xavier Estivill, Eulàlia Martí
J Clin Invest. 2016 Nov 1; 126(11): 4319–4330. Published online 2016 Oct 10. doi: 10.1172/JCI83185
PMCID:
PMC5096913
AbstractArticlePDF–1.2M
8.
Hypothalamic phosphodiesterase-3B pathway mediates anorectic and body weight reducing effects of insulin in male mice
Maitrayee Sahu, Prashanth Anamthathmakula, Abhiram Sahu
Neuroendocrinology. Author manuscript; available in PMC 2018 Jan 1.
Published in final edited form as: Neuroendocrinology. 2017; 104(2): 145–156. Published online 2016 Mar 23. doi: 10.1159/000445523
PMCID:
PMC5035167
AbstractArticlePDF–759K
9.
Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue
Faiyaz Ahmad, Youn Wook Chung, Yan Tang, Steven C. Hockman, Shiwei Liu, Yusuf Khan, Kevin Huo, Eric Billings, Marcelo J. Amar, Alan T. Remaley, Vincent C. Manganiello
Sci Rep. 2016; 6: 28056. Published online 2016 Jun 20. doi: 10.1038/srep28056
PMCID:
PMC4913246
AbstractArticlePDF–1.7M
10.
Leptin receptor expressing neurons express phosphodiesterase-3B (PDE3B) and leptin induces STAT3 activation in PDE3B neurons in the mouse hypothalamus
Maitrayee Sahu, Abhiram Sahu
Peptides. Author manuscript; available in PMC 2016 Nov 1.
Published in final edited form as: Peptides. 2015 Nov; 73: 35–42. Published online 2015 Aug 20. doi: 10.1016/j.peptides.2015.08.011
PMCID:
PMC4641794
AbstractArticlePDF–903K
11.
The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin
Lisa M. DiPilato, Faiyaz Ahmad, Matthew Harms, Patrick Seale, Vincent Manganiello, Morris J. Birnbaum
Mol Cell Biol. 2015 Aug; 35(16): 2752–2760. Prepublished online 2015 Jun 1. Published online 2015 Jul 20. doi: 10.1128/MCB.00422-15
PMCID:
PMC4508315
AbstractArticlePDF–446K
12.
Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury
Youn Wook Chung, Claudia Lagranha, Yong Chen, Junhui Sun, Guang Tong, Steven C. Hockman, Faiyaz Ahmad, Shervin G. Esfahani, Dahae H. Bae, Nazari Polidovitch, Jian Wu, Dong Keun Rhee, Beom Seob Lee, Marjan Gucek, Mathew P. Daniels, Christine A. Brantner, Peter H. Backx, Elizabeth Murphy, Vincent C. Manganiello
Proc Natl Acad Sci U S A. 2015 Apr 28; 112(17): E2253–E2262. Published online 2015 Apr 15. doi: 10.1073/pnas.1416230112
PMCID:
PMC4418886
AbstractArticlePDF–1.3M
13.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
14.
Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1
Jonathan Mowers, Maeran Uhm, Shannon M Reilly, Joshua Simon, Dara Leto, Shian-Huey Chiang, Louise Chang, Alan R Saltiel
eLife. 2013; 2: e01119. Published online 2013 Dec 24. doi: 10.7554/eLife.01119
PMCID:
PMC3869376
AbstractArticlePDF–2.5M
15.
EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
Haruya Ohno, Kosaku Shinoda, Kana Ohyama, Louis Z. Sharp, Shingo Kajimura
Nature. Author manuscript; available in PMC 2014 Jun 5.
Published in final edited form as: Nature. 2013 Dec 5; 504(7478): 163–167. Published online 2013 Nov 6. doi: 10.1038/nature12652
PMCID:
PMC3855638
AbstractArticlePDF–1.8M
16.
Regulation of the Pro-inflammatory Cytokine Osteopontin by GIP in Adipocytes - A role for the Transcription Factor NFAT and Phosphodiesterase 3B
Bilal Omar, Elin Banke, Emilia Guiguis, Lina Åkesson, Vincent Manganiello, Valeriya Lyssenko, Leif Groop, Maria F. Gomez, Eva Degerman
Biochem Biophys Res Commun. Author manuscript; available in PMC 2013 Sep 7.
Published in final edited form as: Biochem Biophys Res Commun. 2012 Sep 7; 425(4): 812–817. Published online 2012 Aug 7. doi: 10.1016/j.bbrc.2012.07.157
PMCID:
PMC3759516
AbstractArticlePDF–1.5M
17.
A Role for Phosphodiesterase 3B in Acquisition of Brown Fat Characteristics by White Adipose Tissue in Male Mice
Emilia Guirguis, Steven Hockman, Youn Wook Chung, Faiyaz Ahmad, Oksana Gavrilova, Nalini Raghavachari, Yanqin Yang, Gang Niu, Xiaoyuan Chen, Zu Xi Yu, Shiwei Liu, Eva Degerman, Vincent Manganiello
Endocrinology. 2013 Sep; 154(9): 3152–3167. Published online 2013 Jun 13. doi: 10.1210/en.2012-2185
PMCID:
PMC3749478
AbstractArticle
18.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
19.
Ablation of Calcineurin Aβ Reveals Hyperlipidemia and Signaling Cross-talks with Phosphodiesterases
Hee Yun Suk, Chen Zhou, Teddy T. C. Yang, Hong Zhu, Raymond Y. L. Yu, Opeyemi Olabisi, XiaoYong Yang, Deborah Brancho, Ja-Young Kim, Philipp E. Scherer, Philippe G. Frank, Michael P. Lisanti, John W. Calvert, David J. Lefer, Jeffery D. Molkentin, Alessandra Ghigo, Emilio Hirsch, Jianping Jin, Chi-Wing Chow
J Biol Chem. 2013 Feb 1; 288(5): 3477–3488. Published online 2012 Dec 20. doi: 10.1074/jbc.M112.419150
PMCID:
PMC3561567
AbstractArticlePDF–2.2M
20.
Integrating Cardiac PIP3 and cAMP Signaling through a PKA Anchoring Function of p110γ
Alessia Perino, Alessandra Ghigo, Enrico Ferrero, Fulvio Morello, Gaetano Santulli, George S. Baillie, Federico Damilano, Allan J. Dunlop, Catherine Pawson, Romy Walser, Renzo Levi, Fiorella Altruda, Lorenzo Silengo, Lorene K. Langeberg, Gitte Neubauer, Stephane Heymans, Giuseppe Lembo, Matthias P. Wymann, Reinhard Wetzker, Miles D. Houslay, Guido Iaccarino, John D. Scott, Emilio Hirsch
Mol Cell. Author manuscript; available in PMC 2012 Jan 24.
Published in final edited form as: Mol Cell. 2011 Apr 8; 42(1): 84–95. doi: 10.1016/j.molcel.2011.01.030
PMCID:
PMC3265115
AbstractArticlePDF–2.7M

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