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Select item 106980001.

Microbial products linked to steatohepatitis are reduced by deletion of nuclear hormone receptor SHP in mice

Ryan Mifflin, Jung Eun Park, Mikang Lee, Prasant Kumar Jena, Yu-Jui Yvonne Wan, Hazel A. Barton, Mirjavid Aghayev, Takhar Kasumov, Li Lin, Xinwen Wang, Robert Novak, Feng Li, He Huang, Leah P. Shriver, Yoon-Kwang Lee

J Lipid Res. 2023 Dec; 64(12): 100469. Published online 2023 Nov 2. doi: 10.1016/j.jlr.2023.100469

PMCID:: PMC10698000

Abstract Article PDF–3.8M

Select item 106659422.

Deletion of hepatic small heterodimer partner ameliorates development of nonalcoholic steatohepatitis in mice

Yoon-Kwang Lee, Jung Eun Park, Mikang Lee, Ryan Mifflin, Yang Xu, Robert Novak, Yanqiao Zhang, James P. Hardwick

J Lipid Res. 2023 Nov; 64(11): 100454. Published online 2023 Oct 10. doi: 10.1016/j.jlr.2023.100454

PMCID:: PMC10665942

Abstract Article PDF–2.3M

Select item 103596373.

Transgenic mice lacking FGF15/19-SHP phosphorylation display altered bile acids and gut bacteria, promoting nonalcoholic fatty liver disease

Young-Chae Kim, Ming Qi, Xingchen Dong, Sunmi Seok, Hao Sun, Byron Kemper, Ting Fu, Jongsook Kim Kemper

J Biol Chem. 2023 Aug; 299(8): 104946. Published online 2023 Jun 20. doi: 10.1016/j.jbc.2023.104946

PMCID:: PMC10359637

Abstract Article PDF–3.2M

Select item 102901024.

NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation

Isidoro Cobo, Sumit Paliwal, Cristina Bodas, Irene Felipe, Júlia Melià-Alomà, Ariadna Torres, Jaime Martínez-Villarreal, Marina Malumbres, Fernando García, Irene Millán, Natalia del Pozo, Joo-Cheol Park, Ray J. MacDonald, Javier Muñoz, Raúl Méndez, Francisco X. Real

Nat Commun. 2023; 14: 3761. Published online 2023 Jun 23. doi: 10.1038/s41467-023-39291-x

PMCID:: PMC10290102

Abstract Article PDF–3.4M

Select item 91133605.

Loss of Hepatic Small Heterodimer Partner Elevates Ileal Bile Acids and Alters Cell Cycle-related Genes in Male Mice

Ryan Philip Henry Shaw, Peter Kolyvas, Nathanlown Dang, Angela Hyon, Keith Bailey, Sayeepriyadarshini Anakk

Endocrinology. 2022 Jun; 163(6): bqac052. Published online 2022 Apr 22. doi: 10.1210/endocr/bqac052

Correction in:: Endocrinology. 2024 Apr; 165(4): bqae027.

PMCID:: PMC9113360

Abstract Article

Select item 84100146.

The role of SHP/REV-ERBα/CYP4A axis in the pathogenesis of alcohol-associated liver disease

Zhihong Yang, Rana V. Smalling, Yi Huang, Yanchao Jiang, Praveen Kusumanchi, Will Bogaert, Li Wang, Don A. Delker, Nicholas J. Skill, Sen Han, Ting Zhang, Jing Ma, Nazmul Huda, Suthat Liangpunsakul

JCI Insight. 2021 Aug 23; 6(16): e140687. Published online 2021 Aug 23. doi: 10.1172/jci.insight.140687

PMCID:: PMC8410014

Abstract Article PDF–11M

Select item 83539527.

FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption

Bethan L. Clifford, Leslie R. Sedgeman, Kevin J. Williams, Pauline Morand, Angela Cheng, Kelsey E. Jarrett, Alvin P. Chan, Madelaine C. Brearley-Sholto, Annika Wahlström, Julianne W. Ashby, William Barshop, James Wohlschlegel, Anna C. Calkin, Yingying Liu, Anders Thorell, Peter J. Meikle, Brian G. Drew, Julia J. Mack, Hanns-Ulrich Marschall, Elizabeth J. Tarling, Peter A. Edwards, Thomas Q. de Aguiar Vallim

Cell Metab. Author manuscript; available in PMC 2022 Aug 3.

Published in final edited form as: Cell Metab. 2021 Aug 3; 33(8): 1671–1684.e4. Published online 2021 Jul 15. doi: 10.1016/j.cmet.2021.06.012

PMCID:: PMC8353952

Abstract Article PDF–3.1M

Select item 82566328.

Deletion of Intestinal SHP Impairs Short-term Response to Cholic Acid Challenge in Male Mice

James T Nguyen, Ryan Riessen, Tongyu Zhang, Collin Kieffer, Sayeepriyadarshini Anakk

Endocrinology. 2021 Aug; 162(8): bqab063. Published online 2021 Mar 26. doi: 10.1210/endocr/bqab063

PMCID:: PMC8256632

Abstract Article

Select item 80599219.

Nuclear receptors FXR and SHP regulate protein N-glycan modifications in the liver

Bhoomika Mathur, Asif Shajahan, Waqar Arif, Qiushi Chen, Nicholas J. Hand, Lara K. Abramowitz, Kristina Schoonjans, Daniel J. Rader, Auinash Kalsotra, John A. Hanover, Parastoo Azadi, Sayeepriyadarshini Anakk

Sci Adv. 2021 Apr; 7(17): eabf4865. Published online 2021 Apr 21. doi: 10.1126/sciadv.abf4865

PMCID:: PMC8059921

Abstract Article PDF–909K

Select item 768635010.

Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A

Young-Chae Kim, Sunmi Seok, Yang Zhang, Jian Ma, Bo Kong, Grace Guo, Byron Kemper, Jongsook Kim Kemper

Nat Commun. 2020; 11: 5969. Published online 2020 Nov 24. doi: 10.1038/s41467-020-19803-9

PMCID:: PMC7686350

Abstract Article PDF–2.0M

Select item 726384311.

Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis

Kang Ho Kim, Jong Min Choi, Feng Li, Armando Arizpe, Clavia Ruth Wooton-Kee, Sayeepriyadarshini Anakk, Sung Yun Jung, Milton J Finegold, David D Moore

Endocrinology. 2018 Jun; 159(6): 2435–2446. Published online 2018 Apr 26. doi: 10.1210/en.2018-00110

PMCID:: PMC7263843

Abstract Article

Select item 698384412.

Disruption of hepatic small heterodimer partner induces dissociation of steatosis and inflammation in experimental nonalcoholic steatohepatitis

Nancy Magee, An Zou, Priyanka Ghosh, Forkan Ahamed, Don Delker, Yuxia Zhang

J Biol Chem. 2020 Jan 24; 295(4): 994–1008. Published online 2019 Dec 12. doi: 10.1074/jbc.RA119.010233

PMCID:: PMC6983844

Abstract Article PDF–5.8M

Select item 667204813.

The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation

Shengyi Sun, Sherwin Kelekar, Steven A. Kliewer, David J. Mangelsdorf

Genes Dev. 2019 Aug 1; 33(15-16): 1083–1094. doi: 10.1101/gad.326868.119

PMCID:: PMC6672048

Abstract Article PDF–7.3M

Select item 654958214.

Small Heterodimer Partner Regulates Dichotomous T Cell Expansion by Macrophages

Sayyed Hamed Shahoei, Young-Chae Kim, Samuel J Cler, Liqian Ma, Sayeepriyadarshini Anakk, Jongsook K Kemper, Erik R Nelson

Endocrinology. 2019 Jul; 160(7): 1573–1589. Published online 2019 May 3. doi: 10.1210/en.2019-00025

PMCID:: PMC6549582

Abstract Article

Select item 640919615.

Small Heterodimer Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse Intestine and Cholesterol Absorption

Young-Chae Kim, Sangwon Byun, Sunmi Seok, Grace Guo, H. Eric Xu, Byron Kemper, Jongsook Kim Kemper

Gastroenterology. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: Gastroenterology. 2019 Mar; 156(4): 1052–1065. Published online 2018 Dec 3. doi: 10.1053/j.gastro.2018.11.061

PMCID:: PMC6409196

Abstract Article PDF–1.3M

Select item 627609416.

Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity

Tianpeng Zhang, Fangjun Yu, Lianxia Guo, Min Chen, Xue Yuan, Baojian Wu

Theranostics. 2018; 8(19): 5246–5258. Published online 2018 Oct 22. doi: 10.7150/thno.28676

PMCID:: PMC6276094

Abstract Article PDF–1.7M

Select item 618909717.

Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation

Jung-Ran Noh, Yong-Hoon Kim, Don-Kyu Kim, Jung Hwan Hwang, Kyoung-Shim Kim, Dong-Hee Choi, Seon-Jin Lee, Hee Gu Lee, Tae Geol Lee, Hong-Lei Weng, Steven Dooley, Hueng-Sik Choi, Chul-Ho Lee

Sci Rep. 2018; 8: 15222. Published online 2018 Oct 15. doi: 10.1038/s41598-018-33660-z

PMCID:: PMC6189097

Abstract Article PDF–6.1M

Select item 598620618.

Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis

An Zou, Nancy Magee, Fengyan Deng, Sarah Lehn, Cuncong Zhong, Yuxia Zhang

J Biol Chem. 2018 Jun 1; 293(22): 8656–8671. Published online 2018 Apr 17. doi: 10.1074/jbc.RA117.001653

PMCID:: PMC5986206

Abstract Article PDF–4.2M

Select item 595342319.

Diet-dependent retinoid effects on liver gene expression include stellate and inflammation markers and parallel effects of the nuclear repressor, Shp

Meghan Maguire, Justin R. Bushkofsky, Michele Campaigne Larsen, Yee Hoon Foong, Sherry A. Tanumihardjo, Colin R. Jefcoate

J Nutr Biochem. Author manuscript; available in PMC 2018 May 15.

Published in final edited form as: J Nutr Biochem. 2017 Sep; 47: 63–74. Published online 2017 Apr 19. doi: 10.1016/j.jnutbio.2017.04.009

PMCID:: PMC5953423

Abstract Article PDF–819K

Select item 587273920.

ChREBP Rather Than SHP Regulates Hepatic VLDL Secretion

Hiroyuki Niwa, Katsumi Iizuka, Takehiro Kato, Wudelehu Wu, Hiromi Tsuchida, Ken Takao, Yukio Horikawa, Jun Takeda

Nutrients. 2018 Mar; 10(3): 321. Published online 2018 Mar 7. doi: 10.3390/nu10030321

PMCID:: PMC5872739

Abstract Article PDF–845K

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