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Items: 1 to 20 of 41

1.
METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib resistance by inhibiting PTPN13 expression
Wei Peng, Jia Fu, Lijun Zhou, Huaxin Duan
Cancer Med. 2024 Jul; 13(13): e7420. Published online 2024 Jul 5. doi: 10.1002/cam4.7420
PMCID:
PMC11225164
AbstractArticlePDF–9.8M
2.
Structural basis of regulated m7G tRNA modification by METTL1-WDR4
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P. Nowak, Thibault Viennet, Esteban Orellana, Shourya S. Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric Fischer, Richard I. Gregory
Nature. Author manuscript; available in PMC 2024 Jun 15.
Published in final edited form as: Nature. 2023 Jan; 613(7943): 391–397. Published online 2023 Jan 4. doi: 10.1038/s41586-022-05566-4
PMCID:
PMC11179147
AbstractArticlePDF–5.7M
3.
METTL1-mediated tRNA m7G methylation and translational dysfunction restricts breast cancer tumorigenesis by fueling cell cycle blockade
Dan Du, Mingxia Zhou, Chenxi Ju, Jie Yin, Chang Wang, Xinyu Xu, Yunqing Yang, Yun Li, Le Cui, Zhengyang Wang, Yuqing Lei, Hongle Li, Fucheng He, Jing He
J Exp Clin Cancer Res. 2024; 43: 154. Published online 2024 May 31. doi: 10.1186/s13046-024-03076-x
PMCID:
PMC11140866
AbstractArticlePDF–17M
4.
QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism
Zhicong Zhao, Ying Qing, Lei Dong, Li Han, Dong Wu, Yangchan Li, Wei Li, Jianhuang Xue, Keren Zhou, Miao Sun, Brandon Tan, Zhenhua Chen, Chao Shen, Lei Gao, Andrew Small, Kitty Wang, Keith Leung, Zheng Zhang, Xi Qin, Xiaolan Deng, Qiang Xia, Rui Su, Jianjun Chen
Cell. Author manuscript; available in PMC 2024 Jul 20.
Published in final edited form as: Cell. 2023 Jul 20; 186(15): 3208–3226.e27. Published online 2023 Jun 27. doi: 10.1016/j.cell.2023.05.047
PMCID:
PMC10527483
AbstractArticlePDF–4.0M
5.
P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC
Mingpeng Zhang, Duo Kan, Boya Zhang, Xueqiao Chen, Chun Wang, Songmao Chen, Wenlong Gao, Zhao Yang, Yang Li, Yutong Chen, Shimiao Zhu, Simeng Wen, Yuanjie Niu, Zhiqun Shang
J Exp Clin Cancer Res. 2023; 42: 215. Published online 2023 Aug 21. doi: 10.1186/s13046-023-02777-z
PMCID:
PMC10440916
AbstractArticlePDF–4.3M
6.
METTL1 gene polymorphisms and Wilms tumor susceptibility in Chinese children: A five-center case-control study
Linqing Deng, Ruixi Hua, Zhengtao Zhang, Jinhong Zhu, Jiao Zhang, Jiwen Cheng, Suhong Li, Haixia Zhou, Guochang Liu, Jing He, Wen Fu
Chin Med J (Engl) 2023 Jul 20; 136(14): 1750–1752. Published online 2023 May 26. doi: 10.1097/CM9.0000000000002739
PMCID:
PMC10344549
ArticlePDF–199K
7.
Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1
Xiaohuan Jin, Zeyuan Guan, Na Hu, Chunjie He, Ping Yin, Zhou Gong, Delin Zhang
Cell Discov. 2023; 9: 65. Published online 2023 Jun 27. doi: 10.1038/s41421-023-00562-y
PMCID:
PMC10300002
ArticlePDF–974K
8.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
9.
Structures and Mechanisms of tRNA Methylation by METTL1-WDR4
Victor M. Ruiz-Arroyo, Rishi Raj, Kesavan Babu, Otgonbileg Onolbaatar, Paul H. Roberts, Yunsun Nam
Nature. Author manuscript; available in PMC 2023 Jul 4.
Published in final edited form as: Nature. 2023 Jan; 613(7943): 383–390. Published online 2023 Jan 4. doi: 10.1038/s41586-022-05565-5
PMCID:
PMC9930641
AbstractArticlePDF–3.4M
10.
Association of RNA m7G Modification Gene Polymorphisms with Pediatric Glioma Risk
Jinhong Zhu, Xiaoping Liu, Wei Chen, Yuxiang Liao, Jiabin Liu, Li Yuan, Jichen Ruan, Jing He
Biomed Res Int. 2023; 2023: 3678327. Published online 2023 Jan 24. doi: 10.1155/2023/3678327
PMCID:
PMC9889142
AbstractArticlePDF–385K
11.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
12.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
13.
METTL1 promotes hepatocarcinogenesis via m7G tRNA modification‐dependent translation control
Zhihang Chen, Wanjie Zhu, Shenghua Zhu, Kaiyu Sun, Junbin Liao, Haining Liu, Zihao Dai, Hui Han, Xuxin Ren, Qingxia Yang, Siyi Zheng, Baogang Peng, Sui Peng, Ming Kuang, Shuibin Lin
Clin Transl Med. 2021 Dec; 11(12): e661. Published online 2021 Dec 12. doi: 10.1002/ctm2.661
PMCID:
PMC8666584
AbstractArticlePDF–15M
14.
METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression
Jieyi Ma, Hui Han, Ying Huang, Chunlong Yang, Siyi Zheng, Tiancai Cai, Jiong Bi, Xiaohui Huang, Ruiming Liu, Libin Huang, Yifeng Luo, Wen Li, Shuibin Lin
Mol Ther. 2021 Dec 1; 29(12): 3422–3435. Published online 2021 Aug 8. doi: 10.1016/j.ymthe.2021.08.005
PMCID:
PMC8636169
AbstractArticlePDF–4.3M
15.
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation
Esteban A. Orellana, Qi Liu, Eliza Yankova, Mehdi Pirouz, Etienne De Braekeleer, Wencai Zhang, Jihoon Lim, Demetrios Aspris, Erdem Sendinc, Dimitrios A. Garyfallos, Muxin Gu, Raja Ali, Alejandro Gutierrez, Sigitas Mikutis, Gonçalo J. L. Bernardes, Eric S. Fischer, Allan Bradley, George S. Vassiliou, Frank J. Slack, Konstantinos Tzelepis, Richard I. Gregory
Mol Cell. Author manuscript; available in PMC 2022 Aug 19.
Published in final edited form as: Mol Cell. 2021 Aug 19; 81(16): 3323–3338.e14. Published online 2021 Aug 4. doi: 10.1016/j.molcel.2021.06.031
PMCID:
PMC8380730
AbstractArticlePDF–2.1M
16.
Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry
Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang
Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118
PMCID:
PMC8364181
AbstractArticlePDF–3.0M
17.
Reciprocal interaction between SIRT6 and APC/C regulates genomic stability
Helin Wang, Kangze Feng, Qingtao Wang, Haiteng Deng
Sci Rep. 2021; 11: 14253. Published online 2021 Jul 9. doi: 10.1038/s41598-021-93684-w
PMCID:
PMC8270898
AbstractArticlePDF–2.6M
18.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
19.
METTL1-mediated m7G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development
Yujie Deng, Zhongyang Zhou, Weidong Ji, Shuibin Lin, Min Wang
Stem Cell Res Ther. 2020; 11: 306. Published online 2020 Jul 22. doi: 10.1186/s13287-020-01814-4
PMCID:
PMC7374972
AbstractArticlePDF–7.1M
20.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M

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