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Select item 111848441.

Iron deficiency affects oxygen transport and activates HIF1 signaling pathway to regulate phenotypic transformation of VSMC in aortic dissection

Yuanyang Chen, Xu Li, Zhiwei Wang, Shun Yuan, Xiaoyan Shen, Xiaoping Xie, Kai Xing, Qingyi Zhu

Mol Med. 2024; 30: 90. Published online 2024 Jun 17. doi: 10.1186/s10020-024-00859-y

PMCID:: PMC11184844

Abstract Article PDF–6.9M

Select item 111642452.

Alternative splicing of CEACAM1 by Hypoxia-Inducible Factor–1α enhances tolerance to hepatic ischemia in mice and humans

Kenneth J. Dery, Hidenobu Kojima, Shoichi Kageyama, Kentaro Kadono, Hirofumi Hirao, Brian Cheng, Yuan Zhai, Douglas G. Farmer, Fady M. Kaldas, Xiaoyi Yuan, Holger K. Eltzschiasg, Jerzy W. Kupiec-Weglinski

Sci Transl Med. Author manuscript; available in PMC 2024 Jun 10.

Published in final edited form as: Sci Transl Med. 2023 Aug 2; 15(707): eadf2059. Published online 2023 Aug 2. doi: 10.1126/scitranslmed.adf2059

PMCID:: PMC11164245

Abstract Article PDF–2.9M

Select item 111598733.

Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c‐Met system via hypoxia inducible factor‐1 in pancreatic cancer

Yoshihiko Kitajima, Takao Ide, Takao Ohtsuka, Kohji Miyazaki

Cancer Sci. 2008 Jul; 99(7): 1341–1347. Published online 2008 Apr 16. doi: 10.1111/j.1349-7006.2008.00828.x

PMCID:: PMC11159873

Abstract Article PDF–265K

Select item 111596674.

Antisense hypoxia‐inducible factor 1α gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinoma

Fengjun Liu, Peijun Wang, Xian Jiang, Gang Tan, Haiquan Qiao, Hongchi Jiang, Geoffrey W. Krissansen, Xueying Sun

Cancer Sci. 2008 Oct; 99(10): 2055–2061. Published online 2008 Oct 14. doi: 10.1111/j.1349-7006.2008.00905.x

PMCID:: PMC11159667

Abstract Article PDF–417K

Select item 111596485.

Clinicopathological significance of nuclear factor‐kappa B, HIF‐1 alpha, and vascular endothelial growth factor expression in stage III colorectal cancer

Hyuk‐Chan Kwon, Sung Hyun Kim, Sung Yong Oh, Suee Lee, Kyung A Kwon, Jong Hoon Lee, Hong‐Jo Choi, Ki‐Jae Park, Hyung‐Sik Lee, Mee Sook Roh, Hyo‐Jin Kim

Cancer Sci. 2010 Jun; 101(6): 1557–1561. Published online 2010 Mar 4. doi: 10.1111/j.1349-7006.2010.01553.x

PMCID:: PMC11159648

Abstract Article PDF–290K

Select item 111361236.

The interaction of superoxide with nitric oxide destabilizes hypoxia-inducible factor-1α

B. Herr, J. Zhou, S. Dröse, B. Brüne

Cell Mol Life Sci. 2007 Dec; 64(24): 3295–3305. Published online 2007 Nov 9. doi: 10.1007/s00018-007-7371-9

PMCID:: PMC11136123

Abstract Article PDF–979K

Select item 111314677.

Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression

H. J. Jeong, P. D. Moon, S. J. Kim, J. U. Seo, T. H. Kang, J. J. Kim, I. C. Kang, J. Y. Um, H. M. Kim, S. H. Hong

Cell Mol Life Sci. 2009 Apr; 66(7): 1309–1319. Published online 2009 Mar 7. doi: 10.1007/s00018-009-9001-1

PMCID:: PMC11131467

Abstract Article PDF–1.4M

Select item 111158528.

15-Deoxy-Δ^12,14-prostaglandin-J₂ reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1α degradation

Gemma Olmos, María I. Arenas, Raquel Bienes, María Jose Calzada, Julián Aragonés, Maria Laura Garcia-Bermejo, Manuel O. Landazuri, Javier Lucio-Cazaña

Cell Mol Life Sci. 2009 Jul; 66(13): 2167–2180. Published online 2009 May 21. doi: 10.1007/s00018-009-0039-x

PMCID:: PMC11115852

Abstract Article PDF–657K

Select item 111156239.

Contribution of hypoxia to Alzheimer’s disease: is HIF-1α a mediator of neurodegeneration?

O. O. Ogunshola, X. Antoniou

Cell Mol Life Sci. 2009 Nov; 66(22): 3555–3563. Published online 2009 Sep 11. doi: 10.1007/s00018-009-0141-0

PMCID:: PMC11115623

Abstract Article PDF–212K

Select item 1111314410.

The HIF-1 transcription complex is essential for translational control of myeloid hematopoietic cell function by maintaining mTOR phosphorylation

Inna M. Yasinska, Bernhard F. Gibbs, Gurprit S. Lall, Vadim V. Sumbayev

Cell Mol Life Sci. 2014 Feb; 71(4): 699–710. Published online 2013 Jul 20. doi: 10.1007/s00018-013-1421-2

PMCID:: PMC11113144

Abstract Article PDF–886K

Select item 1110350211.

Activation of the hypoxia-inducible factor pathway protects against acute ischemic stroke by reprogramming central carbon metabolism

Sarah Madai, Pinar Kilic, Rolf M. Schmidt, Carlos Bas-Orth, Thomas Korff, Michael Büttner, Glynis Klinke, Gernot Poschet, Hugo H. Marti, Reiner Kunze

Theranostics. 2024; 14(7): 2856–2880. Published online 2024 Apr 29. doi: 10.7150/thno.88223

PMCID:: PMC11103502

Abstract Article PDF–3.5M

Select item 1109504612.

NER-factor DDB2 regulates HIF1α and hypoxia-response genes in HNSCC

Prashant V. Bommi, Vaibhav Chand, Nishit K. Mukhopadhyay, Pradip Raychaudhuri, Srilata Bagchi

Oncogene. Author manuscript; available in PMC 2024 May 15.

Published in final edited form as: Oncogene. 2020 Feb; 39(8): 1784–1796. Published online 2019 Nov 18. doi: 10.1038/s41388-019-1105-y

PMCID:: PMC11095046

Abstract Article PDF–1.8M

Select item 1108878413.

Thymic gene expression analysis reveals a potential link between HIF-1A and Th17/Treg imbalance in thymoma associated myasthenia gravis

İlayda Altınönder, Mustafa Kaya, Sibel P. Yentür, Arman Çakar, Hacer Durmuş, Gülçin Yegen, Berker Özkan, Yeşim Parman, Amr H. Sawalha, Guher Saruhan-Direskeneli

J Neuroinflammation. 2024; 21: 126. Published online 2024 May 11. doi: 10.1186/s12974-024-03095-7

PMCID:: PMC11088784

Abstract Article PDF–1.8M

Select item 1108346314.

The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of Neurodegeneration

Elena V. Mitroshina, Maria V. Vedunova

Int J Mol Sci. 2024 May; 25(9): 4581. Published online 2024 Apr 23. doi: 10.3390/ijms25094581

PMCID:: PMC11083463

Abstract Article PDF–1.7M

Select item 1107525915.

CircHIF1A induces cetuximab resistance in colorectal cancer by promoting HIF1α-mediated glycometabolism alteration

Yiting Geng, Xiao Zheng, Dachuan Zhang, Shanshan Wei, Jun Feng, Wei Wang, Luo Zhang, Changping Wu, Wenwei Hu

Biol Direct. 2024; 19: 36. Published online 2024 May 7. doi: 10.1186/s13062-024-00478-x

PMCID:: PMC11075259

Abstract Article PDF–10M

Select item 1105607116.

HIF-1α-mediated LAMC1 overexpression is an unfavorable predictor of prognosis for glioma patients: evidence from pan-cancer analysis and validation experiments

Jianrong Bai, Yangyang Zhao, Kaijia Shi, Yonghao Fan, Yanping Ha, Yan Chen, Botao Luo, Yanda Lu, Wei Jie, Zhihua Shen

J Transl Med. 2024; 22: 391. Published online 2024 Apr 27. doi: 10.1186/s12967-024-05218-3

PMCID:: PMC11056071

Abstract Article PDF–13M

Select item 1102769317.

Activated HIF1α of tumor cells promotes chemoresistance development via recruiting GDF15-producing tumor-associated macrophages in gastric cancer

Shan Yu, Qian Li, Yiyi Yu, Yuehong Cui, Wei Li, Tianshu Liu, Fenglin Liu

Cancer Immunol Immunother. 2020 Oct; 69(10): 1973–1987. Published online 2020 May 9. doi: 10.1007/s00262-020-02598-5

PMCID:: PMC11027693

Abstract Article PDF–8.5M

Select item 1102288318.

Correlation Between HIF1-A Expression and Airway Remodeling in COPD

Lingfang Tan, Xuefeng Yang, Jianxin Zhang, Kebing Zhou

Int J Chron Obstruct Pulmon Dis. 2024; 19: 921–931. Published online 2024 Apr 13. doi: 10.2147/COPD.S447256

PMCID:: PMC11022883

Abstract Article PDF–7.3M

Select item 1101694019.

Mitochondrial dysfunction induced by HIF‐1α under hypoxia contributes to the development of gastric mucosal lesions

Yuelin Xiao, Xianzhi Liu, Kaiduan Xie, Jiajie Luo, Yiwang Zhang, Xiaoli Huang, Jinni Luo, Siwei Tan

Clin Transl Med. 2024 Apr; 14(4): e1653. Published online 2024 Apr 15. doi: 10.1002/ctm2.1653

PMCID:: PMC11016940

Abstract Article PDF–8.7M

Select item 1101466620.

Granulocytic myeloid-derived suppressor cell activity during biofilm infection is regulated by a glycolysis/HIF1a axis

Christopher M. Horn, Prabhakar Arumugam, Zachary Van Roy, Cortney E. Heim, Rachel W. Fallet, Blake P. Bertrand, Dhananjay Shinde, Vinai C. Thomas, Svetlana G. Romanova, Tatiana K. Bronich, Curtis W. Hartman, Kevin L. Garvin, Tammy Kielian

J Clin Invest. 2024 Apr 15; 134(8): e174051. Published online 2024 Feb 29. doi: 10.1172/JCI174051