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Select item 110036351.

Overexpression of RAD54L attenuates osteoarthritis by suppressing the HIF-1α/VEGF signaling pathway: Bioinformatics analysis and experimental validation

Zhengnan Li, Lifeng Xie, Longqiang Zou, Shiliang Xiao, Jun Tao

PLoS One. 2024; 19(4): e0298575. Published online 2024 Apr 9. doi: 10.1371/journal.pone.0298575

PMCID:: PMC11003635

Abstract Article PDF–3.5M

Select item 91063032.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 82115623.

Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L

Jacqueline Nathansen, Vasyl Lukiyanchuk, Linda Hein, Maya-Isabel Stolte, Kerstin Borgmann, Steffen Löck, Ina Kurth, Michael Baumann, Mechthild Krause, Annett Linge, Anna Dubrovska

Oncogene. 2021; 40(24): 4214–4228. Published online 2021 Jun 2. doi: 10.1038/s41388-021-01842-1

PMCID:: PMC8211562

Abstract Article PDF–3.8M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79104595.

Combinatorial CRISPR screen identifies fitness effects of gene paralogues

Nicola A. Thompson, Marco Ranzani, Louise van der Weyden, Vivek Iyer, Victoria Offord, Alastair Droop, Fiona Behan, Emanuel Gonçalves, Anneliese Speak, Francesco Iorio, James Hewinson, Victoria Harle, Holly Robertson, Elizabeth Anderson, Beiyuan Fu, Fengtang Yang, Guido Zagnoli-Vieira, Phil Chapman, Martin Del Castillo Velasco-Herrera, Mathew J. Garnett, Stephen P. Jackson, David J. Adams

Nat Commun. 2021; 12: 1302. Published online 2021 Feb 26. doi: 10.1038/s41467-021-21478-9

PMCID:: PMC7910459

Abstract Article PDF–3.3M

Select item 77304226.

E2F1 Promotes Progression of Bladder Cancer by Modulating RAD54L Involved in Homologous Recombination Repair

Jeong-Yeon Mun, Seung-Woo Baek, Won Young Park, Won-Tae Kim, Seon-Kyu Kim, Yun-Gil Roh, Mi-So Jeong, Gi-Eun Yang, Jong-Ho Lee, Jin Woong Chung, Yung Hyun Choi, In-Sun Chu, Sun-Hee Leem

Int J Mol Sci. 2020 Dec; 21(23): 9025. Published online 2020 Nov 27. doi: 10.3390/ijms21239025

PMCID:: PMC7730422

Abstract Article PDF–2.7M

Select item 75668817.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 73279158.

Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1‐related genes and impairs DNA double‐strand break recognition

Xuanwen Bao, Jing Wang, Guangming Zhou, Attila Aszodi, Veronika Schönitzer, Harry Scherthan, Michael J. Atkinson, Michael Rosemann

FEBS Open Bio. 2020 Jul; 10(7): 1238–1250. Published online 2020 Jun 9. doi: 10.1002/2211-5463.12867

PMCID:: PMC7327915

Abstract Article PDF–3.1M

Select item 57502329.

RAD54 N-terminal domain is a DNA sensor that couples ATP hydrolysis with branch migration of Holliday junctions

Nadish Goyal, Matthew J. Rossi, Olga M. Mazina, Yong Chi, Robert L. Moritz, Bruce E. Clurman, Alexander V. Mazin

Nat Commun. 2018; 9: 34. Published online 2018 Jan 2. doi: 10.1038/s41467-017-02497-x

PMCID:: PMC5750232

Abstract Article PDF–1.2M

Select item 553161110.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 445885411.

Cross-species genomics identifies TAF12, NFYC and RAD54L as choroid plexus carcinoma oncogenes

Yiai Tong, Diana Merino, Birgit Nimmervoll, Kirti Gupta, Yong-Dong Wang, David Finkelstein, James Dalton, David W. Ellison, Xiaotu Ma, Jinghui Zhang, David Malkin, Richard J. Gilbertson

Cancer Cell. Author manuscript; available in PMC 2016 May 11.

Published in final edited form as: Cancer Cell. 2015 May 11; 27(5): 712–727. doi: 10.1016/j.ccell.2015.04.005

PMCID:: PMC4458854

Abstract Article PDF–2.9M

Select item 438107812.

RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells

Jennifer M. Mason, Kritika Dusad, William Douglass Wright, Jennifer Grubb, Brian Budke, Wolf-Dietrich Heyer, Philip P. Connell, Ralph R. Weichselbaum, Douglas K. Bishop

Nucleic Acids Res. 2015 Mar 31; 43(6): 3180–3196. Published online 2015 Mar 12. doi: 10.1093/nar/gkv175

PMCID:: PMC4381078

Abstract Article PDF–14M

Select item 426658813.

A proteome-scale map of the human interactome network

Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal

Cell. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050

PMCID:: PMC4266588

Abstract Article PDF–3.1M

Select item 401096814.

Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1

Shinichi Machida, Motoki Takaku, Masae Ikura, Jiying Sun, Hidekazu Suzuki, Wataru Kobayashi, Aiko Kinomura, Akihisa Osakabe, Hiroaki Tachiwana, Yasunori Horikoshi, Atsuhiko Fukuto, Ryo Matsuda, Kiyoe Ura, Satoshi Tashiro, Tsuyoshi Ikura, Hitoshi Kurumizaka

Sci Rep. 2014; 4: 4863. Published online 2014 May 6. doi: 10.1038/srep04863

PMCID:: PMC4010968

Abstract Article PDF–2.2M

Select item 386161615.

The HECT Type Ubiquitin Ligase NEDL2 Is Degraded by Anaphase-promoting Complex/Cyclosome (APC/C)-Cdh1, and Its Tight Regulation Maintains the Metaphase to Anaphase Transition

Li Lu, Shaohua Hu, Rongfei Wei, Xiao Qiu, Kefeng Lu, Yesheng Fu, Hongchang Li, Guichun Xing, Dong Li, Ruiyun Peng, Fuchu He, Lingqiang Zhang

J Biol Chem. 2013 Dec 13; 288(50): 35637–35650. Published online 2013 Oct 25. doi: 10.1074/jbc.M113.472076

PMCID:: PMC3861616

Abstract Article PDF–4.4M

Select item 365812816.

Variation Within DNA Repair Pathway Genes and Risk of Multiple Sclerosis

Farren B. S. Briggs, Benjamin A. Goldstein, Jacob L. McCauley, Rebecca L. Zuvich, Philip L. De Jager, John D. Rioux, Adrian J. Ivinson, Alastair Compston, David A. Hafler, Stephen L. Hauser, Jorge R. Oksenberg, Stephen J. Sawcer, Margaret A. Pericak-Vance, Jonathan L. Haines, Lisa F. Barcellos, for the International Multiple Sclerosis Genetics Consortium

Am J Epidemiol. 2010 Jul 15; 172(2): 217–224. Published online 2010 Jun 3. doi: 10.1093/aje/kwq086

PMCID:: PMC3658128

Abstract Article PDF–129K

Select item 360183217.

The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress

Jingsong Yuan, Gargi Ghosal, Junjie Chen

Mol Cell. Author manuscript; available in PMC 2013 Aug 10.

Published in final edited form as: Mol Cell. 2012 Aug 10; 47(3): 410–421. Published online 2012 Jun 14. doi: 10.1016/j.molcel.2012.05.025

PMCID:: PMC3601832

Abstract Article PDF–2.8M

Select item 325984618.

Rad51 Protein Stimulates the Branch Migration Activity of Rad54 Protein

Matthew J. Rossi, Alexander V. Mazin

J Biol Chem. 2008 Sep 5; 283(36): 24698–24706. doi: 10.1074/jbc.M800839200

PMCID:: PMC3259846

Abstract Article PDF–711K

Select item 322018619.

Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes

Lin T. Guey, Montserrat García-Closas, Cristiane Murta-Nascimento, Josep Lloreta, Laia Palencia, Manolis Kogevinas, Nathaniel Rothman, Gemma Vellalta, Malu Calle, Gaëlle Marenne, Adonina Tardón, Alfredo Carrato, Reina García-Closas, Consol Serra, Debra T Silverman, Stephen Chanock, Francisco X. Real, Núria Malats

Eur Urol. Author manuscript; available in PMC 2011 Nov 18.

Published in final edited form as: Eur Urol. 2010 Feb; 57(2): 283–292. Published online 2009 Aug 12. doi: 10.1016/j.eururo.2009.08.001

PMCID:: PMC3220186

Abstract Article PDF–595K

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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