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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 61666822.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 60777223.

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115

PMCID:: PMC6077722

Abstract Article PDF–2.4M

Select item 55751304.

Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population

Li Wen, Haijun Han, Qiang Liu, Kunkai Su, Zhongli Yang, Wenyan Cui, Wenji Yuan, Yunlong Ma, Rongli Fan, Jiali Chen, Keran Jiang, Xianzhong Jiang, Thomas J. Payne, Jundong Wang, Ming D. Li

Sci Rep. 2017; 7: 9745. Published online 2017 Aug 29. doi: 10.1038/s41598-017-09492-8

PMCID:: PMC5575130

Abstract Article PDF–1.5M

Select item 55316115.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 50954016.

Unorthodox Acetylcholine Binding Sites Formed by α5 and β3 Accessory Subunits in α4β2* Nicotinic Acetylcholine Receptors

Akansha Jain, Alexander Kuryatov, Jingyi Wang, Theodore M. Kamenecka, Jon Lindstrom

J Biol Chem. 2016 Nov 4; 291(45): 23452–23463. Published online 2016 Sep 19. doi: 10.1074/jbc.M116.749150

PMCID:: PMC5095401

Abstract Article PDF–3.1M

Select item 49756227.

Evidence for association between low frequency variants in CHRNA6/CHRNB3 and antisocial drug dependence

Helen M. Kamens, Robin P. Corley, Phillip A. Richmond, Todd M. Darlington, Robin Dowell, Christian J. Hopfer, Michael C. Stallings, John K. Hewitt, Sandra A. Brown, Marissa A. Ehringer

Behav Genet. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: Behav Genet. 2016 Sep; 46(5): 693–704. Published online 2016 Apr 16. doi: 10.1007/s10519-016-9792-4

PMCID:: PMC4975622

Abstract Article PDF–524K

Select item 49316018.

Crucial roles of the CHRNB3–CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research

L Wen, Z Yang, W Cui, M D Li

Transl Psychiatry. 2016 Jun; 6(6): e843. Published online 2016 Jun 21. doi: 10.1038/tp.2016.103

PMCID:: PMC4931601

Abstract Article PDF–654K

Select item 48943869.

Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy

Brooke Sadler, Gabe Haller, Arpana Agrawal, Rob Culverhouse, Kathleen Bucholz, Andy Brooks, Jay Tischfield, Eric O. Johnson, Howard Edenberg, Marc Schuckit, Nancy Saccone, Laura Bierut, Alison Goate

Sci Rep. 2014; 4: 4497. Published online 2014 Mar 28. doi: 10.1038/srep04497

PMCID:: PMC4894386

Abstract Article PDF–672K

Select item 465515110.

The β3 subunit of the nicotinic acetylcholine receptor: modulation of gene expression and nicotine consumption

Helen M. Kamens, Jill Miyamoto, Matthew S. Powers, Kasey Ro, Marissa Soto, Ryan Cox, Jerry A. Stitzel, Marissa A. Ehringer

Neuropharmacology. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: Neuropharmacology. 2015 Dec; 99: 639–649. Published online 2015 Aug 25. doi: 10.1016/j.neuropharm.2015.08.035

PMCID:: PMC4655151

Abstract Article PDF–1.3M

Select item 464794111.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

Abstract Article

Select item 461721112.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 411336113.

Efficient Expression of Functional (α6β2)₂β3 AChRs in Xenopus Oocytes from Free Subunits Using Slightly Modified α6 Subunits

Carson Kai-Kwong Ley, Alexander Kuryatov, Jingyi Wang, Jon Martin Lindstrom

PLoS One. 2014; 9(7): e103244. Published online 2014 Jul 28. doi: 10.1371/journal.pone.0103244

PMCID:: PMC4113361

Abstract Article PDF–1.4M

Select item 398460414.

Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans

Robert C. Culverhouse, Eric O. Johnson, Naomi Breslau, Dorothy K. Hatsukami, Brooke Sadler, Andrew I. Brooks, Victor M. Hesselbrock, Marc A. Schuckit, Jay A. Tischfield, Alison M. Goate, Nancy L. Saccone, Laura J. Bierut

Addiction. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: Addiction. 2014 May; 109(5): 814–822. Published online 2014 Feb 18. doi: 10.1111/add.12478

PMCID:: PMC3984604

Abstract Article PDF–409K

Select item 388826315.

Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence

Gabe Haller, Manav Kapoor, John Budde, Xiaoling Xuei, Howard Edenberg, John Nurnberger, John Kramer, Andy Brooks, Jay Tischfield, Laura Almasy, Arpana Agrawal, Kathleen Bucholz, John Rice, Nancy Saccone, Laura Bierut, Alison Goate

Hum Mol Genet. 2014 Feb 1; 23(3): 810–819. Published online 2013 Sep 20. doi: 10.1093/hmg/ddt463

PMCID:: PMC3888263

Abstract Article PDF–216K

Select item 388023016.

Effect of Neuronal Nicotinic Acetylcholine Receptor Genes (CHRN) on Longitudinal Cigarettes per Day in Adolescents and Young Adults

Dale S. Cannon, Robin J. Mermelstein, Donald Hedeker, Hilary Coon, Edwin H. Cook, William M. McMahon, Cindy Hamil, Diane Dunn, Robert B. Weiss

Nicotine Tob Res. 2014 Feb; 16(2): 137–144. Published online 2013 Aug 13. doi: 10.1093/ntr/ntt125

PMCID:: PMC3880230

Abstract Article PDF–669K

Select item 387516217.

Nicotinic receptor gene variants interact with attention deficient hyperactive disorder symptoms to predict smoking trajectories from early adolescence to adulthood

Chien-Ti Lee, Bernard F. Fuemmeler, F. Joseph McClernon, Allison Ashley-Koch, Scott H. Kollins

Addict Behav. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: Addict Behav. 2013 Nov; 38(11): 10.1016/j.addbeh.2013.06.013. Published online 2013 Jul 1. doi: 10.1016/j.addbeh.2013.06.013

PMCID:: PMC3875162

Abstract Article PDF–102K

Select item 342740618.

CHRNB3 is more strongly associated with FTCD-based nicotine dependence than cigarettes per day: phenotype definition changes GWAS results

John P. Rice, Sarah Hartz, Arpana Agrawal, Laura Almasy, Siiri Bennett, Naomi Breslau, Kathleen K. Bucholz, Kimberly F. Doheny, Howard J. Edenberg, Alison M. Goate, Victor Hesselbrock, William B. Howells, Eric O. Johnson, John Kramer, Robert F. Krueger, Samuel Kuperman, Cathy Laurie, Teri A. Manolio, Rosalind J. Neuman, John I. Nurnberger, Jr., Bernice Porjesz, Elizabeth Pugh, Erin M. Ramos, Nancy Saccone, Scott Saccone, Marc Schuckit, Laura J. Bierut

Addiction. Author manuscript; available in PMC 2013 Nov 1.

Published in final edited form as: Addiction. 2012 Nov; 107(11): 2019–2028. Published online 2012 Jun 15. doi: 10.1111/j.1360-0443.2012.03922.x

PMCID:: PMC3427406

Abstract Article PDF–824K

Select item 340328919.

CHRNB2 Promoter Region: Association with subjective effects to nicotine and expression differences

Nicole R. Hoft, Jerry A. Stitzel, Kent E. Hutchison, Marissa A. Ehringer

Genes Brain Behav. Author manuscript; available in PMC 2012 Jul 24.

Published in final edited form as: Genes Brain Behav. 2011 Mar; 10(2): 176–185. Published online 2010 Nov 4. doi: 10.1111/j.1601-183X.2010.00650.x

PMCID:: PMC3403289

Abstract Article PDF–736K

Select item 334014520.

Modulation of Gain-of-function α6*-Nicotinic Acetylcholine Receptor by β3 Subunits

Bhagirathi Dash, Ronald J. Lukas

J Biol Chem. 2012 Apr 20; 287(17): 14259–14269. Published online 2012 Feb 7. doi: 10.1074/jbc.M111.322610

PMCID:: PMC3340145

Abstract Article PDF–1.2M

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