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Items: 1 to 20 of 83

1.
Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2
Takafumi Kato, Tsukasa Kusakizako, Chunhuan Jin, Xinyu Zhou, Ryuichi Ohgaki, LiLi Quan, Minhui Xu, Suguru Okuda, Kan Kobayashi, Keitaro Yamashita, Tomohiro Nishizawa, Yoshikatsu Kanai, Osamu Nureki
Nat Commun. 2022; 13: 4714. Published online 2022 Aug 11. doi: 10.1038/s41467-022-32442-6
PMCID:
PMC9372063
AbstractArticlePDF–2.2M
2.
PKCα phosphorylation of GLT-1 at Ser562/563 induces glutamate excitotoxicity in ischemia in mice
Yuqing Wang, Jun Du, Shanshan Lu, Xia Li, Yifei Chen, Chao Yuan, Sheng-Tao Hou, Yizheng Wang
Signal Transduct Target Ther. 2022; 7: 82. Published online 2022 Mar 23. doi: 10.1038/s41392-022-00897-0
PMCID:
PMC8940927
ArticlePDF–2.0M
3.
Polymorphism of rs12294045 in EAAT2 gene is potentially associated with schizophrenia in Chinese Han population
Lina Wang, Tantan Ma, Dongdong Qiao, Kaiyan Cui, Xiaojiao Bi, Chao Han, Limin Yang, Mengmeng Sun, Lanfen Liu
BMC Psychiatry. 2022; 22: 171. Published online 2022 Mar 8. doi: 10.1186/s12888-022-03799-1
PMCID:
PMC8903623
AbstractArticlePDF–1.0M
4.
Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter
Dolores Piniella, Elena Martínez-Blanco, David Bartolomé-Martín, Ana B. Sanz-Martos, Francisco Zafra
Cell Mol Life Sci. 2021 Dec; 78(23): 7733–7756. Published online 2021 Oct 28. doi: 10.1007/s00018-021-03998-1
PMCID:
PMC8629785
AbstractArticlePDF–10M
5.
Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity
Edward Pajarillo, Alexis Digman, Ivan Nyarko-Danquah, Deok-Soo Son, Karam F.A. Soliman, Michael Aschner, Eunsook Lee
J Biol Chem. 2021 Dec; 297(6): 101372. Published online 2021 Oct 29. doi: 10.1016/j.jbc.2021.101372
PMCID:
PMC8626589
AbstractArticlePDF–3.4M
6.
The Glutamate Transporter EAAT2 Is Transiently Expressed in Developing Human Cerebral White Matter
TARA M. DESILVA, HANNAH C. KINNEY, NATALIA S. BORENSTEIN, FELICIA L. TRACHTENBERG, NINA IRWIN, JOSEPH J. VOLPE, PAUL A. ROSENBERG
J Comp Neurol. Author manuscript; available in PMC 2021 Nov 19.
Published in final edited form as: J Comp Neurol. 2007 Apr 20; 501(6): 879–890. doi: 10.1002/cne.21289
PMCID:
PMC8603423
AbstractArticlePDF–2.3M
7.
Downregulation of the Glial GLT1 Glutamate Transporter and Purkinje Cell Dysfunction in a Mouse Model of Myotonic Dystrophy
Géraldine Sicot, Laurent Servais, Diana M. Dinca, Axelle Leroy, Cynthia Prigogine, Fadia Medja, Sandra O. Braz, Aline Huguet-Lachon, Cerina Chhuon, Annie Nicole, Noëmy Gueriba, Ruan Oliveira, Bernard Dan, Denis Furling, Maurice S. Swanson, Ida Chiara Guerrera, Guy Cheron, Geneviève Gourdon, Mário Gomes-Pereira
Cell Rep. Author manuscript; available in PMC 2021 Oct 7.
Published in final edited form as: Cell Rep. 2017 Jun 27; 19(13): 2718–2729. doi: 10.1016/j.celrep.2017.06.006
PMCID:
PMC8496958
AbstractArticlePDF–2.5M
8.
Endocytosis of the glutamate transporter 1 is regulated by Laforin and Malin: implications in Lafora Disease.
Eva Perez-Jimenez, Rosa Viana, Carmen Muñoz-Ballester, Carlos Vendrell-Tornero, Raquel Moll-Diaz, Maria Adelaida Garcia-Gimeno, Pascual Sanz
Glia. Author manuscript; available in PMC 2021 Sep 16.
Published in final edited form as: Glia. 2021 May; 69(5): 1170–1183. Published online 2020 Dec 23. doi: 10.1002/glia.23956
PMCID:
PMC8445078
AbstractArticlePDF–1.7M
9.
Excitatory Amino Acid Transporter EAAT‐2 in Tangle‐bearing Neurons in Alzheimer's Disease
Dietmar Rudolf Thal
Brain Pathol. 2002 Oct; 12(4): 405–411. Published online 2006 Apr 5. doi: 10.1111/j.1750-3639.2002.tb00457.x
PMCID:
PMC8095978
SummaryPDF–277K
10.
An amino-terminal point mutation increases EAAT2 anion currents without affecting glutamate transport rates
Bettina Kolen, Daniel Kortzak, Arne Franzen, Christoph Fahlke
J Biol Chem. 2020 Oct 30; 295(44): 14936–14947. Published online 2020 Aug 20. doi: 10.1074/jbc.RA120.013704
PMCID:
PMC7606670
AbstractArticlePDF–3.2M
11.
A computational approach yields selective inhibitors of human excitatory amino acid transporter 2 (EAAT2)
Kelly L. Damm-Ganamet, Marie-Laure Rives, Alan D. Wickenden, Heather M. McAllister, Taraneh Mirzadegan
J Biol Chem. 2020 Mar 27; 295(13): 4359–4366. Published online 2020 Feb 20. doi: 10.1074/jbc.AC119.011190
PMCID:
PMC7105306
AbstractArticlePDF–1.2M
12.
Assessment of three essential tremor genetic loci in sporadic Parkinson's disease in Eastern China
Ting Gao, Jiong Wu, Ran Zheng, Yi Fang, Chong‐Yao Jin, Yang Ruan, Jin Cao, Jun Tian, Jia‐Li Pu, Bao‐Rong Zhang
CNS Neurosci Ther. 2020 Apr; 26(4): 448–452. Published online 2019 Nov 21. doi: 10.1111/cns.13272
PMCID:
PMC7080431
AbstractArticlePDF–467K
13.
Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer’s molecular signatures
Abhijeet Sharma, Syed Faraz Kazim, Chloe S. Larson, Aarthi Ramakrishnan, Jason D. Gray, Bruce S. McEwen, Paul A. Rosenberg, Li Shen, Ana C. Pereira
Proc Natl Acad Sci U S A. 2019 Oct 22; 116(43): 21800–21811. Published online 2019 Oct 7. doi: 10.1073/pnas.1903566116
PMCID:
PMC6815169
AbstractArticlePDF–2.8M
14.
Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism
Andrew B. Stergachis, Jonai Pujol-Giménez, Gergely Gyimesi, Daniel Fuster, Giusppe Albano, Marina Troxler, Jonathan Picker, Paul A. Rosenberg, Ann Bergin, Jurriaan Peters, Christelle Moufawad El Achkar, Chellamani Harini, Shannon Manzi, Alexander Rotenberg, Matthias A. Hediger, Lance H. Rodan
Ann Neurol. Author manuscript; available in PMC 2019 Dec 1.
Published in final edited form as: Ann Neurol. 2019 Jun; 85(6): 921–926. Published online 2019 Apr 26. doi: 10.1002/ana.25477
PMCID:
PMC6800210
AbstractArticlePDF–1.2M
15.
The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: potential targets for neurotherapeutics
Edward Pajarillo, Asha Rizor, Jayden Lee, Michael Aschner, Eunsook Leea
Neuropharmacology. Author manuscript; available in PMC 2020 Dec 15.
Published in final edited form as: Neuropharmacology. 2019 Dec 15; 161: 107559. Published online 2019 Mar 6. doi: 10.1016/j.neuropharm.2019.03.002
PMCID:
PMC6731169
AbstractArticlePDF–792K
16.
Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer
Marina Bacci, Nicla Lorito, Luigi Ippolito, Matteo Ramazzotti, Simone Luti, Simone Romagnoli, Matteo Parri, Francesca Bianchini, Federica Cappellesso, Federico Virga, Qiong Gao, Bruno M. Simões, Elisabetta Marangoni, Lesley-Ann Martin, Giuseppina Comito, Manuela Ferracin, Elisa Giannoni, Massimiliano Mazzone, Paola Chiarugi, Andrea Morandi
Cell Rep. 2019 Jul 2; 28(1): 104–118.e8. Published online 2019 Jul 2. doi: 10.1016/j.celrep.2019.06.010
PMCID:
PMC6616584
AbstractArticle
17.
Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex
JL Arriza, WA Fairman, JI Wadiche, GH Murdoch, MP Kavanaugh, SG Amara
J Neurosci. 1994 Sep 1; 14(9): 5559–5569. doi: 10.1523/JNEUROSCI.14-09-05559.1994
PMCID:
PMC6577102
AbstractPDF–1.6M
18.
Genetic variant in SLC1A2 is associated with elevated anterior cingulate cortex glutamate and lifetime history of rapid cycling
Marin Veldic, Vincent Millischer, John D. Port, Ada Man-Choi Ho, Yun-Fang Jia, Jennifer R. Geske, Joanna M. Biernacka, Lena Backlund, Susan L. McElroy, David J. Bond, J. Carlos Villaescusa, Michelle Skime, Doo-Sup Choi, Catharina Lavebratt, Martin Schalling, Mark A. Frye
Transl Psychiatry. 2019; 9: 149. Published online 2019 May 23. doi: 10.1038/s41398-019-0483-9
PMCID:
PMC6533282
AbstractArticlePDF–1.3M
19.
Blood-Brain Barrier: From Physiology to Disease and Back
Melanie D. Sweeney, Zhen Zhao, Axel Montagne, Amy R. Nelson, Berislav V. Zlokovic
Physiol Rev. 2019 Jan 1; 99(1): 21–78. Published online 2018 Oct 3. doi: 10.1152/physrev.00050.2017
PMCID:
PMC6335099
AbstractArticle
20.
Novel interaction between Alzheimer’s disease-related protein presenilin 1 and glutamate transporter 1
Katarzyna Marta Zoltowska, Masato Maesako, Joshua Meier, Oksana Berezovska
Sci Rep. 2018; 8: 8718. Published online 2018 Jun 7. doi: 10.1038/s41598-018-26888-2
PMCID:
PMC5992168
AbstractArticlePDF–2.0M

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