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Items: 1 to 20 of 358

1.
A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex
Marisa Bedir, Emily Outwin, Rita Colnaghi, Lydia Bassett, Iga Abramowicz, Mark O’Driscoll
EMBO Rep. 2024 Aug; 25(8): 3432–3455. Published online 2024 Jun 28. doi: 10.1038/s44319-024-00184-9
PMCID:
PMC11315929
AbstractArticlePDF–3.4M
2.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x
PMCID:
PMC11148184
AbstractArticlePDF–8.1M
3.
PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARα
Xinping Huang, Yongfeng Yang, Dan Zhu, Yan Zhao, Min Wei, Ke Li, Hong-hu Zhu, Xiaofeng Zheng
Cell Mol Life Sci. 2022 Jun; 79(6): 319. Published online 2022 May 27. doi: 10.1007/s00018-022-04358-3
PMCID:
PMC11072021
AbstractArticlePDF–9.5M
4.
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells
Casey D. S. Katerndahl, Olivia R. S. Rogers, Ryan B. Day, Ziheng Xu, Nichole M. Helton, Sai Mukund Ramakrishnan, Christopher A. Miller, Timothy J. Ley
Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18): e2317690121. Published online 2024 Apr 22. doi: 10.1073/pnas.2317690121
PMCID:
PMC11067031
AbstractArticlePDF–7.2M
5.
PML‐mediated nuclear loosening permits immunomodulation of mesenchymal stem/stromal cells under inflammatory conditions
Yunpeng Chu, Zishan Jiang, Zheng Gong, Xiaocao Ji, Mengting Zhu, Qianwen Shang, Pixia Gong, Lijuan Cao, Yongjing Chen, Peishan Li, Changshun Shao, Yufang Shi
Cell Prolif. 2024 Apr; 57(4): e13566. Published online 2023 Oct 20. doi: 10.1111/cpr.13566
PMCID:
PMC10984101
AbstractArticlePDF–4.1M
6.
PML modulates epigenetic composition of chromatin to regulate expression of pro-metastatic genes in triple-negative breast cancer
Cristina Fracassi, Martina Ugge', Mohamed Abdelhalim, Ettore Zapparoli, Matilde Simoni, Daniela Magliulo, Davide Mazza, Dejan Lazarevic, Marco J Morelli, Philippe Collas, Rosa Bernardi
Nucleic Acids Res. 2023 Nov 10; 51(20): 11024–11039. Published online 2023 Oct 12. doi: 10.1093/nar/gkad819
PMCID:
PMC10639071
AbstractArticlePDF–2.0M
7.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
8.
Promyelocytic leukemia protein regulates angiogenesis and epithelial–mesenchymal transition to limit metastasis in MDA‐MB‐231 breast cancer cells
Amalia P. Vogiatzoglou, Syrago Spanou, Nikoleta Sachini, Elias Drakos, Christoforos Nikolaou, Takis Makatounakis, Androniki Kretsovali, Joseph Papamatheakis
Mol Oncol. 2023 Oct; 17(10): 2090–2108. Published online 2023 Sep 4. doi: 10.1002/1878-0261.13501
PMCID:
PMC10552902
AbstractArticlePDF–11M
9.
Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
Camila M. Aprosoff, Boris J.A. Dyakov, Vivian H.W. Cheung, Cassandra J. Wong, Mikaela Palandra, Anne-Claude Gingras, Haley D.M. Wyatt
J Proteome Res. 2023 Jun 2; 22(6): 1660–1681. Published online 2023 Apr 18. doi: 10.1021/acs.jproteome.2c00706
PMCID:
PMC10243116
AbstractArticlePDF–13M
10.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
11.
TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2
Xiaoxi Lv, Shanshan Liu, Chang Liu, Yunxuan Li, Tingting Zhang, Jie Qi, Ke Li, Fang Hua, Bing Cui, Xiaowei Zhang, Yuxin Liu, Jiaojiao Yu, Jinmei Yu, Li Li, Xia Li, Zhigang Yao, Bo Huang
Acta Pharm Sin B. 2023 Apr; 13(4): 1631–1647. Published online 2023 Jan 11. doi: 10.1016/j.apsb.2023.01.008
PMCID:
PMC10150180
AbstractArticlePDF–6.7M
12.
PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates
Sabateeshan Mathavarajah, Kathleen L Vergunst, Elias B Habib, Shelby K Williams, Raymond He, Maria Maliougina, Mika Park, Jayme Salsman, Stéphane Roy, Ingo Braasch, Andrew J Roger, David N Langelaan, Graham Dellaire
Nucleic Acids Res. 2023 Apr 24; 51(7): 3185–3204. Published online 2023 Mar 13. doi: 10.1093/nar/gkad152
PMCID:
PMC10123124
AbstractArticlePDF–6.1M
13.
The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA
Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T. Hay
J Cell Biol. 2023 Apr 3; 222(4): e202201027. Published online 2023 Feb 28. doi: 10.1083/jcb.202201027
PMCID:
PMC10005898
AbstractArticlePDF–6.7M
14.
Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma
Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li
Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x
PMCID:
PMC9950447
AbstractArticlePDF–8.4M
15.
Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia
William Villiers, Audrey Kelly, Xiaohan He, James Kaufman-Cook, Abdurrahman Elbasir, Halima Bensmail, Paul Lavender, Richard Dillon, Borbála Mifsud, Cameron S. Osborne
Nat Commun. 2023; 14: 724. Published online 2023 Feb 9. doi: 10.1038/s41467-023-36262-0
PMCID:
PMC9911410
AbstractArticlePDF–3.7M
16.
Crosstalk between PML and p53 in response to TGF-β1: A new mechanism of cardiac fibroblast activation
Di Huang, Dan Zhao, Ming Li, Si-Yu Chang, Ya-Dong Xue, Ning Xu, Si-Jia Li, Nan-Nan Tang, Li-Ling Gong, Yi-Ning Liu, Hang Yu, Qing-Sui Li, Peng-Yu Li, Jia-Li Liu, Hai-Xin Chen, Ming-Bin Liu, Wan-Yu Zhang, Xing-Miao Zhao, Xian-Zhi Lang, Zhen-Dong Li, Yu Liu, Zhi-Yong Ma, Jia-Min Li, Ning Wang, Hai Tian, Ben-Zhi Cai
Int J Biol Sci. 2023; 19(3): 994–1006. Published online 2023 Jan 22. doi: 10.7150/ijbs.76214
PMCID:
PMC9910009
AbstractArticlePDF–5.7M
17.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
18.
PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment
Sonia Missiroli, Mariasole Perrone, Roberta Gafà, Francesco Nicoli, Massimo Bonora, Giampaolo Morciano, Caterina Boncompagni, Saverio Marchi, Magdalena Lebiedzinska-Arciszewska, Bianca Vezzani, Giovanni Lanza, Franz Kricek, Alessandro Borghi, Francesco Fiorica, Keisuke Ito, Mariusz R. Wieckowski, Francesco Di Virgilio, Luigi Abelli, Paolo Pinton, Carlotta Giorgi
Cell Death Differ. 2023 Feb; 30(2): 429–441. Published online 2022 Nov 30. doi: 10.1038/s41418-022-01095-9
PMCID:
PMC9713080
AbstractArticlePDF–4.6M
19.
The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers
Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy
eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676
PMCID:
PMC9708086
AbstractArticlePDF–8.5M
20.
Promyelocytic Leukemia Protein Potently Restricts Human Cytomegalovirus Infection in Endothelial Cells
Sven Seitz, Anna Theresa Heusel, Thomas Stamminger, Myriam Scherer
Int J Mol Sci. 2022 Oct; 23(19): 11931. Published online 2022 Oct 8. doi: 10.3390/ijms231911931
PMCID:
PMC9569661
AbstractArticlePDF–3.3M

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