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Select item 101522371.

circFNDC3B Accelerates Vasculature Formation and Metastasis in Oral Squamous Cell Carcinoma

Xiang Li, Chenxing Wang, Hang Zhang, Yangjie Li, Deqiang Hou, Dingshan Liu, Rongyao Xu, Jie Cheng, Laikui Liu, Yu Fu, Jinhai Ye, Hongbing Jiang

Cancer Res. 2023 May 2; 83(9): 1459–1475. Published online 2023 Feb 22. doi: 10.1158/0008-5472.CAN-22-2585

PMCID:: PMC10152237

Abstract Article PDF–22M

Select item 100603812.

Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer

Wei-Yu Chen, Phan Vu Thuy Dung, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Han-Ru Li, Zi-Qing Chen, Michael Hsiao, Jiaoti Huang, Yu-Ching Wen, Yen-Nien Liu

Redox Biol. 2023 Jun; 62: 102686. Published online 2023 Mar 21. doi: 10.1016/j.redox.2023.102686

PMCID:: PMC10060381

Abstract Article PDF–18M

Select item 97701503.

Blocking MG53^S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury

Fengxiang Lv, Yingfan Wang, Dan Shan, Sile Guo, Gengjia Chen, Li Jin, Wen Zheng, Han Feng, Xiaohu Zeng, Shuo Zhang, Yan Zhang, Xinli Hu, Rui-Ping Xiao

Circ Res. 2022 Dec 2; 131(12): 962–976. Published online 2022 Nov 7. doi: 10.1161/CIRCRESAHA.122.321055

PMCID:: PMC9770150

Abstract Article PDF–7.3M

Select item 94339384.

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB

Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan

EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698

PMCID:: PMC9433938

Abstract Article PDF–9.3M

Select item 94260025.

Haematological profile of malaria patients with G6PD and PKLR variants (erythrocytic enzymopathies): a cross-sectional study in Thailand

Punchalee Mungkalasut, Patcharakorn Kiatamornrak, Watcharapong Jugnam-Ang, Srivicha Krudsood, Poonlarp Cheepsunthorn, Chalisa Louicharoen Cheepsunthorn

Malar J. 2022; 21: 250. Published online 2022 Aug 30. doi: 10.1186/s12936-022-04267-7

PMCID:: PMC9426002

Abstract Article PDF–1.5M

Select item 91989226.

Genetic variants of PKLR are associated with acute pain in sickle cell disease

Xunde Wang, Kate Gardner, Mickias B. Tegegn, Clifton L. Dalgard, Camille Alba, Stephan Menzel, Hamel Patel, Mehdi Pirooznia, Yi-Ping Fu, Fayaz T. Seifuddin, Swee Lay Thein

Blood Adv. 2022 Jun 14; 6(11): 3535–3540. Published online 2022 Jun 13. doi: 10.1182/bloodadvances.2021006668

PMCID:: PMC9198922

Abstract Article PDF–859K

Select item 91197367.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 89905308.

Identification of biochemically neutral positions in liver pyruvate kinase

Tyler A. Martin, Tiffany Wu, Qingling Tang, Larissa L. Dougherty, Daniel J. Parente, Liskin Swint-Kruse, Aron W. Fenton

Proteins. Author manuscript; available in PMC 2022 Apr 8.

Published in final edited form as: Proteins. 2020 Oct; 88(10): 1340–1350. Published online 2020 Jun 27. doi: 10.1002/prot.25953

PMCID:: PMC8990530

Abstract Article PDF–1.0M

Select item 89343529.

Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine differentiation of prostate cancer by ZBTB10 deficiency

Yu-Ching Wen, Wei-Yu Chen, Van Thi Ngoc Tram, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Wassim Abou-Kheir, Jiaoti Huang, Michael Hsiao, Yen-Nien Liu

Cell Death Dis. 2022 Mar; 13(3): 252. Published online 2022 Mar 19. doi: 10.1038/s41419-022-04694-z

PMCID:: PMC8934352

Abstract Article PDF–6.4M

Select item 884896210.

A novel homozygous missense variant p.D339N in the PKLR gene correlates with pyruvate kinase deficiency in a Pakistani family: a case report

Atta Ur Rehman, Abdur Rashid, Zubair Hussain, Khadim Shah

J Med Case Rep. 2022; 16: 66. Published online 2022 Feb 16. doi: 10.1186/s13256-022-03292-z

PMCID:: PMC8848962

Abstract Article PDF–1.3M

Select item 839676911.

Putative pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations

Ohanna Cavalcanti de Lima Bezerra, Lucia Elena Alvarado-Arnez, Nédio Mabunda, Graça Salomé, Amina de Sousa, Fernanda de Souza Gomes Kehdy, Carolinne Sales-Marques, Fernanda Saloum de Neves Manta, Rafaela Mota Andrade, Laís Pereira Ferreira, Thyago Leal-Calvo, Cynthia Chester Cardoso, Kelly Nunes, Mateus H. Gouveia, Sam M. Mbulaiteve, Edward D. Yeboah, Ann Hsing, Ana Carla Pereira Latini, André Luiz Leturiondo, Fabíola da Costa Rodrigues, Ariani Batista Noronha, Cynthia de Oliveira Ferreira, Carolina Talhari, Jamile Leão Rêgo, Léa Cristina de Carvalho Castellucci, Eduardo Tarazona-Santos, Elizeu Fagundes de Carvalho, Diogo Meyer, Roberta Olmo Pinheiro, Ilesh V. Jani, Antonio Guilherme Pacheco, Milton Ozório Moraes

PLoS Negl Trop Dis. 2021 Aug; 15(8): e0009434. Published online 2021 Aug 27. doi: 10.1371/journal.pntd.0009434

PMCID:: PMC8396769

Abstract Article PDF–1.7M

Select item 837641912.

Rheostat functional outcomes occur when substitutions are introduced at nonconserved positions that diverge with speciation

Liskin Swint‐Kruse, Tyler A. Martin, Braelyn M. Page, Tiffany Wu, Paige M. Gerhart, Larissa L. Dougherty, Qingling Tang, Daniel J. Parente, Brian R. Mosier, Leonidas E. Bantis, Aron W. Fenton

Protein Sci. 2021 Sep; 30(9): 1833–1853. Published online 2021 Jun 11. doi: 10.1002/pro.4136

PMCID:: PMC8376419

Abstract Article PDF–4.8M

Select item 836418113.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 830719414.

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation

Sun-Ok Kim, Kyoung Sang Cho, Bo Yeon Kim, Kyung Ho Lee

Int J Mol Sci. 2021 Jul; 22(14): 7572. Published online 2021 Jul 15. doi: 10.3390/ijms22147572

PMCID:: PMC8307194

Abstract Article PDF–2.8M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 778824516.

Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner

Karthickeyan Chella Krishnan, Raquel R. Floyd, Simon Sabir, Dulshan W. Jayasekera, Paola V. Leon-Mimila, Anthony E. Jones, Angel A. Cortez, Varun Shravah, Miklós Péterfy, Linsey Stiles, Samuel Canizales-Quinteros, Ajit S. Divakaruni, Adriana Huertas-Vazquez, Aldons J. Lusis

Cell Mol Gastroenterol Hepatol. 2021; 11(2): 389–406. Published online 2020 Sep 14. doi: 10.1016/j.jcmgh.2020.09.004

PMCID:: PMC7788245

Abstract Article PDF–4.6M

Select item 742732717.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 722681218.

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex

Marissa M. Minor, F. Blaine Hollinger, Adrienne L. McNees, Sung Yun Jung, Antrix Jain, Joseph M. Hyser, Karl-Dimiter Bissig, Betty L. Slagle

Cells. 2020 Apr; 9(4): 834. Published online 2020 Mar 30. doi: 10.3390/cells9040834

PMCID:: PMC7226812

Abstract Article PDF–2.3M

Select item 716998319.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 708730820.

SARS-CoV nucleocapsid protein interacts with cellular pyruvate kinase protein and inhibits its activity

Wei-Yen Wei, Hui-Chun Li, Chiung-Yao Chen, Chee-Hing Yang, Shen-Kao Lee, Chia-Wen Wang, Hsin-Chieh Ma, Yue-Li Juang, Shih-Yen Lo

Arch Virol. 2012; 157(4): 635–645. Published online 2012 Jan 6. doi: 10.1007/s00705-011-1221-7

PMCID:: PMC7087308

Abstract Article PDF–549K

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