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Select item 107854591.

Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer’s disease: A [¹⁸F]PSS232 PET/MRI study

Jie Wang, Yingfang He, Xing Chen, Lin Huang, Junpeng Li, Zhiwen You, Qi Huang, Shuhua Ren, Kun He, Roger Schibli, Linjing Mu, Yihui Guan, Qihao Guo, Jun Zhao, Fang Xie

Alzheimers Res Ther. 2024; 16: 9. Published online 2024 Jan 12. doi: 10.1186/s13195-024-01385-z

PMCID:: PMC10785459

Abstract Article PDF–2.9M

Select item 107493582.

Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis

Izabella B. Q. de Lima, Pablo L. Cardozo, Julia S. Fahel, Juliana P. S. Lacerda, Aline S. Miranda, Antônio L. Teixeira, Fabiola M. Ribeiro

Front Immunol. 2023; 14: 1283331. Published online 2023 Dec 11. doi: 10.3389/fimmu.2023.1283331

PMCID:: PMC10749358

Abstract Article PDF–5.8M

Select item 94898813.

From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems

Cornelia Carey, Nisha Singh, Joel T. Dunn, Teresa Sementa, Maria Andreina Mendez, Hester Velthuis, Andreia C. Pereira, Charlotte Marie Pretzsch, Jamie Horder, Stefan Hader, David J. Lythgoe, Diana-Georgina Rotaru, Anthony Gee, Diana Cash, Mattia Veronese, Declan Murphy, Grainne McAlonan

Transl Psychiatry. 2022; 12: 395. Published online 2022 Sep 20. doi: 10.1038/s41398-022-02143-1

PMCID:: PMC9489881

Abstract Article PDF–1.4M

Select item 87487904.

mGluR5 binding changes during a mismatch negativity task in a multimodal protocol with [¹¹C]ABP688 PET/MR-EEG

Cláudia Régio Brambilla, Tanja Veselinović, Ravichandran Rajkumar, Jörg Mauler, Andreas Matusch, Andrej Ruch, Linda Orth, Shukti Ramkiran, Hasan Sbaihat, Nicolas Kaulen, Nibal Yahya Khudeish, Christine Wyss, Karsten Heekeren, Wolfram Kawohl, Elena Rota Kops, Lutz Tellmann, Jürgen Scheins, Frank Boers, Bernd Neumaier, Johannes Ermert, Markus Lang, Stefan Stüsgen, Hans Herzog, Karl-Josef Langen, N. Jon Shah, Christoph W. Lerche, Irene Neuner

Transl Psychiatry. 2022; 12: 6. Published online 2022 Jan 10. doi: 10.1038/s41398-021-01763-3

PMCID:: PMC8748790

Abstract Article PDF–2.4M

Select item 84246485.

Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations

Chady Nasrallah, Giuseppe Cannone, Julie Briot, Karine Rottier, Alice E. Berizzi, Chia-Ying Huang, Robert B. Quast, Francois Hoh, Jean-Louis Banères, Fanny Malhaire, Ludovic Berto, Anaëlle Dumazer, Joan Font-Ingles, Xavier Gómez-Santacana, Juanlo Catena, Julie Kniazeff, Cyril Goudet, Amadeu Llebaria, Jean-Philippe Pin, Kutti R. Vinothkumar, Guillaume Lebon

Cell Rep. 2021 Aug 31; 36(9): 109648. Published online 2021 Aug 31. doi: 10.1016/j.celrep.2021.109648

PMCID:: PMC8424648

Abstract Article

Select item 83781326.

Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [¹⁸F]FPEB PET

Adam P. Mecca, Kelly Rogers, Zachary Jacobs, Julia W. McDonald, Hannah R. Michalak, Nicole DellaGioia, Wenzhen Zhao, Ansel T Hillmer, Nabeel Nabulsi, Keunpoong Lim, Jim Ropchan, Yiyun Huang, David Matuskey, Irina Esterlis, Richard E. Carson, Christopher H. van Dyck

Neuroimage. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: Neuroimage. 2021 Sep; 238: 118217. Published online 2021 May 27. doi: 10.1016/j.neuroimage.2021.118217

PMCID:: PMC8378132

Abstract Article PDF–849K

Select item 83426107.

In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker

Maria Mody, Yoann Petibon, Paul Han, Darshini Kuruppu, Chao Ma, Daniel Yokell, Ramesh Neelamegam, Marc D. Normandin, Georges El Fakhri, Anna-Liisa Brownell

Sci Rep. 2021; 11: 15897. Published online 2021 Aug 5. doi: 10.1038/s41598-021-94967-y

PMCID:: PMC8342610

Abstract Article PDF–1.4M

Select item 79997118.

Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Idiopathic Autism Spectrum Disorder and Fragile X Syndrome: A Pilot Study

James Robert Brašić, Ayon Nandi, David S. Russell, Danna Jennings, Olivier Barret, Samuel D. Martin, Keith Slifer, Thomas Sedlak, John P. Seibyl, Dean F. Wong, Dejan B. Budimirovic

Int J Mol Sci. 2021 Mar; 22(6): 2863. Published online 2021 Mar 11. doi: 10.3390/ijms22062863

PMCID:: PMC7999711

Abstract Article PDF–1.3M

Select item 76621079.

The selective blockade of metabotropic glutamate receptor-5 attenuates fat accumulation in an in vitro model of benign steatosis

Andrea Ferrigno, Clarissa Berardo, Laura Giuseppina Di Pasqua, Marta Cagna, Veronica Siciliano, Plinio Richelmi, Mariapia Vairetti

Eur J Histochem. 2020 Oct 19; 64(4): 3175. Published online 2020 Nov 10. doi: 10.4081/ejh.2020.3175

PMCID:: PMC7662107

Abstract Article PDF–517K

Select item 754724110.

Astroglial FMRP deficiency cell-autonomously up-regulates miR-128 and disrupts developmental astroglial mGluR5 signaling

Yuqin Men, Liang Ye, Ryan D. Risgaard, Vanessa Promes, Xinyu Zhao, Martin Paukert, Yongjie Yang

Proc Natl Acad Sci U S A. 2020 Oct 6; 117(40): 25092–25103. Published online 2020 Sep 21. doi: 10.1073/pnas.2014080117

PMCID:: PMC7547241

Abstract Article PDF–1.4M

Select item 750080511.

mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia

Hoau-Yan Wang, Mathew L. MacDonald, Karin E. Borgmann-Winter, Anamika Banerjee, Patrick Sleiman, Andrew Tom, Amber Khan, Kuo-Chieh Lee, Panos Roussos, Steven J. Siegel, Scott E Hemby, Warren B. Bilker, Raquel E. Gur, Chang-Gyu Hahn

Mol Psychiatry. Author manuscript; available in PMC 2020 Sep 18.

Published in final edited form as: Mol Psychiatry. 2020 Apr; 25(4): 750–760. Published online 2018 Sep 13. doi: 10.1038/s41380-018-0234-y

PMCID:: PMC7500805

Abstract Article PDF–1.2M

Select item 736631912.

Multiplexed Phosphoproteomic Study of Brain in Patients with Alzheimer's Disease and Age-Matched Cognitively Healthy Controls

Gajanan Sathe, Kiran Kumar Mangalaparthi, Ankit Jain, Jacqueline Darrow, Juan Troncoso, Marilyn Albert, Abhay Moghekar, Akhilesh Pandey

OMICS. April 2020; 24(4): 216–227. Published online 2020 Apr 13. doi: 10.1089/omi.2019.0191

PMCID:: PMC7366319

Abstract Article PDF–829K

Select item 715670213.

Metabotropic glutamate receptor 5 in bulimia nervosa

Yoan Mihov, Valerie Treyer, Funda Akkus, Erika Toman, Gabriella Milos, Simon M. Ametamey, Anass Johayem, Gregor Hasler

Sci Rep. 2020; 10: 6374. Published online 2020 Apr 14. doi: 10.1038/s41598-020-63389-7

PMCID:: PMC7156702

Abstract Article PDF–1.2M

Select item 682565314.

The role of water and protein flexibility in the structure-based virtual screening of allosteric GPCR modulators: an mGlu₅ receptor case study

Zoltán Orgován, György G. Ferenczy, György M. Keserű

J Comput Aided Mol Des. 2019; 33(9): 787–797. Published online 2019 Sep 21. doi: 10.1007/s10822-019-00224-w

PMCID:: PMC6825653

Abstract Article PDF–1.2M

Select item 681522515.

Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5

Nicky Scheefhals, Lisa A.E. Catsburg, Margriet L. Westerveld, Thomas A. Blanpied, Casper C. Hoogenraad, Harold D. MacGillavry

Cell Rep. 2019 Oct 8; 29(2): 258–269.e8. Published online 2019 Oct 8. doi: 10.1016/j.celrep.2019.08.102

PMCID:: PMC6815225

Abstract Article

Select item 675758016.

Tamalin, a PDZ Domain-Containing Protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine Nucleotide Exchange Factor Cytohesins

Jun Kitano, Kouji Kimura, Yoshimitsu Yamazaki, Takeshi Soda, Ryuichi Shigemoto, Yoshiaki Nakajima, Shigetada Nakanishi

J Neurosci. 2002 Feb 15; 22(4): 1280–1289. doi: 10.1523/JNEUROSCI.22-04-01280.2002

PMCID:: PMC6757580

Abstract Article PDF–529K

Select item 672608817.

Interactions between Ephrin-B and Metabotropic Glutamate 1 Receptors in Brain Tissue and Cultured Neurons

L. Calò, V. Bruno, P. Spinsanti, G. Molinari, V. Korkhov, Z. Esposito, M. Patanè, D. Melchiorri, M. Freissmuth, F. Nicoletti

J Neurosci. 2005 Mar 2; 25(9): 2245–2254. doi: 10.1523/JNEUROSCI.4956-04.2005

PMCID:: PMC6726088

Abstract Article PDF–519K

Select item 670960018.

Structural Insights into Metabotropic Glutamate Receptor Activation

Antoine Koehl, Hongli Hu, Dan Feng, Bingfa Sun, Yan Zhang, Michael J Robertson, Matthew Chu, Tong Sun Kobilka, Els Pardon, Jan Steyaert, Jeffrey Tarrasch, Somnath Dutta, Rasmus Fonseca, William I Weis, Jesper M Mathiesen, Georgios Skiniotis, Brian K Kobilka

Nature. Author manuscript; available in PMC 2019 Aug 26.

Published in final edited form as: Nature. 2019 Feb; 566(7742): 79–84. Published online 2019 Jan 23. doi: 10.1038/s41586-019-0881-4

PMCID:: PMC6709600

Abstract Article PDF–5.9M

Select item 669434419.

PDZ Scaffold Protein CAL Couples with Metabotropic Glutamate Receptor 5 to Protect Against Cell Apoptosis and Is a Potential Target in the Treatment of Parkinson’s Disease

Wen Yuan Luo, Su Qian Xing, Ping Zhu, Chen Guang Zhang, Hui Min Yang, Nicholas Van Halm-Lutterodt, Li Gu, Hong Zhang

Neurotherapeutics. 2019 Jul; 16(3): 761–783. Published online 2019 May 9. doi: 10.1007/s13311-019-00730-7

PMCID:: PMC6694344

Abstract Article PDF–13M

Select item 656129820.

In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation

Margaret T. Davis, Ansel Hillmer, Sophie E. Holmes, Robert H. Pietrzak, Nicole DellaGioia, Nabeel Nabulsi, David Matuskey, Gustavo Angarita-Africano, Richard E. Carson, John H. Krystal, Irina Esterlis

Proc Natl Acad Sci U S A. 2019 Jun 4; 116(23): 11490–11495. Published online 2019 May 13. doi: 10.1073/pnas.1818871116

Correction in:: Proc Natl Acad Sci U S A. 2019 Jul 2; 116(27): 13702.

PMCID:: PMC6561298

Abstract Article PDF–807K

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