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Select item 107523751.

Fructose Induced KHK-C Can Increase ER Stress Independent of its Effect on Lipogenesis to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD

Se-Hyung Park, Robert N. Helsley, Taghreed Fadhul, Jennifer L.S. Willoughby, Leila Noetzli, Ho-Chou Tu, Marie H. Solheim, Shiho Fujisaka, Hui Pan, Jonathan M. Dreyfuss, Joanna Bons, Jacob Rose, Christina D. King, Birgit Schilling, Aldons J. Lusis, Calvin Pan, Manoj Gupta, Rohit N. Kulkarni, Kevin Fitzgerald, Philip A. Kern, Senad Divanovic, C. Ronald Kahn, Samir Softic

Metabolism. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Metabolism. 2023 Aug; 145: 155591. Published online 2023 May 23. doi: 10.1016/j.metabol.2023.155591

PMCID:: PMC10752375

Abstract Article PDF–3.2M

Select item 106799012.

Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation

Robert N. Helsley, Se-Hyung Park, Hemendra J. Vekaria, Patrick G. Sullivan, Lindsey R. Conroy, Ramon C. Sun, María del Mar Romero, Laura Herrero, Joanna Bons, Christina D. King, Jacob Rose, Jesse G. Meyer, Birgit Schilling, C. Ronald Kahn, Samir Softic

J Hepatol. Author manuscript; available in PMC 2023 Nov 27.

Published in final edited form as: J Hepatol. 2023 Jul; 79(1): 25–42. Published online 2023 Feb 21. doi: 10.1016/j.jhep.2023.02.010

PMCID:: PMC10679901

Abstract Article PDF–2.8M

Select item 104079553.

Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development

Ilaria Guccini, Guanghui Tang, Trang Thuy To, Laura Di Rito, Solange Le Blanc, Oliver Strobel, Mariantonietta D’Ambrosio, Emiliano Pasquini, Marco Bolis, Pamuditha Silva, Hasan Ali Kabakci, Svenja Godbersen, Andrea Alimonti, Gerald Schwank, Markus Stoffel

iScience. 2023 Aug 18; 26(8): 107368. Published online 2023 Jul 13. doi: 10.1016/j.isci.2023.107368

PMCID:: PMC10407955

Abstract Article PDF–6.2M

Select item 102163604.

High Fructose Corn Syrup Accelerates Kidney Disease and Mortality in Obese Mice with Metabolic Syndrome

Ana Andres-Hernando, David J. Orlicky, Christina Cicerchi, Masanari Kuwabara, Gabriela E. Garcia, Takahiko Nakagawa, Laura Gabriela Sanchez-Lozada, Richard J. Johnson, Miguel A. Lanaspa

Biomolecules. 2023 May; 13(5): 780. Published online 2023 Apr 30. doi: 10.3390/biom13050780

PMCID:: PMC10216360

Abstract Article PDF–3.3M

Select item 89859145.

Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging

Sui Seng Tee, Nathaniel Kim, Quinlan Cullen, Roozbeh Eskandari, Arsen Mamakhanyan, Rami M. Srouji, Rachel Chirayil, Sangmoo Jeong, Mojdeh Shakiba, Edward R. Kastenhuber, Shuibing Chen, Carlie Sigel, Scott W. Lowe, William R. Jarnagin, Craig B. Thompson, Andrea Schietinger, Kayvan R. Keshari

Sci Adv. 2022 Apr; 8(14): eabm7985. Published online 2022 Apr 6. doi: 10.1126/sciadv.abm7985

PMCID:: PMC8985914

Abstract Article PDF–3.9M

Select item 86866856.

Dietary Fructose Improves Intestinal Cell Survival and Nutrient Absorption

Samuel R. Taylor, Shakti Ramsamooj, Roger J. Liang, Alyna Katti, Rita Pozovskiy, Neil Vasan, Seo-Kyoung Hwang, Navid Nahiyaan, Nancy J. Francoeur, Emma M. Schatoff, Jared L. Johnson, Manish A. Shah, Andrew J. Dannenberg, Robert P. Sebra, Lukas E. Dow, Lewis C. Cantley, Kyu Y. Rhee, Marcus D. Goncalves

Nature. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Nature. 2021 Sep; 597(7875): 263–267. Published online 2021 Aug 18. doi: 10.1038/s41586-021-03827-2

PMCID:: PMC8686685

Abstract Article PDF–4.5M

Select item 78215997.

Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor

Ana Andres-Hernando, Thomas J. Jensen, Masanari Kuwabara, David J. Orlicky, Christina Cicerchi, Nanxing Li, Carlos A. Roncal-Jimenez, Gabriela E. Garcia, Takuji Ishimoto, Paul S. Maclean, Petter Bjornstad, Laura Gabriela Sanchez-Lozada, Mehmet Kanbay, Takahiko Nakagawa, Richard J. Johnson, Miguel A. Lanaspa

JCI Insight. 2021 Jan 11; 6(1): e140848. Published online 2021 Jan 11. doi: 10.1172/jci.insight.140848

PMCID:: PMC7821599

Abstract Article PDF–34M

Select item 74739118.

Sugar causes obesity and metabolic syndrome in mice independently of sweet taste

Ana Andres-Hernando, Masanari Kuwabara, David J. Orlicky, Aurelie Vandenbeuch, Christina Cicerchi, Sue C. Kinnamon, Thomas E. Finger, Richard J. Johnson, Miguel A. Lanaspa

Am J Physiol Endocrinol Metab. 2020 Aug 1; 319(2): E276–E290. Published online 2020 Jun 23. doi: 10.1152/ajpendo.00529.2019

PMCID:: PMC7473911

Abstract Article

Select item 73606819.

Peroxisome-Deficiency and HIF-2α Signaling Are Negative Regulators of Ketohexokinase Expression

Tanja Eberhart, Miriam J. Schönenberger, Katharina M. Walter, Khanichi N. Charles, Phyllis L. Faust, Werner J. Kovacs

Front Cell Dev Biol. 2020; 8: 566. Published online 2020 Jul 8. doi: 10.3389/fcell.2020.00566

PMCID:: PMC7360681

Abstract Article PDF–5.6M

Select item 734744410.

Deletion of fructokinase in the liver or in the intestine reveals differential effects on sugar-induced metabolic dysfunction

Ana Andres-Hernando, David J. Orlicky, Masanari Kuwabara, Takuji Ishimoto, Takahiko Nakagawa, Richard J. Johnson, Miguel A. Lanaspa

Cell Metab. Author manuscript; available in PMC 2021 Jul 7.

Published in final edited form as: Cell Metab. 2020 Jul 7; 32(1): 117–127.e3. Published online 2020 Jun 4. doi: 10.1016/j.cmet.2020.05.012

PMCID:: PMC7347444

Abstract Article PDF–2.2M

Select item 698885711.

Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism

Xufei Zhang, Alexandra Grosfeld, Edek Williams, Daniel Vasiliauskas, Sharon Barretto, Lorraine Smith, Mahendra Mariadassou, Catherine Philippe, Fabienne Devime, Chloé Melchior, Guillaume Gourcerol, Nathalie Dourmap, Nicolas Lapaque, Pierre Larraufie, Hervé M. Blottière, Christine Herberden, Philippe Gerard, Jens F. Rehfeld, Ronaldo P. Ferraris, J. Christopher Fritton, Sandrine Ellero-Simatos, Veronique Douard

FASEB J. 2019 Jun; 33(6): 7126–7142. Published online 2019 Apr 2. doi: 10.1096/fj.201801526RR

PMCID:: PMC6988857

Abstract Article

Select item 648785712.

High-fructose corn syrup enhances intestinal tumor growth in mice

Marcus D. Goncalves, Changyuan Lu, Jordan Tutnauer, Travis E. Hartman, Seo-Kyoung Hwang, Charles J Murphy, Chantal Pauli, Roxanne Morris, Sam Taylor, Kaitlyn Bosch, Sukjin Yang, Yumei Wang, Justin Van Riper, H Carl Lekaye, Jatin Roper, Young Kim, Qiuying Chen, Steven S. Gross, Kyu Y. Rhee, Lewis C. Cantley, Jihye Yun

Science. Author manuscript; available in PMC 2020 Mar 22.

Published in final edited form as: Science. 2019 Mar 22; 363(6433): 1345–1349. doi: 10.1126/science.aat8515

PMCID:: PMC6487857

Abstract Article PDF–717K

Select item 646406513.

Correction of gene model annotations improves isoform abundance estimates: the example of ketohexokinase ( Khk)

Christophe D. Chabbert, Tanja Eberhart, Ilaria Guccini, Wilhelm Krek, Werner J. Kovacs

Version 2. F1000Res. 2018; 7: 1956. Published online 2019 Apr 3. doi: 10.12688/f1000research.17082.2

PMCID:: PMC6464065

Abstract Article PDF–4.8M

Select item 639485514.

Lacking Ketohexokinase-A Exacerbates Renal Injury in Streptozotocin-induced Diabetic Mice

Tomohito Doke, Takuji Ishimoto, Takahiro Hayasaki, Satsuki Ikeda, Masako Hasebe, Akiyoshi Hirayama, Tomoyoshi Soga, Noritoshi Kato, Tomoki Kosugi, Naotake Tsuboi, Miguel A. Lanaspa, Richard J. Johnson, Kenji Kadomatsu, Shoichi Maruyama

Metabolism. Author manuscript; available in PMC 2019 Aug 1.

Published in final edited form as: Metabolism. 2018 Aug; 85: 161–170. Published online 2018 Mar 29. doi: 10.1016/j.metabol.2018.03.020

PMCID:: PMC6394855

Abstract Article PDF–1.0M

Select item 598334215.

Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice

Miguel A. Lanaspa, Ana Andres-Hernando, David J. Orlicky, Christina Cicerchi, Cholsoon Jang, Nanxing Li, Tamara Milagres, Masanari Kuwabara, Michael F. Wempe, Joshua D. Rabinowitz, Richard J. Johnson, Dean R. Tolan

J Clin Invest. 2018 Jun 1; 128(6): 2226–2238. Published online 2018 Apr 23. doi: 10.1172/JCI94427

PMCID:: PMC5983342

Abstract Article PDF–8.7M

Select item 586654516.

High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism

Miguel A. Lanaspa, Masanari Kuwabara, Ana Andres-Hernando, Nanxing Li, Christina Cicerchi, Thomas Jensen, David J. Orlicky, Carlos A. Roncal-Jimenez, Takuji Ishimoto, Takahiko Nakagawa, Bernardo Rodriguez-Iturbe, Paul S. MacLean, Richard J. Johnson

Proc Natl Acad Sci U S A. 2018 Mar 20; 115(12): 3138–3143. Published online 2018 Mar 5. doi: 10.1073/pnas.1713837115

Correction in:: Proc Natl Acad Sci U S A. 2018 Oct 2; 115(40): E9509.

PMCID:: PMC5866545

Abstract Article PDF–1.3M

Select item 549591317.

Nutrient sensing by absorptive and secretory progenies of small intestinal stem cells

Kunihiro Kishida, Sarah C. Pearce, Shiyan Yu, Nan Gao, Ronaldo P. Ferraris

Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1; 312(6): G592–G605. Published online 2017 Mar 23. doi: 10.1152/ajpgi.00416.2016

PMCID:: PMC5495913

Abstract Article

Select item 531680718.

Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

Ana Andres-Hernando, Nanxing Li, Christina Cicerchi, Shinichiro Inaba, Wei Chen, Carlos Roncal-Jimenez, Myphuong T. Le, Michael F. Wempe, Tamara Milagres, Takuji Ishimoto, Mehdi Fini, Takahiko Nakagawa, Richard J. Johnson, Miguel A. Lanaspa

Nat Commun. 2017; 8: 14181. Published online 2017 Feb 13. doi: 10.1038/ncomms14181

PMCID:: PMC5316807

Abstract Article PDF–3.2M

Select item 528848419.

Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice

Zhilin Song (宋志林), Carlos A. Roncal-Jimenez, Miguel A. Lanaspa-Garcia, Sarah A. Oppelt, Masanari Kuwabara, Thomas Jensen, Tamara Milagres, Ana Andres-Hernando, Takuji Ishimoto, Gabriela E. Garcia, Ginger Johnson, Paul S. MacLean, Laura-Gabriela Sanchez-Lozada, Dean R. Tolan, Richard J. Johnson

J Neurophysiol. 2017 Feb 1; 117(2): 646–654. Published online 2016 Nov 16. doi: 10.1152/jn.00781.2016

PMCID:: PMC5288484

Abstract Article

Select item 514223220.

Aging-associated renal disease in mice is fructokinase dependent

Carlos A. Roncal-Jimenez, Takuji Ishimoto, Miguel A. Lanaspa, Tamara Milagres, Ana Andres Hernando, Thomas Jensen, Makoto Miyazaki, Tomohito Doke, Takahiro Hayasaki, Takahiko Nakagawa, Shoichi Marumaya, David A. Long, Gabriela E. Garcia, Masanari Kuwabara, Laura G. Sánchez-Lozada, Duk-Hee Kang, Richard J. Johnson

Am J Physiol Renal Physiol. 2016 Oct 1; 311(4): F722–F730. Published online 2016 Jul 27. doi: 10.1152/ajprenal.00306.2016

PMCID:: PMC5142232

Abstract Article

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