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Select item 111801761.

Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α

Yu Peng, Hui Qian, Wen-Ping Xu, Meng-Chao Xiao, Chen-Hong Ding, Fang Liu, Huan-Yu Hong, Shu-Qing Liu, Xin Zhang, Wei-Fen Xie

Cell Death Dis. 2024 Jun; 15(6): 416. Published online 2024 Jun 15. doi: 10.1038/s41419-024-06819-y

PMCID:: PMC11180176

Abstract Article PDF–5.0M

Select item 108077102.

HNF1α maintains pancreatic α and β cell functions in primary human islets

Mollie F. Qian, Romina J. Bevacqua, Vy M.N. Coykendall, Xiong Liu, Weichen Zhao, Charles A. Chang, Xueying Gu, Xiao-Qing Dai, Patrick E. MacDonald, Seung K. Kim

JCI Insight. 2023 Dec 22; 8(24): e170884. Published online 2023 Dec 22. doi: 10.1172/jci.insight.170884

PMCID:: PMC10807710

Abstract Article PDF–2.3M

Select item 106279203.

Characterisation of HNF1A variants in paediatric diabetes in Norway using functional and clinical investigations to unmask phenotype and monogenic diabetes

Pernille Svalastoga, Alba Kaci, Janne Molnes, Marie H. Solheim, Bente B. Johansson, Lars Krogvold, Torild Skrivarhaug, Eivind Valen, Stefan Johansson, Anders Molven, Jørn V. Sagen, Eirik Søfteland, Lise Bjørkhaug, Erling Tjora, Ingvild Aukrust, Pål R. Njølstad

Diabetologia. 2023; 66(12): 2226–2237. Published online 2023 Oct 5. doi: 10.1007/s00125-023-06012-4

PMCID:: PMC10627920

Abstract Article PDF–1.5M

Select item 104804454.

Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A

Chen Weng, Anniya Gu, Shanshan Zhang, Leina Lu, Luxin Ke, Peidong Gao, Xiaoxiao Liu, Yuntong Wang, Peinan Hu, Dylan Plummer, Elise MacDonald, Saixian Zhang, Jiajia Xi, Sisi Lai, Konstantin Leskov, Kyle Yuan, Fulai Jin, Yan Li

Nat Commun. 2023; 14: 5400. Published online 2023 Sep 5. doi: 10.1038/s41467-023-41228-3

PMCID:: PMC10480445

Abstract Article PDF–8.5M

Select item 103713375.

High-fat diet plus HNF1A variant promotes polyps by activating β-catenin in early-onset colorectal cancer

Heyu Song, Ricky A. Sontz, Matthew J. Vance, Julia M. Morris, Sulaiman Sheriff, Songli Zhu, Suzann Duan, Jiping Zeng, Erika Koeppe, Ritu Pandey, Curtis A. Thorne, Elena M. Stoffel, Juanita L. Merchant

JCI Insight. 2023 Jul 10; 8(13): e167163. Published online 2023 Jul 10. doi: 10.1172/jci.insight.167163

PMCID:: PMC10371337

Abstract Article PDF–7.8M

Select item 103131206.

Molecular characterization and re-interpretation of HNF1A variants identified in Indian MODY subjects towards precision medicine

Babu Kavitha, Sampathkumar Ranganathan, Sundaramoorthy Gopi, Umashankar Vetrivel, Nagarajan Hemavathy, Viswanathan Mohan, Venkatesan Radha

Front Endocrinol (Lausanne) 2023; 14: 1177268. Published online 2023 Jun 16. doi: 10.3389/fendo.2023.1177268

PMCID:: PMC10313120

Abstract Article PDF–3.3M

Select item 101567477.

HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells

Jun Wei Chan, Claire Wen Ying Neo, Soumita Ghosh, Hyungwon Choi, Su Chi Lim, E. Shyong Tai, Adrian Kee Keong Teo

Cell Death Dis. 2023 May; 14(5): 302. Published online 2023 May 3. doi: 10.1038/s41419-023-05827-8

PMCID:: PMC10156747

Abstract Article PDF–4.2M

Select item 100111398.

Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection

Jin Wei, Ajinkya Patil, Clayton K. Collings, Mia Madel Alfajaro, Yu Liang, Wesley L. Cai, Madison S. Strine, Renata B. Filler, Peter C. DeWeirdt, Ruth E. Hanna, Bridget L. Menasche, Arya Ökten, Mario A. Peña-Hernández, Jon Klein, Andrew McNamara, Romel Rosales, Briana L. McGovern, M. Luis Rodriguez, Adolfo García-Sastre, Kris M. White, Yiren Qin, John G. Doench, Qin Yan, Akiko Iwasaki, Thomas P. Zwaka, Jun Qi, Cigall Kadoch, Craig B. Wilen

Nat Genet. 2023; 55(3): 471–483. Published online 2023 Mar 9. doi: 10.1038/s41588-023-01307-z

PMCID:: PMC10011139

Abstract Article PDF–21M

Select item 99805779.

HNF1A regulates the crosstalk between innate immune responses and MAFLD by mediating autophagic degradation of TBK1

Yunfei Qin, Dongbo Qiu, Qi Zhang

Autophagy. 2023; 19(3): 1026–1027. Published online 2022 Aug 11. doi: 10.1080/15548627.2022.2110728

PMCID:: PMC9980577

Abstract Article PDF–362K

Select item 976531110.

Integrated Transcriptomic and Proteomic Analysis Identifies Plasma Biomarkers of Hepatocellular Failure in Alcohol-Associated Hepatitis

Josepmaria Argemi, Komal Kedia, Marina A. Gritsenko, Ana Clemente-Sanchez, Aliya Asghar, Jose M. Herranz, Zhang-Xu Liu, Stephen R. Atkinson, Richard D. Smith, Trina M. Norden-Krichmar, Le Z. Day, Andrew Stolz, John A. Tayek, Ramon Bataller, Timothy R. Morgan, Jon M. Jacobs, the Southern California Alcoholic Hepatitis Consortium and the InTeam Consortium

Am J Pathol. 2022 Dec; 192(12): 1658–1669. doi: 10.1016/j.ajpath.2022.08.009

PMCID:: PMC9765311

Abstract Article PDF–2.8M

Select item 972913111.

The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations

Lauren A. Stalbow, Michael H. Preuss, Roelof A. J. Smit, Nathalie Chami, Lise Bjørkhaug, Ingvild Aukrust, Anna L. Gloyn, Ruth J. F. Loos

Diabetologia. 2023; 66(1): 116–126. Published online 2022 Oct 11. doi: 10.1007/s00125-022-05806-2

PMCID:: PMC9729131

Abstract Article PDF–1.2M

Select item 958687412.

The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A

Anthony Beucher, Irene Miguel-Escalada, Diego Balboa, Matías G. De Vas, Miguel Angel Maestro, Javier Garcia-Hurtado, Aina Bernal, Roser Gonzalez-Franco, Pierfrancesco Vargiu, Holger Heyn, Philippe Ravassard, Sagrario Ortega, Jorge Ferrer

Nat Cell Biol. 2022; 24(10): 1528–1540. Published online 2022 Oct 6. doi: 10.1038/s41556-022-00996-8

PMCID:: PMC9586874

Abstract Article PDF–15M

Select item 953919013.

Decreased TCF1 and BCL11B expression predicts poor prognosis for patients with chronic lymphocytic leukemia

Taotao Liang, Xiaojiao Wang, Yanyan Liu, Hao Ai, Qian Wang, Xianwei Wang, Xudong Wei, Yongping Song, Qingsong Yin

Front Immunol. 2022; 13: 985280. Published online 2022 Sep 23. doi: 10.3389/fimmu.2022.985280

PMCID:: PMC9539190

Abstract Article PDF–7.2M

Select item 930010514.

Genome‐wide association of individual vulnerability with alcohol‐associated liver disease: A Korean genome and epidemiology study

Kwang Yoon Kim, Jung Oh Kim, Young‐Sang Kim, Ja‐Eun Choi, Jae‐Min Park, Kunhee Han, Da‐Hyun Park, Yon Chul Park, Bom Taeck Kim, Kyung‐Won Hong

Hepatology. 2022 Feb; 75(2): 391–402. Published online 2021 Dec 6. doi: 10.1002/hep.32115

PMCID:: PMC9300105

Abstract Article PDF–726K

Select item 898801015.

Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants

Laura Kind, Arne Raasakka, Janne Molnes, Ingvild Aukrust, Lise Bjørkhaug, Pål Rasmus Njølstad, Petri Kursula, Thomas Arnesen

J Biol Chem. 2022 Apr; 298(4): 101803. Published online 2022 Mar 4. doi: 10.1016/j.jbc.2022.101803

PMCID:: PMC8988010

Abstract Article PDF–3.1M

Select item 894967716.

HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of HNF4A Promoter Activity with Possible Disruption in Transcription Networks

Effi Haque, Aamir Salam Teeli, Dawid Winiarczyk, Masahiko Taguchi, Shun Sakuraba, Hidetoshi Kono, Paweł Leszczyński, Mariusz Pierzchała, Hiroaki Taniguchi

Genes (Basel) 2022 Mar; 13(3): 413. Published online 2022 Feb 24. doi: 10.3390/genes13030413

PMCID:: PMC8949677

Abstract Article PDF–3.7M

Select item 894872017.

HNF1A Mutations and Beta Cell Dysfunction in Diabetes

Yasutaka Miyachi, Takashi Miyazawa, Yoshihiro Ogawa

Int J Mol Sci. 2022 Mar; 23(6): 3222. Published online 2022 Mar 16. doi: 10.3390/ijms23063222

PMCID:: PMC8948720

Abstract Article PDF–772K

Select item 892147618.

HNF1A：From Monogenic Diabetes to Type 2 Diabetes and Gestational Diabetes Mellitus

Li-Mei Li, Bei-Ge Jiang, Liang-Liang Sun

Front Endocrinol (Lausanne) 2022; 13: 829565. Published online 2022 Mar 1. doi: 10.3389/fendo.2022.829565

PMCID:: PMC8921476

Abstract Article PDF–2.5M

Select item 890508819.

An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function

Ana-Maria Cujba, Mario E. Alvarez-Fallas, Sergio Pedraza-Arevalo, Anna Laddach, Maggie H. Shepherd, Andrew T. Hattersley, Fiona M. Watt, Rocio Sancho

Cell Rep. 2022 Mar 1; 38(9): 110425. Published online 2022 Mar 1. doi: 10.1016/j.celrep.2022.110425

PMCID:: PMC8905088

Abstract Article PDF–6.2M

Select item 889416020.

A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY

Jarno L. T. Kettunen, Elina Rantala, Om P. Dwivedi, Bo Isomaa, Leena Sarelin, Paula Kokko, Liisa Hakaste, Päivi J. Miettinen, Leif C. Groop, Tiinamaija Tuomi

Diabetologia. 2022; 65(4): 632–643. Published online 2021 Dec 24. doi: 10.1007/s00125-021-05631-z

Correction in:: Diabetologia. 2022; 65(5): 912.

PMCID:: PMC8894160

Abstract Article PDF–787K

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