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Select item 109977911.

Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy

Xuan Wang, Molei Liu, Isabelle-Emmanuella Nogues, Tony Chen, Xin Xiong, Clara-Lea Bonzel, Harrison Zhang, Chuan Hong, Yin Xia, Kumar Dahal, Lauren Costa, Jing Cui, VA Million Veteran Program, J. Michael Gaziano, Seoyoung C. Kim, Yuk-Lam Ho, Kelly Cho, Tianxi Cai, Katherine P. Liao

Sci Rep. 2024; 14: 8021. Published online 2024 Apr 5. doi: 10.1038/s41598-024-54063-3

PMCID:: PMC10997791

Abstract Article PDF–1.5M

Select item 107627352.

Possible Role of IL-6R/STAT3/MiRNA-34a Feedback Loop in Osteosarcoma

Marwa Fathy Amer, Abbas Mohamed, Abeer Ismail, Lamiaa Ali Bayoumi, Passant Essam Eldin Shibel, Ghada Nabil Elnaggar

Asian Pac J Cancer Prev. 2023; 24(9): 3269–3274. doi: 10.31557/APJCP.2023.24.9.3269

PMCID:: PMC10762735

Abstract Article PDF–582K

Select item 106823893.

Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells

Amalie C.M. Couch, Shiden Solomon, Rodrigo R.R. Duarte, Alessia Marrocu, Yiqing Sun, Laura Sichlinger, Rugile Matuleviciute, Lucia Dutan Polit, Bjørn Hanger, Amelia Brown, Shahram Kordasti, Deepak P. Srivastava, Anthony C. Vernon

Brain Behav Immun. 2023 May; 110: 43–59. doi: 10.1016/j.bbi.2023.02.007

PMCID:: PMC10682389

Abstract Article PDF–5.1M

Select item 105688284.

Associations between serum estradiol and IL-6/sIL-6R/sgp130 complex in female patients with major depressive disorder

Ting Sun, Qian Chen, Junchi Mei, Yan Li

BMC Psychiatry. 2023; 23: 742. Published online 2023 Oct 12. doi: 10.1186/s12888-023-05248-z

PMCID:: PMC10568828

Abstract Article PDF–1.2M

Select item 102207395.

Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population

Fabíola Brasil Barbosa Rodrigues, Rosilene da Silva, Erika Ferreira dos Santos, Mioni Thieli Figueiredo Magalhães de Brito, Andréa Luciana Soares da Silva, Mauro de Meira Leite, Flávia Póvoa da Costa, Maria de Nazaré do Socorro de Almeida Viana, Kevin Matheus Lima de Sarges, Marcos Henrique Damasceno Cantanhede, Adriana de Oliveira Lameira Veríssimo, Mayara da Silva Carvalho, Daniele Freitas Henriques, Carla Pinheiro da Silva, Igor Brasil Costa, Juliana Abreu Lima Nunes, Iran Barros Costa, Giselle Maria Rachid Viana, Maria Alice Freitas Queiroz, Sandra Souza Lima, Jeferson da Costa Lopes, Maria Karoliny da Silva Torres, Izaura Maria Vieira Cayres Vallinoto, Carlos David Araújo Bichara, Antonio Carlos Rosário Vallinoto, Eduardo José Melo dos Santos

Viruses. 2023 May; 15(5): 1197. Published online 2023 May 19. doi: 10.3390/v15051197

PMCID:: PMC10220739

Abstract Article PDF–280K

Select item 101574706.

Inflammatory bowel diseases, interleukin-6 and interleukin-6 receptor subunit alpha in causal association with cerebral cortical structure: a Mendelian randomization analysis

Chunlong Liu, Shijie Zhu, Jian Zhang, Kuiwu Ren, Kangkang Li, Jiangtao Yu

Front Immunol. 2023; 14: 1154746. Published online 2023 Apr 20. doi: 10.3389/fimmu.2023.1154746

PMCID:: PMC10157470

Abstract Article PDF–3.6M

Select item 98830447.

Interleukin-6 receptor polymorphism attenuates clonal hematopoiesis-mediated coronary artery disease risk among 451,180 individuals in the UK Biobank

Caitlyn Vlasschaert, J. Brett Heimlich, Michael J. Rauh, Pradeep Natarajan, Alexander G. Bick

Circulation. Author manuscript; available in PMC 2024 Jan 24.

Published in final edited form as: Circulation. 2023 Jan 24; 147(4): 358–360. Published online 2023 Jan 23. doi: 10.1161/CIRCULATIONAHA.122.062126

PMCID:: PMC9883044

Article PDF–411K

Select item 96904598.

High Serum Levels of IL-6 Are Associated with Suicide Attempt but Not with High Lethality Suicide Attempts: A Preliminary Case–Control Study

Rosa Giannina Castillo-Avila, Alma Delia Genis-Mendoza, Isela Esther Juárez-Rojop, María Lilia López-Narváez, Diana María Dionisio-García, Germán Alberto Nolasco-Rosales, Miguel Ángel Ramos-Méndez, Yazmín Hernández-Díaz, Carlos Alfonso Tovilla-Zárate, Thelma Beatriz González-Castro, Humberto Nicolini

Int J Environ Res Public Health. 2022 Nov; 19(22): 14735. Published online 2022 Nov 9. doi: 10.3390/ijerph192214735

PMCID:: PMC9690459

Abstract Article PDF–924K

Select item 95872869.

HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer

Guangying Xu, Liling Niu, Youhui Wang, Guang Yang, Xingwu Zhu, Yuan Yao, Gang Zhao, Shaowei Wang, Hui Li

Cell Death Dis. 2022 Oct; 13(10): 888. Published online 2022 Oct 21. doi: 10.1038/s41419-022-05335-1

PMCID:: PMC9587286

Abstract Article PDF–6.5M

Select item 930331610.

Dissecting the IL‐6 pathway in cardiometabolic disease: A Mendelian randomization study on both IL6 and IL6R

Arjen J. Cupido, Folkert W. Asselbergs, Pradeep Natarajan, CHARGE Inflammation Working Group, Paul M. Ridker, G. Kees Hovingh, A. Floriaan Schmidt

Br J Clin Pharmacol. 2022 Jun; 88(6): 2875–2884. Published online 2022 Jan 28. doi: 10.1111/bcp.15191

PMCID:: PMC9303316

Abstract Article PDF–1.6M

Select item 918645111.

miR-451a targeting IL-6R activates JAK2/STAT3 pathway, thus regulates proliferation and apoptosis of multiple myeloma cells

Lingling Xu, Yuning Yao, Ting Lu, Libo Jiang

J Musculoskelet Neuronal Interact. 2022; 22(2): 251–260.

PMCID:: PMC9186451

Abstract Article PDF–2.5M

Select item 913821012.

Co-Occurrence of Interleukin-6 Receptor Asp358Ala Variant and High Plasma Levels of IL-6: An Evidence of IL-6 Trans-Signaling Activation in Deep Vein Thrombosis (DVT) Patients

Rossella Salemi, Giuseppe Gattuso, Barbara Tomasello, Alessandro Lavoro, Agostino Gaudio, Massimo Libra, Salvatore Santo Signorelli, Saverio Candido

Biomolecules. 2022 May; 12(5): 681. Published online 2022 May 10. doi: 10.3390/biom12050681

PMCID:: PMC9138210

Abstract Article PDF–661K

Select item 904667513.

Cumulative Evidence for Associations Between Genetic Variants in Interleukin 6 Receptor Gene and Human Diseases and Phenotypes

Min Zhang, Ye Bai, Yutong Wang, Huijie Cui, Mingshuang Tang, Lanbing Wang, Xin Wang, Dongqing Gu

Front Immunol. 2022; 13: 860703. Published online 2022 Apr 14. doi: 10.3389/fimmu.2022.860703

PMCID:: PMC9046675

Abstract Article PDF–1.1M

Select item 903294114.

Genome-wide pleiotropy analysis of coronary artery disease and pneumonia identifies shared immune pathways

Zhi Yu, Seyedeh M. Zekavat, Sara Haidermota, Rachel Bernardo, Bryan T. MacDonald, Peter Libby, Hilary K. Finucane, Pradeep Natarajan

Sci Adv. 2022 Apr; 8(16): eabl4602. Published online 2022 Apr 22. doi: 10.1126/sciadv.abl4602

PMCID:: PMC9032941

Abstract Article PDF–1.0M

Select item 899815815.

Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers

Dan Høgdall, Colm J. O’Rourke, Christian Dehlendorff, Ole F. Larsen, Lars H. Jensen, Astrid Z. Johansen, Hien Dang, Valentina M. Factor, Mie Grunnet, Morten Mau-Sørensen, Douglas V.N.P. Oliveira, Dorte Linnemann, Mogens K. Boisen, Xin W. Wang, Julia S. Johansen, Jesper B. Andersen

Clin Cancer Res. Author manuscript; available in PMC 2022 Apr 11.

Published in final edited form as: Clin Cancer Res. 2020 Nov 1; 26(21): 5655–5667. Published online 2020 Sep 15. doi: 10.1158/1078-0432.CCR-19-2700