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Select item 112408731.

Precision Dosing for Tacrolimus Using Genotypes and Clinical Factors in Kidney Transplant Recipients of European Ancestry

Mahmoud Al-Kofahi, William S. Oetting, David P. Schladt, Rory P. Remmel, Weihua Guan, Baolin Wu, Casey R. Dorr, Roslyn B. Mannon, Arthur J. Matas, Ajay K. Israni, Pamala A. Jacobson

J Clin Pharmacol. Author manuscript; available in PMC 2024 Jul 12.

Published in final edited form as: J Clin Pharmacol. 2021 Aug; 61(8): 1035–1044. Published online 2021 Feb 26. doi: 10.1002/jcph.1823

PMCID:: PMC11240873

Abstract Article PDF–806K

Select item 111597482.

Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel‐induced leukopenia

Kazuma Kiyotani, Taisei Mushiroda, Michiaki Kubo, Hitoshi Zembutsu, Yuichi Sugiyama, Yusuke Nakamura

Cancer Sci. 2008 May; 99(5): 967–972. Published online 2008 Feb 20. doi: 10.1111/j.1349-7006.2008.00765.x

PMCID:: PMC11159748

Abstract Article PDF–101K

Select item 109663833.

Bone marrow niche chemoprotection of metastatic solid tumors mediated by CYP3A4

Gabriel Ghiaur, Kenneth C. Valkenburg, Christopher Esteb, Alexander Ambinder, Philip H. Imus, Kenneth J. Pienta, Richard J. Jones

Cancer. Author manuscript; available in PMC 2024 Mar 27.

Published in final edited form as: Cancer. 2023 Jun 1; 129(11): 1744–1751. Published online 2023 Feb 25. doi: 10.1002/cncr.34704

PMCID:: PMC10966383

Abstract Article PDF–775K

Select item 108403334.

Functional maturation of cytochromes P450 3A4 and 2D6 relies on GAPDH- and Hsp90-Dependent heme allocation

Sidra Islam, Dhanya Thamaraparambil Jayaram, Pranjal Biswas, Dennis J. Stuehr

J Biol Chem. 2024 Feb; 300(2): 105633. Published online 2024 Jan 8. doi: 10.1016/j.jbc.2024.105633

PMCID:: PMC10840333

Abstract Article PDF–2.2M

Select item 107324495.

Cyp3A4 *1G polymorphism is associated with alcohol drinking: A 5-year retrospective single centered population-based study in China

Xiaoqing Jia, Xiaoting Zhang, Tao Zhou, Dalong Sun, Rong Li, Na Yang, Zheng Luo

PLoS One. 2023; 18(12): e0295184. Published online 2023 Dec 20. doi: 10.1371/journal.pone.0295184

PMCID:: PMC10732449

Abstract Article PDF–1.1M

Select item 106480856.

Down-Regulation of CYP3A4 by the K_Ca1.1 Inhibition Is Responsible for Overcoming Resistance to Doxorubicin in Cancer Spheroid Models

Susumu Ohya, Junko Kajikuri, Hiroaki Kito, Miki Matsui

Int J Mol Sci. 2023 Nov; 24(21): 15672. Published online 2023 Oct 27. doi: 10.3390/ijms242115672

PMCID:: PMC10648085

Abstract Article PDF–5.7M

Select item 106142047.

The roles of CYP2C19 and CYP3A4 in the in vitro metabolism of β‐eudesmol in human liver: Reaction phenotyping and enzyme kinetics

Nadda Muhamad, Kesara Na‐Bangchang

Pharmacol Res Perspect. 2023 Dec; 11(6): e01149. Published online 2023 Oct 30. doi: 10.1002/prp2.1149

PMCID:: PMC10614204

Abstract Article PDF–1.3M

Select item 105655378.

Effects of CYP3A4 and CYP2C9 genotype on systemic anastrozole and fulvestrant concentrations in SWOG S0226

Delaney V Rutherford, Sarah Medley, Nicholas C Henderson, Christina L Gersch, Ted A Vandenberg, Kathy S Albain, Shaker R Dakhil, Nagendra R Tirumali, Julie R Gralow, Gabriel N Hortobagyi, Lajos Pusztai, Rita S Mehta, Daniel F Hayes, Kelley M Kidwell, N Lynn Henry, William E Barlow, James M Rae, Daniel L Hertz

Pharmacogenomics. 2023 Aug; 24(12): 665–673. Published online 2023 Aug 23. doi: 10.2217/pgs-2023-0097

PMCID:: PMC10565537

Abstract Article PDF–784K

Select item 105237009.

Association between CYP3A4/CYP3A5 genetic polymorphisms and treatment outcomes of atorvastatin worldwide: is there enough research on the Egyptian population?

Mohammed G. Maslub, Mahasen A. Radwan, Nur Aizati Athirah Daud, Abubakar Sha’aban

Eur J Med Res. 2023; 28: 381. Published online 2023 Sep 27. doi: 10.1186/s40001-023-01038-1

PMCID:: PMC10523700

Abstract Article PDF–1.4M

Select item 1048778710.

Potential Association of Cytochrome P450 Copy Number Alteration in Tumour with Chemotherapy Resistance in Lung Adenocarcinoma Patients

Evelyn Incze, Katalin Mangó, Ferenc Fekete, Ádám Ferenc Kiss, Ádám Póti, Tünde Harkó, Judit Moldvay, Dávid Szüts, Katalin Monostory

Int J Mol Sci. 2023 Sep; 24(17): 13380. Published online 2023 Aug 29. doi: 10.3390/ijms241713380

PMCID:: PMC10487787

Abstract Article PDF–1.1M

Select item 1047020011.

Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding

Irina F. Sevrioukova

J Biol Chem. 2023 Sep; 299(9): 105117. Published online 2023 Jul 29. doi: 10.1016/j.jbc.2023.105117

PMCID:: PMC10470200

Abstract Article PDF–2.3M

Select item 1032739612.

The impact of ABCB1, CYP3A4/5 and ABCG2 gene polymorphisms on rivaroxaban trough concentrations and bleeding events in patients with non-valvular atrial fibrillation

Tingting Wu, Shuyi Wu, Li Li, Jing Xiang, Na Wang, Wenjun Chen, Jinhua Zhang

Hum Genomics. 2023; 17: 59. Published online 2023 Jul 7. doi: 10.1186/s40246-023-00506-3

PMCID:: PMC10327396

Abstract Article PDF–729K

Select item 1030948013.

The Influence of CYP3A4 Polymorphism in Sex Steroids as a Risk Factor for Breast Cancer

Melissa Gonzalez Veiga, Rogério Tadeu Felizi, Dayane Guerino Reis, Ivo Carelli Filho, Cesar Eduardo Fernandes, Ricardo Peres do Souto, Emerson Oliveira

Rev Bras Ginecol Obstet. 2018 Nov; 40(11): 699–704. Published online 2018 Oct 18. doi: 10.1055/s-0038-1673365

PMCID:: PMC10309480

Abstract Article PDF–218K

Select item 980667214.

Evaluating the Impacts of CYP3A4*1B and CYP3A5*3 Variations on Pharmacokinetic Behavior and Clinical Outcomes in Multiple Myeloma Patients With Autologous Stem Cell Transplant

JUNAN LI, YU KYOUNG CHO, DOUGLAS W. SBOROV, MITCH A. PHELPS, CRAIG C. HOFMEISTER, MING J. POI

Cancer Genomics Proteomics. 2023 Jan-Feb; 20(1): 9–17. Published online 2023 Jan 3. doi: 10.21873/cgp.20360

PMCID:: PMC9806672

Abstract Article PDF–400K

Select item 972826715.

Detoxification of Aflatoxin B1 Contaminated Maize Using Human CYP3A4

Marie Yamada, Koji Hatsuta, Mayuko Niikawa, Hiromasa Imaishi

J Microbiol Biotechnol. 2020 Aug 28; 30(8): 1207–1213. Published online 2020 May 13. doi: 10.4014/jmb.2003.03032

PMCID:: PMC9728267

Abstract Article PDF–772K

Select item 965243816.

Regulatory variants in a novel distal enhancer regulate the expression of CYP3A4 and CYP3A5

Joseph M. Collins, Adaeze C. Nworu, Somayya J. Mohammad, Liang Li, Chengcheng Li, Chuanjiang Li, Ethan Schwendeman, Mattew Cefalu, Mahmoud Abdel‐Rasoul, Jessie W. Sun, Sakima A. Smith, Danxin Wang

Clin Transl Sci. 2022 Nov; 15(11): 2720–2731. Published online 2022 Sep 20. doi: 10.1111/cts.13398

PMCID:: PMC9652438

Abstract Article PDF–1.0M

Select item 960448317.

Crystal Structure of CYP3A4 Complexed with Fluorol Identifies the Substrate Access Channel as a High-Affinity Ligand Binding Site

Irina F. Sevrioukova

Int J Mol Sci. 2022 Oct; 23(20): 12591. Published online 2022 Oct 20. doi: 10.3390/ijms232012591

PMCID:: PMC9604483

Abstract Article PDF–3.2M

Select item 927270218.

Tacrolimus CYP3A Single-Nucleotide Polymorphisms and Preformed T- and B-Cell Alloimmune Memory Improve Current Pretransplant Rejection-Risk Stratification in Kidney Transplantation

Elena Crespo, Anna Vidal-Alabró, Thomas Jouve, Pere Fontova, Maik Stein, Sonila Mocka, Maria Meneghini, Anett Sefrin, Petra Hruba, Montserrat Gomà, Alba Torija, Laura Donadeu, Alex Favà, Josep M. Cruzado, Edoardo Melilli, Francesc Moreso, Ondrej Viklicky, Frederike Bemelman, Petra Reinke, Josep Grinyó, Nuria Lloberas, Oriol Bestard

Front Immunol. 2022; 13: 869554. Published online 2022 Jun 27. doi: 10.3389/fimmu.2022.869554

PMCID:: PMC9272702

Abstract Article PDF–3.4M

Select item 903631319.

Efavirenz Induces CYP2B6-Mediated Hydroxylation of Bupropion in Healthy Subjects

Sarah M. Robertson, Frank Maldarelli, Ven Natarajan, Elizabeth Formentini, Raul M. Alfaro, Scott R. Penzak

J Acquir Immune Defic Syndr. Author manuscript; available in PMC 2022 Apr 25.

Published in final edited form as: J Acquir Immune Defic Syndr. 2008 Dec 15; 49(5): 513–519. doi: 10.1097/QAI.0b013e318183a425

PMCID:: PMC9036313

Abstract Article PDF–472K

Select item 885794020.

Midazolam as a Probe for Drug–Drug Interactions Mediated by CYP3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation

Ilia G. Denisov, Yelena V. Grinkova, Tyler Camp, Mark A. McLean, Stephen G. Sligar

Biochemistry. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: Biochemistry. 2021 Jun 1; 60(21): 1670–1681. Published online 2021 May 20. doi: 10.1021/acs.biochem.1c00161

PMCID:: PMC8857940

Abstract Article PDF–1.7M

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