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Items: 1 to 20 of 104

1.
Protein SUMOylation promotes cAMP-independent EPAC1 activation
Wenli Yang, Fang C. Mei, Wei Lin, Mark A. White, Li Li, Yue Li, Sheng Pan, Xiaodong Cheng
Cell Mol Life Sci. 2024 Dec; 81(1): 283. Published online 2024 Jul 4. doi: 10.1007/s00018-024-05315-y
PMCID:
PMC11335207
AbstractArticlePDF–2.7M
2.
The role of Epac in the heart
Takayuki Fujita, Masanari Umemura, Utako Yokoyama, Satoshi Okumura, Yoshihiro Ishikawa
Cell Mol Life Sci. 2017 Feb; 74(4): 591–606. Published online 2016 Aug 22. doi: 10.1007/s00018-016-2336-5
PMCID:
PMC11107744
AbstractArticlePDF–1.6M
3.
EPAC1 enhances brown fat growth and beige adipogenesis
Laia Reverte-Salisa, Sana Siddig, Staffan Hildebrand, Xi Yao, Jelena Zurkovic, Michelle Y. Jaeckstein, Joerg Heeren, Frank Lezoualc’h, Natalie Krahmer, Alexander Pfeifer
Nat Cell Biol. 2024; 26(1): 113–123. Published online 2024 Jan 9. doi: 10.1038/s41556-023-01311-9
PMCID:
PMC10791580
AbstractArticlePDF–14M
4.
Cyclic AMP induces reversible EPAC1 condensates that regulate histone transcription
Liliana Felicia Iannucci, Anna Maria D’Erchia, Ernesto Picardi, Daniela Bettio, Filippo Conca, Nicoletta Concetta Surdo, Giulietta Di Benedetto, Deborah Musso, Cristina Arrigoni, Marco Lolicato, Mauro Vismara, Francesca Grisan, Leonardo Salviati, Luciano Milanesi, Graziano Pesole, Konstantinos Lefkimmiatis
Nat Commun. 2023; 14: 5521. Published online 2023 Sep 8. doi: 10.1038/s41467-023-41088-x
PMCID:
PMC10491619
AbstractArticlePDF–11M
5.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
6.
EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression
Aishwarya Krishnan, Aishwarya I. Bhasker, Mithalesh K. Singh, Carlos. I. Rodriguez, Edgardo Castro-Pérez, Sarah Altameemi, Marcos Lares, Hamidullah Khan, Mary Ndiaye, Nihal Ahmad, Stefan M. Schieke, Vijayasaradhi Setaluri
Mol Cancer Res. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cancer Res. 2022 Oct 4; 20(10): 1548–1560. doi: 10.1158/1541-7786.MCR-22-0026
PMCID:
PMC9532357
AbstractArticlePDF–1.1M
7.
Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids
João F. Ferreira, Iris A. L. Silva, Hugo M. Botelho, Margarida D. Amaral, Carlos M. Farinha
Cells. 2022 Aug; 11(15): 2295. Published online 2022 Jul 25. doi: 10.3390/cells11152295
PMCID:
PMC9332071
AbstractArticlePDF–1.8M
8.
Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis
Zhuofu Ni, Xiaodong Cheng
Cells. 2021 Oct; 10(10): 2750. Published online 2021 Oct 14. doi: 10.3390/cells10102750
PMCID:
PMC8534922
AbstractArticlePDF–2.8M
9.
Identification and Characterization of an Affimer Affinity Reagent for the Detection of the cAMP Sensor, EPAC1
Hanna K. Buist, Urszula Luchowska-Stańska, Boy van Basten, Jessica Valli, Brian O. Smith, George S. Baillie, Colin Rickman, Bryon Ricketts, Alex Davidson, Ryan Hannam, Joanne Sunderland, Stephen J. Yarwood
Cells. 2021 Sep; 10(9): 2307. Published online 2021 Sep 3. doi: 10.3390/cells10092307
PMCID:
PMC8465552
AbstractArticlePDF–4.7M
10.
Epac: new emerging cAMP-binding protein
Kyungmin Lee
BMB Rep. 2021 Mar 31; 54(3): 149–156. Published online 2021 Mar 31. doi: 10.5483/BMBRep.2021.54.3.233
PMCID:
PMC8016657
AbstractArticlePDF–1.7M
11.
GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure
Marion Laudette, Karina Formoso, Frank Lezoualc’h
Cells. 2021 Jan; 10(1): 154. Published online 2021 Jan 14. doi: 10.3390/cells10010154
PMCID:
PMC7830799
AbstractArticlePDF–2.1M
12.
LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient
Jongbo Lee, Jumin Park, Ji-hyung Kim, Giwook Lee, Tae-Eun Park, Ki-Jun Yoon, Yoon Ki Kim, Chunghun Lim
PLoS Biol. 2020 Dec; 18(12): e3001002. Published online 2020 Dec 23. doi: 10.1371/journal.pbio.3001002
PMCID:
PMC7757817
AbstractArticlePDF–5.5M
13.
Multiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions
Willem-Jan Pannekoek, Marjolein J. Vliem, Johannes L. Bos
Small GTPases. 2020; 11(5): 346–353. Published online 2018 Feb 17. doi: 10.1080/21541248.2018.1431512
PMCID:
PMC7549671
AbstractArticlePDF–1.2M
14.
RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation
Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen
Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117
PMCID:
PMC7322067
AbstractArticlePDF–2.7M
15.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
16.
Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology
Mark Andrew White, Tamara Tsalkova, Fang C. Mei, Xiaodong Cheng
Cells. 2020 Jan; 9(1): 35. Published online 2019 Dec 21. doi: 10.3390/cells9010035
PMCID:
PMC7016869
AbstractArticlePDF–2.3M
17.
Dysfunctional EAT thickness may promote maladaptive heart remodeling in CVD patients through the ST2-IL33 system, directly related to EPAC protein expression
Elena Vianello, Elena Dozio, Francesco Bandera, Gerd Schmitz, Manuela Nebuloni, Erika Longhi, Lorenza Tacchini, Marco Guazzi, Massimiliano Marco Corsi Romanelli
Sci Rep. 2019; 9: 10331. Published online 2019 Jul 17. doi: 10.1038/s41598-019-46676-w
Correction in:
Sci Rep. 2020; 10: 1182.
PMCID:
PMC6637132
AbstractArticlePDF–1.4M
18.
cAMP regulated EPAC1 supports microvascular density, angiogenic and metastatic properties in a model of triple negative breast cancer
Naveen Kumar, Peeyush Prasad, Eshna Jash, Smruthi Jayasundar, Itender Singh, Neyaz Alam, Nabendu Murmu, S P Somashekhar, Aaron Goldman, Seema Sehrawat
Carcinogenesis. 2018 Oct; 39(10): 1245–1253. Published online 2018 Jul 5. doi: 10.1093/carcin/bgy090
PMCID:
PMC6454463
AbstractArticlePDF–10M
19.
The cAMP effectors, Rap2b and EPAC, are involved in the regulation of the development of the Coxiella burnetii containing vacuole by altering the fusogenic capacity of the vacuole
María Eugenia Mansilla Pareja, Maria Celeste Gaurón, Esteban Robledo, Milton Osmar Aguilera, María Isabel Colombo
PLoS One. 2019; 14(2): e0212202. Published online 2019 Feb 14. doi: 10.1371/journal.pone.0212202
PMCID:
PMC6375611
AbstractArticlePDF–3.3M
20.
PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway
Xiangyu Kong, Ganghao Ai, Dai Wang, Renzhen Chen, Dongbei Guo, Youliang Yao, Kai Wang, Guiye Liang, Fengjie Qi, Wenzhi Liu, Yongxing Zhang
Anal Cell Pathol (Amst) 2019; 2019: 7145198. Published online 2019 Jan 23. doi: 10.1155/2019/7145198
PMCID:
PMC6364102
AbstractArticlePDF–2.6M

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