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Select item 110208831.

Selective epigenetic alterations in RNF43 in pancreatic exocrine cells from high-fat-diet-induced obese mice; implications for pancreatic cancer

Tomoyuki Araki, Naofumi Miwa

BMC Res Notes. 2024; 17: 106. Published online 2024 Apr 15. doi: 10.1186/s13104-024-06757-0

PMCID:: PMC11020883

Abstract Article PDF–1.7M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 90312643.

JAK-STAT1 Signaling Pathway Is an Early Response to Helicobacter pylori Infection and Contributes to Immune Escape and Gastric Carcinogenesis

Xue Li, Kaifeng Pan, Michael Vieth, Markus Gerhard, Wenqing Li, Raquel Mejías-Luque

Int J Mol Sci. 2022 Apr; 23(8): 4147. Published online 2022 Apr 8. doi: 10.3390/ijms23084147

PMCID:: PMC9031264

Abstract Article PDF–3.8M

Select item 89342894.

Loss of Rnf43 accelerates Kras-mediated neoplasia and remodels the tumor immune microenvironment in pancreatic adenocarcinoma

Abdel Nasser Hosein, Gita Dangol, Takashi Okumura, Jason Roszik, Kimal Rajapakshe, Megan Siemann, Mohamed Zaid, Bidyut Ghosh, Maria Monberg, Paola A. Guerrero, Aatur Singhi, Cara L Haymaker, Hans Clevers, Lotfi Abou-Elkacem, Sonja M. Woermann, Anirban Maitra

Gastroenterology. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: Gastroenterology. 2022 Apr; 162(4): 1303–1318.e18. Published online 2021 Dec 30. doi: 10.1053/j.gastro.2021.12.273

PMCID:: PMC8934289

Abstract Article PDF–2.8M

Select item 88796335.

Deficient Rnf43 potentiates hyperactive Kras‐mediated pancreatic preneoplasia initiation and malignant transformation

Xian Zhou, Zhichao Sun, Mengdi Zhang, Xiaoyu Qu, Shuhui Yang, Lianmei Wang, Yanling Jing, Li Li, Weiwei Deng, Fangming Liu, Jin Di, Jie Chen, Jian Wu, Hongbing Zhang

Animal Model Exp Med. 2022 Feb; 5(1): 61–71. Published online 2022 Jan 22. doi: 10.1002/ame2.12203

PMCID:: PMC8879633

Abstract Article PDF–3.7M

Select item 88285516.

RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis

Chanyi Lu, Xiaoli Lin, Jumpei Yamashita, Ranhui Xi, Minliang Zhou, Yali V. Zhang, Hong Wang, Robert F. Margolskee, Bon-Kyoung Koo, Hans Clevers, Ichiro Matsumoto, Peihua Jiang

Stem Cell Reports. 2022 Feb 8; 17(2): 369–383. Published online 2022 Jan 6. doi: 10.1016/j.stemcr.2021.12.002

PMCID:: PMC8828551

Abstract Article PDF–5.5M

Select item 78980357.

Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage Response

Victoria Neumeyer, Anna Brutau-Abia, Michael Allgäuer, Nicole Pfarr, Wilko Weichert, Christina Falkeis-Veits, Elisabeth Kremmer, Michael Vieth, Markus Gerhard, Raquel Mejías-Luque

Cell Mol Gastroenterol Hepatol. 2021; 11(4): 1071–1094. Published online 2020 Nov 11. doi: 10.1016/j.jcmgh.2020.11.005

PMCID:: PMC7898035

Abstract Article PDF–9.3M

Select item 76150498.

Apc-mutant cells deploy Notum to bias clonal competition and drive cancer

Dustin J. Flanagan, Nalle Pentinmikko, Kalle Luopajärvi, Nicky J. Willis, Kathryn Gilroy, Alexander P. Raven, Lynn Mcgarry, Johanna I. Englund, Anna Webb, Sandra Scharaw, Nadia Nasreddin, Michael C. Hodder, Rachel A. Ridgway, Emma Minnee, Nathalie Sphyris, Ella Gilchrist, Arafath K. Najumudeen, Beatrice Romagnolo, Christine Perret, Ann C. Williams, Hans Clevers, Pirjo Nummela, Marianne Lähde, Kari Alitalo, Ville Hietakangas, Ann Hedley, William Clark, Colin Nixon, Kristina Kirschner, E. Yvonne Jones, Ari Ristimäki, Simon Leedham, Paul V. Fish, Jean-Paul Vincent, Pekka Katajisto, Owen J. Sansom

Nature. Author manuscript; available in PMC 2023 Sep 7.

Published in final edited form as: Nature. 2021 Jun 1; 594(7863): 430–435. Published online 2021 Jun 2. doi: 10.1038/s41586-021-03525-z

PMCID:: PMC7615049

Abstract Article PDF–3.9M

Select item 74922649.

A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis

Tadasuke Tsukiyama, Juqi Zou, Jihoon Kim, Shohei Ogamino, Yuki Shino, Takamasa Masuda, Alessandra Merenda, Masaki Matsumoto, Yoichiro Fujioka, Tomonori Hirose, Sayuri Terai, Hidehisa Takahashi, Tohru Ishitani, Keiichi I. Nakayama, Yusuke Ohba, Bon-Kyoung Koo, Shigetsugu Hatakeyama

Nat Commun. 2020; 11: 4586. Published online 2020 Sep 15. doi: 10.1038/s41467-020-18257-3

PMCID:: PMC7492264

Abstract Article PDF–1.8M

Select item 722876610.

R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors

Valerie PI Vidal, Fariba Jian-Motamedi, Samah Rekima, Elodie P Gregoire, Emmanuelle Szenker-Ravi, Marc Leushacke, Bruno Reversade, Marie-Christine Chaboissier, Andreas Schedl

eLife. 2020; 9: e53895. Published online 2020 May 1. doi: 10.7554/eLife.53895

PMCID:: PMC7228766

Abstract Article PDF–10M

Select item 720679311.

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Jin Huk Choi, Xue Zhong, William McAlpine, Tzu-Chieh Liao, Duanwu Zhang, Beibei Fang, Jamie Russell, Sara Ludwig, Evan Nair-Gill, Zhao Zhang, Kuan-wen Wang, Takuma Misawa, Xiaoming Zhan, Mihwa Choi, Tao Wang, Xiaohong Li, Miao Tang, Qihua Sun, Liyang Yu, Anne R. Murray, Eva Marie Y. Moresco, Bruce Beutler

Science. Author manuscript; available in PMC 2020 May 8.

Published in final edited form as: Science. 2019 May 10; 364(6440): eaau0812. doi: 10.1126/science.aau0812

PMCID:: PMC7206793

Abstract Article PDF–2.2M

Select item 709333812.

Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma

Yaqi Li, Jian Li, Renjie Wang, Long Zhang, Guoxiang Fu, Xueying Wang, Yebin Wang, Chuantao Fang, Dandan Zhang, Duo Du, Xiaoji Ma, Mengxue Pan, Qiang Guo, Xiaoya Xu, Xiang Hu, Yi Zhou, Shaobo Mo, Huijun Wang, Jianjun Gao, Shenglin Huang, Yun Liu, Sanjun Cai, Guoqiang Hua, Junjie Peng, Fa-Xing Yu

Protein Cell. 2020 Apr; 11(4): 292–298. Published online 2020 Feb 1. doi: 10.1007/s13238-020-00691-0

PMCID:: PMC7093338

Article PDF–2.2M

Select item 646887613.

Mutated Rnf43 Aggravates Helicobacter Pylori-Induced Gastric Pathology

Victoria Neumeyer, Michael Vieth, Markus Gerhard, Raquel Mejías-Luque

Cancers (Basel) 2019 Mar; 11(3): 372. Published online 2019 Mar 16. doi: 10.3390/cancers11030372

PMCID:: PMC6468876

Abstract Article PDF–4.1M

Select item 636281714.

A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis

Kaitlin J. Basham, Stéphanie Rodriguez, Adina F. Turcu, Antonio M. Lerario, Catriona Y. Logan, Madeline R. Rysztak, Celso E. Gomez-Sanchez, David T. Breault, Bon-Kyoung Koo, Hans Clevers, Roeland Nusse, Pierre Val, Gary D. Hammer

Genes Dev. 2019 Feb 1; 33(3-4): 209–220. doi: 10.1101/gad.317412.118

PMCID:: PMC6362817

Abstract Article PDF–10M

Select item 600350615.

ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling

Abigail Harris, Pam Siggers, Silvia Corrochano, Nick Warr, Danielle Sagar, Daniel T. Grimes, Makoto Suzuki, Rebecca D. Burdine, Feng Cong, Bon-Kyoung Koo, Hans Clevers, Isabelle Stévant, Serge Nef, Sara Wells, Raja Brauner, Bochra Ben Rhouma, Neïla Belguith, Caroline Eozenou, Joelle Bignon-Topalovic, Anu Bashamboo, Ken McElreavey, Andy Greenfield

Proc Natl Acad Sci U S A. 2018 May 22; 115(21): 5474–5479. Published online 2018 May 7. doi: 10.1073/pnas.1801223115

PMCID:: PMC6003506

Abstract Article PDF–1.0M

Select item 447593416.

Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia

Bon-Kyoung Koo, Johan H. van Es, Maaike van den Born, Hans Clevers

Proc Natl Acad Sci U S A. 2015 Jun 16; 112(24): 7548–7550. Published online 2015 May 28. doi: 10.1073/pnas.1508113112

PMCID:: PMC4475934

Abstract Article PDF–1.0M

Select item 343984517.

A Genome-Wide Screen to Identify Transcription Factors Expressed in Pelvic Ganglia of the Lower Urinary Tract

Carrie B. Wiese, Sara Ireland, Nicole L. Fleming, Jing Yu, M. Todd Valerius, Kylie Georgas, Han Sheng Chiu, Jane Brennan, Jane Armstrong, Melissa H. Little, Andrew P. McMahon, E. Michelle Southard-Smith

Front Neurosci. 2012; 6: 130. Published online 2012 Sep 12. doi: 10.3389/fnins.2012.00130

PMCID:: PMC3439845

Abstract Article PDF–1.4M

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 302253419.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 248143120.

Identification of transcripts with enriched expression in the developing and adult pancreas

Brad G Hoffman, Bogard Zavaglia, Joy Witzsche, Teresa Ruiz de Algara, Mike Beach, Pamela A Hoodless, Steven JM Jones, Marco A Marra, Cheryl D Helgason

Genome Biol. 2008; 9(6): R99. Published online 2008 Jun 14. doi: 10.1186/gb-2008-9-6-r99

PMCID:: PMC2481431

Abstract Article PDF–2.2M

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