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Select item 111593431.

Overexpression of CYP2A6 in human colorectal tumors

Yoko Matsuda, Kousuke Saoo, Keiko Yamakawa, Masanao Yokohira, Satoshi Suzuki, Toshiya Kuno, Tetsuya Kamataki, Katsumi Imaida

Cancer Sci. 2007 Oct; 98(10): 1582–1585. Published online 2007 Aug 7. doi: 10.1111/j.1349-7006.2007.00572.x

PMCID:: PMC11159343

Abstract Article PDF–233K

Select item 111583232.

CYP2A6 and the plasma level of 5‐chloro‐2, 4‐dihydroxypyridine are determinants of the pharmacokinetic variability of tegafur and 5‐fluorouracil, respectively, in Japanese patients with cancer given S‐1

Ken‐ichi Fujita, Wataru Yamamoto, Shoji Endo, Hisashi Endo, Fumio Nagashima, Wataru Ichikawa, Ryuhei Tanaka, Toshimichi Miya, Kazuhiro Araki, Keiji Kodama, Yu Sunakawa, Masaru Narabayashi, Keisuke Miwa, Yuichi Ando, Yuko Akiyama, Kaori Kawara, Tetsuya Kamataki, Yasutsuna Sasaki

Cancer Sci. 2008 May; 99(5): 1049–1054. Published online 2008 Apr 1. doi: 10.1111/j.1349-7006.2008.00773.x

PMCID:: PMC11158323

Abstract Article PDF–179K

Select item 107720403.

CYP2A6 associates with respiratory disease risk and younger age of diagnosis: a phenome-wide association Mendelian Randomization study

Haidy Giratallah, Meghan J Chenoweth, Jennie G Pouget, Ahmed El-Boraie, Alaa Alsaafin, Caryn Lerman, Jo Knight, Rachel F Tyndale

Hum Mol Genet. 2024 Jan 15; 33(2): 198–210. Published online 2023 Oct 6. doi: 10.1093/hmg/ddad172

PMCID:: PMC10772040

Abstract Article PDF–1.9M

Select item 104994824.

Genotype Frequencies of 50 Polymorphisms for 241 Japanese Non-cancer Patients

Nobuyuki Hamajima, Toshiko Saito, Keitaro Matsuo, Takashi Suzuki, Tsuneya Nakamura, Akio Matsuura, Katashi Okuma, Kazuo Tajima

J Epidemiol. 2002; 12(3): 229–236. Published online 2007 Nov 30. doi: 10.2188/jea.12.229

PMCID:: PMC10499482

Abstract Article PDF–588K

Select item 96340515.

Association of CYP2A6 Gene Deletion with Cigarette Smoking Status in Japanese Adults

Masahiko Ando, Nobuyuki Hamajima, Noritaka Ariyoshi, Tetsuya Kamataki, Keitaro Matsuo, Yoshiyuki Ohno

J Epidemiol. 2003; 13(3): 176–181. Published online 2007 Nov 30. doi: 10.2188/jea.13.176

PMCID:: PMC9634051

Abstract Article PDF–492K

Select item 94782726.

CYP2A6 gene polymorphism and severity of coronary atherosclerosis in Indonesian male smokers: A pilot study

Idar Mappangara, Irawan Yusuf, Ali Aspar Mappahya, Andriany Qanitha

Medicine (Baltimore) 2022 Sep 16; 101(37): e30308. Published online 2022 Sep 16. doi: 10.1097/MD.0000000000030308

PMCID:: PMC9478272

Abstract Article PDF–558K

Select item 90811367.

Accuracy and applications of sequencing and genotyping approaches for CYP2A6 and homologous genes

Alec W.R. Langlois, Ahmed El-Boraie, Koya Fukunaga, Taisei Mushiroda, Michiaki Kubo, Caryn Lerman, Jo Knight, Steven E. Scherer, Meghan J. Chenoweth, Rachel F. Tyndale

Pharmacogenet Genomics. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Pharmacogenet Genomics. 2022 Jun 1; 32(4): 159–172. Published online 2022 Feb 21. doi: 10.1097/FPC.0000000000000466

PMCID:: PMC9081136

Abstract Article PDF–1.3M

Select item 87426418.

Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes

Ahmed El‐Boraie, Julie‐Anne Tanner, Andy Z.X. Zhu, Katrina G. Claw, Bhagwat Prasad, Erin G. Schuetz, Kenneth E. Thummel, Koya Fukunaga, Taisei Mushiroda, Michiaki Kubo, Neal L. Benowitz, Caryn Lerman, Rachel F. Tyndale

Clin Transl Sci. 2022 Jan; 15(1): 204–220. Published online 2021 Sep 25. doi: 10.1111/cts.13135

PMCID:: PMC8742641

Abstract Article PDF–795K

Select item 87194509.

Roles of cytochrome P450 2A6 in the oxidation of flavone, 4´-hydroxyflavone, and 4´-, 3´-, and 2´-methoxyflavones by human liver microsomes

Haruna Nagayoshi, Norie Murayama, Shigeo Takenaka, Vitchan Kim, Donghak Kim, Masayuki Komori, Hiroshi Yamazaki, F. Peter Guengerich, Tsutomu Shimada

Xenobiotica. Author manuscript; available in PMC 2021 Dec 31.

Published in final edited form as: Xenobiotica. 2021 Sep; 51(9): 995–1009. Published online 2021 Aug 4. doi: 10.1080/00498254.2021.1950866

PMCID:: PMC8719450

Abstract Article PDF–1.5M

Select item 846973010.

Deciphering Structural Alterations Associated with Activity Reductions of Genetic Polymorphisms in Cytochrome P450 2A6 Using Molecular Dynamics Simulations

Koichi Kato, Tomoki Nakayoshi, Rika Nokura, Hiroki Hosono, Masahiro Hiratsuka, Yoshinobu Ishikawa, Eiji Kurimoto, Akifumi Oda

Int J Mol Sci. 2021 Sep; 22(18): 10119. Published online 2021 Sep 19. doi: 10.3390/ijms221810119

PMCID:: PMC8469730

Abstract Article PDF–8.6M

Select item 837209211.

Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population

Natasha Monte, Karla B. C. C. Pantoja, Juliana C. G. Rodrigues, Darlen C. de Carvalho, Tereza C. B. Azevedo, Esdras E. B. Pereira, Paulo P. de Assumpção, Sidney E. B. dos Santos, Marianne R. Fernandes, Ney P. C. dos Santos

Mol Genet Genomic Med. 2021 Jul; 9(7): e1694. Published online 2021 May 29. doi: 10.1002/mgg3.1694

PMCID:: PMC8372092

Abstract Article PDF–450K

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 804593213.

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition

Yahya Benslimane, María Sánchez‐Osuna, Jasmin Coulombe‐Huntington, Thierry Bertomeu, Danielle Henry, Caroline Huard, Éric Bonneil, Pierre Thibault, Mike Tyers, Lea Harrington

Aging Cell. 2021 Apr; 20(4): e13331. Published online 2021 Mar 4. doi: 10.1111/acel.13331

PMCID:: PMC8045932

Abstract Article PDF–1.9M

Select item 793122814.

Cytochrome P450 2A6 is associated with macrophage polarization and is a potential biomarker for hepatocellular carcinoma

Tao Jiang, Ai‐song Zhu, Chu‐qi Yang, Chu‐yun Xu, Dan‐qian Yang, Zhao‐huan Lou, Guang‐ji Zhang

FEBS Open Bio. 2021 Mar; 11(3): 670–683. Published online 2021 Feb 5. doi: 10.1002/2211-5463.13089

PMCID:: PMC7931228

Abstract Article PDF–5.7M

Select item 779754915.

Influence of CYP4F2, ApoE, and CYP2A6 gene polymorphisms on the variability of Warfarin dosage requirements and susceptibility to cardiovascular disease in Jordan

Laith N. AL-Eitan, Ayah Y. Almasri, Adan H. Alnaamneh, Hatem A. Aman, Nasr N. Alrabadi, Rame H Khasawneh, Mansour A. Alghamdi

Int J Med Sci. 2021; 18(3): 826–834. Published online 2021 Jan 1. doi: 10.7150/ijms.51546

PMCID:: PMC7797549

Abstract Article PDF–408K

Select item 779302616.

Dissecting The Genetic Overlap Of Smoking Behaviors, Lung Cancer, And Chronic Obstructive Pulmonary Disease: A Focus On Nicotinic Receptors and Nicotine Metabolizing Enzyme

Michael J. Bray, Li-Shiun Chen, Louis Fox, Dana B. Hancock, Robert C. Culverhouse, Sarah M. Hartz, Eric O. Johnson, Mengzhen Liu, James D. McKay, Nancy L. Saccone, John E. Hokanson, Scott I. Vrieze, Rachel F. Tyndale, Timothy B. Baker, Laura J. Bierut

Genet Epidemiol. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: Genet Epidemiol. 2020 Oct; 44(7): 748–758. Published online 2020 Aug 16. doi: 10.1002/gepi.22331

PMCID:: PMC7793026

Abstract Article PDF–1.2M

Select item 752702717.

Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity

Ahmed El-Boraie, Taraneh Taghavi, Meghan J. Chenoweth, Koya Fukunaga, Taisei Mushiroda, Michiaki Kubo, Caryn Lerman, Nicole L. Nollen, Neal L. Benowitz, Rachel F. Tyndale

Addict Biol. Author manuscript; available in PMC 2020 Sep 30.

Published in final edited form as: Addict Biol. 2020 Jan; 25(1): e12741. Published online 2019 Feb 27. doi: 10.1111/adb.12741

PMCID:: PMC7527027

Abstract Article PDF–2.1M

Select item 737595218.

Genetic variants in CYP2A6 and UGT1A9 genes associated with urinary nicotine metabolites in young Mexican smokers

Gissela Borrego-Soto, Yadira X. Perez-Paramo, Gang Chen, Sandra K. Santuario-Facio, Jesus Santos-Guzman, Rodolfo Posadas-Valay, Fatima M. Alvarado-Monroy, Isaias Balderas-Renteria, Ramses Medina-Gonzalez, Rocio Ortiz-Lopez, Philip Lazarus, Augusto Rojas-Martinez

Pharmacogenomics J. 2020; 20(4): 586–594. Published online 2020 Jan 21. doi: 10.1038/s41397-020-0147-4

PMCID:: PMC7375952

Abstract Article PDF–964K

Select item 705754919.

Association of CYP2A6 gene deletion with cancers in Japanese elderly: an autopsy study

Maidina Abudushataer, Noriko Sato, Makiko Mieno, Motoji Sawabe, Masaaki Muramatsu, Tomio Arai

BMC Cancer. 2020; 20: 186. Published online 2020 Mar 4. doi: 10.1186/s12885-020-6663-4

PMCID:: PMC7057549

Abstract Article PDF–710K

Select item 643878020.

Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes

Haruna Nagayoshi, Norie Murayama, Kensaku Kakimoto, Shigeo Takenaka, Jun Katahira, Young-Ran Lim, Vitchan Kim, Donghak Kim, Hiroshi Yamazaki, Masayuki Komori, F. Peter Guengerich, Tsutomu Shimada

Xenobiotica. Author manuscript; available in PMC 2019 Jul 1.

Published in final edited form as: Xenobiotica. 2019 Jul; 49(7): 791–802. Published online 2018 Sep 28. doi: 10.1080/00498254.2018.1505064

PMCID:: PMC6438780

Abstract Article PDF–3.9M

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