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Select item 105476471.

Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity

Qiankun Luo, Yanfeng Pan, Qiang Fu, Xu Zhang, Shuai Zhou, Pengfei Yu, Huiyuan Tian, Pan Liu, Song Chen, Hongwei Zhang, Tao Qin

Cell Biol Toxicol. 2023; 39(5): 2069–2087. Published online 2022 Feb 10. doi: 10.1007/s10565-022-09695-4

PMCID:: PMC10547647

Abstract Article PDF–9.5M

Select item 91197362.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 88752973.

CRL4^AMBRA1 is a master regulator of D-type cyclins

Daniele Simoneschi, Gergely Rona, Nan Zhou, Yeon-Tae Jeong, Shaowen Jiang, Giacomo Milletti, Arnaldo A. Arbini, Alfie O’Sullivan, Andrew A. Wang, Sorasicha Nithikasem, Sarah Keegan, Yik Siu, Valentina Cianfanelli, Emiliano Maiani, Francesca Nazio, Francesco Cecconi, Francesco Boccalatte, David Fenyö, Drew R. Jones, Luca Busino, Michele Pagano

Nature. Author manuscript; available in PMC 2022 Apr 14.

Published in final edited form as: Nature. 2021 Apr; 592(7856): 789–793. Published online 2021 Apr 14. doi: 10.1038/s41586-021-03445-y

PMCID:: PMC8875297

Abstract Article PDF–6.0M

Select item 85722254.

Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells

Chen Wang, Jie Zeng, Li-Jie Li, Min Xue, Si-Li He

Cell Death Dis. 2021 Nov; 12(11): 1055. Published online 2021 Nov 6. doi: 10.1038/s41419-021-04342-y

PMCID:: PMC8572225

Abstract Article PDF–7.2M

Select item 83310225.

Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition

Jennifer P. Ditano, Nandini Sakurikar, Alan Eastman

Cell Cycle. 2021; 20(13): 1308–1319. Published online 2021 Jun 22. doi: 10.1080/15384101.2021.1938813

PMCID:: PMC8331022

Abstract Article PDF–2.1M

Select item 81981326.

Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis

Arun Pandian Chandrasekaran, Sang Hyeon Woo, Neha Sarodaya, Byung Ho Rhie, Apoorvi Tyagi, Soumyadip Das, Bharathi Suresh, Na Re Ko, Seung Jun Oh, Kye-Seong Kim, Suresh Ramakrishna

Int J Mol Sci. 2021 Jun; 22(11): 5766. Published online 2021 May 28. doi: 10.3390/ijms22115766

PMCID:: PMC8198132

Abstract Article PDF–2.2M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78387368.

miRNA-497 Negatively Regulates the Growth and Motility of Chondrosarcoma Cells by Targeting Cdc25A

Yandong Lu, Fangguo Li, Tao Xu, Jie Sun

Oncol Res. 2016; 23(4): 155–163. Published online 2016 Mar 25. doi: 10.3727/096504016X14519157902681

PMCID:: PMC7838736

Abstract Article PDF–7.2M

Select item 77580509.

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

Jennifer L. Franks, Raquel C. Martinez-Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L. Bolhuis, Taylor P. Enrico, Ryan D. Mouery, Jeffrey S. Damrauer, Feng Yan, Joseph S. Harrison, M. Ben Major, Katherine A. Hoadley, Aussie Suzuki, Scott B. Rothbart, Nicholas G. Brown, Michael J. Emanuele

PLoS Biol. 2020 Dec; 18(12): e3000975. Published online 2020 Dec 11. doi: 10.1371/journal.pbio.3000975

PMCID:: PMC7758050

Abstract Article PDF–4.2M

Select item 768579810.

TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer

Qiannan Yang, Bojun Yu, Jing Sun

Biomed Res Int. 2020; 2020: 4625123. Published online 2020 Nov 17. doi: 10.1155/2020/4625123

PMCID:: PMC7685798

Abstract Article PDF–1.7M

Select item 765923911.

Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti‐cancer therapy?

Hidemasa Goto, Ichiro Izawa, Ping Li, Masaki Inagaki

Cancer Sci. 2012 Jul; 103(7): 1195–1200. Published online 2012 Apr 23. doi: 10.1111/j.1349-7006.2012.02280.x

PMCID:: PMC7659239

Abstract Article PDF–410K

Select item 756688112.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 756664913.

Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer

Soumyadip Das, Arun Pandian Chandrasekaran, Bharathi Suresh, Saba Haq, Jae-Hyeok Kang, Su-Jae Lee, Jaewon Kim, Jaesang Kim, Sanghyuk Lee, Hyongbum Henry Kim, Kye-Seong Kim, Suresh Ramakrishna

Cell Death Differ. 2020 Nov; 27(11): 3004–3020. Published online 2020 May 15. doi: 10.1038/s41418-020-0557-5

PMCID:: PMC7566649

Abstract Article PDF–6.0M

Select item 736438414.

Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors

David L. Myer, Susan B. Robbins, Moying Yin, Gregory P. Boivin, Yang Liu, Kenneth D. Greis, El Mustapha Bahassi, Peter J. Stambrook

Mutat Res. Author manuscript; available in PMC 2020 Jul 16.

Published in final edited form as: Mutat Res. 2011 Sep 1; 714(1-2): 1–10. Published online 2011 Mar 3. doi: 10.1016/j.mrfmmm.2011.02.006

PMCID:: PMC7364384

Abstract Article PDF–1.4M

Select item 716998315.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 701512216.

Silencing CDC25A inhibits the proliferation of liver cancer cells by downregulating IL-6 in vitro and in vivo

Si Chen, Yanping Tang, Chun Yang, Kezhi Li, Xiaoqing Huang, Ji Cao

Int J Mol Med. 2020 Mar; 45(3): 743–752. Published online 2020 Jan 9. doi: 10.3892/ijmm.2020.4461

PMCID:: PMC7015122

Abstract Article PDF–1.5M

Select item 700245417.

STAT5-dependent regulation of CDC25A by miR-16 controls proliferation and differentiation in FLT3-ITD acute myeloid leukemia

Gabrielle Sueur, Alison Boutet, Mathilde Gotanègre, Véronique Mansat-De Mas, Arnaud Besson, Stéphane Manenti, Sarah Bertoli

Sci Rep. 2020; 10: 1906. Published online 2020 Feb 5. doi: 10.1038/s41598-020-58651-x

PMCID:: PMC7002454

Abstract Article PDF–2.2M

Select item 689109718.

Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability

Divya Achuthankutty, Roshan Singh Thakur, Peter Haahr, Saskia Hoffmann, Alexandros P. Drainas, Anna H. Bizard, Joachim Weischenfeldt, Ian D. Hickson, Niels Mailand

J Cell Biol. 2019 Dec 2; 218(12): 3943–3953. Published online 2019 Oct 15. doi: 10.1083/jcb.201905064

PMCID:: PMC6891097

Abstract Article PDF–2.7M

Select item 682328319.

miR‐122‐5p modulates the radiosensitivity of cervical cancer cells by regulating cell division cycle 25A (CDC25A)

Feng‐Na Ding, Bao‐Hong Gao, Xia Wu, Chun‐Wu Gong, Wei‐Qing Wang, Shu‐Mao Zhang

FEBS Open Bio. 2019 Nov; 9(11): 1869–1879. Published online 2019 Sep 29. doi: 10.1002/2211-5463.12730

PMCID:: PMC6823283

Abstract Article PDF–2.5M

Select item 677813720.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

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