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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108643632.

Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy

Yan Guo, Pan Xiang, Xiaojiao Sun, Wei Liu, Jiafeng Zhou, Bin Yin, Lin Hou, Boqin Qiang, Huiliang Li, Pengcheng Shu, Xiaozhong Peng

Signal Transduct Target Ther. 2024; 9: 32. Published online 2024 Feb 14. doi: 10.1038/s41392-024-01742-2

PMCID:: PMC10864363

Abstract Article PDF–9.9M

Select item 106378253.

Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein

Hisazumi Matsuki, Shintaro Mandai, Hiroki Shiwaku, Takaaki Koide, Naohiro Takahashi, Tomoki Yanagi, Shunsuke Inaba, Saaya Ida, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Hidehiko Takahashi, Shinichi Uchida

Aging (Albany NY) 2023 Oct 31; 15(20): 10972–10995. Published online 2023 Oct 25. doi: 10.18632/aging.205164

PMCID:: PMC10637825

Abstract Article PDF–2.7M

Select item 105524334.

Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau

Manuel Schweighauser, Alexey G. Murzin, Jennifer Macdonald, Isabelle Lavenir, R. Anthony Crowther, Sjors H.W. Scheres, Michel Goedert

Acta Neuropathol Commun. 2023; 11: 160. Published online 2023 Oct 5. doi: 10.1186/s40478-023-01658-y

PMCID:: PMC10552433

Abstract Article PDF–5.1M

Select item 105038115.

Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer’s disease–related mouse models

Debashis Dutta, Malabendu Jana, Ramesh Kumar Paidi, Moumita Majumder, Sumita Raha, Sridevi Dasarathy, Kalipada Pahan

J Clin Invest. 2023 Sep 15; 133(18): e161987. Published online 2023 Sep 15. doi: 10.1172/JCI161987

PMCID:: PMC10503811

Abstract Article PDF–29M

Select item 104098856.

The cellular basis of mechanosensation in mammalian tongue

Yalda Moayedi, Shan Xu, Sophie K. Obayashi, Benjamin U. Hoffman, Gregory J. Gerling, Ellen A. Lumpkin

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Feb 28; 42(2): 112087. Published online 2023 Feb 9. doi: 10.1016/j.celrep.2023.112087

PMCID:: PMC10409885

Abstract Article PDF–2.0M

Select item 103904927.

Three-dimensional molecular architecture of mouse organogenesis

Fangfang Qu, Wenjia Li, Jian Xu, Ruifang Zhang, Jincan Ke, Xiaodie Ren, Xiaogao Meng, Lexin Qin, Jingna Zhang, Fangru Lu, Xin Zhou, Xi Luo, Zhen Zhang, Minhan Wang, Guangming Wu, Duanqing Pei, Jiekai Chen, Guizhong Cui, Shengbao Suo, Guangdun Peng

Nat Commun. 2023; 14: 4599. Published online 2023 Jul 31. doi: 10.1038/s41467-023-40155-7

PMCID:: PMC10390492

Abstract Article PDF–13M

Select item 103572138.

Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early Feature of Different Human and Experimental Tauopathies

Geri Meduri, Kevin Guillemeau, Corentin Daguinot, Omar Dounane, Melanie Genet, Luigi Ferrara, Beatrice Chambraud, Etienne Emile Baulieu, Julien Giustiniani

J Alzheimers Dis. 2023; 94(1): 313–331. Prepublished online 2023 May 20. Published online 2023 Jun 27. doi: 10.3233/JAD-230127

PMCID:: PMC10357213

Abstract Article PDF–3.4M

Select item 102495109.

Tau and GSK-3β are critical contributors to α-synuclein-mediated post-stroke brain damage

Suresh L Mehta, TaeHee Kim, Bharath Chelluboina, Raghu Vemuganti

Neuromolecular Med. Author manuscript; available in PMC 2023 Jun 8.

Published in final edited form as: Neuromolecular Med. 2023 Mar; 25(1): 94–101. Published online 2022 Nov 30. doi: 10.1007/s12017-022-08731-0

PMCID:: PMC10249510

Abstract Article PDF–691K

Select item 1016685510.

Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience

Joe C. Udeochu, Sadaf Amin, Yige Huang, Li Fan, Eileen Ruth S. Torres, Gillian K. Carling, Bangyan Liu, Hugo McGurran, Guillermo Coronas-Samano, Grant Kauwe, Gergey Alzaem Mousa, Man Ying Wong, Pearly Ye, Ravi Kumar Nagiri, Iris Lo, Julia Holtzman, Carlo Corona, Allan Yarahmady, Michael T. Gill, Ravikiran M. Raju, Sue-Ann Mok, Shiaoching Gong, Wenjie Luo, Mingrui Zhao, Tara E. Tracy, Rajiv R. Ratan, Li-Huei Tsai, Subhash C. Sinha, Li Gan

Nat Neurosci. 2023; 26(5): 737–750. Published online 2023 Apr 24. doi: 10.1038/s41593-023-01315-6

PMCID:: PMC10166855

Abstract Article PDF–9.7M

Select item 1015430911.

Neurogenic timing of the inferior olive subdivisions is related to the olivocerebellar projection topography

Yuanjun Luo, Yuhan Chao, Richard Nana Abankwah Owusu-Mensah, Jingyun Zhang, Tatsumi Hirata, Izumi Sugihara

Sci Rep. 2023; 13: 7114. Published online 2023 May 2. doi: 10.1038/s41598-023-33497-1

PMCID:: PMC10154309

Abstract Article PDF–7.0M

Select item 1012655512.

Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy

Stacy A. Hussong, Andy Q. Banh, Candice E. Van Skike, Angela O. Dorigatti, Stephen F. Hernandez, Matthew J. Hart, Beatriz Ferran, Haneen Makhlouf, Maria Gaczynska, Pawel A. Osmulski, Salome A. McAllen, Kelly T. Dineley, Zoltan Ungvari, Viviana I. Perez, Rakez Kayed, Veronica Galvan

Nat Commun. 2023; 14: 2367. Published online 2023 Apr 25. doi: 10.1038/s41467-023-37840-y

PMCID:: PMC10126555

Abstract Article PDF–4.4M

Select item 1012117313.

Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer’s disease

Lan-Ting Zhou, Dan Liu, Hui-Cong Kang, Lu Lu, He-Zhou Huang, Wen-Qing Ai, Yang Zhou, Man-Fei Deng, Hao Li, Zhi-Qiang Liu, Wei-Feng Zhang, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Jian-Jun Jia, Avijite Kumer Sarkar, Saldin Sharaydeh, Jie Wang, Heng-Ye Man, Marcel Schilling, Lars Bertram, Youming Lu, Ziyuan Guo, Ling-Qiang Zhu

Sci Adv. 2023 Apr; 9(16): eabq7105. Published online 2023 Apr 21. doi: 10.1126/sciadv.abq7105

PMCID:: PMC10121173

Abstract Article PDF–2.9M

Select item 1010870614.

A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development

Rhian Stavely, Ryo Hotta, Richard A. Guyer, Nicole Picard, Ahmed A. Rahman, Meredith Omer, Adam Soos, Emoke Szocs, Jessica Mueller, Allan M. Goldstein, Nandor Nagy

Development. 2023 Mar 1; 150(5): dev201090. Published online 2023 Mar 6. doi: 10.1242/dev.201090

PMCID:: PMC10108706

Abstract Article

Select item 1010857615.

KDM6B cooperates with Tau and regulates synaptic plasticity and cognition via inducing VGLUT1/2

Yanan Wang, Nitin Khandelwal, Shuiqiao Liu, Mi Zhou, Lei Bao, Jennifer E Wang, Ashwani Kumar, Chao Xing, Jay Gibson, Yingfei Wang

Mol Psychiatry. Author manuscript; available in PMC 2023 Apr 17.

Published in final edited form as: Mol Psychiatry. 2022 Dec; 27(12): 5213–5226. Published online 2022 Aug 26. doi: 10.1038/s41380-022-01750-0

PMCID:: PMC10108576

Abstract Article PDF–3.0M

Select item 1009551016.

Deregulated Transcription and Proteostasis in Adult mapt Knockout Mouse

Pol Andrés-Benito, África Flores, Sara Busquet-Areny, Margarita Carmona, Karina Ausín, Paz Cartas-Cejudo, Mercedes Lachén-Montes, José Antonio Del Rio, Joaquín Fernández-Irigoyen, Enrique Santamaría, Isidro Ferrer

Int J Mol Sci. 2023 Apr; 24(7): 6559. Published online 2023 Mar 31. doi: 10.3390/ijms24076559

PMCID:: PMC10095510

Abstract Article PDF–5.6M

Select item 1007248217.

A seeding-based neuronal model of tau aggregation for use in drug discovery

Ines S. Amorim, Sylvie Challal, Laetitia Cistarelli, Thierry Dorval, Laurene Abjean, Manuelle Touzard, Nicolas Arbez, Arnaud François, Fany Panayi, Ross Jeggo, Erika Cecon, Atsuro Oishi, Julie Dam, Ralf Jockers, Patricia Machado

PLoS One. 2023; 18(4): e0283941. Published online 2023 Apr 4. doi: 10.1371/journal.pone.0283941

PMCID:: PMC10072482

Abstract Article PDF–3.1M

Select item 1006903918.

Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer’s disease

Kanza M. Khan, Nagalakshmi Balasubramanian, Gabriel Gaudencio, Ruixiang Wang, Govindhasamy Pushpavathi Selvakumar, Louis Kolling, Samantha Pierson, Satya M. Tadinada, Ted Abel, Marco Hefti, Catherine A. Marcinkiewcz

Acta Neuropathol Commun. 2023; 11: 57. Published online 2023 Apr 3. doi: 10.1186/s40478-023-01546-5

PMCID:: PMC10069039

Abstract Article PDF–7.0M

Select item 1002476119.

Aberrant survival of hippocampal Cajal-Retzius cells leads to memory deficits, gamma rhythmopathies and susceptibility to seizures in adult mice

Martina Riva, Stéphanie Moriceau, Annunziato Morabito, Elena Dossi, Candela Sanchez-Bellot, Patrick Azzam, Andrea Navas-Olive, Beatriz Gal, Francesco Dori, Elena Cid, Fanny Ledonne, Sabrina David, Fabrice Trovero, Magali Bartolomucci, Eva Coppola, Nelson Rebola, Antoine Depaulis, Nathalie Rouach, Liset Menendez de la Prida, Franck Oury, Alessandra Pierani

Nat Commun. 2023; 14: 1531. Published online 2023 Mar 18. doi: 10.1038/s41467-023-37249-7

PMCID:: PMC10024761

Abstract Article PDF–6.2M

Select item 995095720.

Median eminence myelin continuously turns over in adult mice

Sophie Buller, Sara Kohnke, Robert Hansford, Takahiro Shimizu, William D. Richardson, Clemence Blouet

Mol Metab. 2023 Mar; 69: 101690. Published online 2023 Feb 4. doi: 10.1016/j.molmet.2023.101690

PMCID:: PMC9950957

Abstract Article PDF–4.1M

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