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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 96718812.

N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA

Xiang Zhang, Huilong Yin, Xiaofang Zhang, Xunliang Jiang, Yongkang Liu, Haolin Zhang, Yingran Peng, Da Li, Yanping Yu, Jinbao Zhang, Shuli Cheng, Angang Yang, Rui Zhang

Nat Commun. 2022; 13: 7038. Published online 2022 Nov 17. doi: 10.1038/s41467-022-34808-2

PMCID:: PMC9671881

Abstract Article PDF–6.4M

Select item 64595103.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 58635464.

LATS1 and LATS2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ

Jing Yi, Li Lu, Kilangsungla Yanger, Wenqi Wang, Bo Hwa Sohn, Ben Z. Stanger, Min Zhang, James F. Martin, Jaffer A. Ajani, Junjie Chen, Ju-Seog Lee, Shumei Song, Randy L. Johnson

Hepatology. Author manuscript; available in PMC 2018 Mar 22.

Published in final edited form as: Hepatology. 2016 Nov; 64(5): 1757–1772. Published online 2016 Sep 30. doi: 10.1002/hep.28768

PMCID:: PMC5863546

Abstract Article PDF–873K

Select item 54815575.

Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice

Jose M. Irimia, Catalina M. Meyer, Dyann M. Segvich, Sneha Surendran, Anna A. DePaoli-Roach, Nuria Morral, Peter J. Roach

J Biol Chem. 2017 Jun 23; 292(25): 10455–10464. Published online 2017 May 8. doi: 10.1074/jbc.M117.786525

PMCID:: PMC5481557

Abstract Article PDF–2.8M

Select item 51333526.

Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation

Sandip K. Bose, Irina Hutson, Charles A. Harris

Endocrinology. 2016 Dec; 157(12): 4943–4960. Published online 2016 Oct 18. doi: 10.1210/en.2016-1615

PMCID:: PMC5133352

Abstract Article

Select item 51333497.

Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion

Kristen E. Syring, Kayla A. Boortz, James K. Oeser, Alessandro Ustione, Kenneth A. Platt, Melanie K. Shadoan, Owen P. McGuinness, David W. Piston, David R. Powell, Richard M. O'Brien

Endocrinology. 2016 Dec; 157(12): 4534–4541. Published online 2016 Oct 18. doi: 10.1210/en.2016-1573

PMCID:: PMC5133349

Abstract Article

Select item 49464278.

Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series

Caitlyn E. Bowman, Liang Zhao, Thomas Hartung, Michael J. Wolfgang

Mol Cell Biol. 2016 Aug 1; 36(15): 2089–2104. Prepublished online 2016 May 23. Published online 2016 Jul 14. doi: 10.1128/MCB.00166-16

PMCID:: PMC4946427

Abstract Article PDF–3.4M

Select item 41048589.

Structural basis for the recruitment of glycogen synthase by glycogenin

Elton Zeqiraj, Xiaojing Tang, Roger W. Hunter, Mar García-Rocha, Andrew Judd, Maria Deak, Alexander von Wilamowitz-Moellendorff, Igor Kurinov, Joan J. Guinovart, Mike Tyers, Kei Sakamoto, Frank Sicheri

Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28): E2831–E2840. Published online 2014 Jun 30. doi: 10.1073/pnas.1402926111

PMCID:: PMC4104858

Abstract Article PDF–1.7M

Select item 383702910.

Glucose-6-Phosphate–Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis

Alexander von Wilamowitz-Moellendorff, Roger W. Hunter, Mar García-Rocha, Li Kang, Iliana López-Soldado, Louise Lantier, Kashyap Patel, Mark W. Peggie, Carlos Martínez-Pons, Martin Voss, Joaquim Calbó, Patricia T.W. Cohen, David H. Wasserman, Joan J. Guinovart, Kei Sakamoto

Diabetes. 2013 Dec; 62(12): 4070–4082. Published online 2013 Nov 16. doi: 10.2337/db13-0880

PMCID:: PMC3837029

Abstract Article PDF–2.1M

Select item 377383811.

PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and G_L expression

Fabio Zani, Ludovic Breasson, Barbara Becattini, Ana Vukolic, Jean-Pierre Montani, Urs Albrecht, Alessandro Provenzani, Juergen A. Ripperger, Giovanni Solinas

Mol Metab. 2013 Aug; 2(3): 292–305. Published online 2013 Jul 1. doi: 10.1016/j.molmet.2013.06.006

PMCID:: PMC3773838

Abstract Article PDF–3.9M

Select item 357241012.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 316848814.

A Stratified Transcriptomics Analysis of Polygenic Fat and Lean Mouse Adipose Tissues Identifies Novel Candidate Obesity Genes

Nicholas M. Morton, Yvonne B. Nelson, Zoi Michailidou, Emma M. Di Rollo, Lynne Ramage, Patrick W. F. Hadoke, Jonathan R. Seckl, Lutz Bunger, Simon Horvat, Christopher J. Kenyon, Donald R. Dunbar

PLoS One. 2011; 6(9): e23944. Published online 2011 Sep 7. doi: 10.1371/journal.pone.0023944

PMCID:: PMC3168488

Abstract Article PDF–870K

Select item 298832315.

Hepatic Overexpression of a Constitutively Active Form of Liver Glycogen Synthase Improves Glucose Homeostasis

Susana Ros, Delia Zafra, Jordi Valles-Ortega, Mar García-Rocha, Stephen Forrow, Jorge Domínguez, Joaquim Calbó, Joan J. Guinovart

J Biol Chem. 2010 Nov 26; 285(48): 37170–37177. Published online 2010 Sep 14. doi: 10.1074/jbc.M110.157396

PMCID:: PMC2988323

Abstract Article PDF–3.0M

Select item 290336716.

CLOCK Regulates Circadian Rhythms of Hepatic Glycogen Synthesis through Transcriptional Activation of Gys2

Ryosuke Doi, Katsutaka Oishi, Norio Ishida

J Biol Chem. 2010 Jul 16; 285(29): 22114–22121. Published online 2010 Apr 29. doi: 10.1074/jbc.M110.110361

PMCID:: PMC2903367

Abstract Article PDF–1.7M

Select item 285708717.

Impaired Glucose Tolerance and Predisposition to the Fasted State in Liver Glycogen Synthase Knock-out Mice

Jose M. Irimia, Catalina M. Meyer, Caron L. Peper, Lanmin Zhai, Cheryl B. Bock, Stephen F. Previs, Owen P. McGuinness, Anna DePaoli-Roach, Peter J. Roach

J Biol Chem. 2010 Apr 23; 285(17): 12851–12861. Published online 2010 Feb 23. doi: 10.1074/jbc.M110.106534

PMCID:: PMC2857087

Abstract Article PDF–2.3M

Select item 279828418.

The Imprinted Phlda2 Gene Regulates Extraembryonic Energy Stores

S. J. Tunster, B. Tycko, R. M. John

Mol Cell Biol. 2010 Jan; 30(1): 295–306. Published online 2009 Nov 2. doi: 10.1128/MCB.00662-09

PMCID:: PMC2798284

Abstract Article PDF–4.9M

Select item 277114519.

Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors

S. Mandard, R. Stienstra, P. Escher, N. S. Tan, I. Kim, F. J. Gonzalez, W. Wahli, B. Desvergne, M. Müller, S. Kersten

Cell Mol Life Sci. 2007 May; 64(9): 1145. Published online 2007 Apr 16. doi: 10.1007/s00018-007-7006-1

PMCID:: PMC2771145

Abstract Article PDF–1.0M

Select item 142215520.

In vivo role of the HNF4α AF-1 activation domain revealed by exon swapping

Nadège Briançon, Mary C Weiss

EMBO J. 2006 Mar 22; 25(6): 1253–1262. Published online 2006 Feb 23. doi: 10.1038/sj.emboj.7601021

PMCID:: PMC1422155

Abstract Article PDF–593K

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