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Select item 111694711.

REST-dependent downregulation of von Hippel-Lindau tumor suppressor promotes autophagy in SHH-medulloblastoma

Ashutosh Singh, Donghang Cheng, Jyothishmathi Swaminathan, Yanwen Yang, Yan Zheng, Nancy Gordon, Vidya Gopalakrishnan

Sci Rep. 2024; 14: 13596. Published online 2024 Jun 12. doi: 10.1038/s41598-024-63371-7

PMCID:: PMC11169471

Abstract Article PDF–16M

Select item 111158522.

15-Deoxy-Δ^12,14-prostaglandin-J₂ reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1α degradation

Gemma Olmos, María I. Arenas, Raquel Bienes, María Jose Calzada, Julián Aragonés, Maria Laura Garcia-Bermejo, Manuel O. Landazuri, Javier Lucio-Cazaña

Cell Mol Life Sci. 2009 Jul; 66(13): 2167–2180. Published online 2009 May 21. doi: 10.1007/s00018-009-0039-x

PMCID:: PMC11115852

Abstract Article PDF–657K

Select item 110146723.

VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis

Melissa M. Wolf, Matthew Z. Madden, Emily N. Arner, Jackie E. Bader, Xiang Ye, Logan Vlach, Megan L. Tigue, Madelyn D. Landis, Patrick B. Jonker, Zaid Hatem, KayLee K. Steiner, Dakim K. Gaines, Bradley I. Reinfeld, Emma S. Hathaway, Fuxue Xin, M. Noor Tantawy, Scott M. Haake, Eric Jonasch, Alexander Muir, Vivian L. Weiss, Kathryn E. Beckermann, W. Kimryn Rathmell, Jeffrey C. Rathmell

J Clin Invest. 2024 Apr 15; 134(8): e173934. Published online 2024 Apr 15. doi: 10.1172/JCI173934

PMCID:: PMC11014672

Abstract Article PDF–9.8M

Select item 110146684.

Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis

Cheng Zhang, Miaomiao Yu, Austin J. Hepperla, Zhao Zhang, Rishi Raj, Hua Zhong, Jin Zhou, Lianxin Hu, Jun Fang, Hongyi Liu, Qian Liang, Liwei Jia, Chengheng Liao, Sichuan Xi, Jeremy M. Simon, Kexin Xu, Zhijie Liu, Yunsun Nam, Payal Kapur, Qing Zhang

J Clin Invest. 2024 Apr 15; 134(8): e175703. Published online 2024 Apr 15. doi: 10.1172/JCI175703

PMCID:: PMC11014668

Abstract Article PDF–16M

Select item 110146645.

VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas

Hyemin Lee, Li Zhuang, Boyi Gan

J Clin Invest. 2024 Apr 15; 134(8): e179560. Published online 2024 Apr 15. doi: 10.1172/JCI179560

PMCID:: PMC11014664

Abstract Article PDF–606K

Select item 109430206.

VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation

Zheng Wang, Meisi Yan, Leiguang Ye, Qimin Zhou, Yuran Duan, Hongfei Jiang, Lei Wang, Yuan Ouyang, Huahe Zhang, Yuli Shen, Guimei Ji, Xiaohan Chen, Qi Tian, Liwei Xiao, Qingang Wu, Ying Meng, Guijun Liu, Leina Ma, Bo Lei, Zhimin Lu, Daqian Xu

EMBO J. 2024 Mar; 43(6): 931–955. Published online 2024 Feb 15. doi: 10.1038/s44318-024-00051-2

PMCID:: PMC10943020

Abstract Article PDF–7.2M

Select item 107276447.

Does the VHL polymorphisms rs779805 and rs1642742 affect renal cell carcinoma susceptibility, prognosis and survival in Central European population?

Magdalena Chrabańska, Nikola Szweda-Gandor, Bogna Drozdzowska

Medicine (Baltimore) 2023 Dec 15; 102(50): e36540. Published online 2023 Dec 15. doi: 10.1097/MD.0000000000036540

PMCID:: PMC10727644

Abstract Article PDF–573K

Select item 101819358.

Hypoxia switches TET1 from being tumor-suppressive to oncogenic

Qi Yang, Hui Dang, Jiaxin Liu, Xingye Wang, Jingyuan Wang, Xinhui Lan, Meiju Ji, Mingzhao Xing, Peng Hou

Oncogene. 2023; 42(20): 1634–1648. Published online 2023 Apr 5. doi: 10.1038/s41388-023-02659-w

PMCID:: PMC10181935

Abstract Article PDF–5.3M

Select item 101048249.

Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism

Jie Shen, Qian Zha, Qian-hua Yang, Yue-qian Zhou, Xiao Liang, Ying-jie Chen, Gui-xia Qi, Xiao-jin Zhang, Wen-bing Yao, Xiang-dong Gao, Song Chen

Acta Pharmacol Sin. 2023 May; 44(5): 940–953. Published online 2022 Nov 10. doi: 10.1038/s41401-022-01014-1

PMCID:: PMC10104824

Abstract Article PDF–6.3M

Select item 1007034410.

PIN1 and CDK1 cooperatively govern pVHL stability and suppressive functions

Jiayi Chen, Mei Li, Yeqing Liu, Tangming Guan, Xiao Yang, Yalei Wen, Yingjie Zhu, Zeyu Xiao, Xiangchun Shen, Haoxing Zhang, Hui Tang, Tongzheng Liu

Cell Death Differ. 2023 Apr; 30(4): 1082–1095. Published online 2023 Feb 23. doi: 10.1038/s41418-023-01128-x

PMCID:: PMC10070344

Abstract Article PDF–5.0M

Select item 1003818611.

Suppressive effects of iron chelation in clear cell renal cell carcinoma and their dependency on VHL inactivation

Christopher J. Greene, Nitika J. Sharma, Peter N. Fiorica, Emily Forrester, Gary J. Smith, Kenneth W. Gross, Eric C. Kauffman

Free Radic Biol Med. Author manuscript; available in PMC 2023 Mar 24.

Published in final edited form as: Free Radic Biol Med. 2019 Mar; 133: 295–309. Published online 2018 Dec 13. doi: 10.1016/j.freeradbiomed.2018.12.013

PMCID:: PMC10038186

Abstract Article PDF–2.2M

Select item 1001715812.

Positive Feedback Regulation of Circular RNA Hsa_circ_0000566 and HIF-1α promotes Osteosarcoma Progression and Glycolysis Metabolism

Shuying Shen, Yining Xu, Zhe Gong, Teng Yao, Di Qiao, Yizhen Huang, Zhenlei Zhang, Jun Gao, Haonan Ni, Zhanping Jin, Yingchun Zhu, Hongfei Wu, Qingxin Wang, Xiangqian Fang, Kangmao Huang, Jianjun Ma

Aging Dis. 2023 Apr 1; 14(2): 529–547. Published online 2023 Apr 1. doi: 10.14336/AD.2022.0826

PMCID:: PMC10017158

Abstract Article PDF–1.9M

Select item 995957113.

Two Single Nucleotide Polymorphisms in the Von Hippel-Lindau Tumor Suppressor Gene in Patients with Clear Cell Renal Cell Carcinoma

Magdalena Chrabańska, Nikola Szweda-Gandor, Bogna Drozdzowska

Int J Mol Sci. 2023 Feb; 24(4): 3778. Published online 2023 Feb 14. doi: 10.3390/ijms24043778

PMCID:: PMC9959571

Abstract Article PDF–295K

Select item 994693714.

LncRNA MALAT1 promotes growth and metastasis of head and neck squamous cell carcinoma by repressing VHL through a non-canonical function of EZH2

Yuansheng Duan, Kai Yue, Beibei Ye, Peng Chen, Jin Zhang, Qinghua He, Yue Wu, Qingchuan Lai, Hong Li, Yansheng Wu, Chao Jing, Xudong Wang

Cell Death Dis. 2023 Feb; 14(2): 149. Published online 2023 Feb 22. doi: 10.1038/s41419-023-05667-6

Correction in:: Cell Death Dis. 2023 Aug; 14(8): 522.

PMCID:: PMC9946937

Abstract Article PDF–6.5M

Select item 989205715.

MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma

Shouhua Zhang, Hongyan Xu, Weiming Li, Jianfeng Ji, Qifang Jin, Leifeng Chen, Qiang Gan, Qiang Tao, Yong Chai

Pathol Oncol Res. 2023; 29: 1610801. Published online 2023 Jan 19. doi: 10.3389/pore.2023.1610801

PMCID:: PMC9892057

Abstract Article PDF–1.9M

Select item 988081216.

High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells

Songbiao Zhu, Wenxi Ding, Yuling Chen, Weixuan Wang, Renhua Xu, Chongdong Liu, Xiaohui Liu, Haiteng Deng

Genomics Proteomics Bioinformatics. 2022 Aug; 20(4): 657–669. Published online 2021 Feb 27. doi: 10.1016/j.gpb.2019.12.002

PMCID:: PMC9880812

Abstract Article PDF–2.9M

Select item 982795517.

PHD3 inhibits cell proliferation through hydroxylation of PAX2 at proline 9: PHD3 hydroxylates PAX2

Jie Lun, Yuxin Wang, Qiang Gao, Yu Wang, Hongwei Zhang, Jing Fang

Acta Biochim Biophys Sin (Shanghai) 2022 May; 54(5): 708–715. Published online 2022 Apr 27. doi: 10.3724/abbs.2022043

PMCID:: PMC9827955

Abstract Article PDF–3.3M

Select item 968188418.

Mutation of the proline P81 into a serine modifies the tumour suppressor function of the von Hippel–Lindau gene in the ccRCC

Franck Chesnel, Emmanuelle Jullion, Olivier Delalande, Anne Couturier, Adrien Alusse, Xavier Le Goff, Marion Lenglet, Betty Gardie, Caroline Abadie, Yannick Arlot-Bonnemains

Br J Cancer. 2022 Nov 23; 127(11): 1954–1962. Published online 2022 Sep 29. doi: 10.1038/s41416-022-01985-2

PMCID:: PMC9681884

Abstract Article PDF–989K

Select item 945724819.

USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer

Haibiao Xie, Jin Zhou, Xijuan Liu, Yawei Xu, Austin J. Hepperla, Jeremy M. Simon, Tao Wang, Hongwei Yao, Chengheng Liao, Albert S. Baldwin, Kan Gong, Qing Zhang

Proc Natl Acad Sci U S A. 2022 Sep 6; 119(36): e2119854119. Published online 2022 Aug 29. doi: 10.1073/pnas.2119854119

PMCID:: PMC9457248

Abstract Article PDF–3.1M

Select item 942384920.

An IDH-independent mechanism of DNA hypermethylation upon VHL inactivation in cancer

Artem V. Artemov, Svetlana Zhenilo, Daria Kaplun, Alexey Starshin, Alexey Sokolov, Alexander M. Mazur, Justyna Szpotan, Maciej Gawronski, Martyna Modrzejewska, Daniel Gackowski, Egor B. Prokhortchouk

Epigenetics. 2022; 17(8): 894–905. Published online 2021 Sep 8. doi: 10.1080/15592294.2021.1971372

PMCID:: PMC9423849

Abstract Article PDF–2.8M

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