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Select item 105206431.

PUM1 Promotes Tumor Progression by Activating DEPTOR‐Meditated Glycolysis in Gastric Cancer

Songcheng Yin, Huifang Liu, Zhijun Zhou, Xiaoyu Xu, Pengliang Wang, Wei Chen, Guofei Deng, Han Wang, Hong Yu, Liang Gu, Mingyu Huo, Min Li, Leli Zeng, Yulong He, Changhua Zhang

Adv Sci (Weinh) 2023 Sep; 10(27): 2301190. Published online 2023 Jul 19. doi: 10.1002/advs.202301190

PMCID:: PMC10520643

Abstract Article PDF–6.8M

Select item 99279332.

The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells

Shizhen Zhang, Xiahong You, Yawen Zheng, Yanwen Shen, Xiufang Xiong, Yi Sun

J Clin Invest. 2023 Feb 15; 133(4): e162434. Published online 2023 Feb 15. doi: 10.1172/JCI162434

PMCID:: PMC9927933

Abstract Article PDF–11M

Select item 95189923.

DFNA5 inhibits colorectal cancer proliferation by suppressing the mTORC1/2 signaling pathways via upregulation of DEPTOR

Jing Guo, Junhui Yu, Mingchao Mu, Zilu Chen, Zhengshui Xu, Chenye Zhao, Kui Yang, Jianbao Zheng, Xiao Qin, Wei Zhao, Xuejun Sun

Cell Cycle. 2022; 21(20): 2165–2178. Published online 2022 Aug 3. doi: 10.1080/15384101.2022.2088570

PMCID:: PMC9518992

Abstract Article PDF–3.8M

Select item 92875504.

NUMB facilitates autophagy initiation through targeting SCF^β-TrCP2 complex

Hao Li, Shuangshuang Shu, Miaomiao Zhou, Ying Chen, An Xiao, Yuanyuan Ma, Fengxin Zhu, Zheng Hu, Jing Nie

Cell Death Differ. 2022 Jul; 29(7): 1409–1422. Published online 2022 Jan 11. doi: 10.1038/s41418-022-00930-3

PMCID:: PMC9287550

Abstract Article PDF–4.3M

Select item 92792855.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 89336996.

Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation

Mario Vega, Yu Chen, Yijiang Shi, Joseph Gera, Alan Lichtenstein

J Biol Chem. 2022 Apr; 298(4): 101750. Published online 2022 Feb 23. doi: 10.1016/j.jbc.2022.101750

PMCID:: PMC8933699

Abstract Article PDF–1.6M

Select item 85516557.

Tyrosine phosphorylation of DEPTOR functions as a molecular switch to activate mTOR signaling

Laurence M. Gagné, Nadine Morin, Noémie Lavoie, Nicolas Bisson, Jean-Philippe Lambert, Frédérick A. Mallette, Marc-Étienne Huot

J Biol Chem. 2021 Nov; 297(5): 101291. Published online 2021 Oct 9. doi: 10.1016/j.jbc.2021.101291

PMCID:: PMC8551655

Abstract Article PDF–3.5M

Select item 84396578.

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

Maren Heimhalt, Alex Berndt, Jane Wagstaff, Madhanagopal Anandapadamanaban, Olga Perisic, Sarah Maslen, Stephen McLaughlin, Conny Wing-Heng Yu, Glenn R Masson, Andreas Boland, Xiaodan Ni, Keitaro Yamashita, Garib N Murshudov, Mark Skehel, Stefan M Freund, Roger L Williams

eLife. 2021; 10: e68799. Published online 2021 Sep 14. doi: 10.7554/eLife.68799

PMCID:: PMC8439657

Abstract Article PDF–7.0M

Select item 84396499.

Regulation of human mTOR complexes by DEPTOR

Matthias Wälchli, Karolin Berneiser, Francesca Mangia, Stefan Imseng, Louise-Marie Craigie, Edward Stuttfeld, Michael N Hall, Timm Maier

eLife. 2021; 10: e70871. Published online 2021 Sep 14. doi: 10.7554/eLife.70871

PMCID:: PMC8439649

Abstract Article PDF–7.4M

Select item 828051510.

Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis

Marina Serrano-Maciá, Jorge Simón, Maria J. González-Rellan, Mikel Azkargorta, Naroa Goikoetxea-Usandizaga, Fernando Lopitz-Otsoa, Diego Saenz De Urturi, Rubén Rodríguez-Agudo, Sofia Lachiondo-Ortega, Maria Mercado-Gomez, Virginia Gutiérrez de Juan, Maider Bizkarguenaga, David Fernández-Ramos, Xabier Buque, Guido A. Baselli, Luca V.C. Valenti, Paula Iruzubieta, Javier Crespo, Erica Villa, Jesus M. Banales, Matias A. Avila, Jose J.G. Marin, Patricia Aspichueta, James Sutherland, Rosa Barrio, Ugo Mayor, Félix Elortza, Dimitris P. Xirodimas, Rubén Nogueiras, Teresa C. Delgado, María Luz Martínez-Chantar

Mol Metab. 2021 Nov; 53: 101275. Published online 2021 Jun 18. doi: 10.1016/j.molmet.2021.101275

PMCID:: PMC8280515

Abstract Article PDF–4.0M

Select item 812021211.

DEPTOR stabilizes ErbB2 to promote the proliferation and survival of ErbB2-positive breast cancer cells

Yanli Bi, Xiaoyu Chen, Bajin Wei, Linchen Wang, Longyuan Gong, Haomin Li, Xiufang Xiong, Yongchao Zhao

Theranostics. 2021; 11(13): 6355–6369. Published online 2021 Apr 19. doi: 10.7150/thno.51286

PMCID:: PMC8120212

Abstract Article PDF–3.0M

Select item 804704312.

Nuclear ErbB2 represses DEPTOR transcription to inhibit autophagy in breast cancer cells

Yanli Bi, Longyuan Gong, Pengyuan Liu, Xiufang Xiong, Yongchao Zhao

Cell Death Dis. 2021 Apr; 12(4): 397. Published online 2021 Apr 14. doi: 10.1038/s41419-021-03686-9

PMCID:: PMC8047043

Abstract Article PDF–4.3M

Select item 793767413.

Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways

Jin Hwa Cho, Kidae Kim, Sung Ah Kim, Sungryul Park, Bi-Oh Park, Jong-Hwan Kim, Seon-Young Kim, Min Jee Kwon, Myeong Hoon Han, Sung Bae Lee, Byoung Chul Park, Sung Goo Park, Jeong-Hoon Kim, Sunhong Kim

Cell Death Differ. 2021 Mar; 28(3): 900–914. Published online 2020 Oct 27. doi: 10.1038/s41418-020-00649-z

PMCID:: PMC7937674

Abstract Article PDF–3.9M

Select item 783498714.

Function of Deptor and its roles in hematological malignancies

Mario Morales-Martinez, Alan Lichtenstein, Mario I. Vega

Aging (Albany NY) 2021 Jan 15; 13(1): 1528–1564. Published online 2021 Jan 7. doi: 10.18632/aging.202462

PMCID:: PMC7834987

Abstract Article PDF–2.6M

Select item 779745315.

Regulatory role of DEPTOR-mediated cellular autophagy and mitochondrial reactive oxygen species in angiogenesis in multiple myeloma

Jizhen Wang, Junmin Chen, Dongbiao Qiu, Zhiyong Zeng

Int J Mol Med. 2021 Feb; 47(2): 643–658. Published online 2020 Dec 24. doi: 10.3892/ijmm.2020.4831

PMCID:: PMC7797453

Abstract Article PDF–3.8M

Select item 766172616.

DEPTOR is a direct p53 target that suppresses cell growth and chemosensitivity

Danrui Cui, Xiaoqing Dai, Longyuan Gong, Xiaoyu Chen, Linchen Wang, Xiufang Xiong, Yongchao Zhao

Cell Death Dis. 2020 Nov; 11(11): 976. Published online 2020 Nov 12. doi: 10.1038/s41419-020-03185-3

PMCID:: PMC7661726

Abstract Article PDF–1.7M

Select item 752934917.

PTH/PTHrP-SIK3 mediated pathway affects skeletogenesis through altered mTOR signaling

Fabiana Csukasi, Ivan Duran, Maya Barad, Tomas Barta, Iva Gudernova, Lukas Trantirek, Jorge Martin, Caroline Y. Kuo, Jeremy Woods, Hane Lee, Daniel H. Cohn, Pavel Krejci, Deborah Krakow

Sci Transl Med. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Sci Transl Med. 2018 Sep 19; 10(459): eaat9356. doi: 10.1126/scitranslmed.aat9356

PMCID:: PMC7529349

Abstract Article PDF–1.8M

Select item 716998318.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 704745419.

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

Richard J. Allen, Beatriz Guillen-Guio, Justin M. Oldham, Shwu-Fan Ma, Amy Dressen, Megan L. Paynton, Luke M. Kraven, Ma'en Obeidat, Xuan Li, Michael Ng, Rebecca Braybrooke, Maria Molina-Molina, Brian D. Hobbs, Rachel K. Putman, Phuwanat Sakornsakolpat, Helen L. Booth, William A. Fahy, Simon P. Hart, Mike R. Hill, Nik Hirani, Richard B. Hubbard, Robin J. McAnulty, Ann B. Millar, Vidyia Navaratnam, Eunice Oballa, Helen Parfrey, Gauri Saini, Moira K. B. Whyte, Yingze Zhang, Naftali Kaminski, Ayodeji Adegunsoye, Mary E. Strek, Margaret Neighbors, Xuting R. Sheng, Gunnar Gudmundsson, Vilmundur Gudnason, Hiroto Hatabu, David J. Lederer, Ani Manichaikul, John D. Newell, Jr., George T. O’Connor, Victor E. Ortega, Hanfei Xu, Tasha E. Fingerlin, Yohan Bossé, Ke Hao, Philippe Joubert, David C. Nickle, Don D. Sin, Wim Timens, Dominic Furniss, Andrew P. Morris, Krina T. Zondervan, Ian P. Hall, Ian Sayers, Martin D. Tobin, Toby M. Maher, Michael H. Cho, Gary M. Hunninghake, David A. Schwartz, Brian L. Yaspan, Philip L. Molyneaux, Carlos Flores, Imre Noth, R. Gisli Jenkins, Louise V. Wain

Am J Respir Crit Care Med. 2020 Mar 1; 201(5): 564–574. Published online 2019 Nov 11. doi: 10.1164/rccm.201905-1017OC

PMCID:: PMC7047454

Abstract Article PDF–943K

Select item 701866320.

DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals

Xiaoyu Chen, Xiufang Xiong, Danrui Cui, Fei Yang, Dongping Wei, Haomin Li, Jianfeng Shu, Yanli Bi, Xiaoqing Dai, Longyuan Gong, Yi Sun, Yongchao Zhao

Oncogene. 2020; 39(7): 1557–1571. Published online 2019 Nov 4. doi: 10.1038/s41388-019-1085-y

PMCID:: PMC7018663

Abstract Article PDF–4.3M

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