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Select item 111056051.

The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker?

Alexey A. Tinkov, Geir Bjørklund, Anatoly V. Skalny, Arne Holmgren, Margarita G. Skalnaya, Salvatore Chirumbolo, Jan Aaseth

Cell Mol Life Sci. 2018 May; 75(9): 1567–1586. Published online 2018 Jan 11. doi: 10.1007/s00018-018-2745-8

PMCID:: PMC11105605

Abstract Article PDF–1.8M

Select item 108403502.

Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif

Wuyang Shi, Shibo Sun, Haowen Liu, Yao Meng, Kangshuai Ren, Guoying Wang, Minghui Liu, Jiaqi Wu, Yue Zhang, Huang Huang, Meiyun Shi, Weiping Xu, Qiang Ma, Bingbing Sun, Jianqiang Xu

Redox Biol. 2024 Apr; 70: 103050. Published online 2024 Jan 18. doi: 10.1016/j.redox.2024.103050

PMCID:: PMC10840350

Abstract Article PDF–14M

Select item 106715213.

Keratinocytes Exposed to Blue or Red Light: Proteomic Characterization Showed Cytoplasmic Thioredoxin Reductase 1 and Aldo-Keto Reductase Family 1 Member C3 Triggered Expression

Raffaella Lazzarini, Maria Fiorella Tartaglione, Veronica Ciarapica, Francesco Piva, Matteo Giulietti, Gianluca Fulgenzi, Margherita Martelli, Caterina Ledda, Ermanno Vitale, Marco Malavolta, Lory Santarelli, Massimo Bracci

Int J Mol Sci. 2023 Nov; 24(22): 16189. Published online 2023 Nov 10. doi: 10.3390/ijms242216189

PMCID:: PMC10671521

Abstract Article PDF–4.8M

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100142325.

Combined thioredoxin reductase and glutaminase inhibition exerts synergistic anti-tumor activity in MYC-high high-grade serous ovarian carcinoma

Prahlad V. Raninga, Yaowu He, Keshava K. Datta, Xue Lu, Uma R. Maheshwari, Pooja Venkat, Chelsea Mayoh, Harsha Gowda, Murugan Kalimutho, John D. Hooper, Kum Kum Khanna

Mol Ther. 2023 Mar 1; 31(3): 729–743. Published online 2022 Dec 21. doi: 10.1016/j.ymthe.2022.12.011

PMCID:: PMC10014232

Abstract Article PDF–3.0M

Select item 98334506.

Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury

Colin T. Shearn, Aimee L. Anderson, Colin G. Miller, Reed C. Noyd, Michael W. Devereaux, Nata Balasubramaniyan, David J. Orlicky, Edward E. Schmidt, Ronald J. Sokol

Hepatol Commun. 2023 Jan; 7(1): e0020. Published online 2023 Jan 10. doi: 10.1097/HC9.0000000000000020

PMCID:: PMC9833450

Abstract Article PDF–1.7M

Select item 98231317.

Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth

David J. Wisniewski, Mariya S. Liyasova, Soumya Korrapati, Xu Zhang, Shashikala Ratnayake, Qingrong Chen, Samuel F. Gilbert, Alexis Catalano, Donna Voeller, Daoud Meerzaman, Udayan Guha, Natalie Porat-Shliom, Christina M. Annunziata, Stanley Lipkowitz

J Biol Chem. 2023 Jan; 299(1): 102766. Published online 2022 Dec 5. doi: 10.1016/j.jbc.2022.102766

PMCID:: PMC9823131

Abstract Article PDF–2.5M

Select item 97922518.

Qian Huang, Maocuo Peng, Yiya Gu, Jixing Wu, Yuan Zhan, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jinkun Chen, Jungang Xie

Oxid Med Cell Longev. 2022; 2022: 7067623. Published online 2022 Dec 19. doi: 10.1155/2022/7067623

PMCID:: PMC9792251

Abstract Article PDF–1.9M

Select item 96265939.

USF2-mediated upregulation of TXNRD1 contributes to hepatocellular carcinoma progression by activating Akt/mTOR signaling

Wen-ya Huang, Zhi-bin Liao, Jia-cheng Zhang, Xin Zhang, Hong-wei Zhang, Hui-fang Liang, Zun-yi Zhang, Tao Yang, Jia Yu, Ke-shuai Dong

Cell Death Dis. 2022 Nov; 13(11): 917. Published online 2022 Nov 1. doi: 10.1038/s41419-022-05363-x

PMCID:: PMC9626593

Abstract Article PDF–4.6M

Select item 948193310.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 940585311.

Selenocysteine Machinery Primarily Supports TXNRD1 and GPX4 Functions and Together They Are Functionally Linked with SCD and PRDX6

Didac Santesmasses, Vadim N. Gladyshev

Biomolecules. 2022 Aug; 12(8): 1049. Published online 2022 Jul 28. doi: 10.3390/biom12081049

PMCID:: PMC9405853

Abstract Article PDF–2.0M

Select item 927928512.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 916684813.

Correlation between TXNRD1/HO-1 expression and response to neoadjuvant chemoradiation therapy in patients with esophageal squamous cell carcinoma

Ryujiro Akaishi, Fumiyoshi Fujishima, Hirotaka Ishida, Junichi Tsunokake, Takuro Yamauchi, Yusuke Gokon, Shunsuke Ueki, Toshiaki Fukutomi, Hiroshi Okamoto, Kai Takaya, Chiaki Sato, Yusuke Taniyama, Tomohiro Nakamura, Naoki Nakaya, Takashi Kamei, Hironobu Sasano

Esophagus. 2022; 19(3): 436–443. Published online 2022 Jan 8. doi: 10.1007/s10388-021-00904-3

PMCID:: PMC9166848

Abstract Article PDF–906K

Select item 910272614.

VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway

Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu, Xuegong Fan

J Transl Med. 2022; 20: 212. Published online 2022 May 13. doi: 10.1186/s12967-022-03416-5

PMCID:: PMC9102726

Abstract Article PDF–15M

Select item 889702215.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 885704916.

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Tara E. Tracy, Jesus Madero-Pérez, Danielle L. Swaney, Timothy S. Chang, Michelle Moritz, Csaba Konrad, Michael E. Ward, Erica Stevenson, Ruth Hüttenhain, Grant Kauwe, Maria Mercedes, Lauren Sweetland-Martin, Xu Chen, Sue-Ann Mok, Man Ying Wong, Maria Telpoukhovskaia, Sang-Won Min, Chao Wang, Peter Dongmin Sohn, Jordie Martin, Yungui Zhou, Wenjie Luo, John Q. Trojanowski, Virginia M.Y. Lee, Shiaoching Gong, Giovanni Manfredi, Giovanni Coppola, Nevan J. Krogan, Daniel H. Geschwind, Li Gan

Cell. Author manuscript; available in PMC 2022 Feb 19.

Published in final edited form as: Cell. 2022 Feb 17; 185(4): 712–728.e14. Published online 2022 Jan 20. doi: 10.1016/j.cell.2021.12.041

PMCID:: PMC8857049

Abstract Article PDF–3.6M

Select item 880885817.

Patients with Osteoarthritis and Kashin-Beck Disease Display Distinct CpG Methylation Profiles in the DIO2, GPX3, and TXRND1 Promoter Regions

Rongqiang Zhang, Hao Guo, Xiaoli Yang, Dandan Zhang, Di Zhang, Qiang Li, Chen Wang, Xuena Yang, Yongmin Xiong

Cartilage. 2021 Dec; 13(1 Suppl): 797S–808S. Published online 2021 Jan 16. doi: 10.1177/1947603520988165

PMCID:: PMC8808858

Abstract Article PDF–4.2M

Select item 879394218.

Methionine Restriction Exposes a Targetable Redox Vulnerability of Triple-Negative Breast Cancer Cells by Inducing Thioredoxin Reductase

Dmitry Malin, Yoonkyu Lee, Olga Chepikova, Elena Strekalova, Alexis Carlson, Vincent L. Cryns

Breast Cancer Res Treat. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Breast Cancer Res Treat. 2021 Dec; 190(3): 373–387. Published online 2021 Sep 22. doi: 10.1007/s10549-021-06398-y

PMCID:: PMC8793942

Abstract Article PDF–2.2M

Select item 869057419.

Induction of Oxidative Stress via Inhibition of Thioredoxin Reductase 1 is an Effective Therapeutic Approach for Hepatocellular Carcinoma

Derek Lee, Iris Ming-Jing Xu, David Kung-Chun Chiu, Josef Leibold, Aki Pui-Wah Tse, Macus Hao-Ran Bao, Vincent Wai-Hin Yuen, Cerise Yuen-Ki Chan, Robin Kit-Ho Lai, Don Wai-Ching Chin, Daniel For-Fan Chan, Tan-To Cheung, Siu-Ho Chok, Chun-Ming Wong, Scott W. Lowe, Irene Oi-Lin Ng, Carmen Chak-Lui Wong

Hepatology. Author manuscript; available in PMC 2021 Dec 21.

Published in final edited form as: Hepatology. 2019 Apr; 69(4): 1768–1786. Published online 2019 Mar 21. doi: 10.1002/hep.30467

PMCID:: PMC8690574

Abstract Article PDF–3.1M

Select item 846297420.

Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes

Weijun Gui, Siqi Shen, Zhihao Zhuang

J Am Chem Soc. Author manuscript; available in PMC 2021 Nov 18.

Published in final edited form as: J Am Chem Soc. 2020 Nov 18; 142(46): 19493–19501. Published online 2020 Nov 3. doi: 10.1021/jacs.9b12426

PMCID:: PMC8462974

Abstract Article PDF–975K

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