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Select item 112251941.

UCHL3 promotes hepatocellular carcinoma progression by stabilizing EEF1A1 through deubiquitination

Jie Zhao, Qiang Huo, Ji Zhang, Kexiang Sun, Jinhui Guo, Feng Cheng, Xiaoge Hu, Qiuran Xu

Biol Direct. 2024; 19: 53. Published online 2024 Jul 4. doi: 10.1186/s13062-024-00495-w

PMCID:: PMC11225194

Abstract Article PDF–11M

Select item 108913382.

Elongation factor 1A1 regulates metabolic substrate preference in mammalian cells

Rachel B. Wilson, Alexandra M. Kozlov, Helia Hatam Tehrani, Jessica S. Twumasi-Ankrah, Yun Jin Chen, Matthew J. Borrelli, Cynthia G. Sawyez, Siddhant Maini, Trevor G. Shepherd, Robert C. Cumming, Dean H. Betts, Nica M. Borradaile

J Biol Chem. 2024 Mar; 300(3): 105684. Published online 2024 Jan 23. doi: 10.1016/j.jbc.2024.105684

PMCID:: PMC10891338

Abstract Article PDF–4.3M

Select item 108697063.

Chp1 is a dedicated chaperone at the ribosome that safeguards eEF1A biogenesis

Melania Minoia, Jany Quintana-Cordero, Katharina Jetzinger, Ilgin Eser Kotan, Kathryn Jane Turnbull, Michela Ciccarelli, Anna E. Masser, Dorina Liebers, Eloïse Gouarin, Marius Czech, Vasili Hauryliuk, Bernd Bukau, Günter Kramer, Claes Andréasson

Nat Commun. 2024; 15: 1382. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45645-w

PMCID:: PMC10869706

Abstract Article PDF–2.5M

Select item 108508184.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 108447485.

Methylation of elongation factor 1A by yeast Efm4 or human eEF1A-KMT2 involves a beta-hairpin recognition motif and crosstalks with phosphorylation

Joshua J. Hamey, Amy Nguyen, Mahdi Haddad, Xabier Vázquez-Campos, Paige G. Pfeiffer, Marc R. Wilkins

J Biol Chem. 2024 Feb; 300(2): 105639. Published online 2024 Jan 8. doi: 10.1016/j.jbc.2024.105639

PMCID:: PMC10844748

Abstract Article PDF–4.9M

Select item 107649586.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 106176737.

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg

Science. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021

PMCID:: PMC10617673

Abstract Article PDF–3.6M

Select item 102841178.

Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry

Fenglong Jiao, Leah J. Salituro, Clinton Yu, Craig B. Gutierrez, Scott D. Rychnovsky, Lan Huang

Anal Chem. Author manuscript; available in PMC 2023 Jun 21.

Published in final edited form as: Anal Chem. 2023 Jan 31; 95(4): 2532–2539. Published online 2023 Jan 18. doi: 10.1021/acs.analchem.2c04986

PMCID:: PMC10284117

Abstract Article PDF–2.5M

Select item 102794699.

Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein

Sean A. Burnap, Ana Maria Ortega-Prieto, Jose M. Jimenez-Guardeño, Hashim Ali, Kaloyan Takov, Matthew Fish, Manu Shankar-Hari, Mauro Giacca, Michael H. Malim, Manuel Mayr

Mol Cell Proteomics. 2023 Aug; 22(8): 100600. Published online 2023 Jun 19. doi: 10.1016/j.mcpro.2023.100600

PMCID:: PMC10279469

Abstract Article PDF–3.2M

Select item 1026505710.

Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1‐EEF1A1 Axis

Mingli Li, Lu Yang, Anthony K. N. Chan, Sheela Pangeni Pokharel, Qiao Liu, Nicole Mattson, Xiaobao Xu, Wen‐Han Chang, Kazuya Miyashita, Priyanka Singh, Leisi Zhang, Maggie Li, Jun Wu, Jinhui Wang, Bryan Chen, Lai N. Chan, Jaewoong Lee, Xu Hannah Zhang, Steven T. Rosen, Markus Müschen, Jun Qi, Jianjun Chen, Kevin Hiom, Alexander J. R. Bishop, Chun‐Wei Chen

Adv Sci (Weinh) 2023 Jun; 10(17): 2206584. Published online 2023 Apr 19. doi: 10.1002/advs.202206584

PMCID:: PMC10265057

Abstract Article PDF–10M

Select item 1024099811.

PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805

Yunpeng Bai, Guimei Yu, Hong-Ming Zhou, Ovini Amarasinghe, Yuan Zhou, Peipei Zhu, Qinglin Li, Lujuan Zhang, Frederick Nguele Meke, Yiming Miao, Eli Chapman, W. Andy Tao, Zhong-Yin Zhang

Autophagy. 2023; 19(5): 1562–1581. Published online 2022 Nov 7. doi: 10.1080/15548627.2022.2140558

PMCID:: PMC10240998

Abstract Article PDF–4.4M

Select item 1023742212.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1015862413.

The RNA‐binding protein Snd1/Tudor‐SN regulates hypoxia‐responsive gene expression

Juha Saarikettu, Saara Lehmusvaara, Marko Pesu, Ilkka Junttila, Juha Partanen, Petra Sipilä, Matti Poutanen, Jie Yang, Teemu Haikarainen, Olli Silvennoinen

FASEB Bioadv. 2023 May; 5(5): 183–198. Published online 2023 Feb 21. doi: 10.1096/fba.2022-00115

PMCID:: PMC10158624

Abstract Article PDF–7.2M

Select item 1015161514.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 1014884315.

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin

Naphat Chantaravisoot, Piriya Wongkongkathep, Nuttiya Kalpongnukul, Narawit Pacharakullanon, Pornchai Kaewsapsak, Chaiyaboot Ariyachet, Joseph A. Loo, Fuyuhiko Tamanoi, Trairak Pisitkun

Sci Rep. 2023; 13: 7037. Published online 2023 Apr 29. doi: 10.1038/s41598-023-33872-y

PMCID:: PMC10148843

Abstract Article PDF–11M

Select item 1006216516.

SARS-CoV-2 ORF8 Protein Induces Endoplasmic Reticulum Stress-like Responses and Facilitates Virus Replication by Triggering Calnexin: an Unbiased Study

Xuefeng Wang, Wenqi Wang, Tiecheng Wang, Jianzhong Wang, Yuhang Jiang, Xue Wang, Ze Qiu, Na Feng, Weiyang Sun, Chang Li, Songtao Yang, Xianzhu Xia, Hongbin He, Yuwei Gao

J Virol. 2023 Mar; 97(3): e00011-23. Published online 2023 Mar 6. doi: 10.1128/jvi.00011-23

PMCID:: PMC10062165

Abstract Article PDF–2.9M

Select item 1003899217.

Calpain activity is negatively regulated by a KCTD7–Cullin-3 complex via non-degradative ubiquitination

Jaiprakash Sharma, Shalaka Mulherkar, Uan-I Chen, Yan Xiong, Lakshya Bajaj, Byoung-Kyu Cho, Young Ah Goo, Hon-Chiu Eastwood Leung, Kimberley F. Tolias, Marco Sardiello

Cell Discov. 2023; 9: 32. Published online 2023 Mar 24. doi: 10.1038/s41421-023-00533-3

PMCID:: PMC10038992

Abstract Article PDF–15M

Select item 1001870218.

Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3

Hao-Yuan Wang, Haojun Yang, Mikael Holm, Harrison Tom, Keely Oltion, Amjad Ayad Qatran Al-Khdhairawi, Jean-Frédéric F. Weber, Scott C. Blanchard, Davide Ruggero, Jack Taunton

Nat Chem. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Nat Chem. 2022 Dec; 14(12): 1443–1450. Published online 2022 Sep 19. doi: 10.1038/s41557-022-01039-3