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Select item 112099351.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 109168662.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 107709603.

Localization, traffic and function of Rab34 in adipocyte lipid and endocrine functions

Jaime López-Alcalá, Ana Gordon, Andrés Trávez, Carmen Tercero-Alcázar, Alejandro Correa-Sáez, María Jesús González-Rellán, Oriol A. Rangel-Zúñiga, Amaia Rodríguez, Antonio Membrives, Gema Frühbeck, Rubén Nogueiras, Marco A. Calzado, Rocío Guzmán-Ruiz, María M. Malagón

J Biomed Sci. 2024; 31: 2. Published online 2024 Jan 5. doi: 10.1186/s12929-023-00990-8

PMCID:: PMC10770960

Abstract Article PDF–16M

Select item 104810914.

Pathogenic RAB34 variants impair primary cilium assembly and cause a novel oral-facial-digital syndrome

Ange-Line Bruel, Anil Kumar Ganga, Lenka Nosková, Irene Valenzuela, Jelena Martinovic, Yannis Duffourd, Marie Zikánová, Filip Majer, Stanislav Kmoch, Markéta Mohler, Jingbo Sun, Lauren K Sweeney, Núria Martínez-Gil, Christel Thauvin-Robinet, David K Breslow

Hum Mol Genet. 2023 Sep 15; 32(18): 2822–2831. Published online 2023 Jun 29. doi: 10.1093/hmg/ddad109

PMCID:: PMC10481091

Abstract Article PDF–1.0M

Select item 103459635.

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

Amr El Zawily, Frederick S. Vizeacoumar, Renuka Dahiya, Sara L. Banerjee, Kalpana K. Bhanumathy, Hussain Elhasasna, Glinton Hanover, Jessica C. Sharpe, Malkon G. Sanchez, Paul Greidanus, R. Greg Stacey, Kyung-Mee Moon, Ilya Alexandrov, Juha P. Himanen, Dimitar B. Nikolov, Humphrey Fonge, Aaron P. White, Leonard J. Foster, Bingcheng Wang, Behzad M. Toosi, Nicolas Bisson, Tajib A. Mirzabekov, Franco J. Vizeacoumar, Andrew Freywald

Clin Cancer Res. 2023 Jul 14; 29(14): 2686–2701. Published online 2023 Mar 28. doi: 10.1158/1078-0432.CCR-22-2535

PMCID:: PMC10345963

Abstract Article PDF–13M

Select item 102374226.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 95699557.

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation

Yulemi Gonzalez Quesada, Luc DesGroseillers

Int J Mol Sci. 2022 Oct; 23(19): 11588. Published online 2022 Sep 30. doi: 10.3390/ijms231911588

PMCID:: PMC9569955

Abstract Article PDF–2.1M

Select item 94819338.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 93383139.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

Select item 930881910.

Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector

Amrita Rai, Anurag K. Singh, Nathalie Bleimling, Guido Posern, Ingrid R. Vetter, Roger S. Goody

Nat Commun. 2022; 13: 4262. Published online 2022 Jul 23. doi: 10.1038/s41467-022-31831-1

PMCID:: PMC9308819

Abstract Article PDF–7.3M

Select item 923162311.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 904055612.

A protein interaction landscape of breast cancer

Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Michael J. McGregor, Patrick O’Leary, Denise Wolf, Erica Stevenson, Tzeh Keong Foo, Dominique Mitchell, Kari A. Herrington, Denise P. Muñoz, Beril Tutuncuoglu, Kuei-Ho Chen, Fan Zheng, Jason F. Kreisberg, Morgan E. Diolaiti, John D. Gordan, Jean-Philippe Coppé, Danielle L. Swaney, Bing Xia, Laura van ’t Veer, Alan Ashworth, Trey Ideker, Nevan Krogan

Science. Author manuscript; available in PMC 2022 Apr 26.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf3066. Published online 2021 Oct 1. doi: 10.1126/science.abf3066

PMCID:: PMC9040556

Abstract Article PDF–2.2M

Select item 886447213.

Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network

Rebecca Elizabeth Kattan, Han Han, Gayoung Seo, Bing Yang, Yongqi Lin, Max Dotson, Stephanie Pham, Yahya Menely, Wenqi Wang

Mol Cell Proteomics. 2022 Feb; 21(2): 100195. Published online 2022 Jan 8. doi: 10.1016/j.mcpro.2022.100195

PMCID:: PMC8864472

Abstract Article PDF–3.6M

Select item 828272214.

Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway

Anil Kumar Ganga, Margaret C. Kennedy, Mai E. Oguchi, Shawn Gray, Kendall E. Oliver, Tracy A. Knight, Enrique M. De La Cruz, Yuta Homma, Mitsunori Fukuda, David K. Breslow

Curr Biol. Author manuscript; available in PMC 2022 Jul 12.

Published in final edited form as: Curr Biol. 2021 Jul 12; 31(13): 2895–2905.e7. Published online 2021 May 13. doi: 10.1016/j.cub.2021.04.075

PMCID:: PMC8282722

Abstract Article PDF–1.0M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 810809316.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary

Cell. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050

PMCID:: PMC8108093

Abstract Article PDF–3.5M

Select item 764232717.

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

Dick J. H. van den Boomen, Agata Sienkiewicz, Ilana Berlin, Marlieke L. M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques J. C. Neefjes, Paul J. Lehner

Nat Commun. 2020; 11: 5559. Published online 2020 Nov 3. doi: 10.1038/s41467-020-19032-0

PMCID:: PMC7642327

Abstract Article PDF–12M

Select item 747671218.

A comprehensive analysis of Rab GTPases reveals a role for Rab34 in serum starvation-induced primary ciliogenesis

Mai E. Oguchi, Koki Okuyama, Yuta Homma, Mitsunori Fukuda

J Biol Chem. 2020 Sep 4; 295(36): 12674–12685. Published online 2020 Jul 15. doi: 10.1074/jbc.RA119.012233

PMCID:: PMC7476712

Abstract Article PDF–4.0M

Select item 739233419.

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells

Seung W. Ryu, Rose Stewart, D. Chase Pectol, Nicolette A. Ender, Oshadi Wimalarathne, Ji-Hoon Lee, Carlos P. Zanini, Antony Harvey, Jon M. Huibregtse, Peter Mueller, Tanya T. Paull

PLoS Biol. 2020 Jul; 18(7): e3000606. Published online 2020 Jul 20. doi: 10.1371/journal.pbio.3000606

PMCID:: PMC7392334

Abstract Article PDF–2.7M

Select item 729072120.

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation

Danielle G. May, Kelsey L. Scott, Alexandre R. Campos, Kyle J. Roux

Cells. 2020 May; 9(5): 1070. Published online 2020 Apr 25. doi: 10.3390/cells9051070

PMCID:: PMC7290721

Abstract Article PDF–9.2M

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