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Select item 111409071.

Knockout mice with pituitary malformations help identify human cases of hypopituitarism

Julian Martinez-Mayer, Michelle L. Brinkmeier, Sean P. O’Connell, Arnold Ukagwu, Marcelo A. Marti, Mirta Miras, Maria V. Forclaz, Maria G. Benzrihen, Leonard Y. M. Cheung, Sally A. Camper, Buffy S. Ellsworth, Lori T. Raetzman, Maria I. Pérez-Millán, Shannon W. Davis

Genome Med. 2024; 16: 75. Published online 2024 May 31. doi: 10.1186/s13073-024-01347-y

PMCID:: PMC11140907

Abstract Article PDF–4.4M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108967233.

Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation

Wenmin Xia, Preethi Veeragandham, Yu Cao, Yayun Xu, Torrey E. Rhyne, Jiaxin Qian, Chao-Wei Hung, Peng Zhao, Ying Jones, Hui Gao, Christopher Liddle, Ruth T. Yu, Michael Downes, Ronald M. Evans, Mikael Rydén, Martin Wabitsch, Zichen Wang, Hiroyuki Hakozaki, Johannes Schöneberg, Shannon M. Reilly, Jianfeng Huang, Alan R. Saltiel

Nat Metab. 2024; 6(2): 273–289. Published online 2024 Jan 29. doi: 10.1038/s42255-024-00978-0

PMCID:: PMC10896723

Abstract Article PDF–18M

Select item 107693504.

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders

Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C. Goetz

Version 1. bioRxiv. Preprint. 2023 Dec 21. doi: 10.1101/2023.12.20.572700

PMCID:: PMC10769350

Abstract Article PDF–11M

Select item 103808555.

Impaired Insulin Signaling Mediated by the Small GTPase Rac1 in Skeletal Muscle of the Leptin-Deficient Obese Mouse

Man Piu Chan, Nobuyuki Takenaka, Takaya Satoh

Int J Mol Sci. 2023 Jul; 24(14): 11531. Published online 2023 Jul 16. doi: 10.3390/ijms241411531

PMCID:: PMC10380855

Abstract Article PDF–3.3M

Select item 83443816.

RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal

Syed S. Hussain, Tuyet-Minh Tran, Timothy B. Ware, Melissa A. Luse, Christopher T. Prevost, Ashley N. Ferguson, Jennifer A. Kashatus, Ku-Lung Hsu, David F. Kashatus

Cell Rep. Author manuscript; available in PMC 2021 Aug 6.

Published in final edited form as: Cell Rep. 2021 Jul 27; 36(4): 109451. doi: 10.1016/j.celrep.2021.109451

PMCID:: PMC8344381

Abstract Article PDF–3.3M

Select item 83132397.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 82167198.

RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

Máté Nászai, Karen Bellec, Yachuan Yu, Alvaro Román-Fernández, Emma Sandilands, Joel Johansson, Andrew D Campbell, Jim C Norman, Owen J Sansom, David M Bryant, Julia B Cordero

eLife. 2021; 10: e63807. Published online 2021 Jun 7. doi: 10.7554/eLife.63807

PMCID:: PMC8216719

Abstract Article PDF–7.7M

Select item 79387709.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 660581310.

Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system

Andrea Ommer, Gianluca Figlia, Jorge A. Pereira, Anna Lena Datwyler, Joanne Gerber, Jonathan DeGeer, Giovanna Lalli, Ueli Suter

J Cell Biol. 2019 Jul 1; 218(7): 2350–2369. Published online 2019 Jun 14. doi: 10.1083/jcb.201811150

PMCID:: PMC6605813

Abstract Article PDF–4.5M

Select item 660580311.

RalGTPases contribute to Schwann cell repair after nerve injury via regulation of process formation

Jorge Galino, Ilaria Cervellini, Ning Zhu, Nina Stöberl, Meike Hütte, Florence R. Fricker, Garrett Lee, Lucy McDermott, Giovanna Lalli, David L.H. Bennett

J Cell Biol. 2019 Jul 1; 218(7): 2370–2387. Published online 2019 Jun 14. doi: 10.1083/jcb.201811002

PMCID:: PMC6605803

Abstract Article PDF–3.8M

Select item 645951012.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 645900213.

RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes

Joel Johansson, Mate Naszai, Michael C. Hodder, Karen A. Pickering, Bryan W. Miller, Rachel A. Ridgway, Yachuan Yu, Pascal Peschard, Saskia Brachmann, Andrew D. Campbell, Julia B. Cordero, Owen J. Sansom

Cell Stem Cell. 2019 Apr 4; 24(4): 592–607.e7. doi: 10.1016/j.stem.2019.02.002

PMCID:: PMC6459002

Abstract Article PDF–7.0M

Select item 606503714.

RalA controls glucose homeostasis by regulating glucose uptake in brown fat

Yuliya Skorobogatko, Morgan Dragan, Claudia Cordon, Shannon M. Reilly, Chao-Wei Hung, Wenmin Xia, Peng Zhao, Martina Wallace, Denise E. Lackey, Xiao-Wei Chen, Olivia Osborn, Juliane G. Bogner-Strauss, Dan Theodorescu, Christian M. Metallo, Jerrold M. Olefsky, Alan R. Saltiel

Proc Natl Acad Sci U S A. 2018 Jul 24; 115(30): 7819–7824. Published online 2018 Jun 18. doi: 10.1073/pnas.1801050115

PMCID:: PMC6065037

Abstract Article PDF–909K

Select item 586671915.

Placentation defects are highly prevalent in embryonic lethal mouse mutants

Vicente Perez-Garcia, Elena Fineberg, Robert Wilson, Alexander Murray, Cecilia Icoresi Mazzeo, Catherine Tudor, Arnold Sienerth, Jacqueline K. White, Elizabeth Tuck, Edward J. Ryder, Diane Gleeson, Emma Siragher, Hannah Wardle-Jones, Nicole Staudt, Neha Wali, John Collins, Stefan Geyer, Elisabeth M. Busch-Nentwich, Antonella Galli, James C. Smith, Elizabeth Robertson, David J. Adams, Wolfgang J. Weninger, Timothy Mohun, Myriam Hemberger

Nature. Author manuscript; available in PMC 2018 Sep 14.

Published in final edited form as: Nature. 2018 Mar 22; 555(7697): 463–468. Published online 2018 Mar 14. doi: 10.1038/nature26002

PMCID:: PMC5866719

Abstract Article PDF–7.4M

Select item 538122616.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 497380617.

Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling

Archana Pawar, Jeremy A. Meier, Anwesha Dasgupta, Neha Diwanji, Neha Deshpande, Kritika Saxena, Natasha Buwa, Siddhi Inchanalkar, Martin Alexander Schwartz, Nagaraj Balasubramanian

Cell Signal. 2016 Sep; 28(9): 1225–1236. doi: 10.1016/j.cellsig.2016.05.023

PMCID:: PMC4973806

Abstract Article PDF–1.6M

Select item 456625518.

Divergent Roles of CAAX Motif-signaled Posttranslational Modifications in the Regulation and Subcellular Localization of Ral GTPases

Leanna R. Gentry, Akiyuki Nishimura, Adrienne D. Cox, Timothy D. Martin, Denis Tsygankov, Motohiro Nishida, Timothy C. Elston, Channing J. Der

J Biol Chem. 2015 Sep 11; 290(37): 22851–22861. Published online 2015 Jul 27. doi: 10.1074/jbc.M115.656710

PMCID:: PMC4566255

Abstract Article PDF–1.8M

Select item 413384819.

Elevated RalA activity in the hippocampus of PI3Kγ knock-out mice lacking NMDAR-dependent long-term depression

Su-Eon Sim, Hye-Ryeon Lee, Jae-Ick Kim, Sun-Lim Choi, Joseph Bakes, Deok-Jin Jang, Kyungmin Lee, Kihoon Han, Eunjoon Kim, Bong-Kiun Kaang

BMB Rep. 2013 Feb; 46(2): 103–106. doi: 10.5483/BMBRep.2013.46.2.143

PMCID:: PMC4133848

Abstract Article PDF–331K

Select item 400776820.

RalA promotes a direct exocyst–Par6 interaction to regulate polarity in neuronal development

Amlan Das, Sangeetha Gajendra, Katarzyna Falenta, Madeleine J. Oudin, Pascal Peschard, Shanshan Feng, Bin Wu, Christopher J. Marshall, Patrick Doherty, Wei Guo, Giovanna Lalli

J Cell Sci. 2014 Feb 1; 127(3): 686–699. doi: 10.1242/jcs.145037

PMCID:: PMC4007768

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