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Select item 13346491.

Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gβγ

Motohiko Sato, Mary J. Cismowski, Eiji Toyota, Alan V. Smrcka, Pamela A. Lucchesi, William M. Chilian, Stephen M. Lanier

Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3): 797–802. Published online 2006 Jan 9. doi: 10.1073/pnas.0507467103

PMCID:: PMC1334649

Abstract Article PDF–426K

Select item 27815392.

Activator of G Protein Signaling 8 (AGS8) Is Required for Hypoxia-induced Apoptosis of Cardiomyocytes: ROLE OF Gβγ AND CONNEXIN 43 (CX43)

Motohiko Sato, Qibin Jiao, Takashi Honda, Reiko Kurotani, Eiji Toyota, Satoshi Okumura, Tatsuo Takeya, Susumu Minamisawa, Stephen M. Lanier, Yoshihiro Ishikawa

J Biol Chem. 2009 Nov 6; 284(45): 31431–31440. Published online 2009 Sep 1. doi: 10.1074/jbc.M109.014068

PMCID:: PMC2781539

Abstract Article PDF–3.4M

Select item 30590093.

Expression of Water-soluble, Ligand-binding Concatameric Extracellular Domains of the Human Neuronal Nicotinic Receptor α4 and β2 Subunits in the Yeast Pichia pastoris: GLYCOSYLATION IS NOT REQUIRED FOR LIGAND BINDING

Christos Stergiou, Paraskevi Zisimopoulou, Socrates J. Tzartos

J Biol Chem. 2011 Mar 18; 286(11): 8884–8892. Published online 2011 Jan 20. doi: 10.1074/jbc.M110.171645

PMCID:: PMC3059009

Abstract Article PDF–1.5M

Select item 59269604.

Overexpression of Urokinase‐type Plasminogen Activator in Human Gastric Cancer Cell Line (AGS) Induces Tumorigenicity in Severe Combined Immunodeficient Mice

Yang‐Kyu Choi, Byung‐Il Yoon, Yoon‐Hoh Kook, Young‐Suk Won, Jin‐Hyun Kim, Chul‐Ho Lee, Byung‐Hwa Hyun, Goo‐Taeg Oh, John Sipley, Dae‐Yong Kim

Jpn J Cancer Res. 2002 Feb; 93(2): 151–156. doi: 10.1111/j.1349-7006.2002.tb01253.x

PMCID:: PMC5926960

Summary PDF–3.6M

Select item 39548315.

Protection of Cardiomyocytes from the Hypoxia-Mediated Injury by a Peptide Targeting the Activator of G-Protein Signaling 8

Motohiko Sato, Masahiro Hiraoka, Hiroko Suzuki, Miho Sakima, Abdullah Al Mamun, Yukiko Yamane, Takayuki Fujita, Utako Yokoyama, Satoshi Okumura, Yoshihiro Ishikawa

PLoS One. 2014; 9(3): e91980. Published online 2014 Mar 14. doi: 10.1371/journal.pone.0091980

PMCID:: PMC3954831

Abstract Article PDF–2.4M

Select item 54168836.

Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion

Peng Li, Juan Du, John L. Goodier, Jingwei Hou, Jian Kang, Haig H. Kazazian, Jr, Ke Zhao, Xiao-Fang Yu

Nucleic Acids Res. 2017 May 5; 45(8): 4619–4631. Published online 2017 Mar 15. doi: 10.1093/nar/gkx178

PMCID:: PMC5416883

Abstract Article PDF–2.0M

Select item 55736787.

AIM2-Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA

Yuki Nakaya, Jingtao Lilue, Spyridon Stavrou, Eileen A. Moran, Susan R. Ross

mBio. 2017 Jul-Aug; 8(4): e00944-17. Published online 2017 Jul 5. doi: 10.1128/mBio.00944-17

PMCID:: PMC5573678

Abstract Article PDF–2.6M

Select item 49787008.

Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1

Jonathan Maelfait, Anne Bridgeman, Adel Benlahrech, Chiara Cursi, Jan Rehwinkel

Cell Rep. 2016 Aug 9; 16(6): 1492–1501. Published online 2016 Jul 28. doi: 10.1016/j.celrep.2016.07.002

PMCID:: PMC4978700

Abstract Article PDF–2.8M

Select item 48556879.

Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response

Karen J Mackenzie, Paula Carroll, Laura Lettice, Žygimantė Tarnauskaitė, Kaalak Reddy, Flora Dix, Ailsa Revuelta, Erika Abbondati, Rachel E Rigby, Björn Rabe, Fiona Kilanowski, Graeme Grimes, Adeline Fluteau, Paul S Devenney, Robert E Hill, Martin AM Reijns, Andrew P Jackson

EMBO J. 2016 Apr 15; 35(8): 831–844. Published online 2016 Feb 22. doi: 10.15252/embj.201593339

PMCID:: PMC4855687

Abstract Article PDF–801K

Select item 482781510.

Alterations in Fibronectin Type III Domain Containing 1 Protein Gene Are Associated with Hypertension

Alan Y. Deng, Cristina Chauvet, Annie Ménard

PLoS One. 2016; 11(4): e0151399. Published online 2016 Apr 11. doi: 10.1371/journal.pone.0151399

PMCID:: PMC4827815

Abstract Article PDF–715K

Select item 473128911.

Neuroradiologic patterns and novel imaging findings in Aicardi-Goutières syndrome

Roberta La Piana, Carla Uggetti, Federico Roncarolo, Adeline Vanderver, Ivana Olivieri, Davide Tonduti, Guy Helman, Umberto Balottin, Elisa Fazzi, Yanick J. Crow, John Livingston, Simona Orcesi

Neurology. 2016 Jan 5; 86(1): 28–35. doi: 10.1212/WNL.0000000000002228

PMCID:: PMC4731289

Abstract Article PDF–628K

Select item 438220212.

Characterization of Human Disease Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1

Yanick J. Crow, Diana S. Chase, Johanna Lowenstein Schmidt, Marcin Szynkiewicz, Gabriella M.A. Forte, Hannah L. Gornall, Anthony Oojageer, Beverley Anderson, Amy Pizzino, Guy Helman, Mohamed S. Abdel-Hamid, Ghada M. Abdel-Salam, Sam Ackroyd, Alec Aeby, Guillermo Agosta, Catherine Albin, Stavit Allon-Shalev, Montse Arellano, Giada Ariaudo, Vijay Aswani, Riyana Babul-Hirji, Eileen M. Baildam, Nadia Bahi-Buisson, Kathryn M. Bailey, Christine Barnerias, Magalie Barth, Roberta Battini, Michael W. Beresford, Geneviève Bernard, Marika Bianchi, Thierry Billette de Villemeur, Edward M. Blair, Miriam Bloom, Alberto B. Burlina, Maria Luisa Carpanelli, Daniel R. Carvalho, Manuel Castro-Gago, Anna Cavallini, Cristina Cereda, Kate E. Chandler, David A. Chitayat, Abigail E. Collins, Concepcion Sierra Corcoles, Nuno J.V. Cordeiro, Giovanni Crichiutti, Lyvia Dabydeen, Russell C. Dale, Stefano D’Arrigo, Christian G.E.L. De Goede, Corinne De Laet, Liesbeth M.H. De Waele, Ines Denzler, Isabelle Desguerre, Koenraad Devriendt, Maja Di Rocco, Michael C. Fahey, Elisa Fazzi, Colin D. Ferrie, António Figueiredo, Blanca Gener, Cyril Goizet, Nirmala R. Gowrinathan, Kalpana Gowrishankar, Donncha Hanrahan, Bertrand Isidor, Bülent Kara, Nasaim Khan, Mary D. King, Edwin P. Kirk, Ram Kumar, Lieven Lagae, Pierre Landrieu, Heinz Lauffer, Vincent Laugel, Roberta La Piana, Ming J. Lim, Jean-Pierre S.-M. Lin, Tarja Linnankivi, Mark T. Mackay, Daphna R. Marom, Charles Marques Lourenço, Shane A. McKee, Isabella Moroni, Jenny E.V. Morton, Marie-Laure Moutard, Kevin Murray, Rima Nabbout, Sheela Nampoothiri, Noemi Nunez-Enamorado, Patrick J. Oades, Ivana Olivieri, John R. Ostergaard, Belén Pérez-Dueñas, Julie S. Prendiville, Venkateswaran Ramesh, Magnhild Rasmussen, Luc Régal, Federica Ricci, Marlène Rio, Diana Rodriguez, Agathe Roubertie, Elisabetta Salvatici, Karin A. Segers, Gyanranjan P. Sinha, Doriette Soler, Ronen Spiegel, Tommy I. Stödberg, Rachel Straussberg, Kathryn J. Swoboda, Mohnish Suri, Uta Tacke, Tiong Y. Tan, Johann te Water Naude, Keng Wee Teik, Maya Mary Thomas, Marianne Till, Davide Tonduti, Enza Maria Valente, Rudy Noel Van Coster, Marjo S. van der Knaap, Grace Vassallo, Raymon Vijzelaar, Julie Vogt, Geoffrey B. Wallace, Evangeline Wassmer, Hannah J. Webb, William P. Whitehouse, Robyn N. Whitney, Maha S. Zaki, Sameer M. Zuberi, John H. Livingston, Flore Rozenberg, Pierre Lebon, Adeline Vanderver, Simona Orcesi, Gillian I. Rice

Am J Med Genet A. Author manuscript; available in PMC 2016 Feb 1.

Published in final edited form as: Am J Med Genet A. 2015 Feb; 0(2): 296–312. Published online 2015 Jan 16. doi: 10.1002/ajmg.a.36887

PMCID:: PMC4382202

Abstract Article PDF–973K

Select item 435884113.

RNA degradation in antiviral immunity and autoimmunity

Rachel E. Rigby, Jan Rehwinkel

Trends Immunol. 2015 Mar; 36(3): 179–188. doi: 10.1016/j.it.2015.02.001

PMCID:: PMC4358841

Abstract Article PDF–513K

Select item 431868414.

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

Jeongmin Ryoo, Jongsu Choi, Changhoon Oh, Sungchul Kim, Minji Seo, Seokyoung Kim, Daekwan Seo, Jongkyu Kim, Tommy E. White, Alberto Brandariz-Nunez, Felipe Diaz-Griffero, Cheol-Heui Yun, Joseph A. Hollenbaugh, Baek Kim, Daehyun Baek, Kwangseog Ahn

Nat Med. Author manuscript; available in PMC 2015 Feb 5.

Published in final edited form as: Nat Med. 2014 Aug; 20(8): 936–941. Published online 2014 Jul 20. doi: 10.1038/nm.3626

PMCID:: PMC4318684

Abstract Article PDF–1.4M

Select item 392492515.

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage

Ruth Clifford, Tania Louis, Pauline Robbe, Sam Ackroyd, Adam Burns, Adele T. Timbs, Glen Wright Colopy, Helene Dreau, Francois Sigaux, Jean Gabriel Judde, Margalida Rotger, Amalio Telenti, Yea-Lih Lin, Philippe Pasero, Jonathan Maelfait, Michalis Titsias, Dena R. Cohen, Shirley J. Henderson, Mark T. Ross, David Bentley, Peter Hillmen, Andrew Pettitt, Jan Rehwinkel, Samantha J. L. Knight, Jenny C. Taylor, Yanick J. Crow, Monsef Benkirane, Anna Schuh

Blood. 2014 Feb 13; 123(7): 1021–1031. Prepublished online 2013 Dec 12. doi: 10.1182/blood-2013-04-490847

PMCID:: PMC3924925

Abstract Article

Select item 388797616.

Identification of Two HIV Inhibitors that also Inhibit Human RNaseH2

Junghwan Kim, Jaewan Yoon, MoonKyeong Ju, Yunmi Lee, Tae-Hee Kim, Junwon Kim, Peter Sommer, Zaesung No, Jonathan Cechetto, Sung-Jun Han

Mol Cells. 2013 Sep 30; 36(3): 212–218. Published online 2013 Sep 2. doi: 10.1007/s10059-013-2348-z

PMCID:: PMC3887976

Abstract Article PDF–6.9M

Select item 377094617.

SAMHD1-dependent retroviral control and escape in mice

Jan Rehwinkel, Jonathan Maelfait, Anne Bridgeman, Rachel Rigby, Bruce Hayward, Rachel A Liberatore, Paul D Bieniasz, Greg J Towers, Luis F Moita, Yanick J Crow, David T Bonthron, Caetano Reis e Sousa

EMBO J. 2013 Sep 11; 32(18): 2454–2462. Published online 2013 Jul 19. doi: 10.1038/emboj.2013.163

PMCID:: PMC3770946

Abstract Article PDF–651K

Select item 371432518.

Synonymous mutations in RNASEH2A create cryptic splice sites impairing RNase H2 enzyme function in Aicardi-Goutières syndrome

Gillian I. Rice, Martin A.M. Reijns, Stephanie R. Coffin, Gabriella M.A. Forte, Beverley H. Anderson, Marcin Szynkiewicz, Hannah Gornall, David Gent, Andrea Leitch, Maria P. Botella, Elisa Fazzi, Blanca Gener, Lieven Lagae, Ivana Olivieri, Simona Orcesi, Kathryn J. Swoboda, Fred W. Perrino, Andrew P. Jackson, Yanick J. Crow

Hum Mutat. Author manuscript; available in PMC 2014 Aug 1.

Published in final edited form as: Hum Mutat. 2013 Aug; 34(8): 1066–1070. Published online 2013 May 13. doi: 10.1002/humu.22336

PMCID:: PMC3714325

Abstract Article PDF–612K

Select item 350875219.

Family History of Autoimmune Disease in Patients with Aicardi-Goutières Syndrome

Johanna L. Schmidt, Ivana Olivieri, Jodie M. Vento, Elisa Fazzi, Heather Gordish-Dressman, Simona Orcesi, Adeline Vanderver

Clin Dev Immunol. 2012; 2012: 206730. Published online 2012 Nov 11. doi: 10.1155/2012/206730

PMCID:: PMC3508752

Abstract Article PDF–473K

Select item 340950220.

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

Bjoern Hiller, Martin Achleitner, Silke Glage, Ronald Naumann, Rayk Behrendt, Axel Roers

J Exp Med. 2012 Jul 30; 209(8): 1419–1426. doi: 10.1084/jem.20120876

PMCID:: PMC3409502

Abstract Article PDF–1.5M

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