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Select item 86009211.

Mechanisms of cytokine release syndrome and neurotoxicity of CAR T-cell therapy and associated prevention and management strategies

Xinyi Xiao, Shengkang Huang, Sifei Chen, Yazhuo Wang, Qihang Sun, Xinjie Xu, Yuhua Li

J Exp Clin Cancer Res. 2021; 40: 367. Published online 2021 Nov 18. doi: 10.1186/s13046-021-02148-6

PMCID:: PMC8600921

Abstract Article PDF–2.0M

Select item 83522842.

Cytokines Are at the Heart of It: Cytokine Release Syndrome Underlies Cardiovascular Effects of CAR T Cell

Anna B. Catino

JACC CardioOncol. 2020 Jun; 2(2): 204–206. Published online 2020 Jun 16. doi: 10.1016/j.jaccao.2020.05.006

PMCID:: PMC8352284

Abstract Article PDF–111K

Select item 84323223.

The Many Faces of Cytokine Release Syndrome-Related Coagulopathy

Jiasheng Wang, John Doran

Clin Hematol Int. 2021 Mar; 3(1): 3–12. Published online 2021 Jan 28. doi: 10.2991/chi.k.210117.001

PMCID:: PMC8432322

Abstract Article PDF–992K

Select item 84357614.

Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis

Chiara Musiu, Simone Caligola, Alessandra Fiore, Alessia Lamolinara, Cristina Frusteri, Francesco Domenico Del Pizzo, Francesco De Sanctis, Stefania Canè, Annalisa Adamo, Francesca Hofer, Roza Maria Barouni, Andrea Grilli, Serena Zilio, Paolo Serafini, Evelina Tacconelli, Katia Donadello, Leonardo Gottin, Enrico Polati, Domenico Girelli, Ildo Polidoro, Piera Amelia Iezzi, Domenico Angelucci, Andrea Capece, Ying Chen, Zheng-Li Shi, Peter J. Murray, Marco Chilosi, Ido Amit, Silvio Bicciato, Manuela Iezzi, Vincenzo Bronte, Stefano Ugel

Cell Death Differ. 2022 Feb; 29(2): 420–438. Published online 2021 Sep 13. doi: 10.1038/s41418-021-00866-0

PMCID:: PMC8435761

Abstract Article PDF–9.4M

Select item 84626225.

Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial

Stephan Kadauke, Regina M. Myers, Yimei Li, Richard Aplenc, Diane Baniewicz, David M. Barrett, Allison Barz Leahy, Colleen Callahan, Joseph G. Dolan, Julie C. Fitzgerald, Whitney Gladney, Simon F. Lacey, Hongyan Liu, Shannon L. Maude, Regina McGuire, Laura S. Motley, David T. Teachey, Gerald B. Wertheim, Lisa Wray, Amanda M. DiNofia, Stephan A. Grupp

J Clin Oncol. 2021 Mar 10; 39(8): 920–930. Published online 2021 Jan 8. doi: 10.1200/JCO.20.02477

PMCID:: PMC8462622

Abstract Article PDF–1.8M

Select item 84897776.

Is Prophylaxis the Only Way Out for Cytokine Release Syndrome Associated With Chimeric Antigen T-cell Therapy?

Prashil Dave, Elisa Pallares Vela, Ivan Cancarevic

Cureus. 2021 Sep; 13(9): e17709. Published online 2021 Sep 4. doi: 10.7759/cureus.17709

PMCID:: PMC8489777

Abstract Article PDF–144K

Select item 84974217.

CMV and HSV Pneumonia after Immunosuppressive Agents for Treatment of Cytokine Release Syndrome due to Chimeric Antigen Receptor-Modified T (CAR-T)-Cell Immunotherapy

Madeleine R. Heldman, Jimmy Ma, Jordan Gauthier, Riley A. O’Hara, Andrew J. Cowan, Leah M. Yoke, Lisa So, Elizabeth Gulleen, Elizabeth R. Duke, Catherine Liu, Cameron J. Turtle, Joshua A. Hill

J Immunother. Author manuscript; available in PMC 2022 Jan 1.

Published in final edited form as: J Immunother. 2021 Nov-Dec; 44(9): 351–354. doi: 10.1097/CJI.0000000000000388

PMCID:: PMC8497421

Abstract Article PDF–757K

Select item 85252348.

Modified EASIX predicts severe cytokine release syndrome and neurotoxicity after chimeric antigen receptor T cells

Martina Pennisi, Miriam Sanchez-Escamilla, Jessica R. Flynn, Roni Shouval, Ana Alarcon Tomas, Mari Lynn Silverberg, Connie Batlevi, Renier J. Brentjens, Parastoo B. Dahi, Sean M. Devlin, Claudia Diamonte, Sergio Giralt, Elizabeth F. Halton, Tania Jain, Molly Maloy, Elena Mead, Maria Lia Palomba, Josel Ruiz, Bianca Santomasso, Craig S. Sauter, Michael Scordo, Gunjan L. Shah, Jae H. Park, Lucrecia Yanez San Segundo, Miguel-Angel Perales

Blood Adv. 2021 Sep 14; 5(17): 3397–3406. Prepublished online 2021 Aug 25. Published online 2021 Sep 7. doi: 10.1182/bloodadvances.2020003885

PMCID:: PMC8525234

Abstract Article PDF–1.1M

Select item 85267129.

Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy

Xia Li, Mi Shao, Xiangjun Zeng, Pengxu Qian, He Huang

Signal Transduct Target Ther. 2021; 6: 367. Published online 2021 Oct 20. doi: 10.1038/s41392-021-00764-4

Correction in:: Signal Transduct Target Ther. 2021; 6: 403.

PMCID:: PMC8526712

Abstract Article PDF–2.9M

Select item 855597310.

Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trial

Jozefien Declercq, Karel F A Van Damme, Elisabeth De Leeuw, Bastiaan Maes, Cedric Bosteels, Simon J Tavernier, Stefanie De Buyser, Roos Colman, Maya Hites, Gil Verschelden, Tom Fivez, Filip Moerman, Ingel K Demedts, Nicolas Dauby, Nicolas De Schryver, Elke Govaerts, Stefaan J Vandecasteele, Johan Van Laethem, Sebastien Anguille, Jeroen van der Hilst, Benoit Misset, Hans Slabbynck, Xavier Wittebole, Fabienne Liénart, Catherine Legrand, Marc Buyse, Dieter Stevens, Fre Bauters, Leen J M Seys, Helena Aegerter, Ursula Smole, Victor Bosteels, Levi Hoste, Leslie Naesens, Filomeen Haerynck, Linos Vandekerckhove, Pieter Depuydt, Eva van Braeckel, Sylvie Rottey, Isabelle Peene, Catherine Van Der Straeten, Frank Hulstaert, Bart N Lambrecht

Lancet Respir Med. 2021 Dec; 9(12): 1427–1438. Published online 2021 Oct 29. doi: 10.1016/S2213-2600(21)00377-5

PMCID:: PMC8555973

Abstract Article PDF–1.2M

Select item 858260111.

Risk, Characteristics and Biomarkers of Cytokine Release Syndrome in Patients with Relapsed/Refractory AML or MDS Treated with CD3xCD123 Bispecific Antibody APVO436

Fatih M. Uckun, Justin Watts, Alice S. Mims, Prapti Patel, Eunice Wang, Paul J. Shami, Elizabeth Cull, Cynthia Lee, Christopher R. Cogle, Tara L. Lin

Cancers (Basel) 2021 Nov; 13(21): 5287. Published online 2021 Oct 21. doi: 10.3390/cancers13215287

PMCID:: PMC8582601

Abstract Article PDF–934K

Select item 858507012.

Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences

Tor Henrik Anderson Tvedt, Anh Khoi Vo, Øystein Bruserud, Håkon Reikvam

J Clin Med. 2021 Nov; 10(21): 5190. Published online 2021 Nov 6. doi: 10.3390/jcm10215190

PMCID:: PMC8585070

Abstract Article PDF–639K

Select item 859146213.

Cytokine release syndrome and tumor lysis syndrome in a multiple myeloma patient treated with palliative radiotherapy: A case report and review of the literature

Axel Cailleteau, Cyrille Touzeau, Bastien Jamet, Valentine Guimas, Emmanuel Jouglar, Stéphane Supiot

Clin Transl Radiat Oncol. 2022 Jan; 32: 24–28. Published online 2021 Nov 12. doi: 10.1016/j.ctro.2021.11.004

PMCID:: PMC8591462

Abstract Article PDF–1.9M

Select item 834301814.

Cytokine Release Syndrome Is an Independent Risk Factor Associated With Platelet Transfusion Refractoriness After CAR-T Therapy for Relapsed/Refractory Acute Lymphoblastic Leukemia

Yadan Liu, Bin Liang, Yan Liu, Guoqing Wei, Wenjun Wu, Luxin Yang, Li Yang, He Huang, Jue Xie, Yongxian Hu

Front Pharmacol. 2021; 12: 702152. Published online 2021 Jul 23. doi: 10.3389/fphar.2021.702152

PMCID:: PMC8343018

Abstract Article PDF–944K

Select item 862781015.

Cytokine Release Syndrome Induced by Immune-checkpoint Inhibitor Therapy for Non-small-cell Lung Cancer

Makiko Yomota, Kie Mirokuji, Masahiro Sakaguchi, Yasuyuki Kitahara, Fangyi Chin, Keigo Setoguchi, Yukio Hosomi

Intern Med. 2021 Nov 1; 60(21): 3459–3462. Published online 2021 Mar 29. doi: 10.2169/internalmedicine.5922-20

PMCID:: PMC8627810

Abstract Article PDF–478K

Select item 865002316.

Predictive role of endothelial cell activation in cytokine release syndrome after chimeric antigen receptor T cell therapy for acute lymphoblastic leukaemia

Fei Hong, Ming Shi, Jiang Cao, Ying Wang, Yanqing Gong, Hui Gao, Zhenyu Li, Junnian Zheng, Lingyu Zeng, Aili He, Kailin Xu

J Cell Mol Med. 2021 Dec; 25(24): 11063–11074. Published online 2021 Nov 3. doi: 10.1111/jcmm.17029

PMCID:: PMC8650023

Abstract Article PDF–1.5M

Select item 865629317.

Delayed cytokine release syndrome after neoadjuvant nivolumab: a case report and literature review

Aaron T Ciner, Howard S Hochster, David A August, Darren R Carpizo, Kristen R Spencer

Immunotherapy. 2021 Sep; 13(13): 1071–1078. Published online 2021 Jul 21. doi: 10.2217/imt-2020-0329

PMCID:: PMC8656293

Abstract Article PDF–777K

Select item 869143018.

Effect of Chloroquine and Hydroxychloroquine on Cytokine Release Syndrome in Patients with COVID-19

Bilal Ahmad, Naeem ul Hassan, Bismillah Sehar, Falak Zeb, Dur e Nayab, Fuad Ahmad Siddiqui

Clin Med Res. 2021 Dec; 19(4): 179–182. doi: 10.3121/cmr.2021.1659

PMCID:: PMC8691430

Abstract Article PDF–248K

Select item 871850619.

Case Report: Fatal Complications of BK Virus-Hemorrhagic Cystitis and Severe Cytokine Release Syndrome Following BK Virus-Specific T-Cells

Elizabeth M. Holland, Corina Gonzalez, Elliot Levy, Vladimir A. Valera, Heather Chalfin, Jacquelyn Klicka-Skeels, Bonnie Yates, David E. Kleiner, Colleen Hadigan, Hema Dave, Haneen Shalabi, Dennis D. Hickstein, Helen C. Su, Michael Grimley, Alexandra F. Freeman, Nirali N. Shah

Front Immunol. 2021; 12: 801281. Published online 2021 Dec 17. doi: 10.3389/fimmu.2021.801281

PMCID:: PMC8718506

Abstract Article PDF–44M

Select item 872931120.

Tocilizumab and Cytokine Release Syndrome in COVID-19 Pneumonia: Experience From a Single Center in Pakistan

Muhammad Hassan, Fibhaa Syed, Maria Zafar, Mansoor Iqbal, Naveed Ullah Khan, Hafiza Faiza Mushtaq, Mazhar Badshah

Cureus. 2021 Dec; 13(12): e20219. Published online 2021 Dec 6. doi: 10.7759/cureus.20219

PMCID:: PMC8729311

Abstract Article PDF–110K

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