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Select item 29162251.

Hepatitis C virus NS4 protein impairs the Th1 polarization of immature dendritic cells

A Takaki, M Tatsukawa, Y Iwasaki, K Koike, Y Noguchi, H Shiraha, K Sakaguchi, E Nakayama, K Yamamoto

J Viral Hepat. 2010 Aug; 17(8): 555–562. doi: 10.1111/j.1365-2893.2009.01213.x

PMCID:: PMC2916225

Abstract Article PDF–443K

Select item 96960572.

The CD8+ and CD4+ T Cell Immunogen Atlas of Zika Virus Reveals E, NS1 and NS4 Proteins as the Vaccine Targets

Hangjie Zhang, Wenling Xiao, Min Zhao, Yingze Zhao, Yongli Zhang, Dan Lu, Shuangshuang Lu, Qingxu Zhang, Weiyu Peng, Liumei Shu, Jie Zhang, Sai Liu, Kexin Zong, Pengyan Wang, Beiwei Ye, Shihua Li, Shuguang Tan, Fuping Zhang, Jianfang Zhou, Peipei Liu, Guizhen Wu, Xuancheng Lu, George F. Gao, William J. Liu

Viruses. 2022 Nov; 14(11): 2332. Published online 2022 Oct 25. doi: 10.3390/v14112332

PMCID:: PMC9696057

Abstract Article PDF–1.9M

Select item 2377483.

Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions.

R Bartenschlager, L Ahlborn-Laake, J Mous, H Jacobsen

J Virol. 1993 Jul; 67(7): 3835–3844. doi: 10.1128/jvi.67.7.3835-3844.1993

PMCID:: PMC237748

Summary Page Browse PDF–2.6M

Select item 2490764.

Mouse hepatitis virus S RNA sequence reveals that nonstructural proteins ns4 and ns5a are not essential for murine coronavirus replication.

K Yokomori, M M Lai

J Virol. 1991 Oct; 65(10): 5605–5608. doi: 10.1128/jvi.65.10.5605-5608.1991

PMCID:: PMC249076

Summary Page Browse PDF–894K

Select item 88787685.

Comparative Virus-Host Protein Interactions of the Bluetongue Virus NS4 Virulence Factor

Aurore Fablet, Cindy Kundlacz, Juliette Dupré, Edouard Hirchaud, Lydie Postic, Corinne Sailleau, Emmanuel Bréard, Stéphan Zientara, Damien Vitour, Grégory Caignard

Viruses. 2022 Feb; 14(2): 182. Published online 2022 Jan 19. doi: 10.3390/v14020182

PMCID:: PMC8878768

Abstract Article PDF–3.4M

Select item 2655676.

Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3.

P Simmonds, K A Rose, S Graham, S W Chan, F McOmish, B C Dow, E A Follett, P L Yap, H Marsden

J Clin Microbiol. 1993 Jun; 31(6): 1493–1503. doi: 10.1128/jcm.31.6.1493-1503.1993

PMCID:: PMC265567

Summary Page Browse PDF–2.0M

Select item 12115107.

Minimal T-Cell-Stimulatory Sequences and Spectrum of HLA Restriction of Immunodominant CD4⁺ T-Cell Epitopes within Hepatitis C Virus NS3 and NS4 Proteins

J. T. Gerlach, A. Ulsenheimer, N. H. Grüner, M.-C. Jung, W. Schraut, C.-A. Schirren, M. Heeg, S. Scholz, K. Witter, R. Zahn, A. Vogler, R. Zachoval, G. R. Pape, H. M. Diepolder

J Virol. 2005 Oct; 79(19): 12425–12433. doi: 10.1128/JVI.79.19.12425-12433.2005

PMCID:: PMC1211510

Abstract Article PDF–326K

Select item 18872718.

Immunohistochemical detection of the NS4 antigen of hepatitis C virus and its relation to histopathology.

K. Blight, R. Rowland, P. D. Hall, R. R. Lesniewski, R. Trowbridge, J. T. LaBrooy, E. J. Gowans

Am J Pathol. 1993 Dec; 143(6): 1568–1573.

PMCID:: PMC1887271

Summary Page Browse PDF–1.1M

Select item 28844329.

Generation and Characterization of Chimeric Antibodies against NS3, NS4, NS5, and Core Antigens of Hepatitis C Virus

Bailin Tu, Robert N. Ziemann, Bryan C. Tieman, David J. Hawksworth, Joan Tyner, James Scheffel, Mary S. Pinkus, Susan E. Brophy, Jeffrey M. Werneke, Robin Gutierrez, Michael White

Clin Vaccine Immunol. 2010 Jun; 17(6): 1040–1047. Published online 2010 Apr 28. doi: 10.1128/CVI.00068-10

PMCID:: PMC2884432

Abstract Article PDF–1.2M

Select item 219108010.

Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C

J Exp Med. 1993 Jul 1; 178(1): 17–25. doi: 10.1084/jem.178.1.17

PMCID:: PMC2191080

Summary PDF–1.0M

Select item 712723611.

Bovine coronaviruses associated with enteric and respiratory diseases in Canadian dairy cattle display different reactivities to anti-HE monoclonal antibodies and distinct amino acid changes in their HE, S and ns4.9 protein

Anne-Marie Gélinas, Martine Boutin, A.Marie-Josée Sasseville, Serge Dea

Virus Res. 2001 Jul 1; 76(1): 43–57. Published online 2001 May 22. doi: 10.1016/S0168-1702(01)00243-X

PMCID:: PMC7127236

Abstract Article PDF–207K

Select item 708940112.

NS4/5 mutations enhance flavivirus Bamaga virus infectivity and pathogenicity in vitro and in vivo

Agathe M. G. Colmant, Helle Bielefeldt-Ohmann, Laura J. Vet, Caitlin A. O’Brien, Richard A. Bowen, Airn E. Hartwig, Steven Davis, Thisun B. H. Piyasena, Gervais Habarugira, Jessica J. Harrison, Jody Hobson-Peters, Roy A. Hall

PLoS Negl Trop Dis. 2020 Mar; 14(3): e0008166. Published online 2020 Mar 23. doi: 10.1371/journal.pntd.0008166

PMCID:: PMC7089401

Abstract Article PDF–2.8M

Select item 392121113.

Nonstructural Protein NS4 of Rice Stripe Virus Plays a Critical Role in Viral Spread in the Body of Vector Insects

Wei Wu, Limin Zheng, Hongyan Chen, Dongsheng Jia, Fan Li, Taiyun Wei

PLoS One. 2014; 9(2): e88636. Published online 2014 Feb 11. doi: 10.1371/journal.pone.0088636

PMCID:: PMC3921211

Abstract Article PDF–1.4M

Select item 441109314.

Characterising Non-Structural Protein NS4 of African Horse Sickness Virus

Lizahn Zwart, Christiaan A. Potgieter, Sarah J. Clift, Vida van Staden

PLoS One. 2015; 10(4): e0124281. Published online 2015 Apr 27. doi: 10.1371/journal.pone.0124281

PMCID:: PMC4411093

Abstract Article PDF–7.5M

Select item 493476415.

Bluetongue Virus NS4 Protein Is an Interferon Antagonist and a Determinant of Virus Virulence

Maxime Ratinier, Andrew E. Shaw, Gerald Barry, Quan Gu, Luigina Di Gialleonardo, Anna Janowicz, Mariana Varela, Richard E. Randall, Marco Caporale, Massimo Palmarini

J Virol. 2016 Jun 1; 90(11): 5427–5439. Prepublished online 2016 Mar 23. Published online 2016 May 12. doi: 10.1128/JVI.00422-16

PMCID:: PMC4934764

Abstract Article PDF–4.0M

Select item 509421516.

Impact of Hepatitis C Virus/Schistosoma mansoni Coinfection on the Circulating Levels of HCV-NS4 Protein and Extracellular-Matrix Deposition in Patients with Different Hepatic Fibrosis Stages

Abdelfattah M. Attallah, Sanaa O. Abdallah, Mohamed S. Albannan, Mohamed M. Omran, Ahmed A. Attallah, Khaled Farid

Am J Trop Med Hyg. 2016 Nov 2; 95(5): 1044–1050. doi: 10.4269/ajtmh.16-0129

PMCID:: PMC5094215

Abstract Article PDF–961K

Select item 529780417.

Discrepancy between Hepatitis C Virus Genotypes and NS4-Based Serotypes: Association with Their Subgenomic Sequences

Nan Nwe Win, Shingo Nakamoto, Tatsuo Kanda, Hiroki Takahashi, Azusa Takahashi-Nakaguchi, Shin Yasui, Masato Nakamura, Shuang Wu, Fumio Imazeki, Shigeru Mikami, Osamu Yokosuka, Tohru Gonoi, Hiroshi Shirasawa

Int J Mol Sci. 2017 Jan; 18(1): 172. Published online 2017 Jan 17. doi: 10.3390/ijms18010172