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Items: 1 to 20 of 489

1.
Serotype-Specific Regulation of Dengue Virus NS5 Protein Subcellular Localization
Colin Xinru Cheng, Min Jie Alvin Tan, Kitti Wing Ki Chan, Milly Ming Ju Choy, Noelia Roman, Daniel D. R. Arnold, Amanda Makha Bifani, Sean Yao Zu Kong, Pradeep Bist, Babu K. Nath, Crystall M. D. Swarbrick, Jade K. Forwood, Subhash G. Vasudevan
ACS Infect Dis. 2024 Jun 14; 10(6): 2047–2062. Published online 2024 May 29. doi: 10.1021/acsinfecdis.4c00054
PMCID:
PMC11184549
AbstractArticlePDF–9.7M
2.
Residue K28 of Zika Virus NS5 Protein Is Implicated in Virus Replication and Antagonism of STAT2
Nias Y. G. Peng, Julian D. J. Sng, Yin Xiang Setoh, Alexander A. Khromykh
Microorganisms. 2024 Apr; 12(4): 660. Published online 2024 Mar 26. doi: 10.3390/microorganisms12040660
PMCID:
PMC11052099
AbstractArticlePDF–5.3M
3.
The ZIKV NS5 Protein Aberrantly Alters the Tubulin Cytoskeleton, Induces the Accumulation of Autophagic p62 and Affects IFN Production: HDAC6 Has Emerged as an Anti-NS5/ZIKV Factor
Silvia Pérez-Yanes, Iria Lorenzo-Sánchez, Romina Cabrera-Rodríguez, Jonay García-Luis, Rodrigo Trujillo-González, Judith Estévez-Herrera, Agustín Valenzuela-Fernández
Cells. 2024 Apr; 13(7): 598. Published online 2024 Mar 29. doi: 10.3390/cells13070598
PMCID:
PMC11011779
AbstractArticlePDF–2.5M
4.
Identification of Novel Non-Nucleoside Inhibitors of Zika Virus NS5 Protein Targeting MTase Activity
Diego Fiorucci, Micaela Meaccini, Giulio Poli, Maria Alfreda Stincarelli, Chiara Vagaggini, Simone Giannecchini, Priscila Sutto-Ortiz, Bruno Canard, Etienne Decroly, Elena Dreassi, Annalaura Brai, Maurizio Botta
Int J Mol Sci. 2024 Feb; 25(4): 2437. Published online 2024 Feb 19. doi: 10.3390/ijms25042437
PMCID:
PMC10888717
AbstractArticlePDF–5.3M
5.
A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition
Mahamaya Biswal, Wangyuan Yao, Jiuwei Lu, Jianbin Chen, Juliet Morrison, Rong Hai, Jikui Song
Commun Biol. 2024; 7: 76. Published online 2024 Jan 10. doi: 10.1038/s42003-024-05768-8
PMCID:
PMC10776582
AbstractArticlePDF–2.5M
6.
Docking and MM study of non-structural protein (NS5) of Japanese Encephalitis Virus (JEV) with some derivatives of adenosyl
Rakesh Kumar Tiwari, Vinayak Pandey, Harshita Srivastava, Ambrish Kumar Srivastava, Vishnudatt Pandey
Front Chem. 2023; 11: 1258764. Published online 2023 Nov 27. doi: 10.3389/fchem.2023.1258764
PMCID:
PMC10712561
AbstractArticlePDF–1.8M
7.
Design, Synthesis, Evaluation and Molecular Dynamics Simulation of Dengue Virus NS5-RdRp Inhibitors
Keli Zong, Wei Li, Yijie Xu, Xu Zhao, Ruiyuan Cao, Hong Yan, Xingzhou Li
Pharmaceuticals (Basel) 2023 Nov; 16(11): 1625. Published online 2023 Nov 17. doi: 10.3390/ph16111625
PMCID:
PMC10674617
AbstractArticlePDF–9.0M
8.
New oxindole carboxamides as inhibitors of DENV NS5 RdRp: Design, synthesis, docking and Biochemical characterization
Chandra Prakash Koraboina, Parameswari Akshinthala, Naresh Kumar Katari, Ravi Adarasandi, Sreekantha Babu Jonnalagadda, Rambabu Gundla
Heliyon. 2023 Nov; 9(11): e21510. Published online 2023 Nov 2. doi: 10.1016/j.heliyon.2023.e21510
PMCID:
PMC10665688
AbstractArticlePDF–4.0M
9.
LGP2 directly interacts with flavivirus NS5 RNA-dependent RNA polymerase and downregulates its pre-elongation activities
Zhongyuan Tan, Jiqin Wu, Li Huang, Ting Wang, Zhenhua Zheng, Jianhui Zhang, Xianliang Ke, Yuan Zhang, Yan Liu, Hanzhong Wang, Jianping Tao, Peng Gong
PLoS Pathog. 2023 Sep; 19(9): e1011620. Published online 2023 Sep 1. doi: 10.1371/journal.ppat.1011620
PMCID:
PMC10501626
AbstractArticlePDF–3.8M
10.
Broad-spectrum small-molecule inhibitors targeting the SAM-binding site of flavivirus NS5 methyltransferase
Subodh Kumar Samrat, Qamar Bashir, Yiding Huang, Carl William Trieshmann, Anil Mathew Tharappel, Ran Zhang, Ke Chen, Y. Geoge Zheng, Zhong Li, Hongmin Li
ACS Infect Dis. Author manuscript; available in PMC 2024 Jul 14.
Published in final edited form as: ACS Infect Dis. 2023 Jul 14; 9(7): 1319–1333. Published online 2023 Jun 22. doi: 10.1021/acsinfecdis.2c00571
PMCID:
PMC10436986
AbstractArticlePDF–1.9M
11.
Antiviral Activity of an Indole-Type Compound Derived from Natural Products, Identified by Virtual Screening by Interaction on Dengue Virus NS5 Protein
Leidy Lorena García-Ariza, Natalia González-Rivillas, Cindy Johanna Díaz-Aguirre, Cristian Rocha-Roa, Leonardo Padilla-Sanabria, Jhon Carlos Castaño-Osorio
Viruses. 2023 Jul; 15(7): 1563. Published online 2023 Jul 17. doi: 10.3390/v15071563
PMCID:
PMC10384440
AbstractArticlePDF–3.8M
12.
Exploring the inhibitory potential of Nigella sativa against dengue virus NS2B/NS3 protease and NS5 polymerase using computational approaches
Mamuna Mukhtar, Haris Ahmed Khan, Najam us Sahar Sadaf Zaidi
RSC Adv. 2023 Jun 15; 13(27): 18306–18322. Published online 2023 Jun 16. doi: 10.1039/d3ra02613b
PMCID:
PMC10273825
AbstractArticlePDF–5.5M
13.
Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation
María Mora Gonzalez Lopez Ledesma, Guadalupe Costa Navarro, Horacio M. Pallares, Ana Paletta, Federico De Maio, Nestor G. Iglesias, Leopoldo Gebhard, Santiago Oviedo Rouco, Diego S. Ojeda, Luana de Borba, María Giraldo, Ricardo Rajsbaum, Ana Ceballos, Nevan J. Krogan, Priya S. Shah, Andrea V. Gamarnik
Proc Natl Acad Sci U S A. 2023 Jun 6; 120(23): e2220005120. Published online 2023 May 30. doi: 10.1073/pnas.2220005120
PMCID:
PMC10266027
AbstractArticlePDF–3.1M
14.
Evaluation of NS4A, NS4B, NS5 and 3′UTR Genetic Determinants of WNV Lineage 1 Virulence in Birds and Mammals
Lise Fiacre, Steeve Lowenski, Céline Bahuon, Marine Dumarest, Bénédicte Lambrecht, Maha Dridi, Emmanuel Albina, Jennifer Richardson, Stéphan Zientara, Miguel-Ángel Jiménez-Clavero, Nathalie Pardigon, Gaëlle Gonzalez, Sylvie Lecollinet
Viruses. 2023 May; 15(5): 1094. Published online 2023 Apr 29. doi: 10.3390/v15051094
PMCID:
PMC10222181
AbstractArticlePDF–3.7M
15.
Prediction of human protein interactome of dengue virus non-structural protein 5 (NS5) and its downstream immunological implications
Priya Bhatnagar, Prashant Bajpai, Jatin Shrinet, Murali Krishna Kaja, Anmol Chandele, Ramakrishnan Sitaraman
3 Biotech. 2023 Jun; 13(6): 180. Published online 2023 May 12. doi: 10.1007/s13205-023-03569-0
PMCID:
PMC10182223
AbstractArticlePDF–1.9M
16.
Splicing factor SF3B3, a NS5-binding protein, restricts ZIKV infection by targeting GCH1
Tanxiu Chen, Hao Yang, Penghui Liu, Moliduer Hamiti, Xintian Zhang, Yi Xu, Wenqi Quan, Yong Zhang, Wenhai Yu, Li Jiao, Tingfu Du, Juemin Xi, Bin Yin, Wei Zhou, Shuaiyao Lu, Xiaozhong Peng
Virol Sin. 2023 Apr; 38(2): 222–232. Published online 2022 Dec 23. doi: 10.1016/j.virs.2022.12.005
PMCID:
PMC10176263
AbstractArticlePDF–3.4M
17.
Molecular mimicry between Zika virus and central nervous system inflammatory demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens
Laise Carolina França, Fabrícia Lima Fontes-Dantas, Diogo Gomes Garcia, Amanda Dutra de Araújo, João Paulo da Costa Gonçalves, Cláudia Cecília da Silva Rêgo, Elielson Veloso da Silva, Osvaldo José Moreira do Nascimento, Fernanda Cristina Rueda Lopes, Alice Laschuk Herlinger, Renato Santana de Aguiar, Orlando da Costa Ferreira Junior, Fernando Faria Andrade Figueira, Jorge Paes Barreto Marcondes de Souza, Joelma Freire De Mesquita, Soniza Vieira Alves-Leon
Arq Neuropsiquiatr. 2023 Apr; 81(4): 357–368. Published online 2023 May 9. doi: 10.1055/s-0043-1768698
PMCID:
PMC10169219
AbstractArticlePDF–2.5M
18.
Identification of Orbivirus Non-Structural Protein 5 (NS5), Its Role and Interaction with RNA/DNA in Infected Cells
Fauziah Mohd Jaafar, Baptiste Monsion, Peter P. C. Mertens, Houssam Attoui
Int J Mol Sci. 2023 Apr; 24(7): 6845. Published online 2023 Apr 6. doi: 10.3390/ijms24076845
PMCID:
PMC10095184
AbstractArticlePDF–12M
19.
Small-Molecule Inhibitor of Flaviviral NS3-NS5 Interaction with Broad-Spectrum Activity and Efficacy In Vivo
Marta Celegato, Mattia Sturlese, Vivian Vasconcelos Costa, Marta Trevisan, Angélica Samer Lallo Dias, Ingredy Beatriz Souza Passos, Celso Martins Queiroz-Junior, Lorenzo Messa, Annagiulia Favaro, Stefano Moro, Mauro Martins Teixeira, Arianna Loregian, Beatrice Mercorelli
mBio. 2023 Jan-Feb; 14(1): e03097-22. Published online 2023 Jan 9. doi: 10.1128/mbio.03097-22
PMCID:
PMC9973282
AbstractArticlePDF–3.3M
20.
Differential Gene Expression Pattern of Importin β3 and NS5 in C6/36 Cells Acutely and Persistently Infected with Dengue Virus 2
María Leticia Ávila-Ramírez, Ana Laura Reyes-Reyes, Rodolfo Gamaliel Avila-Bonilla, Mariana Salas-Benito, Doris Cerecedo, María Esther Ramírez-Moreno, María Elena Villagrán-Herrera, Ricardo Francisco Mercado-Curiel, Juan Santiago Salas-Benito
Pathogens. 2023 Feb; 12(2): 191. Published online 2023 Jan 27. doi: 10.3390/pathogens12020191
PMCID:
PMC9966734
AbstractArticlePDF–1.4M

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