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Select item 112489961.

Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals

Fangfang Lu, Hongtu Zhao, Yaxin Dai, Yingdi Wang, Chia-Hsueh Lee, Matthew Freeman

Mol Cell. 2024 Jun 6; 84(11): 2152–2165.e5. doi: 10.1016/j.molcel.2024.04.025

PMCID:: PMC11248996

Abstract Article PDF–6.6M

Select item 112146252.

Inter-cell type interactions that control JNK signaling in the Drosophila intestine

Peng Zhang, Stephen M. Pronovost, Marco Marchetti, Chenge Zhang, Xiaoyu Kang, Tahmineh Kandelouei, Christopher Li, Bruce A. Edgar

Nat Commun. 2024; 15: 5493. Published online 2024 Jun 28. doi: 10.1038/s41467-024-49786-w

PMCID:: PMC11214625

Abstract Article PDF–8.9M

Select item 111733283.

Role of iRhom2 in Olfaction: Implications for Odorant Receptor Regulation and Activity-Dependent Adaptation

Stephanie A. Azzopardi, Hsiu-Yi Lu, Sebastien Monette, Ariana I. Rabinowitsch, Jane E. Salmon, Hiroaki Matsunami, Carl P. Blobel

Int J Mol Sci. 2024 Jun; 25(11): 6079. Published online 2024 May 31. doi: 10.3390/ijms25116079

PMCID:: PMC11173328

Abstract Article PDF–3.7M

Select item 111318114.

A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis

Y. Wang, X. Guan, K. L. Fok, S. Li, X. Zhang, S. Miao, S. Zong, S. S. Koide, H. C. Chan, L. Wang

Cell Mol Life Sci. 2008 Dec; 65(23): 3822–3829. Published online 2008 Oct 27. doi: 10.1007/s00018-008-8452-0

PMCID:: PMC11131811

Abstract Article PDF–965K

Select item 110668785.

The derlin Dfm1 couples retrotranslocation of a folded protein domain to its proteasomal degradation

Daniela G. Vitali, Daniel Fonseca, Pedro Carvalho

J Cell Biol. 2024 May 6; 223(5): e202308074. Published online 2024 Mar 5. doi: 10.1083/jcb.202308074

PMCID:: PMC11066878

Abstract Article PDF–4.8M

Select item 110604216.

Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease

Satoshi Kubo, Jill M. Fritz, Hayley M. Raquer-McKay, Rhea Kataria, Ivan Vujkovic-Cvijin, Ahmad Al-Shaibi, Yikun Yao, Lixin Zheng, Juan Zou, Alex D. Waldman, Xinyi Jing, Taylor K. Farley, Ann Y. Park, Andrew J. Oler, Adrian K. Charles, Melanie Makhlouf, Eman H. AbouMoussa, Reem Hasnah, Luis R. Saraiva, Sundar Ganesan, Abdulrahman Ahmed Al-Subaiey, Helen Matthews, Emilio Flano, Hyun Hee Lee, Alexandra F. Freeman, Asena Pınar Sefer, Ersin Sayar, Erkan Çakır, Elif Karakoc-Aydiner, Safa Baris, Yasmine Belkaid, Ahmet Ozen, Bernice Lo, Michael J. Lenardo

Nat Immunol. Author manuscript; available in PMC 2024 Apr 30.

Published in final edited form as: Nat Immunol. 2022 Jan; 23(1): 75–85. Published online 2021 Dec 22. doi: 10.1038/s41590-021-01093-y

PMCID:: PMC11060421

Abstract Article PDF–4.3M

Select item 109910587.

iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I

Matteo Calligaris, Donatella P. Spanò, Simone Bonelli, Stephan A. Müller, Claudia Carcione, Danilo D’apolito, Giandomenico Amico, Monica Miele, Mariangela Di Bella, Giovanni Zito, Elisa Nuti, Armando Rossello, Carl P. Blobel, Stefan F. Lichtenthaler, Simone D. Scilabra

Cell Mol Life Sci. 2024 Dec; 81(1): 163. Published online 2024 Apr 4. doi: 10.1007/s00018-024-05201-7

PMCID:: PMC10991058

Abstract Article PDF–5.6M

Select item 108037248.

Arabidopsis ACYL CARRIER PROTEIN4 and RHOMBOID LIKE10 act independently in chloroplast phosphatidate synthesis

Yang Xu, Shrikaar Kambhampati, Stewart A Morley, Ron Cook, John Froehlich, Doug K Allen, Christoph Benning

Plant Physiol. 2023 Dec; 193(4): 2661–2676. Published online 2023 Sep 2. doi: 10.1093/plphys/kiad483

PMCID:: PMC10803724

Abstract Article PDF–1.7M

Select item 106182479.

Apelin is expressed in intimal smooth muscle cells and promotes their phenotypic transition

Luís Miguel Cardoso Dos Santos, Pascal Azar, Cécile Brun, Stéphane König, Angela Roatti, Alex J. Baertschi, Chiraz Chaabane, Marie-Luce Bochaton-Piallat

Sci Rep. 2023; 13: 18736. Published online 2023 Oct 31. doi: 10.1038/s41598-023-45470-z

PMCID:: PMC10618247

Abstract Article PDF–4.7M

Select item 1051971010.

Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis

Enrico Radaelli, Charles-Antoine Assenmacher, Jillian Verrelle, Esha Banerjee, Florence Manero, Salim Khiati, Anais Girona, Guillermo Lopez-Lluch, Placido Navas, Marco Spinazzi

eLife. 2023; 12: e84710. Published online 2023 Jul 28. doi: 10.7554/eLife.84710

PMCID:: PMC10519710

Abstract Article PDF–23M

Select item 1035701011.

Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice

Ariana I. Rabinowitsch, Thorsten Maretzky, Gisela Weskamp, Coline Haxaire, Johanna Tueshaus, Stefan F. Lichtenthaler, Sébastien Monette, Carl P. Blobel

J Cell Sci. 2023 Jul 1; 136(13): jcs260910. Published online 2023 Jul 7. doi: 10.1242/jcs.260910

PMCID:: PMC10357010

Abstract Article

Select item 1035583712.

The opening dynamics of the lateral gate regulates the activity of rhomboid proteases

Claudia Bohg, Carl Öster, Berke Türkaydin, Michael Lisurek, Pascal Sanchez-Carranza, Sascha Lange, Tillmann Utesch, Han Sun, Adam Lange

Sci Adv. 2023 Jul; 9(29): eadh3858. Published online 2023 Jul 19. doi: 10.1126/sciadv.adh3858

PMCID:: PMC10355837

Abstract Article PDF–1.1M

Select item 1024272113.

Endoplasmic reticulum–bound ANAC013 factor is cleaved by RHOMBOID-LIKE 2 during the initial response to hypoxia in Arabidopsis thaliana

Emese Eysholdt-Derzsó, Tilo Renziehausen, Stephanie Frings, Stephanie Frohn, Kira von Bongartz, Clara P. Igisch, Justina Mann, Lisa Häger, Julia Macholl, David Leisse, Niels Hoffmann, Katharina Winkels, Pia Wanner, Jonas De Backer, Xiaopeng Luo, Margret Sauter, Inge De Clercq, Joost T. van Dongen, Jos H. M. Schippers, Romy R. Schmidt-Schippers

Proc Natl Acad Sci U S A. 2023 Mar 14; 120(11): e2221308120. Published online 2023 Mar 10. doi: 10.1073/pnas.2221308120

PMCID:: PMC10242721

Abstract Article PDF–13M

Select item 1015334614.

Hanjuan Gong, Hailun Xie, Zhimin Huangfu, Shuxian Zhang, Yi Tang, Ming Xiao, Ming Li, Yalan Wang

FEBS Open Bio. 2023 May; 13(5): 881–897. Published online 2023 Apr 5. doi: 10.1002/2211-5463.13598

PMCID:: PMC10153346

Abstract Article PDF–5.3M

Select item 995052715.

Ectopic RING activity at the ER membrane differentially impacts ERAD protein quality control pathways

Adrian B. Mehrtash, Mark Hochstrasser

J Biol Chem. 2023 Mar; 299(3): 102927. Published online 2023 Jan 19. doi: 10.1016/j.jbc.2023.102927

PMCID:: PMC9950527

Abstract Article PDF–2.2M

Select item 992963516.

An ERAD‐independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis

Satarupa Bhaduri, Analine Aguayo, Yusuke Ohno, Marco Proietto, Jasmine Jung, Isabel Wang, Rachel Kandel, Narinderbir Singh, Ikran Ibrahim, Amit Fulzele, Eric J Bennett, Akio Kihara, Sonya E Neal

EMBO J. 2023 Feb; 42(4): e112275. Published online 2022 Nov 9. doi: 10.15252/embj.2022112275

PMCID:: PMC9929635

Abstract Article PDF–4.7M

Select item 988991517.

The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth

Marina Badenes, Emma Burbridge, Ioanna Oikonomidi, Abdulbasit Amin, Érika de Carvalho, Lindsay Kosack, Camila Mariano, Pedro Domingos, Pedro Faísca, Colin Adrain

Life Sci Alliance. 2023 Apr; 6(4): e202201644. Published online 2023 Jan 31. doi: 10.26508/lsa.202201644

PMCID:: PMC9889915

Abstract Article PDF–3.0M

Select item 984152518.

Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy

Edita Poláchová, Kathrin Bach, Elena Heuten, Stancho Stanchev, Anežka Tichá, Philipp Lampe, Pavel Majer, Thomas Langer, Marius K. Lemberg, Kvido Stříšovský

J Med Chem. 2023 Jan 12; 66(1): 251–265. Published online 2022 Dec 21. doi: 10.1021/acs.jmedchem.2c01092

PMCID:: PMC9841525

Abstract Article PDF–5.7M

Select item 979388719.

Plasmodium vivax rhomboid-like protease 1 gene diversity in Thailand

Touchchapol Mataradchakul, Chairat Uthaipibull, Francois Nosten, Joel Vega-Rodriguez, Marcelo Jacobs-Lorena, Usa Lek-Uthai

Exp Parasitol. Author manuscript; available in PMC 2022 Dec 27.

Published in final edited form as: Exp Parasitol. 2017 Oct; 181: 1–6. Published online 2017 Jul 6. doi: 10.1016/j.exppara.2017.06.007

PMCID:: PMC9793887

Abstract Article PDF–673K

Select item 976949820.

Distinction between Enterococcus faecium and Enterococcus lactis by a gluP PCR-Based Assay for Accurate Identification and Diagnostics

Mireya Viviana Belloso Daza, Ana C. Almeida-Santos, Carla Novais, Antónia Read, Valquíria Alves, Pier Sandro Cocconcelli, Ana R. Freitas, Luísa Peixe

Microbiol Spectr. 2022 Nov-Dec; 10(6): e03268-22. Published online 2022 Dec 1. doi: 10.1128/spectrum.03268-22

PMCID:: PMC9769498

Abstract Article PDF–1.9M

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