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Select item 104151831.

The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets

Jeeyun Chung, Joongkyu Park, Zon Weng Lai, Talley J. Lambert, Ruth C. Richards, Jiuchun Zhang, Tobias C. Walther, Robert V. Farese, Jr.

Nat Cell Biol. 2023; 25(8): 1101–1110. Published online 2023 Jul 13. doi: 10.1038/s41556-023-01178-w

PMCID:: PMC10415183

Abstract Article PDF–14M

Select item 91403442.

Methylation Heterogeneity and Gene Expression of SPG20 in Solid Tumors

Vincenza Ylenia Cusenza, Luca Braglia, Raffaele Frazzi

Genes (Basel) 2022 May; 13(5): 861. Published online 2022 May 12. doi: 10.3390/genes13050861

PMCID:: PMC9140344

Abstract Article PDF–977K

Select item 86003963.

KLF4, DAPK1 and SPG20 promoter methylation is not affected by DNMT1 silencing and hypomethylating drugs in lymphoma cells

Raffaele Frazzi, Vincenza Ylenia Cusenza, Mariaelena Pistoni, Laura Canovi, Luciano Cascione, Francesco Bertoni, Francesco Merli

Oncol Rep. 2022 Jan; 47(1): 10. Published online 2021 Nov 8. doi: 10.3892/or.2021.8221

PMCID:: PMC8600396

Abstract Article PDF–1.9M

Select item 65646914.

Methylomics analysis identifies a putative STAT3 target, SPG20, as a noninvasive epigenetic biomarker for early detection of gastric cancer

Kuo-Liang Wei, Jian-Liang Chou, Yin-Chen Chen, Hongchuan Jin, Yu-Min Chuang, Cheng-Shyong Wu, Michael W. Y. Chan

PLoS One. 2019; 14(6): e0218338. Published online 2019 Jun 13. doi: 10.1371/journal.pone.0218338

PMCID:: PMC6564691

Abstract Article PDF–1.5M

Select item 55802555.

Lack of Spartin Protein in Troyer Syndrome: A Loss-of-Function Disease Mechanism?

Dr. Joanna C. Bakowska, Dr. Heng Wang, Dr. Baozhong Xin, Dr. Charlotte J. Sumner, Dr. Craig Blackstone

Arch Neurol. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: Arch Neurol. 2008 Apr; 65(4): 520–524. doi: 10.1001/archneur.65.4.520

PMCID:: PMC5580255

Abstract Article PDF–659K

Select item 54950316.

SPG20 mutation in three siblings with familial hereditary spastic paraplegia

Leila Dardour, Filip Roelens, Valerie Race, Erika Souche, Maureen Holvoet, Koen Devriendt

Cold Spring Harb Mol Case Stud. 2017 Jul; 3(4): a001537. doi: 10.1101/mcs.a001537

PMCID:: PMC5495031

Abstract Article PDF–911K

Select item 54313897.

Detection of SPG20 gene promoter-methylated DNA, as a novel epigenetic biomarker, in plasma for colorectal cancer diagnosis using the MethyLight method

Nayebali Rezvani, Reza Alibakhshi, Assad Vaisi-Raygani, Homayoon Bashiri, Massoud Saidijam

Oncol Lett. 2017 May; 13(5): 3277–3284. Published online 2017 Mar 7. doi: 10.3892/ol.2017.5815

PMCID:: PMC5431389

Abstract Article PDF–711K

Select item 54134488.

Novel Homozygous Missense Mutation in SPG20 Gene Results in Troyer Syndrome Associated with Mitochondrial Cytochrome c Oxidase Deficiency

Ronen Spiegel, Devorah Soiferman, Avraham Shaag, Stavit Shalev, Orly Elpeleg, Ann Saada

JIMD Rep. 2017; 33: 55–60. Published online 2016 Aug 19. doi: 10.1007/8904_2016_580

PMCID:: PMC5413448

Abstract Article PDF–213K

Select item 35587109.

Detection of Hypermethylated Spastic Paraplegia-20 in Stool Samples of Patients with Colorectal Cancer

Hao Zhang, Yong-Chun Song, Cheng-Xue Dang

Int J Med Sci. 2013; 10(3): 230–234. Published online 2013 Jan 13. doi: 10.7150/ijms.5278

PMCID:: PMC3558710

Abstract Article PDF–288K

Select item 317436510.

SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis

G E Lind, C Raiborg, S A Danielsen, T O Rognum, E Thiis-Evensen, G Hoff, A Nesbakken, H Stenmark, R A Lothe

Oncogene. 2011 Sep 15; 30(37): 3967–3978. Published online 2011 Apr 18. doi: 10.1038/onc.2011.109

PMCID:: PMC3174365

Abstract Article PDF–805K

Select item 308480311.

SPG20 Protein Spartin Associates with Cardiolipin via Its Plant-Related Senescence Domain and Regulates Mitochondrial Ca²⁺ Homeostasis

Dinesh C. Joshi, Joanna C. Bakowska

PLoS One. 2011; 6(4): e19290. Published online 2011 Apr 29. doi: 10.1371/journal.pone.0019290

PMCID:: PMC3084803

Abstract Article PDF–1.5M

Select item 294746612.

SPG20 Protein Spartin Is Recruited to Midbodies by ESCRT-III Protein Ist1 and Participates in Cytokinesis

Benoît Renvoisé, Rell L. Parker, Dong Yang, Joanna C. Bakowska, James H. Hurley, Craig Blackstone

Mol Biol Cell. 2010 Oct 1; 21(19): 3293–3303. doi: 10.1091/mbc.E09-10-0879

PMCID:: PMC2947466

Abstract Article PDF–4.0M

Select item 276269013.

Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5

Thomas L. Edwards, Virginia E. Clowes, Hilda T. H. Tsang, James W. Connell, Christopher M. Sanderson, J. Paul Luzio, Evan Reid

Biochem J. 2009 Oct 1; 423(Pt 1): 31–39. Prepublished online 2009 Jul 6. Published online 2009 Sep 14. doi: 10.1042/BJ20082398

Correction in:: Biochem J. 2009 Nov 1; 423(Pt 3): 442.

PMCID:: PMC2762690

Abstract Article PDF–1.6M

Select item 269915414.

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover

Scott W. Eastman, Mina Yassaee, Paul D. Bieniasz

J Cell Biol. 2009 Mar 23; 184(6): 881–894. doi: 10.1083/jcb.200808041

PMCID:: PMC2699154

Abstract Article PDF–2.9M

Select item 185503015.

Troyer Syndrome Protein Spartin Is Mono-Ubiquitinated and Functions in EGF Receptor Trafficking

Joanna C. Bakowska, Henri Jupille, Parvin Fatheddin, Rosa Puertollano, Craig Blackstone

Mol Biol Cell. 2007 May; 18(5): 1683–1692. doi: 10.1091/mbc.E06-09-0833

PMCID:: PMC1855030

Abstract Article PDF–1.4M

Select item 1111489116.

WWP1: a versatile ubiquitin E3 ligase in signaling and diseases

Xu Zhi, Ceshi Chen

Cell Mol Life Sci. 2012 May; 69(9): 1425–1434. Published online 2011 Nov 4. doi: 10.1007/s00018-011-0871-7

PMCID:: PMC11114891

Abstract Article PDF–866K

Select item 1033585417.

Mutant SPART causes defects in mitochondrial protein import and bioenergetics reversed by Coenzyme Q

Chiara Diquigiovanni, Nicola Rizzardi, Antje Kampmeier, Irene Liparulo, Francesca Bianco, Bianca De Nicolo, Erica Cataldi-Stagetti, Elisabetta Cuna, Giulia Severi, Marco Seri, Miriam Bertrand, Tobias B. Haack, Adela Della Marina, Frederik Braun, Romana Fato, Alma Kuechler, Christian Bergamini, Elena Bonora

Open Biol. 2023 Jul; 13(7): 230040. Published online July 12, 2023. doi: 10.1098/rsob.230040

PMCID:: PMC10335854

Abstract Article PDF–1.6M

Select item 754964918.

miR-206 knockout shows it is critical for myogenesis and directly regulates newly identified target mRNAs

Georgiana M. Salant, Kimngan L. Tat, James A. Goodrich, Jennifer F. Kugel

RNA Biol. 2020; 17(7): 956–965. Published online 2020 Mar 11. doi: 10.1080/15476286.2020.1737443

PMCID:: PMC7549649

Abstract Article PDF–2.7M

Select item 685745819.

Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation

Agatha Schlüter, Juan Sandoval, Stéphane Fourcade, Angel Díaz‐Lagares, Montserrat Ruiz, Patrizia Casaccia, Manel Esteller, Aurora Pujol

Brain Pathol. 2018 Nov; 28(6): 902–919. Published online 2018 Apr 10. doi: 10.1111/bpa.12595

PMCID:: PMC6857458

Abstract Article PDF–1.4M

Select item 655147320.

Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells

Darawalee Wangsa, Rüdiger Braun, Christina H. Stuelten, Markus Brown, Kerry M. Bauer, Georg Emons, Leigh A. Weston, Yue Hu, Howard H. Yang, Maria Vila-Casadesús, Maxwell P. Lee, Philip Brauer, Lidia Warner, Madhvi Upender, Amanda B. Hummon, Jordi Camps, Thomas Ried

Neoplasia. 2019 Jul; 21(7): 721–729. Published online 2019 Jun 4. doi: 10.1016/j.neo.2019.04.009