PMC Links for Nucleotide (Select 1709991) - PMC

Select item 59924591.

Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity

Baehyun Shin, Roy Jung, Hyejin Oh, Gwen E. Owens, Hyeongseok Lee, Seung Kwak, Ramee Lee, Susan L. Cotman, Jong-Min Lee, Marcy E. MacDonald, Ji-Joon Song, Ravi Vijayvargia, Ihn Sik Seong

Mol Ther Nucleic Acids. 2018 Jun 1; 11: 416–428. Published online 2018 Mar 16. doi: 10.1016/j.omtn.2018.03.008

PMCID:: PMC5992459

Abstract Article PDF–1.9M

Select item 56586752.

AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington’s disease

J Miniarikova, V Zimmer, R Martier, C C Brouwers, C Pythoud, K Richetin, M Rey, J Lubelski, M M Evers, S J van Deventer, H Petry, N Déglon, P Konstantinova

Gene Ther. 2017 Oct; 24(10): 630–639. Prepublished online 2017 Aug 3. Published online 2017 Sep 14. doi: 10.1038/gt.2017.71

PMCID:: PMC5658675

Abstract Article PDF–2.7M

Select item 50144633.

Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease

Jana Miniarikova, Ilaria Zanella, Angelina Huseinovic, Tom van der Zon, Evelyn Hanemaaijer, Raygene Martier, Annemart Koornneef, Amber L Southwell, Michael R Hayden, Sander J van Deventer, Harald Petry, Pavlina Konstantinova

Mol Ther Nucleic Acids. 2016 Mar; 5(3): e297. Published online 2016 Mar 22. doi: 10.1038/mtna.2016.7

PMCID:: PMC5014463

Abstract Article PDF–12M

Select item 48463974.

Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

Ravi Vijayvargia, Raquel Epand, Alexander Leitner, Tae-Yang Jung, Baehyun Shin, Roy Jung, Alejandro Lloret, Randy Singh Atwal, Hyeongseok Lee, Jong-Min Lee, Ruedi Aebersold, Hans Hebert, Ji-Joon Song, Ihn Sik Seong

eLife. 2016; 5: e11184. Published online 2016 Mar 22. doi: 10.7554/eLife.11184

PMCID:: PMC4846397

Abstract Article PDF–1.9M

Select item 44611405.

CAG repeat lengths ≥335 attenuate the phenotype in the R6/2 Huntington’s disease transgenic mouse

I. Dragatsis, D. Goldowitz, N. Del Mar, Y.P. Deng, C.A. Meade, Li Liu, Z. Sun, P. Dietrich, J. Yue, A. Reiner

Neurobiol Dis. Author manuscript; available in PMC 2015 Jun 9.

Published in final edited form as: Neurobiol Dis. 2009 Mar; 33(3): 315–330. Published online 2008 Nov 6. doi: 10.1016/j.nbd.2008.10.009

PMCID:: PMC4461140

Abstract Article PDF–3.1M

Select item 28073666.

Huntingtin facilitates polycomb repressive complex 2

Ihn Sik Seong, Juliana M. Woda, Ji-Joon Song, Alejandro Lloret, Priyanka D. Abeyrathne, Caroline J. Woo, Gillian Gregory, Jong-Min Lee, Vanessa C. Wheeler, Thomas Walz, Robert E. Kingston, James F. Gusella, Ronald A. Conlon, Marcy E. MacDonald

Hum Mol Genet. 2010 Feb 15; 19(4): 573–583. Published online 2009 Nov 23. doi: 10.1093/hmg/ddp524

PMCID:: PMC2807366

Abstract Article PDF–357K

Select item 26569667.

Intrastriatal rAAV-Mediated Delivery of Anti-huntingtin shRNAs Induces Partial Reversal of Disease Progression in R6/1 Huntington’s Disease Transgenic Mice

Edgardo Rodriguez-Lebron, Eileen M. Denovan-Wright, Kevin Nash, Alfred S. Lewin, Ronald J. Mandel

Mol Ther. Author manuscript; available in PMC 2009 Mar 17.

Published in final edited form as: Mol Ther. 2005 Oct; 12(4): 618–633. doi: 10.1016/j.ymthe.2005.05.006

PMCID:: PMC2656966

Abstract Article PDF–1.4M

Select item 18696198.

Molecular Profile of Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis

Christopher J Edwards, Jeffrey L Feldman, Jonathan Beech, Kathleen M Shields, Jennifer A Stover, William L Trepicchio, Glenn Larsen, Brian MJ Foxwell, Fionula M Brennan, Marc Feldmann, Debra D Pittman

Mol Med. 2007 Jan-Feb; 13(1-2): 40–58. doi: 10.2119/2006-000056.Edwards

PMCID:: PMC1869619

Abstract Article PDF–6.9M

Select item 1563079.

A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila

Barbara L. Apostol, Alexsey Kazantsev, Simona Raffioni, Katalin Illes, Judit Pallos, Laszlo Bodai, Natalia Slepko, James E. Bear, Frank B. Gertler, Steven Hersch, David E. Housman, J. Lawrence Marsh, Leslie Michels Thompson

Proc Natl Acad Sci U S A. 2003 May 13; 100(10): 5950–5955. Published online 2003 May 1. doi: 10.1073/pnas.2628045100

PMCID:: PMC156307

Abstract Article PDF–334K

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