PMC Links for Nucleotide (Select 408772009) - PMC

Select item 60536571.

Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis

Hidetoshi Tsushima, Yuning J. Tang, Vijitha Puviindran, Shu-Hsuan Claire Hsu, Puviindran Nadesan, Chunying Yu, Hongyuan Zhang, Anthony J. Mirando, Matthew J. Hilton, Benjamin A. Alman

Development. 2018 Jul 1; 145(13): dev162396. Published online 2018 Jul 9. doi: 10.1242/dev.162396

PMCID:: PMC6053657

Abstract Article

Select item 60533472.

CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting

Yuanyuan Zhang, Yi Liu, Liqun Chen, Yiguo Wang, Jinbo Han

Protein Cell. 2018 Aug; 9(8): 729–732. Published online 2018 Apr 20. doi: 10.1007/s13238-018-0538-3

PMCID:: PMC6053347

Article PDF–556K

Select item 55772463.

PPARα-dependent Insig2a overexpression inhibits SREBP-1c processing during fasting

Jae-Ho Lee, Hye Suk Kang, Hyeon Young Park, Young-Ah Moon, Yu Na Kang, Byung-Chul Oh, Dae-Kyu Song, Jae-Hoon Bae, Seung-Soon Im

Sci Rep. 2017; 7: 9958. Published online 2017 Aug 30. doi: 10.1038/s41598-017-10523-7

PMCID:: PMC5577246

Abstract Article PDF–5.9M

Select item 54541174.

Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver

Seonghwan Hwang, Andrew D. Nguyen, Youngah Jo, Luke J. Engelking, James Brugarolas, Russell A. DeBose-Boyd

J Biol Chem. 2017 Jun 2; 292(22): 9382–9393. Published online 2017 Apr 17. doi: 10.1074/jbc.M117.788562

PMCID:: PMC5454117

Abstract Article PDF–586K

Select item 50235025.

SETDB2 links glucocorticoid to lipid metabolism through Insig2a regulation

Manuel Roqueta-Rivera, Ryan M Esquejo, Peter E Phelan, Katalin Sandor, Bence Daniel, Fabienne Foufelle, Jun Ding, Xiaoman Li, Sepideh Khorasanizadeh, Timothy F Osborne

Cell Metab. Author manuscript; available in PMC 2017 Sep 13.

Published in final edited form as: Cell Metab. 2016 Sep 13; 24(3): 474–484. Published online 2016 Aug 25. doi: 10.1016/j.cmet.2016.07.025

PMCID:: PMC5023502

Abstract Article PDF–3.1M

Select item 11840406.

Schoenheimer effect explained – feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

Luke J. Engelking, Guosheng Liang, Robert E. Hammer, Kiyosumi Takaishi, Hiroshi Kuriyama, Bret M. Evers, Wei-Ping Li, Jay D. Horton, Joseph L. Goldstein, Michael S. Brown

J Clin Invest. 2005 Sep 1; 115(9): 2489–2498. Published online 2005 Aug 11. doi: 10.1172/JCI25614

PMCID:: PMC1184040

Abstract Article PDF–1.2M

Select item 1522627.

Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis

Daisuke Yabe, Ryutaro Komuro, Guosheng Liang, Joseph L. Goldstein, Michael S. Brown

Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6): 3155–3160. Published online 2003 Mar 6. doi: 10.1073/pnas.0130116100

PMCID:: PMC152262

Abstract Article PDF–256K

Select item 1305328.

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

Daisuke Yabe, Michael S. Brown, Joseph L. Goldstein

Proc Natl Acad Sci U S A. 2002 Oct 1; 99(20): 12753–12758. Published online 2002 Sep 19. doi: 10.1073/pnas.162488899

PMCID:: PMC130532

Abstract Article PDF–296K

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