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Items: 1 to 20 of 136

1.
Loss of p53 drives neuron reprogramming in head and neck cancer
Moran Amit, Hideaki Takahashi, Mihnea Paul Dragomir, Antje Lindemann, Frederico O. Gleber-Netto, Curtis R. Pickering, Simone Anfossi, Abdullah A. Osman, Yu Cai, Rong Wang, Erik Knutsen, Masayoshi Shimizu, Cristina Ivan, Xiayu Rao, Jing Wang, Deborah A. Silverman, Samantha Tam, Mei Zhao, Carlos Caulin, Assaf Zinger, Ennio Tasciotti, Patrick M. Dougherty, Adel El-Naggar, George A. Calin, Jeffrey N. Myers
Nature. Author manuscript; available in PMC 2022 Dec 6.
Published in final edited form as: Nature. 2020 Feb; 578(7795): 449–454. Published online 2020 Feb 12. doi: 10.1038/s41586-020-1996-3
PMCID:
PMC9723538
AbstractArticlePDF–2.8M
2.
A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies
Steffen Boettcher, Peter G. Miller, Rohan Sharma, Marie McConkey, Matthew Leventhal, Andrei V. Krivtsov, Andrew O. Giacomelli, Waihay Wong, Jesi Kim, Sherry Chao, Kari J. Kurppa, Xiaoping Yang, Kirsten Milenkowic, Federica Piccioni, David E. Root, Frank G. Rücker, Yael Flamand, Donna Neuberg, R. Coleman Lindsley, Pasi A. Jänne, William C. Hahn, Tyler Jacks, Hartmut Döhner, Scott A. Armstrong, Benjamin L. Ebert
Science. Author manuscript; available in PMC 2020 Jul 1.
Published in final edited form as: Science. 2019 Aug 9; 365(6453): 599–604. doi: 10.1126/science.aax3649
PMCID:
PMC7327437
AbstractArticlePDF–996K
3.
Alpha-ketoglutarate links p53 to cell fate during tumor suppression
John P. Morris, IV, Jossie J. Yashinskie, Richard Koche, Rohit Chandwani, Sha Tian, Chi-Chao Chen, Timour Baslan, Zoran S. Marinkovic, Francisco J. Sánchez-Rivera, Steven D. Leach, Carlos Carmona-Fontaine, Craig B. Thompson, Lydia W.S. Finley, Scott W. Lowe
Nature. Author manuscript; available in PMC 2020 Mar 18.
Published in final edited form as: Nature. 2019 Sep; 573(7775): 595–599. Published online 2019 Sep 18. doi: 10.1038/s41586-019-1577-5
PMCID:
PMC6830448
AbstractArticlePDF–5.6M
4.
Loss of p53 triggers Wnt-dependent systemic inflammation to drive breast cancer metastasis
Max D. Wellenstein, Seth B. Coffelt, Danique E.M. Duits, Martine H. van Miltenburg, Maarten Slagter, Iris de Rink, Linda Henneman, Sjors M. Kas, Stefan Prekovic, Cheei-Sing Hau, Kim Vrijland, Anne Paulien Drenth, Renske de Korte-Grimmerink, Eva Schut, Ingrid van der Heijden, Wilbert Zwart, Lodewyk F.A. Wessels, Ton N. Schumacher, Jos Jonkers, Karin E. de Visser
Nature. Author manuscript; available in PMC 2020 Jan 31.
Published in final edited form as: Nature. 2019 Jul 3; 572(7770): 538–542. Published online 2019 Jul 31. doi: 10.1038/s41586-019-1450-6
PMCID:
PMC6707815
AbstractArticlePDF–5.7M
5.
Serine starvation induces stress and p53 dependent metabolic remodeling in cancer cells
Oliver D. K. Maddocks, Celia R. Berkers, Susan M. Mason, Liang Zheng, Karen Blyth, Eyal Gottlieb, Karen H. Vousden
Nature. Author manuscript; available in PMC 2019 Apr 26.
Published in final edited form as: Nature. 2013 Jan 24; 493(7433): 542–546. Published online 2012 Dec 16. doi: 10.1038/nature11743
PMCID:
PMC6485472
AbstractArticlePDF–1021K
6.
De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome
Tsutomu Toki, Kenichi Yoshida, RuNan Wang, Sou Nakamura, Takanobu Maekawa, Kumiko Goi, Megumi C. Katoh, Seiya Mizuno, Fumihiro Sugiyama, Rika Kanezaki, Tamayo Uechi, Yukari Nakajima, Yusuke Sato, Yusuke Okuno, Aiko Sato-Otsubo, Yusuke Shiozawa, Keisuke Kataoka, Yuichi Shiraishi, Masashi Sanada, Kenichi Chiba, Hiroko Tanaka, Kiminori Terui, Tomohiko Sato, Takuya Kamio, Hirotoshi Sakaguchi, Shouichi Ohga, Madoka Kuramitsu, Isao Hamaguchi, Akira Ohara, Hitoshi Kanno, Satoru Miyano, Seiji Kojima, Akira Ishiguro, Kanji Sugita, Naoya Kenmochi, Satoru Takahashi, Koji Eto, Seishi Ogawa, Etsuro Ito
Am J Hum Genet. 2018 Sep 6; 103(3): 440–447. Published online 2018 Aug 23. doi: 10.1016/j.ajhg.2018.07.020
PMCID:
PMC6128301
AbstractArticlePDF–1.6M
7.
Integrative Clinical Genomics of Metastatic Cancer
Dan R. Robinson, Yi-Mi Wu, Robert J. Lonigro, Pankaj Vats, Erin Cobain, Jessica Everett, Xuhong Cao, Erica Rabban, Chandan Kumar-Sinha, Victoria Raymond, Scott Schuetze, Ajjai Alva, Javed Siddiqui, Rashmi Chugh, Francis Worden, Mark M. Zalupski, Jeffrey Innis, Rajen J. Mody, Scott A. Tomlins, David Lucas, Laurence H. Baker, Nithya Ramnath, Ann F. Schott, Daniel F. Hayes, Joseph Vijai, Kenneth Offit, Elena M. Stoffel, J. Scott Roberts, David C. Smith, Lakshmi P. Kunju, Moshe Talpaz, Marcin Cieslik, Arul M. Chinnaiyan
Nature. Author manuscript; available in PMC 2018 Jun 11.
Published in final edited form as: Nature. 2017 Aug 17; 548(7667): 297–303. Published online 2017 Aug 2. doi: 10.1038/nature23306
PMCID:
PMC5995337
AbstractArticlePDF–3.6M
8.
MiR-766 induces p53 accumulation and G2/M arrest by directly targeting MDM4
Qingqing Wang, Luke A. Selth, David F. Callen
Oncotarget. 2017 May 2; 8(18): 29914–29924. Published online 2017 Feb 20. doi: 10.18632/oncotarget.15530
PMCID:
PMC5444713
AbstractArticlePDF–6.4M
9.
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
Florian T. Merkle, Sulagna Ghosh, Nolan Kamitaki, Jana Mitchell, Yishai Avior, Curtis Mello, Seva Kashin, Shila Mekhoubad, Dusko Ilic, Maura Charlton, Genevieve Saphier, Robert E. Handsaker, Giulio Genovese, Shiran Bar, Nissim Benvenisty, Steven A. McCarroll, Kevin Eggan
Nature. Author manuscript; available in PMC 2017 Oct 26.
Published in final edited form as: Nature. 2017 May 11; 545(7653): 229–233. Published online 2017 Apr 26. doi: 10.1038/nature22312
PMCID:
PMC5427175
AbstractArticlePDF–2.8M
10.
The p53-SET Interplays Reveal A New Mode of Acetylation-dependent Regulation
Donglai Wang, Ning Kon, Gorka Lasso, Le Jiang, Wenchuan Leng, Wei-Guo Zhu, Jun Qin, Barry Honig, Wei Gu
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Oct 6; 538(7623): 118–122. Published online 2016 Sep 14. doi: 10.1038/nature19759
PMCID:
PMC5333498
AbstractArticlePDF–4.5M
11.
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53
Kyoung Wan Yoon, Sanguine Byun, Eunjeong Kwon, So-Young Hwang, Kiki Chu, Masatsugu Hiraki, Seung-Hee Jo, Astrid Weins, Samy Hakroush, Angelika Cebulla, David B. Sykes, Anna Greka, Peter Mundel, David E. Fisher, Anna Mandinova, Sam W. Lee
Science. Author manuscript; available in PMC 2017 Jan 5.
Published in final edited form as: Science. 2015 Jul 31; 349(6247): 1261669. doi: 10.1126/science.1261669
PMCID:
PMC5215039
AbstractArticlePDF–2.9M
12.
Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress
In Hye Lee, Yoshichika Kawai, Maria M. Fergusson, Ilsa I. Rovira, Alexander J. R. Bishop, Noboru Motoyama, Liu Cao, Toren Finkel
Science. Author manuscript; available in PMC 2016 Jan 21.
Published in final edited form as: Science. 2012 Apr 13; 336(6078): 225–228. doi: 10.1126/science.1218395
Correction in:
volume 341 on page 457
PMCID:
PMC4721513
AbstractArticlePDF–631K
13.
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Wen Xue, Lars Zender, Cornelius Miething, Ross A. Dickins, Eva Hernando, Valery Krizhanovsky, Carlos Cordon-Cardo, Scott W. Lowe
Nature. Author manuscript; available in PMC 2015 Oct 12.
Published in final edited form as: Nature. 2007 Feb 8; 445(7128): 656–660. Published online 2007 Jan 24. doi: 10.1038/nature05529
Correction in:
volume 473 on page 544
PMCID:
PMC4601097
AbstractArticlePDF–472K
14.
A microRNA component of the p53 tumour suppressor network
Lin He, Xingyue He, Lee P. Lim, Elisa de Stanchina, Zhenyu Xuan, Yu Liang, Wen Xue, Lars Zender, Jill Magnus, Dana Ridzon, Aimee L. Jackson, Peter S. Linsley, Caifu Chen, Scott W. Lowe, Michele A. Cleary, Gregory J. Hannon
Nature. Author manuscript; available in PMC 2015 Oct 1.
Published in final edited form as: Nature. 2007 Jun 28; 447(7148): 1130–1134. Published online 2007 Jun 6. doi: 10.1038/nature05939
PMCID:
PMC4590999
AbstractArticlePDF–509K
15.
Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth
Jiajun Zhu, Morgan A. Sammons, Greg Donahue, Zhixun Dou, Masoud Vedadi, Matthaeus Getlik, Dalia Barsyte-Lovejoy, Rima Al-Awar, Bryson W. Katona, Ali Shilatifard, Jing Huang, Xianxin Hua, Cheryl H. Arrowsmith, Shelley L. Berger
Nature. Author manuscript; available in PMC 2016 Mar 10.
Published in final edited form as: Nature. 2015 Sep 10; 525(7568): 206–211. Published online 2015 Sep 2. doi: 10.1038/nature15251
PMCID:
PMC4568559
AbstractArticlePDF–2.7M
16.
Ferroptosis as a p53-mediated activity during tumour suppression
Le Jiang, Ning Kon, Tongyuan Li, Shang–Jui Wang, Tao Su, Hanina Hibshoosh, Richard Baer, Wei Gu
Nature. Author manuscript; available in PMC 2015 Jun 4.
Published in final edited form as: Nature. 2015 Apr 2; 520(7545): 57–62. Published online 2015 Mar 18. doi: 10.1038/nature14344
PMCID:
PMC4455927
AbstractArticlePDF–1.6M
17.
The Role of TP53 Mutations in the Origin and Evolution of Therapy-Related AML
Terrence N. Wong, Giridharan Ramsingh, Andrew L. Young, Christopher A. Miller, Waseem Touma, John S. Welch, Tamara L. Lamprecht, Dong Shen, Jasreet Hundal, Robert S. Fulton, Sharon Heath, Jack D. Baty, Jeffery M. Klco, Li Ding, Elaine R. Mardis, Peter Westervelt, John F. DiPersio, Matthew J. Walter, Timothy A. Graubert, Timothy J. Ley, Todd Druley, Daniel C. Link, Richard K. Wilson
Nature. Author manuscript; available in PMC 2015 Aug 26.
Published in final edited form as: Nature. 2015 Feb 26; 518(7540): 552–555. Published online 2014 Dec 8. doi: 10.1038/nature13968
PMCID:
PMC4403236
ArticlePDF–1.9M
18.
Inappropriate p53 Activation During Development Induces Features of CHARGE Syndrome
Jeanine L. Van Nostrand, Colleen A. Brady, Heiyoun Jung, Daniel R. Fuentes, Margaret M. Kozak, Thomas M. Johnson, Chieh-Yu Lin, Chien-Jung Lin, Donald L. Swiderski, Hannes Vogel, Jonathan A. Bernstein, Tania Attié-Bitach, Ching-Pin Chang, Joanna Wysocka, Donna M. Martin, Laura D. Attardi
Nature. Author manuscript; available in PMC 2015 Apr 9.
Published in final edited form as: Nature. 2014 Oct 9; 514(7521): 228–232. Published online 2014 Aug 3. doi: 10.1038/nature13585
PMCID:
PMC4192026
ArticlePDF–3.0M
19.
p53 dynamics control cell fate
Jeremy E. Purvis, Kyle W. Karhohs, Caroline Mock, Eric Batchelor, Alexander Loewer, Galit Lahav
Science. Author manuscript; available in PMC 2014 Sep 12.
Published in final edited form as: Science. 2012 Jun 15; 336(6087): 1440–1444. doi: 10.1126/science.1218351
PMCID:
PMC4162876
AbstractArticlePDF–1.1M
20.
Increased Oxidative Metabolism in the Li–Fraumeni Syndrome
Ping-yuan Wang, Wenzhe Ma, Joon-Young Park, Francesco S. Celi, Ross Arena, Jeong W. Choi, Qais A. Ali, Dotti J. Tripodi, Jie Zhuang, Cory U. Lago, Louise C. Strong, S. Lalith Talagala, Robert S. Balaban, Ju-Gyeong Kang, Paul M. Hwang
N Engl J Med. Author manuscript; available in PMC 2014 Aug 6.
Published in final edited form as: N Engl J Med. 2013 Mar 14; 368(11): 1027–1032. doi: 10.1056/NEJMoa1214091
PMCID:
PMC4123210
AbstractArticlePDF–645K

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