PMC Articles for PubChem BioAssay (Select 1345597) - PMC

Select item 53984151.

Pexmetinib: a novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia

Lohith Bachegowda, Kerry Morrone, Shannon L. Winski, Ioannis Mantzaris, Matthias Bartenstein, Nandini Ramachandra, Orsi Giricz, Vineeth Sukrithan, George Nwankwo, Samira Shahnaz, Tushar Bhagat, Sanchari Bhattacharyya, Amer Assal, Aditi Shastri, Shanisha Gordon-Mitchell, Andrea Pellagatti, Jacqueline Boultwood, Carolina Schinke, Yiting Yu, Chandan Guha, James Rizzi, Jennifer Garrus, Suzy Brown, Lance Wollenberg, Grant Hogeland, Dale Wright, Mark Munson, Mareli Rodriguez, Stefan Gross, David Chantry, Yiyu Zou, Leonidas Platanias, Laurence E. Burgess, Kith Pradhan, Ulrich Steidl, Amit Verma

Cancer Res. Author manuscript; available in PMC 2017 Aug 15.

Published in final edited form as: Cancer Res. 2016 Aug 15; 76(16): 4841–4849. Published online 2016 Jun 10. doi: 10.1158/0008-5472.CAN-15-3062

PMCID:: PMC5398415

Abstract Article PDF–2.1M

Select item 48851092.

Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

Craig Fraser, John C. Dawson, Reece Dowling, Douglas R. Houston, Jason T. Weiss, Alison F. Munro, Morwenna Muir, Lea Harrington, Scott P. Webster, Margaret C. Frame, Valerie G. Brunton, E. Elizabeth Patton, Neil O. Carragher, Asier Unciti-Broceta

J Med Chem. 2016 May 26; 59(10): 4697–4710. Published online 2016 Apr 26. doi: 10.1021/acs.jmedchem.6b00065

PMCID:: PMC4885109

Abstract Article PDF–5.6M

Select item 48625863.

Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia

John C Byrd, Bonnie Harrington, Susan O’Brien, Jeffrey A Jones, Anna Schuh, Steve Devereux, Jorge Chaves, William G Wierda, Farrukh T Awan, Jennifer R Brown, Peter Hillmen, Deborah M Stephens, Paolo Ghia, Jacqueline C Barrientos, John M Pagel, Jennifer Woyach, Dave Johnson, Jane Huang, Xiaolin Wang, Brian J Lannutti, Todd Covey, Maria Fardis, Jesse McGreivy, Ahmed Hamdy, Wayne Rothbaum, Raquel Izumi, Thomas G Diacovo, Amy J Johnson, Richard R Furman

N Engl J Med. Author manuscript; available in PMC 2016 Jul 28.

Published in final edited form as: N Engl J Med. 2016 Jan 28; 374(4): 323–332. Published online 2015 Dec 7. doi: 10.1056/NEJMoa1509981

PMCID:: PMC4862586

Abstract Article PDF–390K

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