PMC Articles for PubChem BioAssay (Select 1345761) - PMC

Select item 44998251.

Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor

Alexei S. Karpov, Payman Amiri, Cornelia Bellamacina, Marie-Helene Bellance, Werner Breitenstein, Dylan Daniel, Regis Denay, Doriano Fabbro, Cesar Fernandez, Inga Galuba, Stephanie Guerro-Lagasse, Sascha Gutmann, Linda Hinh, Wolfgang Jahnke, Julia Klopp, Albert Lai, Mika K. Lindvall, Sylvia Ma, Henrik Möbitz, Sabina Pecchi, Gabriele Rummel, Kevin Shoemaker, Joerg Trappe, Charles Voliva, Sandra W. Cowan-Jacob, Andreas L. Marzinzik

ACS Med Chem Lett. 2015 Jul 9; 6(7): 776–781. Published online 2015 May 22. doi: 10.1021/acsmedchemlett.5b00102

PMCID:: PMC4499825

Abstract Article PDF–2.9M

Select item 43536352.

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

Sean W. Deacon, Alexander Beeser, Jami A. Fukui, Ulrike E. E. Rennefahrt, Cynthia Myers, Jonathan Chernoff, Jeffrey R. Peterson

Chem Biol. Author manuscript; available in PMC 2015 Mar 9.

Published in final edited form as: Chem Biol. 2008 Apr; 15(4): 322–331. doi: 10.1016/j.chembiol.2008.03.005

PMCID:: PMC4353635

Abstract Article PDF–1.7M

Select item 40272483.

PAK1: A Therapeutic Target for Cancer Treatment

Ahmed F. Abdel-Magid

ACS Med Chem Lett. 2013 May 9; 4(5): 431–432. Published online 2013 Mar 19. doi: 10.1021/ml400101g

PMCID:: PMC4027248

Article PDF–213K

Select item 37900094.

FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas

Silvia Licciulli, Jasna Maksimoska, Chun Zhou, Scott Troutman, Smitha Kota, Qin Liu, Sergio Duron, David Campbell, Jonathan Chernoff, Jeffrey Field, Ronen Marmorstein, Joseph L. Kissil

J Biol Chem. 2013 Oct 4; 288(40): 29105–29114. Published online 2013 Aug 19. doi: 10.1074/jbc.M113.510933

PMCID:: PMC3790009

Abstract Article PDF–2.1M

Select item 36193025.

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

Bridget M. Dolan, Sergio G. Duron, David A. Campbell, Benedikt Vollrath, B. S. Shankaranarayana Rao, Hui-Yeon Ko, Gregory G. Lin, Arvind Govindarajan, Se-Young Choi, Susumu Tonegawa

Proc Natl Acad Sci U S A. 2013 Apr 2; 110(14): 5671–5676. Published online 2013 Mar 18. doi: 10.1073/pnas.1219383110

PMCID:: PMC3619302

Abstract Article PDF–454K

Select item 35312446.

Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)

Roberta Pireddu, Kara D. Forinash, Nan N. Sun, Mathew P. Martin, Shen-Shu Sung, Brian Alexander, Jin-Yi Zhu, Wayne C. Guida, Ernst Schönbrunn, Saïd M. Sebti, Nicholas J. Lawrence

Medchemcomm. Author manuscript; available in PMC 2013 Jun 1.

Published in final edited form as: Medchemcomm. 2012 Jun 1; 3(6): 699–709. Published online 2012 Jan 27. doi: 10.1039/C2MD00320A

PMCID:: PMC3531244

Abstract Article PDF–2.7M

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