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Select item 88506601.

The P300 acetyltransferase inhibitor C646 promotes membrane translocation of insulin receptor protein substrate and interaction with the insulin receptor

Jinghua Peng, Balamurugan Ramatchandirin, Yu Wang, Alexia Pearah, Kopperuncholan Namachivayam, Risa M. Wolf, Kimberley Steele, Krishnan MohanKumar, Liqing Yu, Shaodong Guo, Morris F. White, Akhil Maheshwari, Ling He

J Biol Chem. 2022 Mar; 298(3): 101621. Published online 2022 Jan 21. doi: 10.1016/j.jbc.2022.101621

PMCID:: PMC8850660

Abstract Article PDF–3.9M

Select item 78944222.

Effects of the histone acetylase inhibitor C646 on growth and differentiation of adipose-derived stem cells

Zhimin Wang, Xiao Wang, Meiyu Bi, Xiao Hu, Qing Wang, Hao Liang, Dongjun Liu

Cell Cycle. 2021; 20(4): 392–405. Published online 2021 Jan 25. doi: 10.1080/15384101.2021.1876389

PMCID:: PMC7894422

Abstract Article PDF–2.5M

Select item 77270163.

Histone Acetyltransferase p300 Inhibitor Improves Coronary Flow Reserve in SIRT3 (Sirtuin 3) Knockout Mice

Han Su, Heng Zeng, Xiaochen He, Shai-Hong Zhu, Jian-Xiong Chen

J Am Heart Assoc. 2020 Sep 15; 9(18): e017176. Published online 2020 Aug 31. doi: 10.1161/JAHA.120.017176

PMCID:: PMC7727016

Abstract Article PDF–1.7M

Select item 73590804.

Acetylation dependent functions of Rab22a-NeoF1 Fusion Protein in Osteosarcoma

Xiaoting Liang, Xin Wang, Yaohui He, Yuanzhong Wu, Li Zhong, Wen Liu, Dan Liao, Tiebang Kang

Theranostics. 2020; 10(17): 7747–7757. Published online 2020 Jun 19. doi: 10.7150/thno.46082

PMCID:: PMC7359080

Abstract Article PDF–2.4M

Select item 71606575.

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology

Simon D. Harding, Elena Faccenda, Christopher Southan, Adam J. Pawson, Pasquale Maffia, Stephen P. H. Alexander, Anthony P. Davenport, Doriano Fabbro, Francesca Levi‐Schaffer, Michael Spedding, Jamie A. Davies

Immunology. 2020 May; 160(1): 10–23. Published online 2020 Mar 2. doi: 10.1111/imm.13175

PMCID:: PMC7160657

Abstract Article PDF–4.1M

Select item 71428336.

27-Hydroxycholesterol-induced EndMT acts via STAT3 signaling to promote breast cancer cell migration by altering the tumor microenvironment

Kailin Jiao, Jing Zhen, Maoxuan Wu, Mengying Teng, Keke Yang, Qian Zhou, Chunyan Hu, Ming Zhou, Yuan Li, Zhong Li

Cancer Biol Med. 2020 Feb 15; 17(1): 88–100. Published online 2020 Feb 15. doi: 10.20892/j.issn.2095-3941.2019.0262

PMCID:: PMC7142833

Abstract Article PDF–1.6M

Select item 68026577.

Inhibition of acetylation of histones 3 and 4 attenuates aortic valve calcification

Jia Gu, Yan Lu, Menqing Deng, Ming Qiu, Yunfan Tian, Yue Ji, Pengyu Zong, Yongfeng Shao, Rui Zheng, Bin Zhou, Xiangqing Kong, Wei Sun

Exp Mol Med. 2019 Jul; 51(7): 1–14. Published online 2019 Jul 10. doi: 10.1038/s12276-019-0272-9

Correction in:: Exp Mol Med. 2024 May; 56(5): 1231–1232.

PMCID:: PMC6802657

Abstract Article PDF–3.5M

Select item 67054428.

Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism

Luigi Formisano, Natascia Guida, Valeria Valsecchi, Maria Cantile, Ornella Cuomo, Antonio Vinciguerra, Giusy Laudati, Giuseppe Pignataro, Rossana Sirabella, Gianfranco Di Renzo, Lucio Annunziato

J Neurosci. 2015 May 13; 35(19): 7332–7348. doi: 10.1523/JNEUROSCI.2174-14.2015

PMCID:: PMC6705442

Abstract Article PDF–3.7M

Select item 64765489.

Three-dimensional analysis reveals altered chromatin interaction by enhancer inhibitors harbors TCF7L2-regulated cancer gene signature

Diana L. Gerrard, Yao Wang, Malaina Gaddis, Yufan Zhou, Junbai Wang, Heather Witt, Shili Lin, Peggy J. Farnham, Victor X. Jin, Seth E. Frietze

J Cell Biochem. Author manuscript; available in PMC 2019 Apr 22.

Published in final edited form as: J Cell Biochem. 2019 Mar; 120(3): 3056–3070. Published online 2018 Dec 11. doi: 10.1002/jcb.27449

PMCID:: PMC6476548

Abstract Article PDF–1.0M

Select item 643369510.

Acetyltransferase p300 inhibitor reverses hypertension‐induced cardiac fibrosis

Rahul Rai, Tianjiao Sun, Veronica Ramirez, Elizabeth Lux, Mesut Eren, Douglas E. Vaughan, Asish K. Ghosh

J Cell Mol Med. 2019 Apr; 23(4): 3026–3031. Published online 2019 Feb 1. doi: 10.1111/jcmm.14162

PMCID:: PMC6433695

Abstract Article PDF–866K

Select item 603910111.

P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-promoting Myofibroblasts

Changwei Dou, Zhikui Liu, Kangsheng Tu, Hongbin Zhang, Chen Chen, Usman Yaqoob, Yuanguo Wang, Jialing Wen, Jan van Deursen, Delphine Sicard, Daniel Tschumperlin, Hongzhi Zou, Wei-Chien Huang, Raul Urrutia, Vijay H. Shah, Ningling Kang

Gastroenterology. Author manuscript; available in PMC 2019 Jun 1.

Published in final edited form as: Gastroenterology. 2018 Jun; 154(8): 2209–2221.e14. Published online 2018 Feb 15. doi: 10.1053/j.gastro.2018.02.015

PMCID:: PMC6039101

Abstract Article PDF–955K

Select item 571338712.

Comparative Proteomic Analysis of Lysine Acetylation in Fish CIK Cells Infected with Aquareovirus

Hong Guo, Jie Zhang, Yaping Wang, Chen Bu, Yanyan Zhou, Qin Fang

Int J Mol Sci. 2017 Nov; 18(11): 2419. Published online 2017 Nov 14. doi: 10.3390/ijms18112419

PMCID:: PMC5713387

Abstract Article PDF–3.0M

Select item 568814413.

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

Jayme L. Dahlin, Kathryn M. Nelson, Jessica M. Strasser, Dalia Barsyte-Lovejoy, Magdalena M. Szewczyk, Shawna Organ, Matthew Cuellar, Gurpreet Singh, Jonathan H. Shrimp, Nghi Nguyen, Jordan L. Meier, Cheryl H. Arrowsmith, Peter J. Brown, Jonathan B. Baell, Michael A. Walters

Nat Commun. 2017; 8: 1527. Published online 2017 Nov 15. doi: 10.1038/s41467-017-01657-3

PMCID:: PMC5688144

Abstract Article PDF–2.3M

Select item 539468214.

Live imaging of H3K9 acetylation in plant cells

Kazuki Kurita, Takuya Sakamoto, Noriyoshi Yagi, Yuki Sakamoto, Akihiro Ito, Norikazu Nishino, Kaori Sako, Minoru Yoshida, Hiroshi Kimura, Motoaki Seki, Sachihiro Matsunaga

Sci Rep. 2017; 7: 45894. Published online 2017 Apr 18. doi: 10.1038/srep45894

PMCID:: PMC5394682

Abstract Article PDF–1.3M

Select item 500763215.

Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin

Carine Robert, Pratik K. Nagaria, Nisha Pawar, Adeoluwa Adewuyi, Ivana Gojo, David J. Meyers, Philip A. Cole, Feyruz V. Rassool

Leuk Res. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: Leuk Res. 2016 Jun; 45: 14–23. Published online 2016 Mar 30. doi: 10.1016/j.leukres.2016.03.007

PMCID:: PMC5007632

Abstract Article PDF–2.2M

Select item 487127716.

The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases

Thea van den Bosch, Alexander Boichenko, Niek G. J. Leus, Maria Eleni Ourailidou, Hannah Wapenaar, Dante Rotili, Antonello Mai, Axel Imhof, Rainer Bischoff, Hidde J. Haisma, Frank J. Dekker

Biochem Pharmacol. Author manuscript; available in PMC 2016 May 18.

Published in final edited form as: Biochem Pharmacol. 2016 Feb 15; 102: 130–140. Published online 2015 Dec 21. doi: 10.1016/j.bcp.2015.12.010

PMCID:: PMC4871277

Abstract Article PDF–1.3M

Select item 481812117.

Inhibition of p300 histone acetyltransferase activity in palate mesenchyme cells attenuates Wnt signaling via aberrant E-cadherin expression

Dennis R. Warner, Scott C. Smith, Irina A. Smolenkova, M. Michele Pisano, Robert M. Greene

Exp Cell Res. Author manuscript; available in PMC 2017 Mar 1.

Published in final edited form as: Exp Cell Res. 2016 Mar 1; 342(1): 32–38. Published online 2016 Feb 24. doi: 10.1016/j.yexcr.2016.02.015

PMCID:: PMC4818121

Abstract Article PDF–944K

Select item 477600318.

C646, a Novel p300/CREB-Binding Protein-Specific Inhibitor of Histone Acetyltransferase, Attenuates Influenza A Virus Infection

Dongming Zhao, Satoshi Fukuyama, Yuko Sakai-Tagawa, Emi Takashita, Jason E. Shoemaker, Yoshihiro Kawaoka

Antimicrob Agents Chemother. 2016 Mar; 60(3): 1902–1906. Prepublished online 2015 Dec 28. Published online 2016 Feb 26. doi: 10.1128/AAC.02055-15

PMCID:: PMC4776003

Abstract Article PDF–1.7M

Select item 474983319.

Inhibition of different histone acetyltransferases (HATs) uncovers transcription-dependent and -independent acetylation-mediated mechanisms in memory formation

Katja Merschbaecher, Lucyna Hatko, Jennifer Folz, Uli Mueller

Learn Mem. 2016 Feb; 23(2): 83–89. Published online 2016 Feb. doi: 10.1101/lm.039438.115

PMCID:: PMC4749833

Abstract Article PDF–582K

Select item 472918620.

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia

G Giotopoulos, W-I Chan, SJ Horton, D Ruau, P Gallipoli, A Fowler, C Crawley, E Papaemmanuil, PJ Campbell, B Göttgens, JM Van Deursen, PA Cole, BJP Huntly

Oncogene. Author manuscript; available in PMC 2016 Jan 27.

Published in final edited form as: Oncogene. 2016 Jan 21; 35(3): 279–289. Published online 2015 Apr 20. doi: 10.1038/onc.2015.92

PMCID:: PMC4729186

Abstract Article PDF–782K

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