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Select item 111677911.

KRAS-mutant non-small cell lung cancer (NSCLC) therapy based on tepotinib and omeprazole combination

Rafael Rosell, Eloisa Jantus-Lewintre, Peng Cao, Xueting Cai, Baojuan Xing, Masaoki Ito, Jose Luis Gomez-Vazquez, Mireia Marco-Jordán, Silvia Calabuig-Fariñas, Andrés Felipe Cardona, Jordi Codony-Servat, Jessica Gonzalez, Kevin València-Clua, Andrés Aguilar, Carlos Pedraz-Valdunciel, Zahra Dantes, Anisha Jain, S Chandan, Miguel Angel Molina-Vila, Oscar Arrieta, Macarena Ferrero, Carlos Camps, Maria González-Cao

Cell Commun Signal. 2024; 22: 324. Published online 2024 Jun 12. doi: 10.1186/s12964-024-01667-x

PMCID:: PMC11167791

Abstract Article PDF–3.2M

Select item 111351322.

Sotorasib with panitumumab in chemotherapy-refractory KRAS G12C-mutated colorectal cancer: a phase 1b trial

Yasutoshi Kuboki, Marwan Fakih, John Strickler, Rona Yaeger, Toshiki Masuishi, Edward J Kim, Christine M Bestvina, Scott Kopetz, Gerald S Falchook, Corey Langer, John Krauss, Sonam Puri, Panli Cardona, Emily Chan, Tracy Varrieur, Lata Mukundan, Abraham Anderson, Qui Tran, David S Hong

Nat Med. Author manuscript; available in PMC 2024 Jul 4.

Published in final edited form as: Nat Med. 2024 Jan; 30(1): 265–270. Published online 2024 Jan 4. doi: 10.1038/s41591-023-02717-6

PMCID:: PMC11135132

Abstract Article PDF–737K

Select item 110615983.

Sotorasib Is a Pan-RAS^G12C Inhibitor Capable of Driving Clinical Response in NRAS^G12C Cancers

Douglas A. Rubinson, Noritaka Tanaka, Ferran Fece de la Cruz, Kevin S. Kapner, Michael H. Rosenthal, Bryanna L. Norden, Haley Barnes, Sara Ehnstrom, Alvin A. Morales-Giron, Lauren K. Brais, Christopher T. Lemke, Andrew J. Aguirre, Ryan B. Corcoran

Cancer Discov. 2024 May 1; 14(5): 727–736. Published online 2024 Jan 18. doi: 10.1158/2159-8290.CD-23-1138

PMCID:: PMC11061598

Abstract Article PDF–12M

Select item 110181654.

Adagrasib Treatment After Sotorasib-Related Hepatotoxicity in Patients With KRAS^G12C-Mutated Non–Small Cell Lung Cancer: A Case Series and Literature Review

Jia Luo, Narjust Florez, Anjali Donnelly, Yanyan Lou, Kevin Lu, Patrick C. Ma, Alexander I. Spira, Debra Ryan, Hatim Husain

JCO Precis Oncol. 2024; 8: e2300644. Published online 2024 Apr 5. doi: 10.1200/PO.23.00644

Correction in:: JCO Precis Oncol. 2024 May; 8: e2400255.

PMCID:: PMC11018165

Abstract Article PDF–576K

Select item 109942475.

The Impact of Exuberance on Equipoise in Oncology Clinical Trials: Sotorasib as Archetype

Tito Fojo, Meredith LaRose, Susan E Bates

Oncologist. 2024 Apr; 29(4): 275–277. Published online 2024 Mar 18. doi: 10.1093/oncolo/oyae042

PMCID:: PMC10994247

Article PDF–122K

Select item 109600986.

Hepatotoxicity in patients with non-small cell lung cancer treated with sotorasib after prior immunotherapy: a comprehensive clinical and pharmacokinetic analysis

Sophie M. Ernst, Maaike M. Hofman, Tessa E. van der Horst, Marthe S. Paats, Frank W.J. Heijboer, Joachim G.J.V. Aerts, Daphne W. Dumoulin, Robin Cornelissen, Jan H. von der Thüsen, Peter de Bruijn, Esther Oomen-de Hoop, Ron H.J. Mathijssen, Stijn L.W. Koolen, Anne-Marie C. Dingemans

eBioMedicine. 2024 Apr; 102: 105074. Published online 2024 Mar 19. doi: 10.1016/j.ebiom.2024.105074

PMCID:: PMC10960098

Abstract Article PDF–699K

Select item 108551017.

Bioinformatics and Experimental Validation for Identifying Biomarkers Associated with AMG510 (Sotorasib) Resistance in KRAS^G12C-Mutated Lung Adenocarcinoma

Peng Lin, Wei Cheng, Xin Qi, Pinglu Zhang, Jianshe Xiong, Jing Li

Int J Mol Sci. 2024 Feb; 25(3): 1555. Published online 2024 Jan 26. doi: 10.3390/ijms25031555

PMCID:: PMC10855101

Abstract Article PDF–6.2M

Select item 107275608.

Sotorasib versus Docetaxel for treatment of US and Chinese patients with advanced non-small-cell lung cancer with KRAS p.G12C-mutated: A cost-effectiveness analysis to inform drug pricing

Yunlin Jiang, Mingye Zhao, Ruolin Liu, Xueping Zheng

Medicine (Baltimore) 2023 Dec 15; 102(50): e36387. Published online 2023 Dec 15. doi: 10.1097/MD.0000000000036387

PMCID:: PMC10727560

Abstract Article PDF–1.4M

Select item 105816269.

Clinical and Genomic Features of Response and Toxicity to Sotorasib in a Real-World Cohort of Patients With Advanced KRAS G12C-Mutant Non–Small Cell Lung Cancer

Rohit Thummalapalli, Ezra Bernstein, Benjamin Herzberg, Bob T. Li, Afsheen Iqbal, Isabel Preeshagul, Fernando C. Santini, Juliana Eng, Marc Ladanyi, Soo-Ryum Yang, Ronglai Shen, Piro Lito, Gregory J. Riely, Joshua K. Sabari, Kathryn C. Arbour

JCO Precis Oncol. 2023; 7: e2300030. Published online 2023 Jun 29. doi: 10.1200/PO.23.00030

PMCID:: PMC10581626

Abstract Article PDF–707K

Select item 1050645610.

Sotorasib in KRAS p.G12C–Mutated Advanced Pancreatic Cancer

J.H. Strickler, H. Satake, T.J. George, R. Yaeger, A. Hollebecque, I. Garrido-Laguna, M. Schuler, T.F. Burns, A.L. Coveler, G.S. Falchook, M. Vincent, Y. Sunakawa, L. Dahan, D. Bajor, S.-Y. Rha, C. Lemech, D. Juric, M. Rehn, G. Ngarmchamnanrith, P. Jafarinasabian, Q. Tran, D.S. Hong

N Engl J Med. Author manuscript; available in PMC 2023 Sep 18.

Published in final edited form as: N Engl J Med. 2023 Jan 5; 388(1): 33–43. Published online 2022 Dec 21. doi: 10.1056/NEJMoa2208470

PMCID:: PMC10506456

Abstract Article PDF–399K

Select item 1041471111.

Long-Term Outcomes and Molecular Correlates of Sotorasib Efficacy in Patients With Pretreated KRAS G12C-Mutated Non–Small-Cell Lung Cancer: 2-Year Analysis of CodeBreaK 100

Grace K. Dy, Ramaswamy Govindan, Vamsidhar Velcheti, Gerald S. Falchook, Antoine Italiano, Jürgen Wolf, Adrian G. Sacher, Toshiaki Takahashi, Suresh S. Ramalingam, Christophe Dooms, Dong-Wan Kim, Alfredo Addeo, Jayesh Desai, Martin Schuler, Pascale Tomasini, David S. Hong, Piro Lito, Qui Tran, Simon Jones, Abraham Anderson, Antreas Hindoyan, Wendy Snyder, Ferdinandos Skoulidis, Bob T. Li

J Clin Oncol. 2023 Jun 20; 41(18): 3311–3317. Published online 2023 Apr 25. doi: 10.1200/JCO.22.02524

PMCID:: PMC10414711

Abstract Article PDF–382K

Select item 1032563012.

Clinical validation of Guardant360 CDx as a blood-based companion diagnostic for sotorasib

Joshua M. Bauml, Bob T. Li, Vamsidhar Velcheti, Ramaswamy Govindan, Alessandra Curioni-Fontecedro, Christophe Dooms, Toshiaki Takahashi, Andrew W. Duda, Justin I. Odegaard, Fernando Cruz-Guilloty, Liming Jin, Ying Zhang, Abraham Anderson, Ferdinandos Skoulidis

Lung Cancer. Author manuscript; available in PMC 2023 Jul 6.

Published in final edited form as: Lung Cancer. 2022 Apr; 166: 270–278. Published online 2021 Oct 19. doi: 10.1016/j.lungcan.2021.10.007

PMCID:: PMC10325630

Abstract Article PDF–753K

Select item 1030954213.

Incidence of Brain Metastases and Preliminary Evidence of Intracranial Activity With Sotorasib in Patients With KRAS^G12C-Mutant Non–Small-Cell Lung Cancer

Giuseppe Lamberti, Ayal Aizer, Biagio Ricciuti, Joao V. Alessi, Federica Pecci, Shu-Chi Tseng, Lynette M. Sholl, Mizuki Nishino, Mark M. Awad

JCO Precis Oncol. 2023; 7: e2200621. Published online 2023 Feb 21. doi: 10.1200/PO.22.00621

PMCID:: PMC10309542

Article PDF–1.6M

Select item 1030876714.

DNA replication stress and mitotic catastrophe mediate sotorasib addiction in KRAS^G12C-mutant cancer

Li-Wen Chiou, Chien-Hui Chan, Yu-Ling Jhuang, Ching-Yao Yang, Yung-Ming Jeng

J Biomed Sci. 2023; 30: 50. Published online 2023 Jun 29. doi: 10.1186/s12929-023-00940-4

PMCID:: PMC10308767

Abstract Article PDF–11M

Select item 1010481415.

Targeting PI3Kα overcomes resistance to KRas^G12C inhibitors mediated by activation of EGFR and/or IGF1R

Wei-liang Qi, Hui-yu Li, Yi Wang, Lan Xu, Jie-ting Deng, Xi Zhang, Yu-xiang Wang, Ling-hua Meng

Acta Pharmacol Sin. 2023 May; 44(5): 1083–1094. Published online 2022 Nov 21. doi: 10.1038/s41401-022-01015-0

PMCID:: PMC10104814

Abstract Article PDF–5.1M

Select item 1000181916.

A Novel Combination of Sotorasib and Metformin Enhances Cytotoxicity and Apoptosis in KRAS-Mutated Non-Small Cell Lung Cancer Cell Lines through MAPK and P70S6K Inhibition

Pedro Barrios-Bernal, José Lucio-Lozada, Maritza Ramos-Ramírez, Norma Hernández-Pedro, Oscar Arrieta

Int J Mol Sci. 2023 Mar; 24(5): 4331. Published online 2023 Feb 22. doi: 10.3390/ijms24054331

PMCID:: PMC10001819

Abstract Article PDF–2.2M

Select item 981437717.

PAK and PI3K pathway activation confers resistance to KRAS^G12C inhibitor sotorasib

Chien-Hui Chan, Li-Wen Chiou, Tsai-Yu Lee, Yun-Ru Liu, Tsung-Han Hsieh, Ching-Yao Yang, Yung-Ming Jeng

Br J Cancer. 2023 Jan 26; 128(1): 148–159. Published online 2022 Nov 1. doi: 10.1038/s41416-022-02032-w

PMCID:: PMC9814377

Abstract Article PDF–2.9M

Select item 971544618.

Sotorasib: A Review in KRAS G12C Mutation-Positive Non-small Cell Lung Cancer

Arnold Lee

Target Oncol. 2022; 17(6): 727–733. Published online 2022 Oct 31. doi: 10.1007/s11523-022-00922-w

Correction in:: Target Oncol. 2023; 18(1): 177.

PMCID:: PMC9715446

Abstract Article PDF–1.1M

Select item 963683919.

Editorial: Recent Approval of Sotorasib as the First Targeted Therapy for KRAS G12C-Mutated Advanced Non-Small Cell Lung Cancer (NSCLC)

Dinah V. Parums

Med Sci Monit. 2022; 28: e938746-1–e938746-3. Prepublished online 2022 Oct 25. Published online 2022 Nov 1. doi: 10.12659/MSM.938746

PMCID:: PMC9636839

Abstract Article PDF–157K

Select item 958361820.

Addressing Atropisomerism in the Development of Sotorasib, a Covalent Inhibitor of KRAS G12C: Structural, Analytical, and Synthetic Considerations

Brian A. Lanman, Andrew T. Parsons, Stephan G. Zech

Acc Chem Res. 2022 Oct 18; 55(20): 2892–2903. Published online 2022 Sep 30. doi: 10.1021/acs.accounts.2c00479

PMCID:: PMC9583618

Abstract Article PDF–5.5M

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