PMC Articles for PubChem Compound (Select 24772860) - PMC

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Items: 14

Select item 89961861.

The Development of Hsp90β-selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition

Sanket J. Mishra, Weiya Liu, Kristin Beebe, Monimoy Banerjee, Caitlin N. Kent, Vitumbiko Munthali, III John Koren, III John A Taylor, Leonard M. Neckers, Jeffrey Holzbeierlein, Brian S. J. Blagg

J Med Chem. Author manuscript; available in PMC 2022 Apr 11.

Published in final edited form as: J Med Chem. 2021 Feb 11; 64(3): 1545–1557. Published online 2021 Jan 11. doi: 10.1021/acs.jmedchem.0c01700

PMCID:: PMC8996186

Abstract Article PDF–2.8M

Select item 65514902.

CFTR interacts with Hsp90 and regulates the phosphorylation of AKT and ERK1/2 in colorectal cancer cells

Kaisheng Liu, Hongtao Jin, Yaomin Guo, Ying Liu, Yong Wan, Pan Zhao, Zhifan Zhou, Jianhong Wang, Maolin Wang, Chang Zou, Weiqing Wu, Zhiqiang Cheng, Yong Dai

FEBS Open Bio. 2019 Jun; 9(6): 1119–1127. Published online 2019 Apr 29. doi: 10.1002/2211-5463.12641

PMCID:: PMC6551490

Abstract Article PDF–2.4M

Select item 64525443.

Hsp90 Inhibitor SNX-2112 Enhances TRAIL-Induced Apoptosis of Human Cervical Cancer Cells via the ROS-Mediated JNK-p53-Autophagy-DR5 Pathway

Liubing Hu, Yan Wang, Zui Chen, Liangshun Fu, Sheng Wang, Xinyue Zhang, Pengchao Zhang, Xueping Lu, Huiyang Jie, Manmei Li, Yifei Wang, Zhong Liu

Oxid Med Cell Longev. 2019; 2019: 9675450. Published online 2019 Mar 25. doi: 10.1155/2019/9675450

PMCID:: PMC6452544

Abstract Article PDF–9.9M

Select item 63459684.

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

Luke Whitesell, Nicole Robbins, David S. Huang, Catherine A. McLellan, Tanvi Shekhar-Guturja, Emmanuelle V. LeBlanc, Catherine S. Nation, Raymond Hui, Ashley Hutchinson, Cathy Collins, Sharanya Chatterjee, Richard Trilles, Jinglin L. Xie, Damian J. Krysan, Susan Lindquist, John A. Porco, Jr., Utpal Tatu, Lauren E. Brown, Juan Pizarro, Leah E. Cowen

Nat Commun. 2019; 10: 402. Published online 2019 Jan 24. doi: 10.1038/s41467-018-08248-w

PMCID:: PMC6345968

Abstract Article PDF–3.6M

Select item 55684235.

Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold

Sanket J. Mishra, Suman Ghosh, Andrew R. Stothert, Chad A. Dickey, Brian S. J. Blagg

ACS Chem Biol. Author manuscript; available in PMC 2018 Jan 20.

Published in final edited form as: ACS Chem Biol. 2017 Jan 20; 12(1): 244–253. Published online 2016 Dec 13. doi: 10.1021/acschembio.6b00747

PMCID:: PMC5568423

Abstract Article PDF–2.9M

Select item 54278396.

Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics

Qingdi Quentin Li, Jian-Jiang Hao, Zheng Zhang, L. Spencer Krane, Kai H. Hammerich, Thomas Sanford, Jane B. Trepel, Len Neckers, Piyush K. Agarwal

Sci Rep. 2017; 7: 201. Published online 2017 Mar 15. doi: 10.1038/s41598-017-00143-6

PMCID:: PMC5427839

Abstract Article PDF–2.5M

Select item 44375857.

A novel HSP90 inhibitor delays castrate resistant prostate cancer without altering serum PSA levels and inhibits osteoclastogenesis

Francois Lamoureux, Christian Thomas, Min-Jean Yin, Hidetoshi Kuruma, Ladan Fazli, Martin E Gleave, Amina Zoubeidi

Clin Cancer Res. Author manuscript; available in PMC 2015 May 19.

Published in final edited form as: Clin Cancer Res. 2011 Apr 15; 17(8): 2301–2313. Published online 2011 Feb 24. doi: 10.1158/1078-0432.CCR-10-3077

Correction in:: volume 17 on page 4916

PMCID:: PMC4437585

Abstract Article PDF–1.3M

Select item 43867738.

Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112

Dong Dong, Xiao Wang, Huailing Wang, Xingwang Zhang, Yifei Wang, Baojian Wu

Int J Nanomedicine. 2015; 10: 2521–2535. Published online 2015 Mar 31. doi: 10.2147/IJN.S79734

PMCID:: PMC4386773

Abstract Article PDF–2.1M

Select item 40791189.

Suppression of Heat Shock Protein 27 Using OGX-427 Induces Endoplasmic Reticulum Stress and Potentiates Heat Shock Protein 90 Inhibitors to Delay Castrate-resistant Prostate Cancer

François Lamoureux, Christian Thomas, Min-Jean Yin, Ladan Fazli, Amina Zoubeidi, Martin E. Gleave

Eur Urol. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Eur Urol. 2014 Jul; 66(1): 145–155. Published online 2013 Dec 29. doi: 10.1016/j.eururo.2013.12.019

Correction in:: Eur Urol. 2016 Jul; 70(1): e27–e28.

PMCID:: PMC4079118

Abstract Article PDF–2.2M

Select item 370010210.

The Unfolded Protein Response Selectively Targets Active Smoothened Mutants

Suresh Marada, Daniel P. Stewart, William J. Bodeen, Young-Goo Han, Stacey K. Ogden

Mol Cell Biol. 2013 Jun; 33(12): 2375–2387. doi: 10.1128/MCB.01445-12

PMCID:: PMC3700102

Abstract Article PDF–2.3M

Select item 326382511.

Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in MET-amplified tumor cells with or without resistance to selective MET inhibition

Thomas Bachleitner-Hofmann, Mark Y. Sun, Chin-Tung Chen, David Liska, Zhaoshi Zeng, Agnes Viale, Adam B. Olshen, Martina Mittlboeck, James G. Christensen, Neal Rosen, David B. Solit, Martin R. Weiser

Clin Cancer Res. Author manuscript; available in PMC 2012 Jan 23.

Published in final edited form as: Clin Cancer Res. 2011 Jan 1; 17(1): 122–133. doi: 10.1158/1078-0432.CCR-10-0253

PMCID:: PMC3263825

Abstract Article PDF–677K

Select item 305706612.

Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth

Sarat Chandarlapaty, Maurizio Scaltriti, Pierdavide Angelini, Qing Ye, Marta Guzman, Clifford A. Hudis, Larry Norton, David B. Solit, Joaquin Arribas, Jose Baselga, Neal Rosen

Oncogene. Author manuscript; available in PMC 2011 Mar 15.

Published in final edited form as: Oncogene. 2010 Jan 21; 29(3): 325–334. Published online 2009 Oct 26. doi: 10.1038/onc.2009.337

PMCID:: PMC3057066

Abstract Article PDF–2.3M

Select item 298081313.

Determination of PF-04928473 in human plasma using liquid chromatography with tandem mass spectrometry

Lokesh Jain, Erin R. Gardner, Jürgen Venitz, Giuseppe Giaccone, Brett E. Houk, William D. Figg

J Chromatogr B Analyt Technol Biomed Life Sci. Author manuscript; available in PMC 2011 Nov 15.

Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Nov 15; 878(30): 3187–3192. Published online 2010 Sep 29. doi: 10.1016/j.jchromb.2010.09.017

PMCID:: PMC2980813

Abstract Article PDF–588K

Select item 263027014.

SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

Yutaka Okawa, Teru Hideshima, Paul Steed, Sonia Vallet, Steven Hall, Ken Huang, John Rice, Amy Barabasz, Brianna Foley, Hiroshi Ikeda, Noopur Raje, Tanyel Kiziltepe, Hiroshi Yasui, Sotaro Enatsu, Kenneth C. Anderson

Blood. 2009 Jan 22; 113(4): 846–855. Prepublished online 2008 Oct 23. doi: 10.1182/blood-2008-04-151928