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Items: 1 to 20 of 30

1.
A Sensitive LC-MS/MS Method for the Simultaneous Determination of Two Thia-Analogous Indirubin N-Glycosides and Indirubin-3′-Monoxime in Plasma and Cell Culture Medium
Alica Fischle, Rico Schwarz, Franziska Wendt, Marcel Kordt, Robert Ramer, Lars Boeckmann, Martin Hein, Peter Langer, Steffen Emmert, Brigitte Vollmar, Burkhard Hinz
Molecules. 2022 May; 27(9): 3031. Published online 2022 May 9. doi: 10.3390/molecules27093031
PMCID:
PMC9101087
AbstractArticlePDF–2.2M
2.
Indirubin-3’-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma
Zhen Yu, Xiaojing Wei, Lanting Liu, Hao Sun, Teng Fang, Lu Wang, Ying Li, Weiwei Sui, Kefei Wang, Yi He, Yaozhong Zhao, Wenyang Huang, Gang An, Fancui Meng, Changjiang Huang, Tengteng Yu, Kenneth C. Anderson, Tao Cheng, Lugui Qiu, Mu Hao
EBioMedicine. 2022 Apr; 78: 103950. Published online 2022 Mar 26. doi: 10.1016/j.ebiom.2022.103950
PMCID:
PMC8958548
AbstractArticlePDF–5.8M
3.
Synergistic effect of plasma-activated medium and novel indirubin derivatives on human skin cancer cells by activation of the AhR pathway
Henrike Rebl, Marie Sawade, Martin Hein, Claudia Bergemann, Manuela Wende, Michael Lalk, Peter Langer, Steffen Emmert, Barbara Nebe
Sci Rep. 2022; 12: 2528. Published online 2022 Feb 15. doi: 10.1038/s41598-022-06523-x
Correction in:
Sci Rep. 2022; 12: 4341.
PMCID:
PMC8847430
AbstractArticlePDF–2.2M
4.
Design, synthesis, structure, in vitro cytotoxic activity evaluation and docking studies on target enzyme GSK-3β of new indirubin-3ʹ-oxime derivatives
Nguyen Trong Dan, Hoang Duc Quang, Vuong Van Truong, Do Huu Nghi, Nguyen Manh Cuong, To Dao Cuong, Tran Quoc Toan, Long Giang Bach, Nguyen Huu Thuan Anh, Nguyen Thi Mai, Ngo Thi Lan, Luu Van Chinh, Pham Minh Quan
Sci Rep. 2020; 10: 11429. Published online 2020 Jul 10. doi: 10.1038/s41598-020-68134-8
PMCID:
PMC7351726
AbstractArticlePDF–2.3M
5.
Development of UHPLC-MS/MS Method for Indirubin-3′-Oxime Derivative as a Novel FLT3 Inhibitor and Pharmacokinetic Study in Rats
Na Yoon Kim, Yong-Chul Kim, Yoon Gyoon Kim
Molecules. 2020 May; 25(9): 2039. Published online 2020 Apr 27. doi: 10.3390/molecules25092039
PMCID:
PMC7248905
AbstractArticlePDF–1.5M
6.
Protocol development for discovery of angiogenesis inhibitors via automated methods using zebrafish
Antonio Mauro, Robin Ng, Jamie Yuanjun Li, Rui Guan, Youdong Wang, Krishna Kumar Singh, Xiao-Yan Wen
PLoS One. 2019; 14(11): e0221796. Published online 2019 Nov 15. doi: 10.1371/journal.pone.0221796
PMCID:
PMC6857904
AbstractArticlePDF–1.6M
7.
Indirubin-3′-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway
Sehee Choi, Pu-Hyeon Cha, Hyun-Yi Kim, Kang-Yell Choi
Exp Mol Med. 2019 Sep; 51(9): 104. Published online 2019 Sep 12. doi: 10.1038/s12276-019-0306-3
PMCID:
PMC6802626
AbstractArticlePDF–1.6M
8.
Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations
Cécile Otten, Jessica Knox, Gwénola Boulday, Mathias Eymery, Marta Haniszewski, Martin Neuenschwander, Silke Radetzki, Ingo Vogt, Kristina Hähn, Coralie De Luca, Cécile Cardoso, Sabri Hamad, Carla Igual Gil, Peter Roy, Corinne Albiges‐Rizo, Eva Faurobert, Jens P von Kries, Mónica Campillos, Elisabeth Tournier‐Lasserve, W Brent Derry, Salim Abdelilah‐Seyfried
EMBO Mol Med. 2018 Oct; 10(10): e9155. Published online 2018 Sep 4. doi: 10.15252/emmm.201809155
PMCID:
PMC6180302
AbstractArticlePDF–2.0M
9.
Targeting of CDK9 with indirubin 3’-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice
Sandra Medina-Moreno, Thomas C. Dowling, Juan C. Zapata, Nhut M. Le, Edward Sausville, Joseph Bryant, Robert R. Redfield, Alonso Heredia
PLoS One. 2017; 12(8): e0183425. Published online 2017 Aug 17. doi: 10.1371/journal.pone.0183425
PMCID:
PMC5560554
AbstractArticlePDF–945K
10.
Computational Drug Target Screening through Protein Interaction Profiles
Santiago Vilar, Elías Quezada, Eugenio Uriarte, Stefano Costanzi, Fernanda Borges, Dolores Viña, George Hripcsak
Sci Rep. 2016; 6: 36969. Published online 2016 Nov 15. doi: 10.1038/srep36969
PMCID:
PMC5109486
AbstractArticlePDF–1.8M
11.
Increased aerobic glycolysis is important for the motility of activated VSMC and inhibited by indirubin-3'-monoxime
Elke H. Heiss, Daniel Schachner, Maddalena Donati, Christoph S. Grojer, Verena M. Dirsch
Vascul Pharmacol. Author manuscript; available in PMC 2016 Aug 1.
Published in final edited form as: Vascul Pharmacol. 2016 Aug; 83: 47–56. Published online 2016 May 14. doi: 10.1016/j.vph.2016.05.002
PMCID:
PMC4939873
AbstractArticlePDF–1.9M
12.
An Application of a Hill-based Response Surface Model for a Drug Combination Experiment on Lung Cancer
Shaoyang Ning, Hongquan Xu, Ibrahim Al-Shyoukh, Jiaying Feng, Ren Sun
Stat Med. Author manuscript; available in PMC 2015 Oct 30.
Published in final edited form as: Stat Med. 2014 Oct 30; 33(24): 4227–4236. Published online 2014 Jun 18. doi: 10.1002/sim.6229
PMCID:
PMC4230824
AbstractArticlePDF–1.2M
13.
The small molecule indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity
O M Choi, Y-H Cho, S Choi, S-H Lee, S H Seo, H-Y Kim, G Han, D S Min, T Park, K Y Choi
Int J Obes (Lond) 2014 Aug; 38(8): 1044–1052. Prepublished online 2013 Nov 15. Published online 2013 Dec 10. doi: 10.1038/ijo.2013.209
PMCID:
PMC4125748
AbstractArticlePDF–4.1M
14.
Indirubin 3′-Monoxime, from a Chinese Traditional Herbal Formula, Suppresses Viremia in Humanized Mice Infected with Multidrug-Resistant HIV
Alonso Heredia, Senthilkumar Natesan, Nhut M. Le, Sandra Medina-Moreno, Juan C. Zapata, Marvin Reitz, Joseph Bryant, Robert R. Redfield
AIDS Res Hum Retroviruses. 2014 May 1; 30(5): 403–406. doi: 10.1089/aid.2013.0249
PMCID:
PMC4010160
ArticlePDF–167K
15.
Indirubin-3′-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration
Tina Blažević, Anja M. Schaible, Katharina Weinhäupl, Daniel Schachner, Felix Nikels, Christina Weinigel, Dagmar Barz, Atanas G. Atanasov, Carlo Pergola, Oliver Werz, Verena M. Dirsch, Elke H. Heiss
Cardiovasc Res. 2014 Mar 1; 101(3): 522–532. Published online 2013 Dec 23. doi: 10.1093/cvr/cvt339
PMCID:
PMC3928003
AbstractArticlePDF–690K
16.
12/15-Lipoxygenase Contributes to Platelet-derived Growth Factor-induced Activation of Signal Transducer and Activator of Transcription 3
Tina Blažević, Andrea V. Schwaiberger, Cornelia E. Schreiner, Daniel Schachner, Anja M. Schaible, Christoph S. Grojer, Atanas G. Atanasov, Oliver Werz, Verena M. Dirsch, Elke H. Heiss
J Biol Chem. 2013 Dec 6; 288(49): 35592–35603. Published online 2013 Oct 28. doi: 10.1074/jbc.M113.489013
PMCID:
PMC3853304
AbstractArticlePDF–2.2M
17.
Gsk-3 β Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats
Luisa F. González Arbeláez, Ignacio A. Pérez Núñez, Susana M. Mosca
Biomed Res Int. 2013; 2013: 317456. Published online 2013 Oct 30. doi: 10.1155/2013/317456
PMCID:
PMC3830772
AbstractArticlePDF–3.1M
18.
An Indirubin Derivative, Indirubin-3′-Monoxime Suppresses Oral Cancer Tumorigenesis through the Downregulation of Survivin
Wan-Yu Lo, Nai-Wen Chang
PLoS One. 2013; 8(8): e70198. Published online 2013 Aug 13. doi: 10.1371/journal.pone.0070198
PMCID:
PMC3742732
AbstractArticlePDF–1.6M
19.
Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors
Kylene Kehn-Hall, Irene Guendel, Lawrence Carpio, Leandros Skaltsounis, Laurent Meijer, Lena Al-Harthi, Joseph P. Steiner, Avindra Nath, Olaf Kutsch, Fatah Kashanchi
Virology. Author manuscript; available in PMC 2013 Jun 10.
Published in final edited form as: Virology. 2011 Jun 20; 415(1): 56–68. Published online 2011 Apr 22. doi: 10.1016/j.virol.2011.03.025
PMCID:
PMC3677548
AbstractArticlePDF–949K
20.
The Nontoxic Cell Cycle Modulator Indirubin Augments Transduction of Adeno-Associated Viral Vectors and Zinc-Finger Nuclease-Mediated Gene Targeting
Shamim H. Rahman, Sylwia Bobis-Wozowicz, Debanjana Chatterjee, Katharina Gellhaus, Kaweh Pars, Regine Heilbronn, Roland Jacobs, Toni Cathomen
Hum Gene Ther. 2013 Jan; 24(1): 67–77. Published online 2012 Oct 16. doi: 10.1089/hum.2012.168
PMCID:
PMC3555098
AbstractArticlePDF–525K

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