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Select item 87948331.

CMG helicase can use ATPγS to unwind DNA: Implications for the rate-limiting step in the reaction mechanism

Nina Y. Yao, Dan Zhang, Olga Yurieva, Michael E. O’Donnell

Proc Natl Acad Sci U S A. 2022 Jan 25; 119(4): e2119580119. Published online 2022 Jan 18. doi: 10.1073/pnas.2119580119

PMCID:: PMC8794833

Abstract Article PDF–1.1M

Select item 84288002.

Structure of an AMPK complex in an inactive, ATP-bound state

Yan Yan, Somnath Mukherjee, Kaleeckal G. Harikumar, Timothy S. Strutzenberg, X. Edward Zhou, Kelly Suino-Powell, Ting-Hai Xu, Ryan D. Sheldon, Jared Lamp, Joseph S. Brunzelle, Katarzyna Radziwon, Abigail Ellis, Scott J. Novick, Irving E. Vega, Russell G. Jones, Laurence J. Miller, H. Eric Xu, Patrick R. Griffin, Anthony A. Kossiakoff, Karsten Melcher

Science. Author manuscript; available in PMC 2021 Sep 9.

Published in final edited form as: Science. 2021 Jul 23; 373(6553): 413–419. doi: 10.1126/science.abe7565

PMCID:: PMC8428800

Abstract Article PDF–1.7M

Select item 82204203.

Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2

Eva Absmeier, Karen Vester, Tahereh Ghane, Dmitry Burakovskiy, Pohl Milon, Petra Imhof, Marina V. Rodnina, Karine F. Santos, Markus C. Wahl

J Biol Chem. 2021 Jul; 297(1): 100829. Published online 2021 May 26. doi: 10.1016/j.jbc.2021.100829

PMCID:: PMC8220420

Abstract Article PDF–5.0M

Select item 77857364.

Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative

Man Pan, Qingyun Zheng, Yuanyuan Yu, Huasong Ai, Yuan Xie, Xin Zeng, Chu Wang, Lei Liu, Minglei Zhao

Nat Commun. 2021; 12: 121. Published online 2021 Jan 5. doi: 10.1038/s41467-020-20359-x

PMCID:: PMC7785736

Abstract Article PDF–2.0M

Select item 77770865.

Pyridoxal kinase inhibition by artemisinins down-regulates inhibitory neurotransmission

Vikram Babu Kasaragod, Anabel Pacios-Michelena, Natascha Schaefer, Fang Zheng, Nicole Bader, Christian Alzheimer, Carmen Villmann, Hermann Schindelin

Proc Natl Acad Sci U S A. 2020 Dec 29; 117(52): 33235–33245. Published online 2020 Dec 14. doi: 10.1073/pnas.2008695117

PMCID:: PMC7777086

Abstract Article PDF–4.0M

Select item 77623136.

Degradation of Intrinsically Disordered Proteins by the NADH 26S Proteasome

Peter Tsvetkov, Nadav Myers, Julia Adler, Yosef Shaul

Biomolecules. 2020 Dec; 10(12): 1642. Published online 2020 Dec 7. doi: 10.3390/biom10121642

PMCID:: PMC7762313

Abstract Article PDF–1.7M

Select item 77367917.

The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA⁺ machine that can switch between oligomeric states

Vishaka Santosh, Faik N Musayev, Rahul Jaiswal, Francisco Zárate-Pérez, Bram Vandewinkel, Caroline Dierckx, Molly Endicott, Kamyar Sharifi, Kelly Dryden, Els Henckaerts, Carlos R Escalante

Nucleic Acids Res. 2020 Dec 16; 48(22): 12983–12999. Published online 2020 Dec 3. doi: 10.1093/nar/gkaa1133

PMCID:: PMC7736791

Abstract Article PDF–8.6M

Select item 76724768.

Structural basis of Mfd-dependent transcription termination

Jing Shi, Aijia Wen, Minxing Zhao, Sha Jin, Linlin You, Yue Shi, Shuling Dong, Xiaoting Hua, Yu Zhang, Yu Feng

Nucleic Acids Res. 2020 Nov 18; 48(20): 11762–11772. Published online 2020 Oct 17. doi: 10.1093/nar/gkaa904

PMCID:: PMC7672476

Abstract Article PDF–6.2M

Select item 75817719.

Adenosine and ATPγS protect against bacterial pneumonia-induced acute lung injury

Christine M. Gross, Anita Kovacs-Kasa, Mary Louise Meadows, Mary Cherian-Shaw, David J. Fulton, Alexander D. Verin

Sci Rep. 2020; 10: 18078. Published online 2020 Oct 22. doi: 10.1038/s41598-020-75224-0

PMCID:: PMC7581771

Abstract Article PDF–1.7M

Select item 755293610.

Differential Effects of Intra- and Extravascular ATP on the Diameter of Porcine Vessels at Different Branching Levels Ex Vivo

Charlotte Ernst, Peter Skov Jensen, Christian Aalkjaer, Toke Bek

Invest Ophthalmol Vis Sci. 2020 Oct; 61(12): 8. Published online 2020 Oct 9. doi: 10.1167/iovs.61.12.8

PMCID:: PMC7552936

Abstract Article PDF–1.1M

Select item 752914811.

Conformational Plasticity of the ClpAP AAA+ Protease Couples Protein Unfolding and Proteolysis

Kyle E. Lopez, Alexandrea N. Rizo, Eric Tse, JiaBei Lin, Nathaniel W. Scull, Aye C. Thwin, Aaron L. Lucius, James Shorter, Daniel R. Southworth

Nat Struct Mol Biol. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Nat Struct Mol Biol. 2020 May; 27(5): 406–416. Published online 2020 Apr 20. doi: 10.1038/s41594-020-0409-5

PMCID:: PMC7529148

Abstract Article PDF–3.1M

Select item 735216512.

Extracellular Adenine Nucleotides and Adenosine Modulate the Growth and Survival of THP-1 Leukemia Cells

Kamila Puchałowicz, Maciej Tarnowski, Marta Tkacz, Dariusz Chlubek, Patrycja Kłos, Violetta Dziedziejko

Int J Mol Sci. 2020 Jun; 21(12): 4425. Published online 2020 Jun 22. doi: 10.3390/ijms21124425

PMCID:: PMC7352165

Abstract Article PDF–1.7M

Select item 733793713.

CryoEM structures of human CMG–ATPγS–DNA and CMG–AND-1 complexes

Neil J Rzechorzek, Steven W Hardwick, Vincentius A Jatikusumo, Dimitri Y Chirgadze, Luca Pellegrini

Nucleic Acids Res. 2020 Jul 9; 48(12): 6980–6995. Published online 2020 May 26. doi: 10.1093/nar/gkaa429

PMCID:: PMC7337937

Abstract Article PDF–11M

Select item 727396814.

Differential mechanisms of adenosine- and ATPγS-induced microvascular endothelial barrier strengthening

Róbert Bátori, Sanjiv Kumar, Zsuzsanna Bordán, Mary Cherian-Shaw, Anita Kovács-Kása, Justin A. MacDonald, David J. R. Fulton, Ferenc Erdődi, Alexander D. Verin

J Cell Physiol. Author manuscript; available in PMC 2020 Jun 5.

Published in final edited form as: J Cell Physiol. 2019 May; 234(5): 5863–5879. Published online 2018 Dec 17. doi: 10.1002/jcp.26419

PMCID:: PMC7273968

Abstract Article PDF–5.5M

Select item 721421815.

Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells

Wojciech Michowski, Joel M. Chick, Chen Chu, Aleksandra Kolodziejczyk, Yichen Wang, Jan M. Suski, Brian Abraham, Lars Anders, Daniel Day, Lukas M. Dunkl, Mitchell Li Cheong Man, Tian Zhang, Phatthamon Laphanuwat, Nickolas A. Bacon, Lijun Liu, Anne Fassl, Samanta Sharma, Tobias Otto, Emanuelle Jecrois, Richard Han, Katharine E. Sweeney, Samuele Marro, Marius Wernig, Yan Geng, Alan Moses, Cheng Li, Steven P. Gygi, Richard A. Young, Piotr Sicinski

Mol Cell. Author manuscript; available in PMC 2021 May 7.

Published in final edited form as: Mol Cell. 2020 May 7; 78(3): 459–476.e13. Published online 2020 Apr 1. doi: 10.1016/j.molcel.2020.03.010

PMCID:: PMC7214218

Abstract Article PDF–2.8M

Select item 710084716.

The structure of the cohesin ATPase elucidates the mechanism of SMC–kleisin ring opening

Kyle W. Muir, Yan Li, Felix Weis, Daniel Panne

Nat Struct Mol Biol. Author manuscript; available in PMC 2020 Aug 17.

Published in final edited form as: Nat Struct Mol Biol. 2020 Mar; 27(3): 233–239. Published online 2020 Feb 17. doi: 10.1038/s41594-020-0379-7

PMCID:: PMC7100847

Abstract Article PDF–3.4M

Select item 700838217.

Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting

Elizabeth A. Sweeny, Amber Tariq, Esin Gurpinar, Michelle S. Go, Matthew A. Sochor, Zhong-Yuan Kan, Leland Mayne, S. Walter Englander, James Shorter

J Biol Chem. 2020 Feb 7; 295(6): 1517–1538. Published online 2019 Dec 27. doi: 10.1074/jbc.RA119.011577

PMCID:: PMC7008382

Abstract Article PDF–5.1M

Select item 694618418.

2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

Soojay Banerjee, Alberto Bartesaghi, Alan Merk, Prashant Rao, Stacie L. Bulfer, Yongzhao Yan, Neal Green, Barbara Mroczkowski, R. Jeffrey Neitz, Peter Wipf, Veronica Falconieri, Raymond J. Deshaies, Jacqueline L. S. Milne, Donna Huryn, Michelle Arkin, Sriram Subramaniam

Science. Author manuscript; available in PMC 2020 Jan 7.

Published in final edited form as: Science. 2016 Feb 19; 351(6275): 871–875. Published online 2016 Jan 28. doi: 10.1126/science.aad7974

PMCID:: PMC6946184

Abstract Article PDF–2.4M

Select item 677318719.

Intracellular ATP Increases Capsaicin-Activated Channel Activity by Interacting with Nucleotide-Binding Domains

Jiyeon Kwak, Myeong Hyeon Wang, Sun Wook Hwang, Tae-Yoon Kim, Soon-Youl Lee, Uhtaek Oh

J Neurosci. 2000 Nov 15; 20(22): 8298–8304. doi: 10.1523/JNEUROSCI.20-22-08298.2000

PMCID:: PMC6773187

Abstract Article PDF–239K

Select item 677250620.

Presynaptic P2X Receptors Facilitate Inhibitory GABAergic Transmission between Cultured Rat Spinal Cord Dorsal Horn Neurons

Sylvain Hugel, Rémy Schlichter

J Neurosci. 2000 Mar 15; 20(6): 2121–2130. doi: 10.1523/JNEUROSCI.20-06-02121.2000

PMCID:: PMC6772506

Abstract Article PDF–175K

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