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Select item 111639621.

Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B cell acute lymphoblastic leukemia

Zhenhua Chen, Keren Zhou, Jianhuang Xue, Andrew Small, Gang Xiao, Le Xuan Truong Nguyen, Zheng Zhang, Emily Prince, Hengyou Weng, Huilin Huang, Zhicong Zhao, Ying Qing, Chao Shen, Wei Li, Li Han, Brandon Tan, Rui Su, Hanjun Qin, Yangchan Li, Dong Wu, Zhaohui Gu, Vu N. Ngo, Xin He, Jianfei Chao, Keith Leung, Kitty Wang, Lei Dong, Xi Qin, Zhenming Cai, Yue Sheng, Yu Chen, Xiwei Wu, Bin Zhang, Yanhong Shi, Guido Marcucci, Zhijian Qian, Mingjiang Xu, Markus Müschen, Jianjun Chen, Xiaolan Deng

Sci Transl Med. Author manuscript; available in PMC 2024 Jun 10.

Published in final edited form as: Sci Transl Med. 2023 Mar 29; 15(689): eabq8513. Published online 2023 Mar 29. doi: 10.1126/scitranslmed.abq8513

PMCID:: PMC11163962

Abstract Article PDF–3.0M

Select item 111590832.

Mutations in the mitochondrial genome confer resistance of cancer cells to anticancer drugs

Satoshi Mizutani, Yasuyuki Miyato, Yujiro Shidara, Sadamitsu Asoh, Akira Tokunaga, Takashi Tajiri, Shigeo Ohta

Cancer Sci. 2009 Sep; 100(9): 1680–1687. Published online 2009 Jun 1. doi: 10.1111/j.1349-7006.2009.01238.x

PMCID:: PMC11159083

Abstract Article PDF–7.1M

Select item 111314623.

Differential insult-dependent recruitment of the intrinsic mitochondrial pathway during neuronal programmed cell death

S. Diwakarla, P. Nagley, M. L. R. Hughes, B. Chen, P. M. Beart

Cell Mol Life Sci. 2009 Jan; 66(1): 156. Published online 2008 Nov 8. doi: 10.1007/s00018-008-8490-7

PMCID:: PMC11131462

Abstract Article PDF–4.8M

Select item 111158114.

Optic atrophy 3 as a protein of the mitochondrial outer membrane induces mitochondrial fragmentation

Seung-Wook Ryu, Hyeon Joo Jeong, Myunghwan Choi, Mariusz Karbowski, Chulhee Choi

Cell Mol Life Sci. 2010 Aug; 67(16): 2839–2850. Published online 2010 Apr 8. doi: 10.1007/s00018-010-0365-z

PMCID:: PMC11115811

Abstract Article PDF–1.1M

Select item 111155795.

Oxidative stress triggers neuronal caspase-independent death: Endonuclease G involvement in programmed cell death-type III

Gavin C. Higgins, Philip M. Beart, Phillip Nagley

Cell Mol Life Sci. 2009 Aug; 66(16): 2773–2787. Published online 2009 Jul 7. doi: 10.1007/s00018-009-0079-2

PMCID:: PMC11115579

Abstract Article PDF–668K

Select item 111151406.

Autophagic activity in cortical neurons under acute oxidative stress directly contributes to cell death

Gavin C. Higgins, Rodney J. Devenish, Philip M. Beart, Phillip Nagley

Cell Mol Life Sci. 2011 Nov; 68(22): 3725–3740. Published online 2011 Mar 25. doi: 10.1007/s00018-011-0667-9

PMCID:: PMC11115140

Abstract Article PDF–2.2M

Select item 111076477.

Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer’s disease

Narendran Annadurai, Khushboo Agrawal, Petr Džubák, Marián Hajdúch, Viswanath Das

Cell Mol Life Sci. 2017 Nov; 74(22): 4159–4169. Published online 2017 Jun 20. doi: 10.1007/s00018-017-2574-1

PMCID:: PMC11107647

Abstract Article PDF–779K

Select item 110378478.

Inhibitory effects of tamoxifen and tumor necrosis factor α on human glioblastoma cells

Koichi Iwasaki, Steven A. Toms, Gene H. Barnett, Melinda L. Estes, Manjula K. Gupta, Barbara P. Barna

Cancer Immunol Immunother. 1995 Jul; 40(4): 228–234. doi: 10.1007/BF01519896

PMCID:: PMC11037847

Abstract Article PDF–862K

Select item 110341129.

Interleukin-4 protects retinal ganglion cells and promotes axon regeneration

Zhaoyang Zuo, Bin Fan, Ziyuan Zhang, Yang Liang, Jing Chi, Guangyu Li

Cell Commun Signal. 2024; 22: 236. Published online 2024 Apr 22. doi: 10.1186/s12964-024-01604-y

PMCID:: PMC11034112

Abstract Article PDF–15M

Select item 1095248210.

Generation of streptocarbazoles with cytotoxicities by pathway engineering and insights into their biosynthesis

Fei Xiao, Mingyuan Xu, Yongmeng Cheng, Tong Li, Kui Hong, Wenli Li

Appl Environ Microbiol. 2024 Mar; 90(3): e02187-23. Published online 2024 Feb 2. doi: 10.1128/aem.02187-23

PMCID:: PMC10952482

Abstract Article PDF–2.1M

Select item 1084831411.

Overexpression of fibroblast growth factor-21 (FGF-21) protects mesenchymal stem cells against caspase-dependent apoptosis induced by oxidative stress and inflammation

Gabriel R. Linares, Yan Leng, Dragan Maric, De-Maw Chuang

Cell Biol Int. Author manuscript; available in PMC 2024 Feb 7.

Published in final edited form as: Cell Biol Int. 2020 Oct; 44(10): 2163–2169. Published online 2020 Jul 21. doi: 10.1002/cbin.11409

PMCID:: PMC10848314

Abstract Article PDF–1011K

Select item 1082096912.

The Inhibition Effect and Mechanism of Staurosporine Isolated from Streptomyces sp. SNC087 Strain on Nasal Polyp

Grace Choi, Eun-Young Lee, Dawoon Chung, Kichul Cho, Woon-Jong Yu, Sang-Jip Nam, Seong-Kook Park, Il-Whan Choi

Mar Drugs. 2024 Jan; 22(1): 39. Published online 2024 Jan 11. doi: 10.3390/md22010039

PMCID:: PMC10820969

Abstract Article PDF–1.9M

Select item 1071796813.

β-Phorbol ester-induced enhancement of exocytosis in large mossy fiber boutons of mouse hippocampus

Takuya Hikima, Rikita Araki, Toru Ishizuka, Hiromu Yawo

J Physiol Sci. 2009 Jul; 59(4): 263–274. Published online 2009 Mar 20. doi: 10.1007/s12576-009-0031-0

PMCID:: PMC10717968

Abstract Article PDF–482K

Select item 1069090914.

Efficacy and toxicity of midostaurin with idarubicin and cytarabine induction in FLT3-mutated acute myeloid leukemia

Julia S. Lee, Charlotte B. Wagner, Stacy Prelewicz, Heena P. Kurish, Robert Walchack, Danielle A. Cenin, Seema Patel, Mimi Lo, Danielle Schlafer, Belinda K. T. Li, R. Donald Harvey III, Bestis Wasef, Jian Ying, Tibor Kovacsovics

Haematologica. 2023 Dec 1; 108(12): 3460–3463. Published online 2023 Jun 22. doi: 10.3324/haematol.2022.281967

PMCID:: PMC10690909

Article PDF–2.2M

Select item 1063265815.

Midostaurin plus daunorubicin or idarubicin for young and older adults with FLT3-mutated AML: a phase 3b trial

Jorge Sierra, Pau Montesinos, Xavier Thomas, Laimonas Griskevicius, Thomas Cluzeau, Denis Caillot, Ollivier Legrand, Clara Minotti, Mario Luppi, Firas Farkas, Bourras-Rezki Bengoudifa, Geralyn Gilotti, Sejla Hodzic, Alessandro Rambaldi, Adriano Venditti

Blood Adv. 2023 Nov 14; 7(21): 6441–6450. Published online 2023 Aug 17. doi: 10.1182/bloodadvances.2023009847

PMCID:: PMC10632658

Abstract Article PDF–661K

Select item 1056488316.

Pyruvate kinase M2 regulates mitochondrial homeostasis in cisplatin-induced acute kidney injury

Wenjia Xie, Qingyun He, Yan Zhang, Xinxin Xu, Ping Wen, Hongdi Cao, Yang Zhou, Jing Luo, Junwei Yang, Lei Jiang

Cell Death Dis. 2023 Oct; 14(10): 663. Published online 2023 Oct 10. doi: 10.1038/s41419-023-06195-z

PMCID:: PMC10564883

Abstract Article PDF–4.2M

Select item 1054283217.

Gemtuzumab ozogamicin plus midostaurin in conjunction with standard intensive therapy for FLT3-mutated acute myeloid leukemia patients – Czech center experience

Barbora Weinbergerová, Martin Čerňan, Tomáš Kabut, Lukáš Semerád, Natália Podstavková, Tomáš Szotkowski, Ivana Ježíšková, Jirí Mayer

Haematologica. 2023 Oct 1; 108(10): 2826–2829. Published online 2023 Feb 23. doi: 10.3324/haematol.2022.282263

PMCID:: PMC10542832

Article PDF–1.3M

Select item 1053189118.

Enhanced Efficiency of the Basal and Induced Apoptosis Process in Mucopolysaccharidosis IVA and IVB Human Fibroblasts

Joanna Brokowska, Lidia Gaffke, Karolina Pierzynowska, Grzegorz Węgrzyn

Int J Mol Sci. 2023 Sep; 24(18): 14119. Published online 2023 Sep 14. doi: 10.3390/ijms241814119

PMCID:: PMC10531891

Abstract Article PDF–1020K

Select item 1049267619.

Treatment with midostaurin and other FLT3 targeting inhibitors is associated with an increased risk of cardiovascular adverse events in patients who underwent allogeneic hematopoietic stem cell transplantation with FLT3-mutated AML

Anjali Cremer, Julius C. Enssle, Saskia Pfaff, Khouloud Kouidri, Fabian Lang, Christian Brandts, Andreas Zeiher, Sebastian Cremer, Björn Steffen, Hubert Serve, Gesine Bug

Ann Hematol. 2023; 102(10): 2903–2908. Published online 2023 Aug 8. doi: 10.1007/s00277-023-05396-y

PMCID:: PMC10492676

Abstract Article PDF–592K

Select item 1048334320.

Midostaurin in addition to intensive chemotherapy in acute myeloid leukemia with t(8;21) and KIT and/or FLT3-ITD mutations: results of the SAL MIDOKIT trial

Leo Ruhnke, Christoph Röllig, Sylvia Herold, Tim Sauer, Christian H. Brandts, Björn Steffen, Kerstin Schäfer-Eckart, Stefan W. Krause, Mathias Hänel, Albrecht Reichle, Sebastian Scholl, Andreas Neubauer, Jan-Henrik Mikesch, Johannes Schetelig, Friedrich Stölzel, Michael Kramer, Annett Haake, Julia Frimmel, Alwin Krämer, Richard Schlenk, Uwe Platzbecker, Hubert Serve, Claudia D. Baldus, Carsten Müller-Tidow, Daniela Aust, Martin Bornhäuser, Gerhard Ehninger, Christian Thiede

Haematologica. 2023 Sep 1; 108(9): 2520–2525. Published online 2023 Feb 9. doi: 10.3324/haematol.2022.281636

PMCID:: PMC10483343

Article PDF–659K

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