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Select item 112413311.

Effect of mTORC Agonism via MHY1485 with and without Rapamycin on C2C12 Myotube Metabolism

Norah E. Cook, Macey R. McGovern, Toheed Zaman, Pamela M. Lundin, Roger A. Vaughan

Int J Mol Sci. 2024 Jul; 25(13): 6819. Published online 2024 Jun 21. doi: 10.3390/ijms25136819

PMCID:: PMC11241331

Abstract Article PDF–2.3M

Select item 84485412.

Targeting the mTOR pathway using novel ATP-competitive inhibitors, Torin1, Torin2 and XL388, in the treatment of glioblastoma

Anubhav G. Amin, Seung Won Jeong, John L. Gillick, Tolga Sursal, Raj Murali, Chirag D. Gandhi, Meena Jhanwar-Uniyal

Int J Oncol. 2021 Oct; 59(4): 83. Published online 2021 Sep 14. doi: 10.3892/ijo.2021.5263

PMCID:: PMC8448541

Abstract Article PDF–825K

Select item 83636473.

The pathogenesis of mesothelioma is driven by a dysregulated translatome

Stefano Grosso, Alberto Marini, Katarina Gyuraszova, Johan Vande Voorde, Aristeidis Sfakianos, Gavin D. Garland, Angela Rubio Tenor, Ryan Mordue, Tanya Chernova, Nobu Morone, Marco Sereno, Claire P. Smith, Leah Officer, Pooyeh Farahmand, Claire Rooney, David Sumpton, Madhumita Das, Ana Teodósio, Catherine Ficken, Maria Guerra Martin, Ruth V. Spriggs, Xiao-Ming Sun, Martin Bushell, Owen J. Sansom, Daniel Murphy, Marion MacFarlane, John P. C. Le Quesne, Anne E. Willis

Nat Commun. 2021; 12: 4920. Published online 2021 Aug 13. doi: 10.1038/s41467-021-25173-7

PMCID:: PMC8363647

Abstract Article PDF–3.0M

Select item 82827924.

Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway

Lin Xu, Xinge Zhang, Yue Xin, Jie Ma, Chenyan Yang, Xi Zhang, Guoqing Hou, Xiaocheng Charlie Dong, Zhaoli Sun, Xiwen Xiong, Xuan Cao

Cell Death Dis. 2021 Jul; 12(7): 710. Published online 2021 Jul 15. doi: 10.1038/s41419-021-03980-6

PMCID:: PMC8282792

Abstract Article PDF–5.1M

Select item 81367815.

eIF4E3 forms an active eIF4F complex during stresses (eIF4F^S) targeting mTOR and re-programs the translatome

Benjamin Weiss, George Edward Allen, Joachim Kloehn, Karim Abid, Pascale Jaquier-Gubler, Joseph Alphonsus Curran

Nucleic Acids Res. 2021 May 21; 49(9): 5159–5176. Published online 2021 Apr 24. doi: 10.1093/nar/gkab267

PMCID:: PMC8136781

Abstract Article PDF–6.2M

Select item 80645646.

Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer

Evelyn M. Mrozek, Vineeta Bajaj, Yanan Guo, Izabela A. Malinowska, Jianming Zhang, David J. Kwiatkowski

PLoS One. 2021; 16(4): e0248380. Published online 2021 Apr 23. doi: 10.1371/journal.pone.0248380

PMCID:: PMC8064564

Abstract Article PDF–4.3M

Select item 80346187.

mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1

Jian-Jun Jia, Roni M Lahr, Michael T Solgaard, Bruno J Moraes, Roberta Pointet, An-Dao Yang, Giovanna Celucci, Tyson E Graber, Huy-Dung Hoang, Marius R Niklaus, Izabella A Pena, Anne K Hollensen, Ewan M Smith, Malik Chaker-Margot, Leonie Anton, Christopher Dajadian, Mark Livingstone, Jaclyn Hearnden, Xu-Dong Wang, Yonghao Yu, Timm Maier, Christian K Damgaard, Andrea J Berman, Tommy Alain, Bruno D Fonseca

Nucleic Acids Res. 2021 Apr 6; 49(6): 3461–3489. Published online 2021 Jan 4. doi: 10.1093/nar/gkaa1239

PMCID:: PMC8034618

Abstract Article PDF–5.0M

Select item 79595048.

MNK2 governs the macrophage antiinflammatory phenotype

Margarita Bartish, Dongmei Tong, Yangxun Pan, Majken Wallerius, Hui Liu, Johannes Ristau, Sabrina de Souza Ferreira, Tatjana Wallmann, Vincent van Hoef, Laia Masvidal, Thomas Kerzel, Anne-Laure Joly, Christophe Goncalves, Samuel E. J. Preston, Talin Ebrahimian, Christina Seitz, Jonas Bergh, Kristian Pietras, Stephanie Lehoux, Luigi Naldini, John Andersson, Mario Leonardo Squadrito, Sonia V. del Rincón, Ola Larsson, Charlotte Rolny

Proc Natl Acad Sci U S A. 2020 Nov 3; 117(44): 27556–27565. Published online 2020 Oct 19. doi: 10.1073/pnas.1920377117

PMCID:: PMC7959504

Abstract Article PDF–3.8M

Select item 79104499.

CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129

Zhanqin Zhang, Hongtao Zhu, Jianguo Hu

Cell Death Dis. 2021 Feb; 12(2): 219. Published online 2021 Feb 26. doi: 10.1038/s41419-021-03486-1

PMCID:: PMC7910449

Abstract Article PDF–3.5M

Select item 779707310.

The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction

Ewan M Smith, Nour El Houda Benbahouche, Katherine Morris, Ania Wilczynska, Sarah Gillen, Tobias Schmidt, Hedda A Meijer, Rebekah Jukes-Jones, Kelvin Cain, Carolyn Jones, Mark Stoneley, Joseph A Waldron, Cameron Bell, Bruno D Fonseca, Sarah Blagden, Anne E Willis, Martin Bushell

Nucleic Acids Res. 2021 Jan 11; 49(1): 458–478. Published online 2020 Dec 17. doi: 10.1093/nar/gkaa1189

PMCID:: PMC7797073

Abstract Article PDF–4.2M

Select item 773896811.

Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells

Rebecca Waetzig, Marie Matthes, Johannes Leister, Gina Penkivech, Tilman Heise, Selim Corbacioglu, Gunhild Sommer

Int J Med Sci. 2021; 18(1): 137–149. Published online 2021 Jan 1. doi: 10.7150/ijms.48393

PMCID:: PMC7738968

Abstract Article PDF–1.3M

Select item 754420012.

eIF4G-driven translation initiation of downstream ORFs in mammalian cells

Risa Nobuta, Kodai Machida, Misaki Sato, Satoshi Hashimoto, Yasuhito Toriumi, Shizuka Nakajima, Daiki Suto, Hiroaki Imataka, Toshifumi Inada

Nucleic Acids Res. 2020 Oct 9; 48(18): 10441–10455. Published online 2020 Sep 17. doi: 10.1093/nar/gkaa728

PMCID:: PMC7544200

Abstract Article PDF–4.8M

Select item 713875013.

IRF-1 mediates the suppressive effects of mTOR inhibition on arterial endothelium

Kai Peng, Xing Fan, Qiannan Li, Yiying Wang, Xiaolin Chen, Pingxi Xiao, Anthony G. Passerini, Scott I. Simon, ChongXiu Sun

J Mol Cell Cardiol. Author manuscript; available in PMC 2021 Mar 1.

Published in final edited form as: J Mol Cell Cardiol. 2020 Mar; 140: 30–41. Published online 2020 Feb 19. doi: 10.1016/j.yjmcc.2020.02.006

PMCID:: PMC7138750

Abstract Article PDF–5.4M

Select item 706865314.

The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1

María Rodríguez-López, Suam Gonzalez, Olivia Hillson, Edward Tunnacliffe, Sandra Codlin, Victor A. Tallada, Jürg Bähler, Charalampos Rallis

Cell Rep. 2020 Mar 10; 30(10): 3240–3249.e4. Published online 2020 Mar 10. doi: 10.1016/j.celrep.2020.02.058

PMCID:: PMC7068653

Abstract Article

Select item 702895415.

Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models

Xu-Xu Zhuang, Sheng-Fang Wang, Yuan Tan, Ju-Xian Song, Zhou Zhu, Zi-Ying Wang, Ming-Yue Wu, Cui-Zan Cai, Zhi-Jian Huang, Jie-Qiong Tan, Huan-Xing Su, Min Li, Jia-Hong Lu

Cell Death Dis. 2020 Feb; 11(2): 128. Published online 2020 Feb 18. doi: 10.1038/s41419-020-2322-6

PMCID:: PMC7028954

Abstract Article PDF–7.2M

Select item 700974016.

Inhibition of mTOR signaling enhances maturation of cardiomyocytes derived from human induced pluripotent stem cells via p53-induced quiescence

Jessica C. Garbern, Aharon Helman, Rebecca Sereda, Mohsen Sarikhani, Aishah Ahmed, Gabriela O. Escalante, Roza Ogurlu, Sean L. Kim, John F. Zimmerman, Alexander Cho, Luke MacQueen, Vassilios J. Bezzerides, Kevin Kit Parker, Douglas A. Melton, Richard T. Lee

Circulation. Author manuscript; available in PMC 2021 Jan 28.

Published in final edited form as: Circulation. 2020 Jan 28; 141(4): 285–300. Published online 2019 Nov 11. doi: 10.1161/CIRCULATIONAHA.119.044205

PMCID:: PMC7009740

Abstract Article PDF–2.1M

Select item 700382317.

Merkel cell polyomavirus oncoproteins induce microRNAs that suppress multiple autophagy genes

Satendra Kumar, Hong Xie, Hao Shi, Jiwei Gao, Carl Christofer Juhlin, Viveca Björnhagen, Anders Höög, Linkiat Lee, Catharina Larsson, Weng‐Onn Lui

Int J Cancer. 2020 Mar 15; 146(6): 1652–1666. Published online 2019 Jun 20. doi: 10.1002/ijc.32503

PMCID:: PMC7003823

Abstract Article PDF–3.2M

Select item 682601818.

mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells

Robert A. Brown, Antanina Voit, Manasa P. Srikanth, Julia A. Thayer, Tami J. Kingsbury, Marlene A. Jacobson, Marta M. Lipinski, Ricardo A. Feldman, Ola Awad

Dis Model Mech. 2019 Oct 1; 12(10): dmm038596. Published online 2019 Oct 16. doi: 10.1242/dmm.038596

PMCID:: PMC6826018

Abstract Article

Select item 641027419.

Translation of Human β-Actin mRNA is Regulated by mTOR Pathway

Irina Eliseeva, Maria Vasilieva, Lev P. Ovchinnikov

Genes (Basel) 2019 Feb; 10(2): 96. Published online 2019 Jan 29. doi: 10.3390/genes10020096

PMCID:: PMC6410274

Abstract Article PDF–1.7M

Select item 635112320.

A cancer associated somatic mutation in LC3B attenuates its binding to E1-like ATG7 protein and subsequent lipidation

Gal Chaim Nuta, Yuval Gilad, Moran Gershoni, Arielle Sznajderman, Tomer Schlesinger, Shani Bialik, Miriam Eisenstein, Shmuel Pietrokovski, Adi Kimchi

Autophagy. 2019; 15(3): 438–452. Published online 2018 Oct 8. doi: 10.1080/15548627.2018.1525476

PMCID:: PMC6351123

Abstract Article PDF–2.7M

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