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Select item 112967061.

Dual targeting of histone deacetylases and MYC as potential treatment strategy for H3-K27M pediatric gliomas

Danielle Algranati, Roni Oren, Bareket Dassa, Liat Fellus-Alyagor, Alexander Plotnikov, Haim Barr, Alon Harmelin, Nir London, Guy Ron, Noa Furth, Efrat Shema

eLife. 2024; 13: RP96257. Published online 2024 Aug 2. doi: 10.7554/eLife.96257

PMCID:: PMC11296706

Abstract Article PDF–5.9M

Select item 112714582.

Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

Rachel Tesla, Charlotte Guhl, Gordon C. Werthmann, Danielle Dixon, Basar Cenik, Yesu Addepalli, Jue Liang, Daniel M. Fass, Zachary Rosenthal, Stephen J. Haggarty, Noelle S. Williams, Bruce A. Posner, Joseph M. Ready, Joachim Herz

Nat Commun. 2024; 15: 6125. Published online 2024 Jul 20. doi: 10.1038/s41467-024-50076-8

PMCID:: PMC11271458

Abstract Article PDF–3.8M

Select item 112537633.

Cantharidin overcomes IL-2Rα signaling-mediated vorinostat resistance in cutaneous T-cell lymphoma through reactive oxygen species

Man Zhu, Wenjun Tang, Xiaoyu Tang, Zeren Zhu, Yina Jiang, Ammar Sarwar, Hongmei Zhang, Dake Chu, Zixi Zhang, Yanmin Zhang

J Immunother Cancer. 2024; 12(7): e009099. Published online 2024 Jul 14. doi: 10.1136/jitc-2024-009099

PMCID:: PMC11253763

Abstract Article PDF–9.4M

Select item 112413814.

SAHA/5-AZA Enhances Acetylation and Degradation of mutp53, Upregulates p21 and Downregulates c-Myc and BRCA-1 in Pancreatic Cancer Cells

Michele Di Crosta, Francesca Chiara Ragone, Rossella Benedetti, Gabriella D’Orazi, Maria Saveria Gilardini Montani, Mara Cirone

Int J Mol Sci. 2024 Jul; 25(13): 7020. Published online 2024 Jun 27. doi: 10.3390/ijms25137020

PMCID:: PMC11241381

Abstract Article PDF–2.7M

Select item 111863615.

HDAC Inhibition Sensitize Hepatocellular Carcinoma to Lenvatinib via Suppressing AKT Activation

Shuai Yan, Lu Chen, Hao Zhuang, Hui Yang, Yinmo Yang, Ning Zhang, Rong Liu

Int J Biol Sci. 2024; 20(8): 3046–3060. Published online 2024 May 19. doi: 10.7150/ijbs.93375

PMCID:: PMC11186361

Abstract Article PDF–11M

Select item 111598496.

Potential efficacy of the oral histone deacetylase inhibitor vorinostat in a phase I trial in follicular and mantle cell lymphoma

Takashi Watanabe, Harumi Kato, Yukio Kobayashi, Satoshi Yamasaki, Yuriko Morita‐Hoshi, Hiroki Yokoyama, Yasuo Morishima, Justin L. Ricker, Tetsuya Otsuki, Akiko Miyagi‐Maesima, Yoshihiro Matsuno, Kensei Tobinai

Cancer Sci. 2010 Jan; 101(1): 196–200. Published online 2009 Sep 10. doi: 10.1111/j.1349-7006.2009.01360.x

PMCID:: PMC11159849

Abstract Article PDF–312K

Select item 111592447.

Histone deacetylase inhibitor enhances sensitivity of non‐small‐cell lung cancer cells to 5‐FU/S‐1 via down‐regulation of thymidylate synthase expression and up‐regulation of p21^waf1/cip1 expression

Rintaro Noro, Akihiko Miyanaga, Yuji Minegishi, Tetsuya Okano, Masahiro Seike, Chie Soeno, Kiyoko Kataoka, Kuniko Matsuda, Akinobu Yoshimura, Akihiko Gemma

Cancer Sci. 2010 Jun; 101(6): 1424–1430. Published online 2010 Mar 10. doi: 10.1111/j.1349-7006.2010.01559.x

PMCID:: PMC11159244

Abstract Article PDF–588K

Select item 111590328.

Loss of RUNX3 expression by histone deacetylation is associated with biliary tract carcinogenesis

Seiji Shio, Yuzo Kodama, Hiroshi Ida, Masahiro Shiokawa, Koji Kitamura, Etsuro Hatano, Shinji Uemoto, Tsutomu Chiba

Cancer Sci. 2011 Apr; 102(4): 776–783. Published online 2011 Feb 10. doi: 10.1111/j.1349-7006.2011.01848.x

PMCID:: PMC11159032

Abstract Article PDF–685K

Select item 111586449.

Differential responsiveness of human hepatoma cells versus normal hepatocytes to TRAIL in combination with either histone deacetylase inhibitors or conventional cytostatics

Johanna Dzieran, James F. Beck, Jürgen Sonnemann

Cancer Sci. 2008 Aug; 99(8): 1685–1692. Published online 2008 Aug 14. doi: 10.1111/j.1349-7006.2008.00868.x

PMCID:: PMC11158644

Abstract Article PDF–556K

Select item 1114258810.

Reversion from basal histone H4 hypoacetylation at the replication fork increases DNA damage in FANCA deficient cells

Benilde García-de Teresa, Cecilia Ayala-Zambrano, Mirna González-Suárez, Bertha Molina, Leda Torres, Alfredo Rodríguez, Sara Frías

PLoS One. 2024; 19(5): e0298032. Published online 2024 May 31. doi: 10.1371/journal.pone.0298032

PMCID:: PMC11142588

Abstract Article PDF–2.3M

Select item 1111587011.

The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition

Chiara Giommarelli, Valentina Zuco, Enrica Favini, Claudio Pisano, Fabrizio Dal Piaz, Nunziatina De Tommasi, Franco Zunino

Cell Mol Life Sci. 2010 Mar; 67(6): 995–1004. Published online 2009 Dec 29. doi: 10.1007/s00018-009-0233-x

PMCID:: PMC11115870

Abstract Article PDF–432K

Select item 1110324412.

The Histone Deacetylase Inhibitor Vorinostat Selectively Sensitizes Fibrosarcoma Cells to Chemotherapy

Erik R. Sampson, Vinit Amin, Edward M. Schwarz, Regis J. O’Keefe, Randy N. Rosier

J Orthop Res. Author manuscript; available in PMC 2024 May 20.

Published in final edited form as: J Orthop Res. 2011 Apr; 29(4): 623–632. Published online 2010 Oct 18. doi: 10.1002/jor.21274

PMCID:: PMC11103244

Abstract Article PDF–1.0M

Select item 1108474313.

KiSS-1 Modulation by Epigenetic Agents Improves the Cisplatin Sensitivity of Lung Cancer Cells

Giovanni Luca Beretta, Desirè Alampi, Cristina Corno, Nives Carenini, Elisabetta Corna, Paola Perego

Int J Mol Sci. 2024 May; 25(9): 5048. Published online 2024 May 6. doi: 10.3390/ijms25095048

PMCID:: PMC11084743

Abstract Article PDF–5.4M

Select item 1104577414.

Apigenin and its combination with Vorinostat induces apoptotic-mediated cell death in TNBC by modulating the epigenetic and apoptotic regulators and related miRNAs

Snehal Nimal, Navanath Kumbhar, Saruchi, Shriya Rathore, Nitin Naik, Sneha Paymal, Rajesh N. Gacche

Sci Rep. 2024; 14: 9540. Published online 2024 Apr 25. doi: 10.1038/s41598-024-60395-x

PMCID:: PMC11045774

Abstract Article PDF–3.9M

Select item 1102880215.

EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors

Frank Neumann, Dominic Kaddu-Mulindwa, Thomas Widmann, Klaus-Dieter Preuss, Gerhard Held, Carsten Zwick, Klaus Roemer, Michael Pfreundschuh, Boris Kubuschok

Cancer Immunol Immunother. 2013 Jul; 62(7): 1211–1222. Published online 2013 Apr 26. doi: 10.1007/s00262-013-1412-z

PMCID:: PMC11028802

Abstract Article PDF–405K

Select item 1098019716.

Suberoylanilide hydroxamic acid attenuates cognitive impairment in offspring caused by maternal surgery during mid-pregnancy

Yunlin Feng, Jia Qin, Yanfei Lu, Mengdie Wang, Shengqiang Wang, Foquan Luo

PLoS One. 2024; 19(3): e0295096. Published online 2024 Mar 29. doi: 10.1371/journal.pone.0295096

PMCID:: PMC10980197

Abstract Article PDF–2.0M

Select item 1095341217.

Inhibition of mitochondrial translocase SLC25A5 and histone deacetylation is an effective combination therapy in neuroblastoma

Janith A. Seneviratne, Daniel R. Carter, Rituparna Mittra, Andrew Gifford, Patrick Y. Kim, Jie‐Si Luo, Chelsea Mayoh, Alice Salib, Aldwin S. Rahmanto, Jayne Murray, Ngan C. Cheng, Zsuzsanna Nagy, Qian Wang, Ane Kleynhans, Owen Tan, Selina K. Sutton, Chengyuan Xue, Sylvia A. Chung, Yizhuo Zhang, Chengtao Sun, Li Zhang, Michelle Haber, Murray D. Norris, Jamie I. Fletcher, Tao Liu, Pierre J. Dilda, Philip J. Hogg, Belamy B. Cheung, Glenn M. Marshall

Int J Cancer. 2023 Apr 1; 152(7): 1399–1413. Published online 2022 Nov 17. doi: 10.1002/ijc.34349

PMCID:: PMC10953412

Abstract Article PDF–7.6M

Select item 1095272618.

The addition of vorinostat to lenalidomide maintenance for patients with newly diagnosed multiple myeloma of all ages: results from ‘Myeloma XI’, a multicentre, open‐label, randomised, phase III trial

Matthew W. Jenner, Charlotte Pawlyn, Faith E. Davies, Tom Menzies, Anna Hockaday, Catherine Olivier, John R. Jones, Kamaraj Karunanithi, Jindriska Lindsay, Bhuvan Kishore, Gordon Cook, Mark T. Drayson, Martin F. Kaiser, Roger G. Owen, Walter Gregory, David A. Cairns, Gareth J. Morgan, Graham H. Jackson, for the UK National Cancer Research Institute (NCRI) Haemato‐oncology Clinical Studies Group

Br J Haematol. 2023 Apr; 201(2): 267–279. Published online 2022 Dec 21. doi: 10.1111/bjh.18600

PMCID:: PMC10952726

Abstract Article PDF–1.6M

Select item 1091358719.

Pan-histone deacetylase inhibitor vorinostat suppresses osteoclastic bone resorption through modulation of RANKL-evoked signaling and ameliorates ovariectomy-induced bone loss

Xiaole Peng, Tianhao Wang, Qing Wang, Yuhu Zhao, Hao Xu, Huilin Yang, Ye Gu, Yunxia Tao, Bangsheng Yan, Yaozeng Xu, Dechun Geng

Cell Commun Signal. 2024; 22: 160. Published online 2024 Mar 4. doi: 10.1186/s12964-024-01525-w

PMCID:: PMC10913587

Abstract Article PDF–11M

Select item 1085604120.

Chemical Epigenetic Regulation Secondary Metabolites Derived from Aspergillus sydowii DL1045 with Inhibitory Activities for Protein Tyrosine Phosphatases

Xuan Shi, Xia Li, Xiaoshi He, Danyang Zhang, Chunshan Quan, Zhilong Xiu, Yuesheng Dong

Molecules. 2024 Feb; 29(3): 670. Published online 2024 Jan 31. doi: 10.3390/molecules29030670

PMCID:: PMC10856041

Abstract Article PDF–3.7M

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