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Select item 112915551.

Integrase inhibitor drugs during pregnancy and congenital anomalies: A case/non‐case study from the global pharmacovigilance database VigiBase®

Laura Saint‐Lary, Isabelle Lacroix, Valériane Leroy, Agnès Sommet

Pharmacol Res Perspect. 2024 Aug; 12(4): e1247. Published online 2024 Jul 31. doi: 10.1002/prp2.1247

PMCID:: PMC11291555

Abstract Article PDF–984K

Select item 112071542.

Neurocognitive profile in HIV subjects on INSTI-regimen- one year follow up: Is there room for optimism?

Nina Brkić-Jovanović, Mina Karaman, Vanja Andrić, Daniela Marić, Snežana Brkić, Vojislava Bugarski-Ignjatović

PLoS One. 2024; 19(6): e0306278. Published online 2024 Jun 26. doi: 10.1371/journal.pone.0306278

PMCID:: PMC11207154

Abstract Article PDF–494K

Select item 109287193.

N-Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants

Pankaj S. Mahajan, Steven J. Smith, Min Li, Robert Craigie, Stephen H. Hughes, Xue Zhi Zhao, Terrence R. Burke, Jr.

ACS Infect Dis. 2024 Mar 8; 10(3): 917–927. Published online 2024 Feb 12. doi: 10.1021/acsinfecdis.3c00525

PMCID:: PMC10928719

Abstract Article PDF–3.2M

Select item 109069224.

Epistatic pathways can drive HIV-1 escape from integrase strand transfer inhibitors

Yuta Hikichi, Jonathan R. Grover, Alicia Schäfer, Walther Mothes, Eric O. Freed

Sci Adv. 2024 Mar 1; 10(9): eadn0042. Published online 2024 Mar 1. doi: 10.1126/sciadv.adn0042

PMCID:: PMC10906922

Abstract Article PDF–15M

Select item 108889675.

Plasma Concentrations of Rosmarinic Acid in Patients on Antiretroviral Therapy: In Silico Exploration Based on Clinical Data

Maja Hitl, Nebojša Pavlović, Snežana Brkić, Gordana Dragović, Branislava Srđenović-Čonić, Nebojša Kladar

Int J Mol Sci. 2024 Feb; 25(4): 2230. Published online 2024 Feb 13. doi: 10.3390/ijms25042230

PMCID:: PMC10888967

Abstract Article PDF–1.6M

Select item 105530216.

Long-term outcomes of highly experienced people with HIV undergoing salvage therapy with raltegravir

Jesús Enrique Patiño Escarcina, Eduardo Martins Netto, Carlos Brites

Medicine (Baltimore) 2023 Oct 6; 102(40): e35407. Published online 2023 Oct 6. doi: 10.1097/MD.0000000000035407

PMCID:: PMC10553021

Abstract Article PDF–666K

Select item 103258107.

Pharmacokinetics, the Immunological Impact, and the Effect on HIV Ex-Vivo Infectivity of Maraviroc, Raltegravir, and Lopinavir in Men Who Have Sex with Men Using Postexposure Prophylaxis

Lorna Leal, Alberto C. Guardo, Luis M. Bedoya, Cristina Rodríguez de Miguel, Núria Climent, Cristina Rovira, Manuela Beltrán, Josep Llach, Jose Alcamí, Angela D.M. Kashuba, Jose M. Gatell, Montserrat Plana, Felipe García

AIDS Res Hum Retroviruses. May 2023; 39(5): 211–221. Published online 2023 May 5. doi: 10.1089/aid.2021.0232

PMCID:: PMC10325810

Abstract Article PDF–468K

Select item 103227788.

Management of Drug Interactions with Inducers: Onset and Disappearance of Induction on Cytochrome P450 3A4 and Uridine Diphosphate Glucuronosyltransferase 1A1 Substrates

Sara Bettonte, Mattia Berton, Felix Stader, Manuel Battegay, Catia Marzolini

Eur J Drug Metab Pharmacokinet. 2023; 48(4): 353–362. Published online 2023 Jun 6. doi: 10.1007/s13318-023-00833-9

PMCID:: PMC10322778

Abstract Article PDF–1.9M

Select item 102890709.

Implementation and Uptake of Raltegravir Granules in Newborns Diagnosed With HIV Through Birth Testing in Maternity Settings in Zimbabwe During the COVID-19 Pandemic

Lise Denoeud-Ndam, Carl Stecker, Precious Andifasi, Angela Mushavi, Talent Maphosa, Mongiwa Zondo, Mildrate Murandu, Gladys Gombakomba, Leila Katirayi, More Mungati, Rebecca Bailey, Rachel Weber, Emilia Rivadeneira, Susan Hrapcak

Pediatr Infect Dis J. 2023 Jul; 42(7): 573–575. Published online 2023 Mar 20. doi: 10.1097/INF.0000000000003906

PMCID:: PMC10289070

Abstract Article PDF–226K

Select item 1020562010.

Second-Generation Human Immunodeficiency Virus Integrase Inhibitors Induce Differentiation Dysregulation and Exert Toxic Effects in Human Embryonic Stem Cell and Mouse Models

Marie-Soleil R Smith, Haneesha Mohan, Abhinav Ajaykumar, Anthony Y Y Hsieh, Lou Martineau, Ronil Patel, Izabella Gadawska, Christopher Sherwood, Lena Serghides, James M Piret, Hélène C F Côté

J Infect Dis. 2022 Dec 1; 226(11): 1992–2001. Published online 2022 Sep 19. doi: 10.1093/infdis/jiac386

PMCID:: PMC10205620

Abstract Article PDF–862K

Select item 1002734411.

Immunologic Change over 72 Weeks Following Raltegravir- Versus Efavirenz-Based Therapy in HIV/HCV-Coinfected Individuals in Vietnam

Cecilia M. Shikuma, Thuy Le, Thao Vu Phuong, Glen M. Chew, Van Vinh Chau Nguyen, Trieu Ly Vo, Chathura Siriwardhana, Dominic Chow, Hayk Ghukasyan, Nath Limpruttidham, Thomas Premeaux, Louie Mar Gangcuangco, Robert Paul, Lishomwa C. Ndhlovu

AIDS Res Hum Retroviruses. June 2022; 38(6): 441–450. Published online 2022 Jun 6. doi: 10.1089/aid.2021.0076

PMCID:: PMC10027344

Abstract Article PDF–293K

Select item 999480312.

Adipocyte differentiation of 3T3-L1 cells under tenofovir alafenamide, tenofovir disoproxil fumarate, and integrase strand transfer inhibitors selective challenge: an in-vitro model

Angelica Perna, Maria A. Carleo, Silvia Mascolo, Alessandra Guida, Marcella Contieri, Carmine Sellitto, Eleonora Hay, Paolo De Blasiis, Angela Lucariello, Germano Guerra, Alfonso Baldi, Antonio De Luca, Paolo Maggi, Vincenzo Esposito

AIDS. 2023 Mar 15; 37(4): 561–570. Published online 2022 Dec 13. doi: 10.1097/QAD.0000000000003455

PMCID:: PMC9994803

Abstract Article PDF–1.7M

Select item 998973613.

HIV-1 subtype F integrase polymorphisms external to the catalytic core domain contribute to severe loss of replication capacity in context of the integrase inhibitor resistance mutation Q148H

Paula C Aulicino, Zoha Momin, Mijael Rozenszajn, Arturo Monzon, Solange Arazi-Caillaud, Rosa Bologna, Andrea Mangano, Jason T Kimata

J Antimicrob Chemother. 2022 Oct; 77(10): 2793–2802. Published online 2022 Jul 28. doi: 10.1093/jac/dkac238

PMCID:: PMC9989736

Abstract Article PDF–2.5M

Select item 993937714.

In silico prediction of potential inhibitors for SARS-CoV-2 Omicron variant using molecular docking and dynamics simulation-based drug repurposing

Eslam A. R. Mohamed, Islam M. Abdel-Rahman, Magdi E. A. Zaki, Ahmad Al-Khdhairawi, Mahmoud M. Abdelhamid, Ahmad M. Alqaisi, Lyana binti Abd Rahim, Bilal Abu-Hussein, Azza A. K. El-Sheikh, Sayed F. Abdelwahab, Heba Ali Hassan

J Mol Model. 2023; 29(3): 70. Published online 2023 Feb 20. doi: 10.1007/s00894-023-05457-z

PMCID:: PMC9939377

Abstract Article PDF–3.8M

Select item 992590915.

Relationship between raltegravir trough plasma concentration and virologic response and the impact of therapeutic drug monitoring during pregnancy

Sabrina Carvalho, Nancy L. Sheehan, Silvie Valois, Fatima Kakkar, Marc Boucher, Ema Ferreira, Isabelle Boucoiran

Int J STD AIDS. 2023 Mar; 34(3): 175–182. Published online 2022 Dec 18. doi: 10.1177/09564624221144489

PMCID:: PMC9925909

Abstract Article PDF–666K

Select item 991951316.

A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors

Pankaj S. Mahajan, Steven J. Smith, Stephen H. Hughes, Xuezhi Zhao, Terrence R. Burke, Jr.

Molecules. 2023 Feb; 28(3): 1428. Published online 2023 Feb 2. doi: 10.3390/molecules28031428

PMCID:: PMC9919513

Abstract Article PDF–2.7M

Select item 978506017.

Different Pathways Conferring Integrase Strand-Transfer Inhibitors Resistance

Clémence Richetta, Nhat Quang Tu, Olivier Delelis

Viruses. 2022 Dec; 14(12): 2591. Published online 2022 Nov 22. doi: 10.3390/v14122591

PMCID:: PMC9785060

Abstract Article PDF–2.7M

Select item 976969718.

Evaluation of Circulating and Archived HIV-1 Integrase Drug-Resistance Variants among Patients on Third-Line ART in Cameroon: Implications for Dolutegravir-Containing Regimens in Resource-Limited Settings

Joseph Fokam, Ezechiel Ngoufack Jagni Semengue, Evariste Molimbou, Naomi-Karell Etame, Maria Mercedes Santoro, Désiré Takou, Leonella Mossiang, Alain Patrice Meledie, Collins Ambe Chenwi, Bouba Yagai, Alex Durand Nka, Beatrice Dambaya, Georges Teto, Aude Christelle Ka’e, Grâce Angong Beloumou, Sandrine Claire Djupsa Ndjeyep, Nadine Fainguem, Aissatou Abba, Aurelie Minelle Ngueko Kengni, Michel Carlos Tommo Tchouaket, Nounouce Pamen Bouba, Serge-Clotaire Billong, Rina Djubgang, Edith Temgoua Saounde, Samuel Martin Sosso, Charles Kouanfack, Anne-Cecile Zoung-Kanyi Bissek, Emmanuel Eben-Moussi, Vittorio Colizzi, Carlo-Federico Perno, Francesca Ceccherini-Silberstein, Alexis Ndjolo

Microbiol Spectr. 2022 Nov-Dec; 10(6): e03420-22. Published online 2022 Oct 19. doi: 10.1128/spectrum.03420-22

PMCID:: PMC9769697

Abstract Article PDF–592K

Select item 974412419.

Dolutegravir in Pregnancy as Compared with Current HIV Regimens in the United States

Kunjal Patel, Yanling Huo, Jennifer Jao, Kathleen M. Powis, Paige L. Williams, Deborah Kacanek, Lynn M. Yee, Ellen G. Chadwick, Stephanie Shiau, Denise L. Jacobson, Sean S. Brummel, Leila Sultan-Beyer, Christian R. Kahlert, Rebecca Zash, George R. Seage, III, Pediatric HIV/AIDS Cohort Study and the Swiss Mother and Child HIV Cohort Study

N Engl J Med. Author manuscript; available in PMC 2023 Mar 1.

Published in final edited form as: N Engl J Med. 2022 Sep 1; 387(9): 799–809. doi: 10.1056/NEJMoa2200600

PMCID:: PMC9744124

Abstract Article PDF–773K

Select item 970443420.

Transfer of antiretroviral drugs into breastmilk: a prospective study from the Swiss Mother and Child HIV Cohort Study

Karoline Aebi-Popp, Christian R Kahlert, Pierre-Alex Crisinel, Laurent Decosterd, Susana Alves Saldanha, Irene Hoesli, Begona Martinez De Tejada, Andrea Duppenthaler, Andri Rauch, Catia Marzolini, Swiss Mother and Child HIV Cohort Study (SHCS)

J Antimicrob Chemother. 2022 Dec; 77(12): 3436–3442. Published online 2022 Sep 30. doi: 10.1093/jac/dkac337

PMCID:: PMC9704434

Abstract Article PDF–158K

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