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Select item 95007411.

Activating PPARβ/δ Protects against Endoplasmic Reticulum Stress-Induced Astrocytic Apoptosis via UCP2-Dependent Mitophagy in Depressive Model

Juan Ji, Shangze Li, Zikai Jiang, Jianbing Yu, Yuqin Sun, Zhenyu Cai, Yinfeng Dong, Xiulan Sun

Int J Mol Sci. 2022 Sep; 23(18): 10822. Published online 2022 Sep 16. doi: 10.3390/ijms231810822

PMCID:: PMC9500741

Abstract Article PDF–44M

Select item 90345352.

PPARβ/δ priming enhances the anti-apoptotic and therapeutic properties of mesenchymal stromal cells in myocardial ischemia–reperfusion injury

Charlotte Sarre, Rafael Contreras-Lopez, Nitirut Nernpermpisooth, Christian Barrere, Sarah Bahraoui, Claudia Terraza, Gautier Tejedor, Anne Vincent, Patricia Luz-Crawford, Kantapich Kongpol, Sarawut Kumphune, Christophe Piot, Joel Nargeot, Christian Jorgensen, Farida Djouad, Stéphanie Barrere-Lemaire

Stem Cell Res Ther. 2022; 13: 167. Published online 2022 Apr 23. doi: 10.1186/s13287-022-02840-0

Correction in:: Stem Cell Res Ther. 2022; 13: 338.

PMCID:: PMC9034535

Abstract Article PDF–1.6M

Select item 85842423.

Gene Doping with Peroxisome-Proliferator-Activated Receptor Beta/Delta Agonists Alters Immunity but Exercise Training Mitigates the Detection of Effects in Blood Samples

Brigitte Sibille, Isabelle Mothe-Satney, Gwenaëlle Le Menn, Doriane Lepouse, Sébastien Le Garf, Elodie Baudoin, Joseph Murdaca, Claudine Moratal, Noura Lamghari, Giulia Chinetti, Jaap G. Neels, Anne-Sophie Rousseau

Int J Mol Sci. 2021 Nov; 22(21): 11497. Published online 2021 Oct 25. doi: 10.3390/ijms222111497

PMCID:: PMC8584242

Abstract Article PDF–1.5M

Select item 82325964.

Cardioprotective Effects of PPARβ/δ Activation against Ischemia/Reperfusion Injury in Rat Heart Are Associated with ALDH2 Upregulation, Amelioration of Oxidative Stress and Preservation of Mitochondrial Energy Production

Ioanna Papatheodorou, Eleftheria Galatou, Georgios-Dimitrios Panagiotidis, Táňa Ravingerová, Antigone Lazou

Int J Mol Sci. 2021 Jun; 22(12): 6399. Published online 2021 Jun 15. doi: 10.3390/ijms22126399

PMCID:: PMC8232596

Abstract Article PDF–2.7M

Select item 80038235.

Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery

Noelia Perez Diaz, Lisa A. Lione, Victoria Hutter, Louise S. Mackenzie

Int J Mol Sci. 2021 Mar; 22(6): 3158. Published online 2021 Mar 19. doi: 10.3390/ijms22063158

PMCID:: PMC8003823

Abstract Article PDF–2.2M

Select item 76869826.

GW0742 activates miR‐17‐5p and inhibits TXNIP/NLRP3‐mediated inflammation after hypoxic‐ischaemic injury in rats and in PC12 cells

Marcin Gamdzyk, Desislava Met Doycheva, Ruiqing Kang, Hong Tang, Zackary D. Travis, Jiping Tang, John H. Zhang

J Cell Mol Med. 2020 Nov; 24(21): 12318–12330. Published online 2020 Oct 9. doi: 10.1111/jcmm.15698

PMCID:: PMC7686982

Abstract Article PDF–1.7M

Select item 75268647.

PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes

Henna Konttinen, Irina Gureviciene, Minna Oksanen, Alexandra Grubman, Sanna Loppi, Mikko T. Huuskonen, Paula Korhonen, Riikka Lampinen, Meike Keuters, Irina Belaya, Heikki Tanila, Katja M. Kanninen, Gundars Goldsteins, Gary Landreth, Jari Koistinaho, Tarja Malm

Glia. Author manuscript; available in PMC 2020 Sep 30.

Published in final edited form as: Glia. 2019 Jan; 67(1): 146–159. Published online 2018 Nov 19. doi: 10.1002/glia.23534

PMCID:: PMC7526864

Abstract Article PDF–871K

Select item 73733268.

Human Endometrial Stromal Cell Differentiation is Stimulated by PPARβ/δ Activation: New Targets for Infertility?

Jie Yu, Sarah L Berga, Wei Zou, Augustine Rajakumar, Mingfei Man, Neil Sidell, Robert N Taylor

J Clin Endocrinol Metab. 2020 Sep; 105(9): 2983–2995. Published online 2020 Jun 28. doi: 10.1210/clinem/dgaa413

PMCID:: PMC7373326

Abstract Article

Select item 72182209.

VCAM-1-targeted and PPARδ-agonist-loaded nanomicelles enhanced suppressing effects on apoptosis and migration of oxidized low-density lipoprotein-induced vascular smooth muscle cells

Gang Wei, Liangang Hao, Xueli Li, Wen Xu, Fuxiang Liu, Qian Peng, Shoutian Lv

Biosci Rep. 2020 May 29; 40(5): BSR20200559. Published online 2020 May 12. doi: 10.1042/BSR20200559

Expression of Concern in:: Biosci Rep. 2020 Jun 26; 40(6): BSR-20200559_EOC.

PMCID:: PMC7218220

Abstract Article PDF–1.2M

Select item 721793810.

Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A

Ashton Faulkner, Eleanor Lynam, Robert Purcell, Coleen Jones, Colleen Lopez, Mary Board, Kay-Dietrich Wagner, Nicole Wagner, Carolyn Carr, Caroline Wheeler-Jones

Sci Rep. 2020; 10: 7849. Published online 2020 May 12. doi: 10.1038/s41598-020-63900-0

PMCID:: PMC7217938

Abstract Article PDF–3.8M

Select item 707815111.

Activation of PPAR-β/δ Attenuates Brain Injury by Suppressing Inflammation and Apoptosis in a Collagenase-Induced Intracerebral Hemorrhage Mouse Model

Xiangming Tang, Kunning Yan, Yingge Wang, Yaping Wang, Hongmei Chen, Jiang Xu, Yaoyao Lu, Xiaohong Wang, Jingyan Liang, Xinjiang Zhang

Neurochem Res. 2020; 45(4): 837–850. Published online 2020 Jan 14. doi: 10.1007/s11064-020-02956-w

PMCID:: PMC7078151

Abstract Article PDF–4.5M

Select item 695283512.

Vascular PPARβ/δ Promotes Tumor Angiogenesis and Progression

Kay-Dietrich Wagner, Siyue Du, Luc Martin, Nathalie Leccia, Jean-François Michiels, Nicole Wagner

Cells. 2019 Dec; 8(12): 1623. Published online 2019 Dec 12. doi: 10.3390/cells8121623

PMCID:: PMC6952835

Abstract Article PDF–23M

Select item 690981413.

PPAR δ inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell

Yi Li, Chenwei Wang, Jiyuan Lu, Ke Huang, Yu Han, Junlin Chen, Yan Yang, Bin Liu

Int J Med Sci. 2019; 16(12): 1593–1603. Published online 2019 Oct 21. doi: 10.7150/ijms.37677

Correction in:: Int J Med Sci. 2023; 20(13): 1791–1792.

PMCID:: PMC6909814

Abstract Article PDF–2.5M

Select item 683092614.

Delayed activation of PPAR-β/δ improves long-term survival in mouse sepsis: effects on organ inflammation and coagulation

Daniel Busch, Amar Kapoor, Pia Rademann, Frank Hildebrand, Soheyl Bahrami, Christoph Thiemermann, Marcin F Osuchowski

Innate Immun. 2018 May; 24(4): 262–273. Published online 2018 Apr 26. doi: 10.1177/1753425918771748

PMCID:: PMC6830926

Abstract Article PDF–715K

Select item 682933315.

Complementary Immunometabolic Effects of Exercise and PPARβ/δ Agonist in the Context of Diet-Induced Weight Loss in Obese Female Mice

Sébastien Le Garf, Joseph Murdaca, Isabelle Mothe-Satney, Brigitte Sibille, Gwenaëlle Le Menn, Giulia Chinetti, Jaap G. Neels, Anne-Sophie Rousseau

Int J Mol Sci. 2019 Oct; 20(20): 5182. Published online 2019 Oct 19. doi: 10.3390/ijms20205182

PMCID:: PMC6829333

Abstract Article PDF–2.4M

Select item 622365016.

Role of PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats

Marcin Gamdzyk, Desislava Met Doycheva, Jay Malaguit, Budbazar Enkhjargal, Jiping Tang, John H. Zhang

Neuropharmacology. Author manuscript; available in PMC 2019 Sep 15.

Published in final edited form as: Neuropharmacology. 2018 Sep 15; 140: 150–161. Published online 2018 Aug 4. doi: 10.1016/j.neuropharm.2018.08.003

PMCID:: PMC6223650

Abstract Article PDF–2.9M

Select item 620844417.

VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity

Belen Palomares, Francisco Ruiz-Pino, Carmen Navarrete, Inmaculada Velasco, Miguel A. Sánchez-Garrido, Carla Jimenez-Jimenez, Carolina Pavicic, Maria J. Vazquez, Giovanni Appendino, M. Luz Bellido, Marco A. Calzado, Manuel Tena-Sempere, Eduardo Muñoz

Sci Rep. 2018; 8: 16092. Published online 2018 Oct 31. doi: 10.1038/s41598-018-34259-0

PMCID:: PMC6208444

Abstract Article PDF–1.7M

Select item 602655818.

Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells

Michael G. Borland, Ellen M. Kehres, Christina Lee, Ashley L. Wagner, Brooke E. Shannon, Prajakta P. Albrecht, Bokai Zhu, Frank J. Gonzalez, Jeffrey M. Peters

Toxicology. Author manuscript; available in PMC 2019 Jul 1.

Published in final edited form as: Toxicology. 2018 Jul 1; 404-405: 25–32. Published online 2018 May 3. doi: 10.1016/j.tox.2018.05.003

PMCID:: PMC6026558

Abstract Article PDF–1.1M

Select item 600816819.

Novel VDR antagonists based on the GW0742 scaffold

Kelly A. Teske, Jonathan W. Bogart, Leggy A. Arnold

Bioorg Med Chem Lett. Author manuscript; available in PMC 2019 Apr 14.

Published in final edited form as: Bioorg Med Chem Lett. 2018 Feb 1; 28(3): 351–354. Published online 2017 Dec 19. doi: 10.1016/j.bmcl.2017.12.041

PMCID:: PMC6008168

Abstract Article PDF–412K

Select item 583768620.

Editor’s Highlight: PPARβ/δ and PPARγ Inhibit Melanoma Tumorigenicity by Modulating Inflammation and Apoptosis

Michael G. Borland, Pei-Li Yao, Ellen M. Kehres, Christina Lee, Amanda M. Pritzlaff, Elizabeth Ola, Ashley L. Wagner, Brooke E. Shannon, Prajakta P. Albrecht, Bokai Zhu, Boo-Hyon Kang, Gavin P. Robertson, Frank J. Gonzalez, Jeffrey M. Peters

Toxicol Sci. 2017 Oct; 159(2): 436–448. Published online 2017 Jul 14. doi: 10.1093/toxsci/kfx147

PMCID:: PMC5837686

Abstract Article PDF–1.6M

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