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Select item 31746521.

Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria

Donald D. Anderson, Cynthia M. Quintero, Patrick J. Stover

Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37): 15163-15168. Published online 2011 Aug 26. doi: 10.1073/pnas.1103623108

PMCID:: PMC3174652

Abstract Article PDF–1.1M

Select item 30395702.

Initial characterization of the human central proteome

Thomas R Burkard, Melanie Planyavsky, Ines Kaupe, Florian P Breitwieser, Tilmann Bürckstümmer, Keiryn L Bennett, Giulio Superti-Furga, Jacques Colinge

BMC Syst Biol. 2011; 5: 17. Published online 2011 Jan 26. doi: 10.1186/1752-0509-5-17

PMCID:: PMC3039570

Abstract Article PDF–2.3M

Select item 30357073.

Identification and Characterization of an Inborn Error of Metabolism Caused by Dihydrofolate Reductase Deficiency

Siddharth Banka, Henk J. Blom, John Walter, Majid Aziz, Jill Urquhart, Christopher M. Clouthier, Gillian I. Rice, Arjan P.M. de Brouwer, Emma Hilton, Grace Vassallo, Andrew Will, Desirée E.C. Smith, Yvo M. Smulders, Ron A. Wevers, Robert Steinfeld, Simon Heales, Yanick J. Crow, Joelle N. Pelletier, Simon Jones, William G. Newman

Am J Hum Genet. 2011 Feb 11; 88(2): 216–225. doi: 10.1016/j.ajhg.2011.01.004

PMCID:: PMC3035707

Abstract Article PDF–969K

Select item 30357064.

Dihydrofolate Reductase Deficiency Due to a Homozygous DHFR Mutation Causes Megaloblastic Anemia and Cerebral Folate Deficiency Leading to Severe Neurologic Disease

Holger Cario, Desirée E.C. Smith, Henk Blom, Nenad Blau, Harald Bode, Karlheinz Holzmann, Ulrich Pannicke, Karl-Peter Hopfner, Eva-Maria Rump, Zuleya Ayric, Elisabeth Kohne, Klaus-Michael Debatin, Yvo Smulders, Klaus Schwarz

Am J Hum Genet. 2011 Feb 11; 88(2): 226–231. doi: 10.1016/j.ajhg.2011.01.007

PMCID:: PMC3035706

Abstract Article PDF–382K

Select item 27655235.

Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes

Vivian Cody, Jim Pace, Jennifer Makin, Jennifer Piraino, Sherry F. Queener, Andre Rosowsky

Biochemistry. Author manuscript; available in PMC 2010 Mar 3.

Published in final edited form as: Biochemistry. 2009 Mar 3; 48(8): 1702–1711. doi: 10.1021/bi801960h

PMCID:: PMC2765523

Abstract Article PDF–3.0M

Select item 27404346.

Multiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate Resistance

Jordan P. Volpato, Brahm J. Yachnin, Jonathan Blanchet, Vanessa Guerrero, Lucie Poulin, Elena Fossati, Albert M. Berghuis, Joelle N. Pelletier

J Biol Chem. 2009 Jul 24; 284(30): 20079–20089. Published online 2009 May 28. doi: 10.1074/jbc.M109.018010

PMCID:: PMC2740434

Abstract Article PDF–1.8M

Select item 27391307.

Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethyl-thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents

Aleem Gangjee, Wei Li, Roy L. Kisliuk, Vivian Cody, Jim Pace, Jennifer Piriano, Jennifer Makin

J Med Chem. Author manuscript; available in PMC 2010 Aug 13.

Published in final edited form as: J Med Chem. 2009 Aug 13; 52(15): 4892–4902. doi: 10.1021/jm900490a

PMCID:: PMC2739130

Abstract Article PDF–4.9M

Select item 5289288.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 69582719.

Quantitative proteomic study of mitoxantrone-resistant NCI-H460 cell-xenograft tumors

Li Su, Shuang Cui, Hongying Zhen, Jiao Liu

Int J Clin Exp Pathol. 2018; 11(5): 2377–2388. Published online 2018 May 1.

PMCID:: PMC6958271

Abstract Article PDF–1.2M

Select item 695721810.

Functional analysis of Rossmann-like domains reveals convergent evolution of topology and reaction pathways

Kirill E. Medvedev, Lisa N. Kinch, R. Dustin Schaeffer, Nick V. Grishin

PLoS Comput Biol. 2019 Dec; 15(12): e1007569. Published online 2019 Dec 23. doi: 10.1371/journal.pcbi.1007569

PMCID:: PMC6957218

Abstract Article PDF–6.3M

Select item 685367511.

A decision-theoretic approach to the evaluation of machine learning algorithms in computational drug discovery

Oliver P Watson, Isidro Cortes-Ciriano, Aimee R Taylor, James A Watson

Bioinformatics. 2019 Nov 15; 35(22): 4656–4663. Published online 2019 May 9. doi: 10.1093/bioinformatics/btz293

PMCID:: PMC6853675

Abstract Article PDF–314K

Select item 658252112.

KekuleScope: prediction of cancer cell line sensitivity and compound potency using convolutional neural networks trained on compound images

Isidro Cortés-Ciriano, Andreas Bender

J Cheminform. 2019; 11: 41. Published online 2019 Jun 19. doi: 10.1186/s13321-019-0364-5

PMCID:: PMC6582521

Abstract Article PDF–2.0M

Select item 633145113.

Unveiling Active Constituents and Potential Targets Related to the Hematinic Effect of Steamed Panax notoginseng Using Network Pharmacology Coupled With Multivariate Data Analyses

Yin Xiong, Yupiao Hu, Lijuan Chen, Zejun Zhang, Yiming Zhang, Ming Niu, Xiuming Cui

Front Pharmacol. 2018; 9: 1514. Published online 2019 Jan 8. doi: 10.3389/fphar.2018.01514

PMCID:: PMC6331451

Abstract Article PDF–7.3M

Select item 610960114.

ANGIOGENIC AND IMMUNOLOGIC PROTEINS IDENTIFIED BY DEEP PROTEOMIC PROFILING OF HUMAN RETINAL AND CHOROIDAL VASCULAR ENDOTHELIAL CELLS: POTENTIAL TARGETS FOR NEW BIOLOGIC DRUGS

Justine R. Smith, Larry L. David, Binoy Appukuttan, Phillip A. Wilmarth

Am J Ophthalmol. Author manuscript; available in PMC 2019 Sep 1.

Published in final edited form as: Am J Ophthalmol. 2018 Sep; 193: 197–229. Published online 2018 Mar 17. doi: 10.1016/j.ajo.2018.03.020

PMCID:: PMC6109601

Abstract Article PDF–826K

Select item 565066615.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes

Stephen PH Alexander, Doriano Fabbro, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators

Br J Pharmacol. 2017 Dec; 174(Suppl Suppl 1): S272–S359. Published online 2017 Oct 21. doi: 10.1111/bph.13877

PMCID:: PMC5650666

Abstract Article PDF–1.8M

Select item 557017916.

TRAPP webserver: predicting protein binding site flexibility and detecting transient binding pockets

Antonia Stank, Daria B. Kokh, Max Horn, Elena Sizikova, Rebecca Neil, Joanna Panecka, Stefan Richter, Rebecca C. Wade

Nucleic Acids Res. 2017 Jul 3; 45(Web Server issue): W325–W330. Published online 2017 Apr 20. doi: 10.1093/nar/gkx277

PMCID:: PMC5570179

Abstract Article PDF–1.7M

Select item 529524017.

Quantitative Proteomic Profiling of Tachyplesin I Targets in U251 Gliomaspheres

Xuan Li, Jianguo Dai, Yongjun Tang, Lulu Li, Gang Jin

Mar Drugs. 2017 Jan; 15(1): 20. Published online 2017 Jan 18. doi: 10.3390/md15010020

PMCID:: PMC5295240

Abstract Article PDF–3.8M

Select item 489521518.

Horizontal gene transfer events reshape the global landscape of arm race between viruses and homo sapiens

Dong-Sheng Chen, Yi-Quan Wu, Wei Zhang, San-Jie Jiang, Shan-Ze Chen

Sci Rep. 2016; 6: 26934. Published online 2016 Jun 7. doi: 10.1038/srep26934

PMCID:: PMC4895215

Abstract Article PDF–1.2M

Select item 478206919.

Quantitative proteomics study of the neuroprotective effects of B12 on hydrogen peroxide-induced apoptosis in SH-SY5Y cells

Lijun Zhong, Juntuo Zhou, Xi Chen, Yaxin Lou, Dan Liu, Xiajuan Zou, Bin Yang, Yuxin Yin, Yan Pan

Sci Rep. 2016; 6: 22635. Published online 2016 Mar 8. doi: 10.1038/srep22635

PMCID:: PMC4782069

Abstract Article PDF–1.4M

Select item 471821120.

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

Stephen PH Alexander, Doriano Fabbro, Eamonn Kelly, Neil Marrion, John A Peters, Helen E Benson, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators

Br J Pharmacol. 2015 Dec; 172(24): 6024–6109. Published online 2015 Dec 9. doi: 10.1111/bph.13354