PMC Links for Protein (Select 20141192) - PMC

Edwige Nicodeme, Kate L. Jeffrey, Uwe Schaefer, Soren Beinke, Scott Dewell, Chun-wa Chung, Rohit Chandwani, Ivan Marazzi, Paul Wilson, Hervé Coste, Julia White, Jorge Kirilovsky, Jose M Lora, Rab K Prinjha, Kevin Lee, Alexander Tarakhovsky

Nature. Author manuscript; available in PMC 2017 May 3.

Published in final edited form as: Nature. 2010 Dec 23; 468(7327): 1119–1123. Published online 2010 Nov 10. doi: 10.1038/nature09589

PMCID:: PMC5415086

Abstract Article PDF–841K

Select item 47482124.

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

Panagis Filippakopoulos, Sarah Picaud, Oleg Fedorov, Marco Keller, Matthias Wrobel, Olaf Morgenstern, Franz Bracher, Stefan Knapp

Bioorg Med Chem. 2012 Mar 15; 20(6): 1878–1886. doi: 10.1016/j.bmc.2011.10.080

PMCID:: PMC4748212

Abstract Article PDF–1.3M

Select item 45144565.

SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage

Ivo A. Hendriks, Louise W. Treffers, Matty Verlaan - de Vries, Jesper V. Olsen, Alfred C.O. Vertegaal

Cell Rep. Author manuscript; available in PMC 2016 Sep 10.

Published in final edited form as: Cell Rep. 2015 Mar 17; 10(10): 1778–1791. Published online 2015 Mar 12. doi: 10.1016/j.celrep.2015.02.033

PMCID:: PMC4514456

Abstract Article PDF–2.4M

Select item 44244106.

System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability

Zhenyu Xiao, Jer-Gung Chang, Ivo A. Hendriks, Jón Otti Sigurðsson, Jesper V. Olsen, Alfred C.O. Vertegaal

Mol Cell Proteomics. 2015 May; 14(5): 1419–1434. doi: 10.1074/mcp.O114.044792

PMCID:: PMC4424410

Abstract Article PDF–2.2M

Select item 42590107.

Uncovering Global SUMOylation Signaling Networks in a Site-Specific Manner

Ivo A. Hendriks, Rochelle C.J. D’Souza, Bing Yang, Matty Verlaan-de Vries, Matthias Mann, Alfred C.O. Vertegaal

Nat Struct Mol Biol. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: Nat Struct Mol Biol. 2014 Oct; 21(10): 927–936. Published online 2014 Sep 14. doi: 10.1038/nsmb.2890

PMCID:: PMC4259010

Abstract Article PDF–2.9M

Select item 41517168.

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Francis Impens, Lilliana Radoshevich, Pascale Cossart, David Ribet

Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34): 12432–12437. Published online 2014 Aug 11. doi: 10.1073/pnas.1413825111

PMCID:: PMC4151716

Abstract Article PDF–1.0M

Select item 38869189.

Brd4 and JMJD6-associated Anti-pause Enhancers in Regulation of Transcriptional Pause Release

Wen Liu, Qi Ma, Kaki Wong, Wenbo Li, Kenny Ohgi, Jie Zhang, Aneel Aggarwal, Michael G. Rosenfeld

Cell. Author manuscript; available in PMC 2014 Dec 19.

Published in final edited form as: Cell. 2013 Dec 19; 155(7): 1581–1595. doi: 10.1016/j.cell.2013.10.056

PMCID:: PMC3886918

Abstract Article PDF–2.7M

Select item 370009510.

BRD4 Coordinates Recruitment of Pause Release Factor P-TEFb and the Pausing Complex NELF/DSIF To Regulate Transcription Elongation of Interferon-Stimulated Genes

Mira C. Patel, Maxime Debrosse, Matthew Smith, Anup Dey, Walter Huynh, Naoyuki Sarai, Tom D. Heightman, Tomohiko Tamura, Keiko Ozato

Mol Cell Biol. 2013 Jun; 33(12): 2497–2507. doi: 10.1128/MCB.01180-12

PMCID:: PMC3700095

Abstract Article PDF–2.5M

Select item 368335811.

The Bromodomain Protein Brd4 Insulates Chromatin from DNA Damage Signaling

Scott R. Floyd, Michael E. Pacold, Qiuying Huang, Scott M. Clarke, Fred C. Lam, Ian G. Cannell, Bryan D. Bryson, Jonathan Rameseder, Michael J. Lee, Emily J. Blake, Anna Fydrych, Richard Ho, Benjamin A. Greenberger, Grace C. Chen, Amanda Maffa, Amanda M. Del Rosario, David E. Root, Anne E. Carpenter, William C. Hahn, David M. Sabatini, Clark C. Chen, Forest M. White, James E. Bradner, Michael B. Yaffe

Nature. Author manuscript; available in PMC 2013 Dec 13.

Published in final edited form as: Nature. 2013 Jun 13; 498(7453): 246–250. Published online 2013 Jun 2. doi: 10.1038/nature12147

PMCID:: PMC3683358

Article PDF–1.4M

Select item 367952012.

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Mark A. Dawson, Rab K. Prinjha, Antje Dittman, George Giotopoulos, Marcus Bantscheff, Wai-In Chan, Samuel C Robson, Chun-wa Chung, Carsten Hopf, Mikhail M. Savitski, Carola Huthmacher, Emma Gudgin, Dave Lugo, Soren Beinke, Trevor D. Chapman, Emma J. Roberts, Peter E Soden, Kurt R. Auger, Olivier Mirguet, Konstanze Doehner, Ruud Delwel, Alan K. Burnett, Phillip Jeffrey, Gerard Drewes, Kevin Lee, Brian J.P Huntly, Tony Kouzarides

Nature. Author manuscript; available in PMC 2013 Jun 12.

Published in final edited form as: Nature. 2011 Oct 2; 478(7370): 529–533. Published online 2011 Oct 2. doi: 10.1038/nature10509

PMCID:: PMC3679520

Abstract Article PDF–4.2M

Select item 364041413.

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

David S. Hewings, Oleg Fedorov, Panagis Filippakopoulos, Sarah Martin, Sarah Picaud, Anthony Tumber, Christopher Wells, Monica M. Olcina, Katherine Freeman, Andrew Gill, Alison J. Ritchie, David W. Sheppard, Angela J. Russell, Ester M. Hammond, Stefan Knapp, Paul E. Brennan, Stuart J. Conway

J Med Chem. 2013 Apr 25; 56(8): 3217–3227. Published online 2013 Mar 21. doi: 10.1021/jm301588r

PMCID:: PMC3640414

Abstract Article PDF–4.0M

Select item 359539614.

Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting

Shwu-Yuan Wu, A-Young Lee, Hsien-Tsung Lai, Hong Zhang, Cheng-Ming Chiang

Mol Cell. Author manuscript; available in PMC 2014 Mar 7.

Published in final edited form as: Mol Cell. 2013 Mar 7; 49(5): 843–857. Published online 2013 Jan 11. doi: 10.1016/j.molcel.2012.12.006

PMCID:: PMC3595396

Abstract Article PDF–5.5M

Select item 352230815.

Bromodomain-containing Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells

Weishi Zhang, Celine Prakash, Calvin Sum, Yue Gong, Yinghui Li, Jeffrey J. T. Kwok, Nina Thiessen, Sven Pettersson, Steven J. M. Jones, Stefan Knapp, Henry Yang, Keh-Chuang Chin

J Biol Chem. 2012 Dec 14; 287(51): 43137–43155. Published online 2012 Oct 19. doi: 10.1074/jbc.M112.413047

PMCID:: PMC3522308

Abstract Article PDF–5.2M

Select item 350612716.

Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

Paul V. Fish, Panagis Filippakopoulos, Gerwyn Bish, Paul E. Brennan, Mark E. Bunnage, Andrew S. Cook, Oleg Federov, Brian S. Gerstenberger, Hannah Jones, Stefan Knapp, Brian Marsden, Karl Nocka, Dafydd R. Owen, Martin Philpott, Sarah Picaud, Michael J. Primiano, Michael J. Ralph, Nunzio Sciammetta, John D. Trzupek

J Med Chem. 2012 Nov 26; 55(22): 9831–9837. Published online 2012 Oct 25. doi: 10.1021/jm3010515

PMCID:: PMC3506127

Abstract Article PDF–2.9M

Select item 343657917.

Down-regulation of NF-κB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition

Guangtao Zhang, Ruijie Liu, Yifei Zhong, Alexander N. Plotnikov, Weijia Zhang, Lei Zeng, Elena Rusinova, Guillermo Gerona-Nevarro, Natasha Moshkina, Jennifer Joshua, Peter Y. Chuang, Michael Ohlmeyer, John Cijiang He, Ming-Ming Zhou

J Biol Chem. 2012 Aug 17; 287(34): 28840–28851. Published online 2012 May 29. doi: 10.1074/jbc.M112.359505

Correction in:: J Biol Chem. 2012 Nov 9; 287(46): 38956.

PMCID:: PMC3436579

Abstract Article PDF–3.2M

Select item 334500918.

BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain

Ballachanda N. Devaiah, Brian A. Lewis, Natasha Cherman, Michael C. Hewitt, Brian K. Albrecht, Pamela G. Robey, Keiko Ozato, Robert J. Sims, III, Dinah S. Singer

Proc Natl Acad Sci U S A. 2012 May 1; 109(18): 6927–6932. Published online 2012 Apr 16. doi: 10.1073/pnas.1120422109

PMCID:: PMC3345009

Abstract Article PDF–719K

Select item 332282119.

Bromodomain Protein Brd4 Associated with Acetylated Chromatin Is Important for Maintenance of Higher-order Chromatin Structure

Ranran Wang, Qing Li, Christine M. Helfer, Jing Jiao, Jianxin You

J Biol Chem. 2012 Mar 30; 287(14): 10738–10752. Published online 2012 Feb 10. doi: 10.1074/jbc.M111.323493

PMCID:: PMC3322821

Abstract Article PDF–3.1M

Select item 323918820.

Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation

Nanping Ai, Xiangming Hu, Feng Ding, Bingfei Yu, Huiping Wang, Xiaodong Lu, Kai Zhang, Yannan Li, Aidong Han, Wen Lin, Runzhong Liu, Ruichuan Chen

Nucleic Acids Res. 2011 Dec; 39(22): 9592–9604. Published online 2011 Sep 2. doi: 10.1093/nar/gkr698

PMCID:: PMC3239188

Abstract Article PDF–3.4M

PMC

Result Filters

Article attributes

Text availability

Publication date

Custom date range

Research Funder

Additional filters

Display Settings:

Send to:

Links from Protein

Items: 1 to 20 of 53

Display Settings:

Send to:

Supplemental Content

Find related data

Recent activity