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Items: 1 to 20 of 27

1.
Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA
Katherine C. Barnett, Julia M. Coronas-Serna, Wen Zhou, Michael J. Ernandes, Anh Cao, Philip J. Kranzusch, Jonathan C. Kagan
Cell. Author manuscript; available in PMC 2020 Mar 7.
Published in final edited form as: Cell. 2019 Mar 7; 176(6): 1432–1446.e11. Published online 2019 Feb 28. doi: 10.1016/j.cell.2019.01.049
PMCID:
PMC6697112
AbstractArticlePDF–2.4M
2.
ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
Huan Lian, Jin Wei, Ru Zang, Wen Ye, Qing Yang, Xia-Nan Zhang, Yun-Da Chen, Yu-Zhi Fu, Ming-Ming Hu, Cao-Qi Lei, Wei-Wei Luo, Shu Li, Hong-Bing Shu
Nat Commun. 2018; 9: 3349. Published online 2018 Aug 22. doi: 10.1038/s41467-018-05559-w
Correction in:
Nat Commun. 2021; 12: 5526.
PMCID:
PMC6105683
AbstractArticlePDF–1.3M
3.
Species-specific deamidation of cGAS by herpes simplex virus UL37 protein facilitates viral replication
Junjie Zhang, Jun Zhao, Simin Xu, Junhua Li, Shanping He, Yi Zeng, Linshen Xie, Na Xie, Ting Liu, Katie Lee, Gil Ju Seo, Lin Chen, Alex C. Stabell, Zanxian Xia, Sara L. Sawyer, Jae Jung, Canhua Huang, Pinghui Feng
Cell Host Microbe. Author manuscript; available in PMC 2018 Aug 16.
Published in final edited form as: Cell Host Microbe. 2018 Aug 8; 24(2): 234–248.e5. doi: 10.1016/j.chom.2018.07.004
PMCID:
PMC6094942
AbstractArticlePDF–2.6M
4.
Structure of the human cGAS–DNA complex reveals enhanced control of immune surveillance
Wen Zhou, Aaron T. Whiteley, Carina C. de Oliveira Mann, Benjamin R. Morehouse, Radostaw P. Nowak, Eric S. Fischer, Nathanael S. Gray, John J. Mekalanos, Philip J. Kranzusch
Cell. Author manuscript; available in PMC 2019 Jul 12.
Published in final edited form as: Cell. 2018 Jul 12; 174(2): 300–311.e11. doi: 10.1016/j.cell.2018.06.026
PMCID:
PMC6084792
AbstractArticlePDF–1.3M
5.
cGAS surveillance of micronuclei links genome instability to innate immunity
Karen J. Mackenzie, Paula Carroll, Carol-Anne Martin, Olga Murina, Adeline Fluteau, Daniel Simpson, Nelly Olova, Hannah Sutcliffe, Jacqueline Rainger, Andrea Robertson, Ruby Osborn, Ann Wheeler, Marcin Nowotny, Nick Gilbert, Tamir Chandra, Martin A. M. Reijns, Andrew P. Jackson
Nature. Author manuscript; available in PMC 2018 Mar 27.
Published in final edited form as: Nature. 2017 Aug 24; 548(7668): 461–465. Published online 2017 Jul 24. doi: 10.1038/nature23449
PMCID:
PMC5870830
AbstractArticlePDF–4.1M
6.
Mitotic progression following DNA damage enables pattern recognition within micronuclei
Shane M Harding, Joseph L Benci, Jerome Irianto, Dennis E Discher, Andy J Minn, Roger A Greenberg
Nature. Author manuscript; available in PMC 2018 Mar 18.
Published in final edited form as: Nature. 2017 Aug 24; 548(7668): 466–470. Published online 2017 Jul 31. doi: 10.1038/nature23470
PMCID:
PMC5857357
AbstractArticlePDF–3.2M
7.
The catalytic mechanism of cyclic GMP‐AMP synthase (cGAS) and implications for innate immunity and inhibition
Justin Hall, Erik C. Ralph, Suman Shanker, Hong Wang, Laura J. Byrnes, Reto Horst, Jimson Wong, Amy Brault, Darren Dumlao, James F. Smith, Leslie A. Dakin, Daniel C. Schmitt, John Trujillo, Fabien Vincent, Matt Griffor, Ann E. Aulabaugh
Protein Sci. 2017 Dec; 26(12): 2367–2380. Published online 2017 Oct 25. doi: 10.1002/pro.3304
PMCID:
PMC5699495
AbstractArticlePDF–784K
8.
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
Justin Hall, Amy Brault, Fabien Vincent, Shawn Weng, Hong Wang, Darren Dumlao, Ann Aulabaugh, Dikran Aivazian, Dana Castro, Ming Chen, Jeffrey Culp, Ken Dower, Joseph Gardner, Steven Hawrylik, Douglas Golenbock, David Hepworth, Mark Horn, Lyn Jones, Peter Jones, Eicke Latz, Jing Li, Lih-Ling Lin, Wen Lin, David Lin, Frank Lovering, Nootaree Niljanskul, Ryan Nistler, Betsy Pierce, Olga Plotnikova, Daniel Schmitt, Suman Shanker, James Smith, William Snyder, Timothy Subashi, John Trujillo, Edyta Tyminski, Guoxing Wang, Jimson Wong, Bruce Lefker, Leslie Dakin, Karen Leach
PLoS One. 2017; 12(9): e0184843. Published online 2017 Sep 21. doi: 10.1371/journal.pone.0184843
PMCID:
PMC5608272
AbstractArticlePDF–8.3M
9.
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
Philip J. Kranzusch, Stephen C. Wilson, Amy S.Y. Lee, James M. Berger, Jennifer A. Doudna, Russell E. Vance
Mol Cell. Author manuscript; available in PMC 2016 Sep 17.
Published in final edited form as: Mol Cell. 2015 Sep 17; 59(6): 891–903. Published online 2015 Aug 20. doi: 10.1016/j.molcel.2015.07.022
PMCID:
PMC4575873
AbstractArticlePDF–2.5M
10.
Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein
Jian-jun Wu, Wenwei Li, Yaming Shao, Denis Avey, Bishi Fu, Joseph Gillen, Travis Hand, Siming Ma, Xia Liu, Wendell Miley, Andreas Konrad, Frank Neipel, Michael Stürzl, Denise Whitby, Hong Li, Fanxiu Zhu
Cell Host Microbe. Author manuscript; available in PMC 2016 Sep 9.
Published in final edited form as: Cell Host Microbe. 2015 Sep 9; 18(3): 333–344. Published online 2015 Aug 27. doi: 10.1016/j.chom.2015.07.015
PMCID:
PMC4567405
AbstractArticlePDF–3.8M
11.
PQBP1 is a Proximal Sensor of the cGAS-dependent Innate Response to HIV-1
Sunnie M. Yoh, Monika Schneider, Janna Seifried, Stephen Soonthornvacharin, Rana E. Akleh, Kevin C. Olivieri, Paul D. De Jesus, Chunhai Ruan, Elisa de Castro, Pedro A. Ruiz, David Germanaud, Vincent des Portes, Adolfo García-Sastre, Renate König, Sumit K. Chanda
Cell. Author manuscript; available in PMC 2016 Jun 4.
Published in final edited form as: Cell. 2015 Jun 4; 161(6): 1293–1305. doi: 10.1016/j.cell.2015.04.050
PMCID:
PMC4503237
AbstractArticlePDF–4.7M
12.
Structure-guided reprogramming of human cGAS dinucleotide linkage specificity
Philip J. Kranzusch, Amy S.Y. Lee, Stephen C. Wilson, Mikhail S. Solovykh, Russell E. Vance, James M. Berger, Jennifer A. Doudna
Cell. Author manuscript; available in PMC 2015 Aug 28.
Published in final edited form as: Cell. 2014 Aug 28; 158(5): 1011–1021. Published online 2014 Aug 14. doi: 10.1016/j.cell.2014.07.028
PMCID:
PMC4157622
AbstractArticlePDF–6.4M
13.
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
Andrea Ablasser, Jonathan L. Schmid-Burgk, Inga Hemmerling, Gabor L. Horvath, Tobias Schmidt, Eicke Latz, Veit Hornung
Nature. Author manuscript; available in PMC 2014 Aug 25.
Published in final edited form as: Nature. 2013 Nov 28; 503(7477): 530–534. Published online 2013 Sep 29. doi: 10.1038/nature12640
PMCID:
PMC4142317
AbstractArticlePDF–2.1M
14.
The Cytosolic DNA Sensor cGAS Forms An Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
Xu Zhang, Jiaxi Wu, Fenghe Du, Hui Xu, Lijun Sun, Zhe Chen, Chad A. Brautigam, Xuewu Zhang, Zhijian J. Chen
Cell Rep. Author manuscript; available in PMC 2014 Mar 30.
Published in final edited form as: Cell Rep. 2014 Feb 13; 6(3): 421–430. Published online 2014 Jan 23. doi: 10.1016/j.celrep.2014.01.003
PMCID:
PMC3969844
AbstractArticlePDF–3.2M
15.
Cyclic GMP-AMP Synthase is Activated by Double-stranded DNA-Induced Oligomerization
Xin Li, Chang Shu, Guanghui Yi, Catherine T. Chaton, Catherine L. Shelton, Jiasheng Diao, Xiaobing Zuo, C Cheng Kao, Andrew B. Herr, Pingwei Li
Immunity. Author manuscript; available in PMC 2014 Dec 12.
Published in final edited form as: Immunity. 2013 Dec 12; 39(6): 10.1016/j.immuni.2013.10.019. doi: 10.1016/j.immuni.2013.10.019
PMCID:
PMC3886715
AbstractArticlePDF–5.6M
16.
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
Lijun Sun, Jiaxi Wu, Fenghe Du, Xiang Chen, Zhijian J. Chen
Science. Author manuscript; available in PMC 2013 Dec 15.
Published in final edited form as: Science. 2013 Feb 15; 339(6121): 10.1126/science.1232458. Published online 2012 Dec 20. doi: 10.1126/science.1232458
PMCID:
PMC3863629
AbstractArticlePDF–4.2M
17.
Cyclic GMP-AMP Synthase is an Innate Immune Sensor of HIV and Other Retroviruses
Daxing Gao, Jiaxi Wu, You-Tong Wu, Fenghe Du, Chukwuemika Aroh, Nan Yan, Lijun Sun, Zhijian J. Chen
Science. Author manuscript; available in PMC 2014 Feb 23.
Published in final edited form as: Science. 2013 Aug 23; 341(6148): 10.1126/science.1240933. Published online 2013 Aug 8. doi: 10.1126/science.1240933
PMCID:
PMC3860819
AbstractArticlePDF–1.6M
18.
Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity
Philip J. Kranzusch, Amy Si-Ying Lee, James M. Berger, Jennifer A. Doudna
Cell Rep. Author manuscript; available in PMC 2013 Nov 30.
Published in final edited form as: Cell Rep. 2013 May 30; 3(5): 1362–1368. Published online 2013 May 23. doi: 10.1016/j.celrep.2013.05.008
PMCID:
PMC3800681
AbstractArticlePDF–924K
19.
Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS
Kazuki Kato, Ryohei Ishii, Eiji Goto, Ryuichiro Ishitani, Fuminori Tokunaga, Osamu Nureki
PLoS One. 2013; 8(10): e76983. Published online 2013 Oct 7. doi: 10.1371/journal.pone.0076983
PMCID:
PMC3792152
AbstractArticlePDF–1.5M
20.
Structural mechanism of cytosolic DNA sensing by cGAS
Filiz Civril, Tobias Deimling, Carina C. de Oliveira Mann, Andrea Ablasser, Manuela Moldt, Gregor Witte, Veit Hornung, Karl-Peter Hopfner
Nature. Author manuscript; available in PMC 2013 Dec 20.
Published in final edited form as: Nature. 2013 Jun 20; 498(7454): 332–337. Published online 2013 May 30. doi: 10.1038/nature12305
PMCID:
PMC3768140
AbstractArticlePDF–1.6M

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